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CY1122984T1 - Καρβαμιδικες ενωσεις και μεθοδοι παρασκευης και χρησης τους - Google Patents

Καρβαμιδικες ενωσεις και μεθοδοι παρασκευης και χρησης τους

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Publication number
CY1122984T1
CY1122984T1 CY20201100357T CY201100357T CY1122984T1 CY 1122984 T1 CY1122984 T1 CY 1122984T1 CY 20201100357 T CY20201100357 T CY 20201100357T CY 201100357 T CY201100357 T CY 201100357T CY 1122984 T1 CY1122984 T1 CY 1122984T1
Authority
CY
Cyprus
Prior art keywords
preparation
methods
compounds
carbamide compounds
disclosure
Prior art date
Application number
CY20201100357T
Other languages
English (en)
Inventor
Justin S Cisar
Cheryl A. Grice
Todd K. Jones
Micah J. NIPHAKIS
Jae Won Chang
Kenneth M. LUM
Benjamin F. Cravatt
Original Assignee
Lundbeck La Jolla Research Center, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck La Jolla Research Center, Inc. filed Critical Lundbeck La Jolla Research Center, Inc.
Publication of CY1122984T1 publication Critical patent/CY1122984T1/el

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/22—Anxiolytics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract

Η γνωστοποίηση αυτή παρέχει ενώσεις και συνθέσεις οι οποίες μπορεί να είναι ρυθμιστές των ΜΑGL και/ή ΑΒΗD6 και τη χρήση τους ως φαρμακευτικοί παράγοντες, διαδικασίες για την παρασκευή τους, και φαρμακευτικές συνθέσεις οι οποίες περιλαμβάνουν γνωστοποιούμενες ενώσεις ως τουλάχιστον έναν δραστικό παράγοντα. Η γνωστοποίηση παρέχει επίσης μέθοδο αγωγής ενός ασθενούς ο οποίος την έχει ανάγκη, όπου ο ασθενής πάσχει από ενδείξεις όπως πόνο, καρκίνο συμπαγούς όγκου και/ή παχυσαρκία η οποία μέθοδος περιλαμβάνει χορήγηση μιας γνωστοποιούμενης ένωσης ή σύνθεσης.
CY20201100357T 2012-01-06 2020-04-15 Καρβαμιδικες ενωσεις και μεθοδοι παρασκευης και χρησης τους CY1122984T1 (el)

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