CY1119087T1 - Κοντα βιοδραστικα πεπτιδια για την προαγωγη της επουλωσης πληγης - Google Patents
Κοντα βιοδραστικα πεπτιδια για την προαγωγη της επουλωσης πληγηςInfo
- Publication number
- CY1119087T1 CY1119087T1 CY20171100747T CY171100747T CY1119087T1 CY 1119087 T1 CY1119087 T1 CY 1119087T1 CY 20171100747 T CY20171100747 T CY 20171100747T CY 171100747 T CY171100747 T CY 171100747T CY 1119087 T1 CY1119087 T1 CY 1119087T1
- Authority
- CY
- Cyprus
- Prior art keywords
- peptides
- disclosed
- mpkekvflkiekmgrnirn
- peptide
- amino acid
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 10
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 8
- 230000000975 bioactive effect Effects 0.000 title 1
- 230000035876 healing Effects 0.000 title 1
- 230000001737 promoting effect Effects 0.000 title 1
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 206010056340 Diabetic ulcer Diseases 0.000 abstract 1
- 108700022013 Insecta cecropin B Proteins 0.000 abstract 1
- 208000028990 Skin injury Diseases 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001617 migratory effect Effects 0.000 abstract 1
- 230000037380 skin damage Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Birds (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Insects & Arthropods (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
Abstract
Αποκαλύπτονται πεπτίδια τα οποία έχουν τέσσερα έως έξι υπόλοιπα αμινοξέος τα οποία διαθέτουν βιολογική δραστικότητα. Τα πεπτίδια αυτά συνιστούν κοντά θραύσματα του πεπτιδίου ΗΒ-107 (MPKEKVFLKIEKMGRNIRN) το οποίο το ίδιο είναι ένα θραύσμα της αντιμικροβιακής πρωτεΐνης κεκροπίνη Β και επιδεικνύει κυτταροδιεγερτικές και μεταναστευτικές ιδιότητες. Τα εφευρετικά πεπτίδια περιέχουν τέσσερα έως έξι γειτονικά υπόλοιπα αμινοξέος που βρίσκονται μεταξύ της θέσης 11 και 16 του ΗΒ-107 (MPKEKVFLKIEKMGRNIRN), δηλαδή EKMGRN. Τα αποκαλυπτόμενα πεπτίδια περιέχουν έναν χρήσιμο παράγοντα για την ιατρική αγωγή ενός τραυματισμού του δέρματος όπως από διαβητικά έλκη. Τα πεπτίδια είναι επίσης αποτελεσματικά στην πρόληψη και την αντιστροφή της επιφανειακής βλάβης του δέρματος που προκύπτει από διάφορες περιβαλλοντικές προσβολές. Κατά σημαντικό τρόπο, τα θεραπευτικά αποτελέσματα των πεπτιδίων εκδηλώνονται σε συγκεντρώσεις ίσες προς ή μεγαλύτερες από αυτές του πεπτιδίου ΗΒ-107 και τοιουτοτρόπως παριστούν ένα λιγότερο ακριβό, περισσότερο ευέλικτο μέσο για την ανάπτυξη αποτελεσματικών θεραπειών. Αποκαλύπτονται επίσης μέθοδοι για την παραγωγή και χρήση των πεπτιδίων αυτών.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361764913P | 2013-02-14 | 2013-02-14 | |
| PCT/US2014/012378 WO2014126681A1 (en) | 2013-02-14 | 2014-01-21 | Short bio-active peptides for promoting wound healing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1119087T1 true CY1119087T1 (el) | 2018-01-10 |
Family
ID=50069319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100747T CY1119087T1 (el) | 2013-02-14 | 2017-07-14 | Κοντα βιοδραστικα πεπτιδια για την προαγωγη της επουλωσης πληγης |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9487558B2 (el) |
| EP (1) | EP2956155B1 (el) |
| JP (1) | JP6348126B2 (el) |
| KR (1) | KR101894829B1 (el) |
| CN (1) | CN105120884B (el) |
| AR (1) | AR094835A1 (el) |
| AU (1) | AU2014216730B2 (el) |
| BR (1) | BR112015019568A2 (el) |
| CA (1) | CA2898717C (el) |
| CY (1) | CY1119087T1 (el) |
| DK (1) | DK2956155T3 (el) |
| ES (1) | ES2633437T3 (el) |
| HK (1) | HK1212243A1 (el) |
| HU (1) | HUE033976T2 (el) |
| MX (1) | MX363955B (el) |
| MY (1) | MY173174A (el) |
| NZ (1) | NZ711281A (el) |
| PL (1) | PL2956155T3 (el) |
| RU (1) | RU2606753C1 (el) |
| SG (1) | SG11201505538QA (el) |
| SI (1) | SI2956155T1 (el) |
| TW (1) | TWI587867B (el) |
| WO (1) | WO2014126681A1 (el) |
| ZA (1) | ZA201505516B (el) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3020342A1 (en) * | 2016-04-08 | 2017-11-23 | Cornell University | A method to enhance wound healing using silk-derived protein |
| EP3312608B1 (en) * | 2016-10-24 | 2019-10-02 | Akribes Biomedical GmbH | Methods for identifying a non-healing skin wound and for monitoring the healing of a skin wound |
| US10232009B1 (en) * | 2017-09-29 | 2019-03-19 | Pro Sunfun Biotech Research And Development Co., Ltd. | Peptide for promoting wound healing, its composition and method of using the same |
| CN108586575B (zh) * | 2018-04-11 | 2020-08-14 | 福建省中科生物股份有限公司 | 一种多肽及其皮肤修复功能的应用 |
| CZ308845B6 (cs) * | 2019-01-21 | 2021-07-07 | Globetech Innovation S.R.O | Farmaceutická směs topicky hojivých peptidových složek pro použití k topické léčbě kožních defektů a/nebo k topickému hojení ran |
| CN116407611A (zh) * | 2021-12-29 | 2023-07-11 | 四川好医生攀西药业有限责任公司 | 一种多肽在制备预防或治疗皮肤损伤疾病产品上的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6360939A (ja) * | 1986-08-29 | 1988-03-17 | Shin Etsu Chem Co Ltd | 抗菌物質 |
| JP2962555B2 (ja) | 1987-07-06 | 1999-10-12 | ヘリックス バイオメディックス，インコーポレイテッド | 溶菌ペプチドによる真核性病原体と新生物の抑制及び繊維芽細胞とリンパ球の刺激 |
| US5861478A (en) | 1987-07-06 | 1999-01-19 | Helix Biomedix, Inc. | Lytic peptides |
| WO2007146269A2 (en) * | 2006-06-13 | 2007-12-21 | Helix Biomedix Inc. | Peptide fragments for inducing synthesis of extracellular matrix proteins |
| PL2125878T3 (pl) * | 2007-01-05 | 2013-08-30 | Helix Biomedix Inc | Krótkie, aktywne biologicznie peptydy do komórkowych i immunologicznych modulacji |
| RU2447896C1 (ru) * | 2010-11-15 | 2012-04-20 | Общество с ограниченной ответственностью "Аллофарм" | Антимикробное вещество |
| US9040662B2 (en) * | 2011-08-25 | 2015-05-26 | University Of Central Florida Research Foundation | Methods and compositions comprising a C-terminal Bax peptide |
-
2014
- 2014-01-21 KR KR1020157024070A patent/KR101894829B1/ko not_active Expired - Fee Related
- 2014-01-21 HU HUE14703220A patent/HUE033976T2/en unknown
- 2014-01-21 CN CN201480009001.0A patent/CN105120884B/zh active Active
- 2014-01-21 PL PL14703220T patent/PL2956155T3/pl unknown
- 2014-01-21 US US14/762,407 patent/US9487558B2/en active Active
- 2014-01-21 BR BR112015019568A patent/BR112015019568A2/pt not_active Application Discontinuation
- 2014-01-21 AU AU2014216730A patent/AU2014216730B2/en not_active Ceased
- 2014-01-21 WO PCT/US2014/012378 patent/WO2014126681A1/en active Application Filing
- 2014-01-21 RU RU2015138925A patent/RU2606753C1/ru not_active IP Right Cessation
- 2014-01-21 SG SG11201505538QA patent/SG11201505538QA/en unknown
- 2014-01-21 JP JP2015558016A patent/JP6348126B2/ja active Active
- 2014-01-21 EP EP14703220.5A patent/EP2956155B1/en active Active
- 2014-01-21 MY MYPI2015702327A patent/MY173174A/en unknown
- 2014-01-21 MX MX2015009404A patent/MX363955B/es active IP Right Grant
- 2014-01-21 SI SI201430277T patent/SI2956155T1/sl unknown
- 2014-01-21 DK DK14703220.5T patent/DK2956155T3/en active
- 2014-01-21 ES ES14703220.5T patent/ES2633437T3/es active Active
- 2014-01-21 CA CA2898717A patent/CA2898717C/en active Active
- 2014-01-21 NZ NZ711281A patent/NZ711281A/en not_active IP Right Cessation
- 2014-01-29 TW TW103103686A patent/TWI587867B/zh not_active IP Right Cessation
- 2014-02-14 AR ARP140100481A patent/AR094835A1/es unknown
-
2015
- 2015-07-31 ZA ZA2015/05516A patent/ZA201505516B/en unknown
-
2016
- 2016-01-13 HK HK16100340.9A patent/HK1212243A1/xx unknown
- 2016-09-20 US US15/270,186 patent/US20170000848A1/en not_active Abandoned
-
2017
- 2017-07-14 CY CY20171100747T patent/CY1119087T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY173174A (en) | 2020-01-02 |
| CN105120884A (zh) | 2015-12-02 |
| AU2014216730A1 (en) | 2015-08-20 |
| PL2956155T3 (pl) | 2017-09-29 |
| WO2014126681A1 (en) | 2014-08-21 |
| AU2014216730B2 (en) | 2015-12-17 |
| CA2898717C (en) | 2019-01-08 |
| TW201446258A (zh) | 2014-12-16 |
| US9487558B2 (en) | 2016-11-08 |
| BR112015019568A2 (pt) | 2017-08-22 |
| KR101894829B1 (ko) | 2018-09-05 |
| EP2956155B1 (en) | 2017-04-19 |
| SG11201505538QA (en) | 2015-08-28 |
| EP2956155A1 (en) | 2015-12-23 |
| SI2956155T1 (sl) | 2017-10-30 |
| CN105120884B (zh) | 2017-08-29 |
| CA2898717A1 (en) | 2014-08-21 |
| US20170000848A1 (en) | 2017-01-05 |
| JP6348126B2 (ja) | 2018-06-27 |
| DK2956155T3 (en) | 2017-07-31 |
| ES2633437T3 (es) | 2017-09-21 |
| US20150353605A1 (en) | 2015-12-10 |
| JP2016513107A (ja) | 2016-05-12 |
| MX2015009404A (es) | 2016-10-07 |
| RU2606753C1 (ru) | 2017-01-10 |
| ZA201505516B (en) | 2016-10-26 |
| MX363955B (es) | 2019-04-08 |
| AR094835A1 (es) | 2015-09-02 |
| HK1212243A1 (en) | 2016-06-10 |
| HUE033976T2 (en) | 2018-02-28 |
| TWI587867B (zh) | 2017-06-21 |
| KR20150116883A (ko) | 2015-10-16 |
| NZ711281A (en) | 2017-12-22 |
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