CY1122792T1 - Παραγωγα μονο- ή δισυποκατεστημενης ινδολης ως αναστολεις αναδιπλασιασμου δαγκειου ιου - Google Patents
Παραγωγα μονο- ή δισυποκατεστημενης ινδολης ως αναστολεις αναδιπλασιασμου δαγκειου ιουInfo
- Publication number
- CY1122792T1 CY1122792T1 CY20201100216T CY201100216T CY1122792T1 CY 1122792 T1 CY1122792 T1 CY 1122792T1 CY 20201100216 T CY20201100216 T CY 20201100216T CY 201100216 T CY201100216 T CY 201100216T CY 1122792 T1 CY1122792 T1 CY 1122792T1
- Authority
- CY
- Cyprus
- Prior art keywords
- mono
- compounds
- disubtituted
- dange
- virus replication
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Η παρούσα εφεύρεση αφορά σε ενώσεις μονο- ή δισυποκατεστημένης ινδόλης, μεθόδους πρόληψης ή θεραπευτικής αντιμετώπισης των μολύνσεων από δάγκειο ιό χρησιμοποιώντας τις εν λόγω ενώσεις και αναφέρεται επίσης σ' αυτές τις ενώσεις για χρήση ως φάρμακο, προτιμότερα για χρήση ως φάρμακο για τη θεραπευτική αντιμετώπιση ή πρόληψη μολύνσεων από δάγκειο ιό. Η παρούσα εφεύρεση αναφέρεται περαιτέρω σε φαρμακευτικές συνθέσεις ή σκευάσματα συνδυασμού των ενώσεων, σε συνθέσεις ή σκευάσματα για χρήση ως φάρμακο, προτιμότερα για την πρόληψη ή τη θεραπευτική αντιμετώπιση μόλυνση από δάγκειο ιό. Η εφεύρεση αναφέρεται επίσης σε διαδικασίες για την παρασκευή των ενώσεων.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15185522 | 2015-09-16 | ||
| EP16163465 | 2016-04-01 | ||
| PCT/EP2016/071852 WO2017046258A1 (en) | 2015-09-16 | 2016-09-15 | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1122792T1 true CY1122792T1 (el) | 2021-05-05 |
Family
ID=56958913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201100216T CY1122792T1 (el) | 2015-09-16 | 2020-03-12 | Παραγωγα μονο- ή δισυποκατεστημενης ινδολης ως αναστολεις αναδιπλασιασμου δαγκειου ιου |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US10786484B2 (el) |
| EP (1) | EP3350163B1 (el) |
| JP (2) | JP7045984B2 (el) |
| KR (1) | KR102676442B1 (el) |
| CN (1) | CN108368044B (el) |
| AU (1) | AU2016323535B2 (el) |
| CA (1) | CA2996856C (el) |
| CL (1) | CL2018000697A1 (el) |
| CO (1) | CO2018003369A2 (el) |
| CR (1) | CR20180214A (el) |
| CY (1) | CY1122792T1 (el) |
| DK (1) | DK3350163T3 (el) |
| EA (1) | EA035679B1 (el) |
| EC (1) | ECSP18020039A (el) |
| ES (1) | ES2778431T3 (el) |
| HK (1) | HK1258320A1 (el) |
| HR (1) | HRP20200408T1 (el) |
| IL (1) | IL258031B (el) |
| JO (1) | JO3633B1 (el) |
| LT (1) | LT3350163T (el) |
| MA (1) | MA42811B1 (el) |
| MD (1) | MD3350163T2 (el) |
| ME (1) | ME03674B (el) |
| MX (1) | MX381632B (el) |
| MY (1) | MY188347A (el) |
| NI (1) | NI201800040A (el) |
| PE (1) | PE20181007A1 (el) |
| PH (1) | PH12018500569B1 (el) |
| PL (1) | PL3350163T3 (el) |
| PT (1) | PT3350163T (el) |
| RS (1) | RS60039B1 (el) |
| SI (1) | SI3350163T1 (el) |
| SM (1) | SMT202000140T1 (el) |
| TW (1) | TWI758256B (el) |
| UA (1) | UA123672C2 (el) |
| UY (1) | UY36904A (el) |
| WO (1) | WO2017046258A1 (el) |
| ZA (1) | ZA201801764B (el) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| KR101818521B1 (ko) * | 2011-11-16 | 2018-01-16 | 대우조선해양 주식회사 | 마이크로채널 열교환기용 2상 유체 공급장치 및 그 방법 |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| MD3390395T2 (ro) | 2015-12-16 | 2021-02-28 | Loxo Oncology Inc | Compuși utili ca inhibitori ai kinazei |
| SG11201808270PA (en) | 2016-03-31 | 2018-10-30 | Janssen Pharmaceuticals Inc | Substituted indoline derivatives as dengue viral replication inhibitors |
| WO2017167950A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indole derivatives as dengue viral replication inhibitors |
| KR102359766B1 (ko) | 2016-04-01 | 2022-02-07 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서 치환된 인돌 화합물 유도체 |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| PE20200342A1 (es) | 2017-05-22 | 2020-02-14 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
| JP7203764B2 (ja) | 2017-05-22 | 2023-01-13 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | デングウイルス複製阻害剤としての置換インドリン誘導体 |
| WO2024178504A1 (en) * | 2023-02-27 | 2024-09-06 | Enveric Biosciences Canada Inc. | Tri-halo-alkoxy-substituted tryptamine derivatives and methods of using |
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| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| AU2002364566B2 (en) | 2001-12-12 | 2009-03-26 | Conforma Therapeutics Corporation | Assays and implements for determining and modulating HSP90 binding activity |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| MX2007008587A (es) | 2005-01-14 | 2007-09-07 | Genelabs Tech Inc | Derivados de indol para tratamiento de infecciones virales. |
| CA2597213A1 (en) | 2005-02-09 | 2006-09-14 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
| FR2928645A1 (fr) * | 2008-03-14 | 2009-09-18 | Sanofi Aventis Sa | Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
| CN102056483A (zh) | 2008-06-03 | 2011-05-11 | 西佳技术公司 | 用于治疗或预防登革病毒感染的小分子抑制剂 |
| MX2011001872A (es) * | 2008-08-18 | 2011-05-23 | Univ Yale | Moduladores de mif. |
| JP5559174B2 (ja) | 2008-08-19 | 2014-07-23 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 冷感−メントール受容体拮抗剤 |
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| GB0910003D0 (en) * | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
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| NZ600816A (en) | 2010-01-15 | 2014-08-29 | Gilead Sciences Inc | Inhibitors of flaviviridae viruses |
| JP5716205B2 (ja) * | 2011-03-29 | 2015-05-13 | 学校法人日本大学 | グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法 |
| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) * | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
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| EP3988549A1 (en) | 2014-01-31 | 2022-04-27 | Bristol-Myers Squibb Company | Macrocycles with heterocyclic p2' groups as factor xia inhibitors |
| PT3201176T (pt) | 2014-10-01 | 2019-03-04 | Janssen Pharmaceuticals Inc | Derivados indol mono- ou dissubstituídos como inibidores da replicação viral do dengue |
| NO2721243T3 (el) | 2014-10-01 | 2018-10-20 | ||
| US10206902B2 (en) | 2014-10-01 | 2019-02-19 | Janssen Pharmaceuticals, Inc. | Mono- or di-substituted indoles as dengue viral replication inhibitors |
| PH12017501272B1 (en) * | 2015-01-16 | 2023-01-11 | Janssen Pharmaceuticals Inc | Indole derivatives as dengue viral replication inhibitors |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) * | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| AU2016350868B2 (en) | 2015-11-03 | 2022-03-31 | Zoetis Services Llc | Sol-gel polymer composites and uses thereof |
| SG11201808270PA (en) | 2016-03-31 | 2018-10-30 | Janssen Pharmaceuticals Inc | Substituted indoline derivatives as dengue viral replication inhibitors |
| JP6788683B2 (ja) | 2016-03-31 | 2020-11-25 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2017167950A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indole derivatives as dengue viral replication inhibitors |
| TWI691596B (zh) | 2016-04-01 | 2020-04-21 | 美商凱特製藥公司 | 嵌合抗原和ｔ細胞受體及使用方法 |
| KR102359766B1 (ko) | 2016-04-01 | 2022-02-07 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서 치환된 인돌 화합물 유도체 |
| US10576085B2 (en) | 2016-04-01 | 2020-03-03 | Signal Pharmaceuticals, Llc | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith |
| ES2928005T3 (es) | 2016-04-01 | 2022-11-14 | Basf Se | Compuestos bicíclicos |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| PL3436030T3 (pl) | 2016-04-01 | 2022-12-19 | Kite Pharma, Inc. | Receptory chimeryczne i sposoby ich zastosowania |
| IL296966A (en) | 2016-04-01 | 2022-12-01 | Amgen Inc | Chimeric flt-3 receptors and methods of using them |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| PE20200342A1 (es) | 2017-05-22 | 2020-02-14 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
| JP7203764B2 (ja) | 2017-05-22 | 2023-01-13 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | デングウイルス複製阻害剤としての置換インドリン誘導体 |
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2016
- 2016-09-06 JO JOP/2016/0197A patent/JO3633B1/ar active
- 2016-09-13 TW TW105129691A patent/TWI758256B/zh not_active IP Right Cessation
- 2016-09-15 RS RS20200272A patent/RS60039B1/sr unknown
- 2016-09-15 ES ES16767235T patent/ES2778431T3/es active Active
- 2016-09-15 JP JP2018513845A patent/JP7045984B2/ja active Active
- 2016-09-15 MA MA42811A patent/MA42811B1/fr unknown
- 2016-09-15 PL PL16767235T patent/PL3350163T3/pl unknown
- 2016-09-15 LT LTEP16767235.1T patent/LT3350163T/lt unknown
- 2016-09-15 PT PT167672351T patent/PT3350163T/pt unknown
- 2016-09-15 US US15/759,844 patent/US10786484B2/en active Active
- 2016-09-15 MY MYPI2018000378A patent/MY188347A/en unknown
- 2016-09-15 CN CN201680053589.9A patent/CN108368044B/zh active Active
- 2016-09-15 SM SM20200140T patent/SMT202000140T1/it unknown
- 2016-09-15 DK DK16767235.1T patent/DK3350163T3/da active
- 2016-09-15 EA EA201890723A patent/EA035679B1/ru not_active IP Right Cessation
- 2016-09-15 AU AU2016323535A patent/AU2016323535B2/en active Active
- 2016-09-15 ME MEP-2020-53A patent/ME03674B/me unknown
- 2016-09-15 CA CA2996856A patent/CA2996856C/en active Active
- 2016-09-15 WO PCT/EP2016/071852 patent/WO2017046258A1/en active Application Filing
- 2016-09-15 UA UAA201804016A patent/UA123672C2/uk unknown
- 2016-09-15 EP EP16767235.1A patent/EP3350163B1/en active Active
- 2016-09-15 KR KR1020187009485A patent/KR102676442B1/ko active Active
- 2016-09-15 PE PE2018000391A patent/PE20181007A1/es unknown
- 2016-09-15 MD MDE20180704T patent/MD3350163T2/ro unknown
- 2016-09-15 CR CR20180214A patent/CR20180214A/es unknown
- 2016-09-15 MX MX2018003256A patent/MX381632B/es unknown
- 2016-09-15 SI SI201630686T patent/SI3350163T1/sl unknown
- 2016-09-15 PH PH1/2018/500569A patent/PH12018500569B1/en unknown
- 2016-09-16 UY UY0001036904A patent/UY36904A/es not_active Application Discontinuation
-
2018
- 2018-03-12 IL IL258031A patent/IL258031B/en active IP Right Grant
- 2018-03-14 EC ECIEPI201820039A patent/ECSP18020039A/es unknown
- 2018-03-15 NI NI201800040A patent/NI201800040A/es unknown
- 2018-03-15 ZA ZA2018/01764A patent/ZA201801764B/en unknown
- 2018-03-15 CL CL2018000697A patent/CL2018000697A1/es unknown
- 2018-03-26 CO CONC2018/0003369A patent/CO2018003369A2/es unknown
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2019
- 2019-01-16 HK HK19100688.6A patent/HK1258320A1/zh not_active IP Right Cessation
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2020
- 2020-03-12 HR HRP20200408TT patent/HRP20200408T1/hr unknown
- 2020-03-12 CY CY20201100216T patent/CY1122792T1/el unknown
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2021
- 2021-08-20 JP JP2021135171A patent/JP2021193092A/ja active Pending
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