CY1123488T1 - Πεντακυκλοθειενυλο και ινδανυλο παραγωγα ουριας ως παραγοντες διανοιξης διαυλου καλιου - Google Patents
Πεντακυκλοθειενυλο και ινδανυλο παραγωγα ουριας ως παραγοντες διανοιξης διαυλου καλιουInfo
- Publication number
- CY1123488T1 CY1123488T1 CY20201101052T CY201101052T CY1123488T1 CY 1123488 T1 CY1123488 T1 CY 1123488T1 CY 20201101052 T CY20201101052 T CY 20201101052T CY 201101052 T CY201101052 T CY 201101052T CY 1123488 T1 CY1123488 T1 CY 1123488T1
- Authority
- CY
- Cyprus
- Prior art keywords
- class
- groups
- unsubstituted
- substituted
- pentacyclothienyl
- Prior art date
Links
- WAQCADIPNPIBPZ-UHFFFAOYSA-N 2,3-dihydro-1h-inden-1-ylurea Chemical class C1=CC=C2C(NC(=O)N)CCC2=C1 WAQCADIPNPIBPZ-UHFFFAOYSA-N 0.000 title 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 229910052700 potassium Inorganic materials 0.000 title 1
- 239000011591 potassium Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229940127315 Potassium Channel Openers Drugs 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- -1 cyclopentathienyl Chemical class 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cosmetics (AREA)
- Fertilizers (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η παρούσα εφεύρεση αποκαλύπτει νέες ενώσεις οι οποίες είναι χρήσιμες ως παράγοντες διάνοιξης διαύλου καλίου, ειδικότερα ως παράγοντες διάνοιξης του διαύλου καλίου Κv7.4. Οι νέες ενώσεις είναι ενώσεις σύμφωνα με τον τύπο Ι, όπου – n = 0 ή 1, - RL είναι υποκαταστάτης επιλεγόμενος από την ομάδα που αποτελείται από ομάδες κατηγορίας μη-υποκατεστημένου ή υποκατεστημένου κυκλοαλκυλίου, ιδίως ομάδες κατηγορίας δικυκλοαλκυλίου, ομάδες κατηγορίας μη-υποκατεστημένου ή υποκατεστημένου φαινυλίου, ομάδες κατηγορίας μη-υποκατεστημένου ή υποκατεστημένου θειενυλίου ή ομάδες κατηγορίας κυκλοπενταθειενυλίου, και ομάδες κατηγορίας μη-υποκατεστημένου ή υποκατεστημένου ινδανυλίου, οι οποίες προαιρετικά περιέχουν ετεροάτομα, και - RR είναι υποκαταστάτης επιλεγόμενος από την ομάδα που αποτελείται από ομάδες κατηγορίας μη-υποκατεστημένου ή υποκατεστημένου φαινυλίου ή ομάδες κατηγορίας μη-υποκατεστημένου ή υποκατεστημένου βενζυλίου, οι οποίες προαιρετικά περιέχουν ετεροάτομα, ή - στερεοϊσομερές, ταυτομερές, προφάρμακο ή άλας, κατά προτίμηση αποδεκτό από φαρμακευτική άποψη άλας αυτών.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17158326.3A EP3366683A1 (en) | 2017-02-28 | 2017-02-28 | Cyclic amides, acteamides and ureas useful as potassium channel openers |
| PCT/EP2018/054820 WO2018158256A2 (en) | 2017-02-28 | 2018-02-27 | Novel compounds useful as potassium channel openers |
| EP18707374.7A EP3484863B1 (en) | 2017-02-28 | 2018-02-27 | Cyclic amides as potassium channel openers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1123488T1 true CY1123488T1 (el) | 2022-03-24 |
Family
ID=58192162
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201100634T CY1123114T1 (el) | 2017-02-28 | 2020-07-09 | Νεες ενωσεις χρησιμες ως παραγοντες διανοιξης διαυλων καλιου |
| CY20201101052T CY1123488T1 (el) | 2017-02-28 | 2020-11-09 | Πεντακυκλοθειενυλο και ινδανυλο παραγωγα ουριας ως παραγοντες διανοιξης διαυλου καλιου |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201100634T CY1123114T1 (el) | 2017-02-28 | 2020-07-09 | Νεες ενωσεις χρησιμες ως παραγοντες διανοιξης διαυλων καλιου |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US11034665B2 (el) |
| EP (3) | EP3366683A1 (el) |
| JP (3) | JP6795713B2 (el) |
| KR (2) | KR102443685B1 (el) |
| CN (2) | CN114105942B (el) |
| AU (2) | AU2018227005B2 (el) |
| BR (2) | BR112019017184B1 (el) |
| CA (2) | CA3238405A1 (el) |
| CL (2) | CL2019002445A1 (el) |
| CY (2) | CY1123114T1 (el) |
| DK (2) | DK3567034T3 (el) |
| ES (2) | ES2813064T3 (el) |
| HR (2) | HRP20201159T1 (el) |
| HU (2) | HUE052703T2 (el) |
| IL (1) | IL268931B (el) |
| LT (2) | LT3484863T (el) |
| MX (2) | MX378574B (el) |
| PH (1) | PH12019550146A1 (el) |
| PL (2) | PL3484863T3 (el) |
| PT (2) | PT3484863T (el) |
| RS (2) | RS60648B1 (el) |
| SI (2) | SI3484863T1 (el) |
| SM (2) | SMT202000471T1 (el) |
| WO (1) | WO2018158256A2 (el) |
| ZA (1) | ZA201905198B (el) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3366683A1 (en) * | 2017-02-28 | 2018-08-29 | Acousia Therapeutics GmbH | Cyclic amides, acteamides and ureas useful as potassium channel openers |
| US20230136562A1 (en) | 2020-04-29 | 2023-05-04 | Idorsia Pharmaceuticals Ltd | Spirourea derivatives |
| CN115702141A (zh) | 2020-06-25 | 2023-02-14 | 爱杜西亚药品有限公司 | 环丁基-脲衍生物 |
| IL302986A (en) * | 2020-11-19 | 2023-07-01 | Acousia Therapeutics Gmbh | Non-Aqueous Gel Composition |
| EP4279061A1 (en) * | 2022-05-18 | 2023-11-22 | Acousia Therapeutics GmbH | Aqueous gel composition |
Family Cites Families (37)
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| JPH0594034A (ja) | 1990-06-29 | 1993-04-16 | Xerox Corp | クラツクのない電子写真画像形成デバイス |
| ES2188095T3 (es) * | 1998-04-15 | 2003-06-16 | Pfizer Prod Inc | Carboxamidas heterociclicas. |
| DE19929076A1 (de) * | 1999-06-25 | 2000-12-28 | Aventis Pharma Gmbh | Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10061876A1 (de) | 2000-12-12 | 2002-06-20 | Aventis Pharma Gmbh | Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| WO2002080898A2 (en) | 2001-04-04 | 2002-10-17 | Wyeth | Methods for treating hyperactive gastric motility |
| US7273866B2 (en) * | 2002-12-20 | 2007-09-25 | Bristol-Myers Squibb Company | 2-aryl thiazole derivatives as KCNQ modulators |
| AU2004222626B2 (en) | 2003-03-21 | 2010-06-24 | H. Lundbeck A/S | Substituted p-diaminobenzene derivatives |
| TWI357901B (en) | 2004-03-12 | 2012-02-11 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivati |
| UA89503C2 (uk) | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
| US20060188445A1 (en) | 2005-02-22 | 2006-08-24 | Fred Hutchinson Cancer Research Center | Assay for compounds that protect against sensory hair cell death and compounds identified by same |
| US7790770B2 (en) * | 2005-11-23 | 2010-09-07 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| WO2007087424A2 (en) | 2006-01-25 | 2007-08-02 | The Johns Hopkins University | Method of treating kcnq related disorders using organozinc compounds |
| WO2007138112A2 (en) | 2006-06-01 | 2007-12-06 | Devgen N.V. | Compounds that interact with ion channels, in particular with ion channels from the kv family |
| US20090118274A1 (en) * | 2007-02-15 | 2009-05-07 | Darin Allen | Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
| DE102007063673B4 (de) | 2007-07-10 | 2018-02-08 | Heraeus Electro-Nite International N.V. | Messverfahren |
| NZ582942A (en) * | 2007-08-01 | 2011-09-30 | Lundbeck & Co As H | Use of kncq potassium channel openers for treating attention deficit hyperactivity disorder (adhd) or aggression |
| HRP20110762T1 (hr) | 2007-10-17 | 2011-11-30 | Sanofi | Supstituirani n-fenilbipirolidinkarboksamidi i njihova upotreba u terapiji |
| CA2707492A1 (en) * | 2007-12-13 | 2009-06-18 | Amgen Inc. | Gamma secretase modulators |
| US7786171B2 (en) * | 2008-04-04 | 2010-08-31 | Abbott Laboratories | Amide derivatives as positive allosteric modulators and methods of use thereof |
| TW201038572A (en) | 2009-03-25 | 2010-11-01 | Gruenenthal Gmbh | Substituted spiro-amide compounds |
| EP2438037A1 (en) * | 2009-06-04 | 2012-04-11 | Merz Pharma GmbH & Co. KGaA | Glycine b antagonists |
| WO2011085351A2 (en) * | 2010-01-11 | 2011-07-14 | The Johns Hopkins University | Method of treating kcnq related disorders |
| DE102010007281A1 (de) | 2010-02-08 | 2011-08-11 | EMC microcollections GmbH, 72070 | Neue Aminoalkyl-oxazol- und Aminoalkyl-thiazolcarbonsäureamide und ihre Anwendung zur Stimulation der endogenen situ Regeneration von Haarsinneszellen im Corti'schen Organ des Innenohres beim Säuger |
| US8586604B2 (en) | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
| TW201217312A (en) * | 2010-09-22 | 2012-05-01 | Gruenenthal Gmbh | Substituted benzamide compounds |
| ES2656972T3 (es) * | 2012-02-23 | 2018-03-01 | Vanderbilt University | Análogos de 5-aminotieno [2,3-c] piridazin-6-carboxamida como moduladores alostéricos positivos del receptor de acetilcolina muscarínico M4 |
| US9416141B2 (en) | 2012-09-28 | 2016-08-16 | University Of Washington Through Its Center For Commercialization | Compounds and methods for preventing, treating and/or protecting against sensory hair cell death |
| WO2014079850A1 (en) * | 2012-11-23 | 2014-05-30 | F. Hoffmann-La Roche Ag | Substituted heterocyclic derivatives |
| US9572815B2 (en) * | 2013-03-15 | 2017-02-21 | St. Jude Children's Research Hospital | Methods and compositions of p27KIP1 transcriptional modulators |
| PL404138A1 (pl) * | 2013-05-31 | 2014-12-08 | Warszawski Uniwersytet Medyczny | Pochodne kwasu benzoesowego jako inhibitory receptora IL-15Rα |
| US20150126507A1 (en) * | 2013-09-05 | 2015-05-07 | Fate Therapeutics, Inc. | Compounds to treat hearing loss |
| TW201609665A (zh) * | 2013-11-05 | 2016-03-16 | 赫孚孟拉羅股份公司 | 作為ＲＯＲｃ調節劑的嗒衍生物 |
| ES2607752T3 (es) * | 2013-11-12 | 2017-04-03 | Acousia Therapeutics Gmbh | Compuestos nuevos para regeneración de células y tejidos terminalmente diferenciados |
| CN105017085B (zh) | 2014-04-28 | 2018-06-29 | 中国科学院上海药物研究所 | 一类kcnq钾通道激动剂、其制备方法和用途 |
| US10399994B2 (en) * | 2015-02-06 | 2019-09-03 | University Of Washington | Compounds and methods for preventing or treating sensory hair cell death |
| GB201601301D0 (en) | 2016-01-25 | 2016-03-09 | Takeda Pharmaceutical | Novel compounds |
| EP3366683A1 (en) | 2017-02-28 | 2018-08-29 | Acousia Therapeutics GmbH | Cyclic amides, acteamides and ureas useful as potassium channel openers |
-
2017
- 2017-02-28 EP EP17158326.3A patent/EP3366683A1/en not_active Withdrawn
-
2018
- 2018-02-27 ES ES18707374T patent/ES2813064T3/es active Active
- 2018-02-27 PL PL18707374T patent/PL3484863T3/pl unknown
- 2018-02-27 CN CN202111376413.6A patent/CN114105942B/zh active Active
- 2018-02-27 ES ES19179900T patent/ES2846772T3/es active Active
- 2018-02-27 RS RS20200895A patent/RS60648B1/sr unknown
- 2018-02-27 EP EP18707374.7A patent/EP3484863B1/en active Active
- 2018-02-27 PL PL19179900T patent/PL3567034T3/pl unknown
- 2018-02-27 PT PT187073747T patent/PT3484863T/pt unknown
- 2018-02-27 KR KR1020217035304A patent/KR102443685B1/ko active Active
- 2018-02-27 MX MX2019010169A patent/MX378574B/es unknown
- 2018-02-27 JP JP2019567399A patent/JP6795713B2/ja active Active
- 2018-02-27 WO PCT/EP2018/054820 patent/WO2018158256A2/en active IP Right Grant
- 2018-02-27 HR HRP20201159TT patent/HRP20201159T1/hr unknown
- 2018-02-27 PT PT191799006T patent/PT3567034T/pt unknown
- 2018-02-27 SI SI201830113T patent/SI3484863T1/sl unknown
- 2018-02-27 MX MX2020010866A patent/MX390303B/es unknown
- 2018-02-27 HU HUE19179900A patent/HUE052703T2/hu unknown
- 2018-02-27 DK DK19179900.6T patent/DK3567034T3/da active
- 2018-02-27 AU AU2018227005A patent/AU2018227005B2/en active Active
- 2018-02-27 US US16/487,933 patent/US11034665B2/en active Active
- 2018-02-27 SI SI201830189T patent/SI3567034T1/sl unknown
- 2018-02-27 CN CN201880014217.4A patent/CN110312710B/zh active Active
- 2018-02-27 DK DK18707374.7T patent/DK3484863T3/da active
- 2018-02-27 EP EP19179900.6A patent/EP3567034B1/en active Active
- 2018-02-27 SM SM20200471T patent/SMT202000471T1/it unknown
- 2018-02-27 RS RS20201546A patent/RS61254B1/sr unknown
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