CY1121805T1 - Νουκλεϊνικο οξυ που περιλαμβανει ή κωδικοποιει στελεχος-βροχο ιστονης και πολυ(α) αλληλουχια ή σημα πολυαδενυλιωσης για αυξηση της εκφρασης ενος κωδικοποιημενου αντιγονου ογκου - Google Patents
Νουκλεϊνικο οξυ που περιλαμβανει ή κωδικοποιει στελεχος-βροχο ιστονης και πολυ(α) αλληλουχια ή σημα πολυαδενυλιωσης για αυξηση της εκφρασης ενος κωδικοποιημενου αντιγονου ογκουInfo
- Publication number
- CY1121805T1 CY1121805T1 CY20191100744T CY191100744T CY1121805T1 CY 1121805 T1 CY1121805 T1 CY 1121805T1 CY 20191100744 T CY20191100744 T CY 20191100744T CY 191100744 T CY191100744 T CY 191100744T CY 1121805 T1 CY1121805 T1 CY 1121805T1
- Authority
- CY
- Cyprus
- Prior art keywords
- nucleic acid
- encoding
- sequence
- poly
- loop
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 5
- 150000007523 nucleic acids Chemical class 0.000 title abstract 4
- 108091034057 RNA (poly(A)) Proteins 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108010033040 Histones Proteins 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 230000008488 polyadenylation Effects 0.000 abstract 2
- 108091026890 Coding region Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Η παρούσα εφεύρεση αφορά σε μία αλληλουχία νουκλεϊνικού οξέος που περιλαμβάνει ή κωδικοποιεί κωδικοποιητική περιοχή που κωδικοποιεί τουλάχιστον ένα πεπτίδιο ή πρωτεΐνη που περιλαμβάνει αντιγόνο όγκου ή θραύσμα, παραλλαγή ή παράγωγο αυτού, τουλάχιστον ένα στέλεχος-βρόχο ιστόνης και πολυ(Α) αλληλουχία ή σήμα πολυαδενυλίωσης. Περαιτέρω, η παρούσα εφεύρεση παρέχει τη χρήση του νουκλεϊνικού οξέος για αύξηση της έκφρασης του εν λόγω κωδικοποιημένου πεπτιδίου ή πρωτεΐνης. Επίσης αποκαλύπτει χρήση αυτού για την παρασκευή μιας φαρμακευτικής σύνθεσης, ειδικώς ενός εμβολίου, π.χ. για χρήση στη θεραπεία καρκίνου ή ασθενειών όγκου. Η παρούσα εφεύρεση περαιτέρω περιγράφει μέθοδο για αύξηση της έκφρασης ενός πεπτιδίου ή πρωτεΐνης που περιλαμβάνει αντιγόνο όγκου ή θραύσμα, παραλλαγή ή παράγωγο αυτού, χρησιμοποιώντας το νουκλεϊνικό οξύ που περιλαμβάνει ή κωδικοποιεί στέλεχος-βρόχο ιστόνης και πολυ(Α) αλληλουχία ή σήμα πολυαδενυλίωσης.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2012/000674 WO2013120500A1 (en) | 2012-02-15 | 2012-02-15 | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen |
| EP13704551.4A EP2814961B1 (en) | 2012-02-15 | 2013-02-15 | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen |
| PCT/EP2013/000459 WO2013120627A1 (en) | 2012-02-15 | 2013-02-15 | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121805T1 true CY1121805T1 (el) | 2020-07-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191100744T CY1121805T1 (el) | 2012-02-15 | 2019-07-11 | Νουκλεϊνικο οξυ που περιλαμβανει ή κωδικοποιει στελεχος-βροχο ιστονης και πολυ(α) αλληλουχια ή σημα πολυαδενυλιωσης για αυξηση της εκφρασης ενος κωδικοποιημενου αντιγονου ογκου |
Country Status (4)
| Country | Link |
|---|---|
| EP (4) | EP2814961B1 (el) |
| CY (1) | CY1121805T1 (el) |
| DK (1) | DK3178488T3 (el) |
| PL (1) | PL3178488T3 (el) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019535839A (ja) | 2016-11-29 | 2019-12-12 | ピュアテック ヘルス エルエルシー | 治療剤の送達のためのエクソソーム |
| JP6738111B1 (ja) * | 2019-10-10 | 2020-08-12 | ＮＵＰｒｏｔｅｉｎ株式会社 | 翻訳促進剤、鋳型核酸、翻訳鋳型の生産方法、および、タンパク質の生産方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1005561A4 (en) * | 1997-03-21 | 2004-03-31 | Enzo Therapeutics Inc A Fully | VECTOR, VIRAL VECTORS AND PACKAGING CELL LINES TO THEIR REPRODUCTION |
| US6423885B1 (en) | 1999-08-13 | 2002-07-23 | Commonwealth Scientific And Industrial Research Organization (Csiro) | Methods for obtaining modified phenotypes in plant cells |
| CA2457959C (en) | 2001-06-05 | 2014-10-28 | Curevac Gmbh | Pharmaceutical composition containing a stabilised mrna optimised for translation in its coding regions |
| DE102004035227A1 (de) * | 2004-07-21 | 2006-02-16 | Curevac Gmbh | mRNA-Gemisch zur Vakzinierung gegen Tumorerkrankungen |
| DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
| EP2429585B1 (en) * | 2009-05-15 | 2018-04-18 | IRX Therapeutics, Inc. | Vaccine immunotherapy |
| WO2011069529A1 (en) * | 2009-12-09 | 2011-06-16 | Curevac Gmbh | Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids |
| WO2012019630A1 (en) * | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
-
2013
- 2013-02-15 DK DK16001897.4T patent/DK3178488T3/da active
- 2013-02-15 EP EP13704551.4A patent/EP2814961B1/en active Active
- 2013-02-15 EP EP16001897.4A patent/EP3178488B1/en active Active
- 2013-02-15 PL PL16001897T patent/PL3178488T3/pl unknown
- 2013-02-15 EP EP19154524.3A patent/EP3527662B1/en active Active
- 2013-02-15 EP EP17207479.1A patent/EP3348644B1/en active Active
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2019
- 2019-07-11 CY CY20191100744T patent/CY1121805T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3527662A1 (en) | 2019-08-21 |
| DK3178488T3 (da) | 2019-06-24 |
| EP2814961A1 (en) | 2014-12-24 |
| EP3348644B1 (en) | 2020-02-12 |
| PL3178488T3 (pl) | 2019-10-31 |
| EP2814961B1 (en) | 2018-01-03 |
| EP3527662B1 (en) | 2022-01-26 |
| EP3178488B1 (en) | 2019-05-01 |
| EP3348644A1 (en) | 2018-07-18 |
| EP3178488A1 (en) | 2017-06-14 |
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