CY1119165T1 - Παραγωγα βενζιμιδαζολονης ως αναστολεις βρωμοπεδιου - Google Patents
Παραγωγα βενζιμιδαζολονης ως αναστολεις βρωμοπεδιουInfo
- Publication number
- CY1119165T1 CY1119165T1 CY20171100624T CY171100624T CY1119165T1 CY 1119165 T1 CY1119165 T1 CY 1119165T1 CY 20171100624 T CY20171100624 T CY 20171100624T CY 171100624 T CY171100624 T CY 171100624T CY 1119165 T1 CY1119165 T1 CY 1119165T1
- Authority
- CY
- Cyprus
- Prior art keywords
- inhibitors
- bromide
- compounds
- benzimidazolone derivatives
- bromopod
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 title 1
- 150000008641 benzimidazolones Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Η δήλωση αυτή αφορά σε χημικές ενώσεις που μπορεί να δρουν ως αναστολείς δραστικότητας ή που κατά τα άλλα μπορεί να ρυθμίζουν την δραστικότητα, πρωτεΐνης που περιέχει βρωμοπεδίο, συμπεριλαμβανομένης πρωτεΐνης 4 που περιέχει βρωμοπεδίο (BRD4) και σε συνθέσεις και φαρμακοτεχνικές μορφές που περιέχουν τέτοιες ενώσεις και μεθόδους χρήσεις και κατασκευής τέτοιων ενώσεων. Οι ενώσεις περιλαμβάνουν ενώσεις του Τύπου (I) όπου R1a, R1b, R2a, R2b, R3 και Χ περιγράφονται στο παρόν.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361805995P | 2013-03-28 | 2013-03-28 | |
| US201361860230P | 2013-07-30 | 2013-07-30 | |
| PCT/US2014/032031 WO2014160873A1 (en) | 2013-03-28 | 2014-03-27 | Benzimidazolone derivatives as bromodomain inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1119165T1 true CY1119165T1 (el) | 2018-02-14 |
Family
ID=50897885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100624T CY1119165T1 (el) | 2013-03-28 | 2017-06-13 | Παραγωγα βενζιμιδαζολονης ως αναστολεις βρωμοπεδιου |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US20160031868A1 (el) |
| EP (1) | EP2978759B1 (el) |
| JP (1) | JP6339175B2 (el) |
| KR (1) | KR101847698B1 (el) |
| CN (1) | CN105102453B (el) |
| AP (1) | AP2015008741A0 (el) |
| AU (1) | AU2014241152B2 (el) |
| BR (1) | BR112015024078A2 (el) |
| CA (1) | CA2907502C (el) |
| CL (1) | CL2015002871A1 (el) |
| CR (1) | CR20150515A (el) |
| CY (1) | CY1119165T1 (el) |
| DK (1) | DK2978759T3 (el) |
| EA (1) | EA029497B1 (el) |
| ES (1) | ES2626397T3 (el) |
| HR (1) | HRP20170750T1 (el) |
| HU (1) | HUE034772T2 (el) |
| IL (1) | IL241186A0 (el) |
| LT (1) | LT2978759T (el) |
| MD (1) | MD4531C1 (el) |
| MX (1) | MX2015013798A (el) |
| MY (1) | MY176634A (el) |
| NZ (1) | NZ711586A (el) |
| PE (1) | PE20151982A1 (el) |
| PH (1) | PH12015502246A1 (el) |
| PL (1) | PL2978759T3 (el) |
| PT (1) | PT2978759T (el) |
| RS (1) | RS56050B1 (el) |
| SG (1) | SG11201507926RA (el) |
| SI (1) | SI2978759T1 (el) |
| SM (1) | SMT201700249T1 (el) |
| TW (1) | TWI530499B (el) |
| UY (1) | UY35516A (el) |
| WO (1) | WO2014160873A1 (el) |
| ZA (1) | ZA201506356B (el) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007345526B2 (en) | 2007-02-01 | 2013-02-28 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular diseases |
| AU2010224523B2 (en) | 2009-03-18 | 2014-05-08 | Resverlogix Corp. | Novel anti-inflammatory agents |
| LT2773354T (lt) | 2011-11-01 | 2019-08-12 | Resverlogix Corp. | Geriamosios greitai atsipalaiduojančios pakeistų chinozolinų vaisto formos |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| US9271978B2 (en) | 2012-12-21 | 2016-03-01 | Zenith Epigenetics Corp. | Heterocyclic compounds as bromodomain inhibitors |
| MX366703B (es) | 2013-03-15 | 2019-07-22 | Incyte Holdings Corp | Heterociclos tricíclicos como inhibidores de la proteína bet. |
| US9662311B2 (en) * | 2013-06-21 | 2017-05-30 | Zenith Epigenetics Ltd. | Substituted bicyclic compounds as bromodomain inhibitors |
| BR112015031073B1 (pt) * | 2013-06-21 | 2022-11-29 | Zenith Epigenetics Ltd | Compostos inibidores bicíclicos de bromodomínio e composição farmacêutica contendo os referidos compostos |
| US9290514B2 (en) | 2013-07-08 | 2016-03-22 | Incyte Holdings Corporation | Tricyclic heterocycles as BET protein inhibitors |
| CN105593224B (zh) | 2013-07-31 | 2021-05-25 | 恒元生物医药科技(苏州)有限公司 | 作为溴结构域抑制剂的新型喹唑啉酮类化合物 |
| WO2015081189A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
| WO2015081203A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
| US9309246B2 (en) | 2013-12-19 | 2016-04-12 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| LT3674302T (lt) | 2014-04-23 | 2023-06-12 | Incyte Holdings Corporation | 1h-pirolo[2,3-c]piridin-7(6h)-onai ir pirazolo[3,4-c]piridin-7(6h)-onai kaip bet baltymų inhibitoriai |
| US9527864B2 (en) | 2014-09-15 | 2016-12-27 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| JP6930913B2 (ja) | 2014-10-14 | 2021-09-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ | 炎症を阻害するためのｃｄｋ９及びｂｒｄ４阻害剤の使用法 |
| US10179125B2 (en) | 2014-12-01 | 2019-01-15 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
| US10710992B2 (en) | 2014-12-01 | 2020-07-14 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
| WO2016092375A1 (en) | 2014-12-11 | 2016-06-16 | Zenith Epigenetics Corp. | Substituted heterocycles as bromodomain inhibitors |
| US10231953B2 (en) | 2014-12-17 | 2019-03-19 | Zenith Epigenetics Ltd. | Inhibitors of bromodomains |
| CN107530356A (zh) | 2015-03-13 | 2018-01-02 | 雷斯韦洛吉克斯公司 | 用于治疗补体相关疾病之组合物及治疗方法 |
| GB201504689D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| GB201504694D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Covalent conjugates |
| WO2016203335A1 (en) | 2015-06-18 | 2016-12-22 | Pfizer Inc. | Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors |
| US20170121347A1 (en) | 2015-10-29 | 2017-05-04 | Incyte Corporation | Amorphous solid form of a bet protein inhibitor |
| WO2017114843A1 (en) | 2015-12-29 | 2017-07-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Xanthine derivative inhibitors of bet proteins |
| PT3472157T (pt) | 2016-06-20 | 2023-05-30 | Incyte Corp | Formas sólidas cristalinas de um inibidor bet |
| WO2018097976A1 (en) * | 2016-11-22 | 2018-05-31 | Gilead Sciences, Inc. | Synthesis of a compound that modulates the activity of bromodomain-containing proteins |
| JP7254075B2 (ja) | 2017-11-06 | 2023-04-07 | サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィック | キサンチン誘導体及びｂｅｔタンパク質のブロモドメインの阻害剤としてのその使用 |
| US11466034B2 (en) * | 2017-12-20 | 2022-10-11 | Betta Pharmaceuticals Co., Ltd. | Compound functioning as bromodomain protein inhibitor, and composition |
| US12358925B2 (en) * | 2019-02-02 | 2025-07-15 | Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd | Targeted ubiquitination degradation BRD4 protein compound, preparation method therefor and application thereof |
| CN109912584B (zh) * | 2019-03-22 | 2021-08-13 | 中国药科大学 | 一种具有抗肿瘤活性的brd4蛋白抑制剂及其制备方法和应用 |
| CA3152923A1 (en) | 2019-09-30 | 2021-04-08 | Keisuke Yamamoto | Bet degrader |
| WO2021237111A1 (en) * | 2020-05-21 | 2021-11-25 | Stemsynergy Therapeutics, Inc. | Notch inhibitors and uses thereof |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| CN117821344B (zh) * | 2024-03-06 | 2024-07-26 | 江苏古道农业科技有限公司 | 一种草甘膦降解菌及其应用 |
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| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
| US5364620A (en) * | 1983-12-22 | 1994-11-15 | Elan Corporation, Plc | Controlled absorption diltiazem formulation for once daily administration |
| US5023252A (en) * | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US5001139A (en) * | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4902514A (en) * | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
| US6162804A (en) | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| EP1620413A2 (en) | 2003-04-30 | 2006-02-01 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| EA201000201A1 (ru) | 2007-08-10 | 2010-12-30 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Азотсодержащие бициклические химические вещества для лечения вирусных инфекций |
| US20100204265A1 (en) | 2009-02-09 | 2010-08-12 | Genelabs Technologies, Inc. | Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections |
| GB0919423D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| ES2786298T3 (es) | 2011-03-03 | 2020-10-09 | Zalicus Pharmaceuticals Ltd | Inhibidores de benzimidazol del canal de sodio |
| GB201114103D0 (en) | 2011-08-17 | 2011-09-28 | Glaxosmithkline Llc | Novel compounds |
| BR112015031073B1 (pt) * | 2013-06-21 | 2022-11-29 | Zenith Epigenetics Ltd | Compostos inibidores bicíclicos de bromodomínio e composição farmacêutica contendo os referidos compostos |
-
2014
- 2014-03-26 TW TW103111238A patent/TWI530499B/zh not_active IP Right Cessation
- 2014-03-27 EP EP14729114.0A patent/EP2978759B1/en active Active
- 2014-03-27 SG SG11201507926RA patent/SG11201507926RA/en unknown
- 2014-03-27 AP AP2015008741A patent/AP2015008741A0/xx unknown
- 2014-03-27 DK DK14729114.0T patent/DK2978759T3/da active
- 2014-03-27 BR BR112015024078A patent/BR112015024078A2/pt not_active Application Discontinuation
- 2014-03-27 MD MDA20150104A patent/MD4531C1/ro not_active IP Right Cessation
- 2014-03-27 WO PCT/US2014/032031 patent/WO2014160873A1/en active Application Filing
- 2014-03-27 HU HUE14729114A patent/HUE034772T2/en unknown
- 2014-03-27 HR HRP20170750TT patent/HRP20170750T1/hr unknown
- 2014-03-27 US US14/774,019 patent/US20160031868A1/en not_active Abandoned
- 2014-03-27 SM SM20170249T patent/SMT201700249T1/it unknown
- 2014-03-27 EA EA201591455A patent/EA029497B1/ru not_active IP Right Cessation
- 2014-03-27 NZ NZ711586A patent/NZ711586A/en not_active IP Right Cessation
- 2014-03-27 CN CN201480018645.6A patent/CN105102453B/zh active Active
- 2014-03-27 PE PE2015002057A patent/PE20151982A1/es not_active Application Discontinuation
- 2014-03-27 KR KR1020157030708A patent/KR101847698B1/ko active Active
- 2014-03-27 PT PT147291140T patent/PT2978759T/pt unknown
- 2014-03-27 MX MX2015013798A patent/MX2015013798A/es unknown
- 2014-03-27 ES ES14729114.0T patent/ES2626397T3/es active Active
- 2014-03-27 SI SI201430191A patent/SI2978759T1/sl unknown
- 2014-03-27 RS RS20170569A patent/RS56050B1/sr unknown
- 2014-03-27 US US14/227,736 patent/US9255089B2/en active Active
- 2014-03-27 JP JP2016505567A patent/JP6339175B2/ja not_active Expired - Fee Related
- 2014-03-27 MY MYPI2015002440A patent/MY176634A/en unknown
- 2014-03-27 CA CA2907502A patent/CA2907502C/en not_active Expired - Fee Related
- 2014-03-27 PL PL14729114T patent/PL2978759T3/pl unknown
- 2014-03-27 LT LTEP14729114.0T patent/LT2978759T/lt unknown
- 2014-03-27 AU AU2014241152A patent/AU2014241152B2/en not_active Ceased
- 2014-03-28 UY UY0001035516A patent/UY35516A/es not_active Application Discontinuation
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2015
- 2015-08-31 ZA ZA2015/06356A patent/ZA201506356B/en unknown
- 2015-09-06 IL IL241186A patent/IL241186A0/en unknown
- 2015-09-24 PH PH12015502246A patent/PH12015502246A1/en unknown
- 2015-09-25 CL CL2015002871A patent/CL2015002871A1/es unknown
- 2015-10-02 CR CR20150515A patent/CR20150515A/es unknown
-
2017
- 2017-06-13 CY CY20171100624T patent/CY1119165T1/el unknown
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