CY1118559T1 - 2,6-DIAMINO-PYRIMIDIN-5-YLO-CARBOXAMIDES AS SUSPENSIONS OF SYK-JAK CHINESE - Google Patents
2,6-DIAMINO-PYRIMIDIN-5-YLO-CARBOXAMIDES AS SUSPENSIONS OF SYK-JAK CHINESEInfo
- Publication number
- CY1118559T1 CY1118559T1 CY20161101026T CY161101026T CY1118559T1 CY 1118559 T1 CY1118559 T1 CY 1118559T1 CY 20161101026 T CY20161101026 T CY 20161101026T CY 161101026 T CY161101026 T CY 161101026T CY 1118559 T1 CY1118559 T1 CY 1118559T1
- Authority
- CY
- Cyprus
- Prior art keywords
- jak
- methods
- syk
- syk kinase
- ylo
- Prior art date
Links
- 239000000725 suspension Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 102000000551 Syk Kinase Human genes 0.000 abstract 3
- 108010016672 Syk Kinase Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται σε ενώσεις του τύπου Ι-ΙΙ και τα φαρμακευτικά αποδεκτά ταυτομερή, άλατα, ή τα στερεοϊσομερή αυτών, τα οποία είναι αναστολείς της κινάσης Syk και/ή JAK. Η παρούσα εφεύρεση επίσης αναφέρεται σε ενδιάμεσα που χρησιμοποιούνται στην σύνθεση τέτοιων ενώσεων, την παρασκευή μίας τέτοιας ένωσης, τις φαρμακευτικές συνθέσεις που περιέχουν μία τέτοια ένωση, τις μεθόδους αναστολής της δραστικότητας της κινάσης Syk και/ή JAK, τις μεθόδους αναστολής της συσσωμάτωσης των αιμοπεταλίων, και τις μεθόδους για την πρόληψη ή τη θεραπεία ενός αριθμού παθήσεων που προκαλούνται τουλάχιστον εν μέρει από την δραστικότητα της κινάσης Syk και/ή JAK, όπως η καρδιαγγειακή νόσος, η φλεγμονώδης νόσος, η αυτοάνοση νόσος και η πολλαπλασιαστική διαταραχή κυττάρων, η θρόμβωση, η αλλεργία, το άσθμα, η ρευματοειδής αρθρίτιδα, η λευχαιμία, ή το λέμφωμα μη-Hodgkin.The present invention relates to compounds of formula I-II and their pharmaceutically acceptable tautomers, salts, or stereoisomers thereof, which are inhibitors of Syk kinase and / or JAK. The present invention also relates to intermediates used in the synthesis of such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibiting the activity of Syk kinase and / or JAK, methods of inhibiting platelet aggregation, and methods for preventing or treating a number of diseases that are at least in part caused by the activity of Syk kinase and / or JAK, such as cardiovascular disease, inflammatory disease, autoimmune disease, and p proliferative cell disorder, thrombosis, allergy, asthma, rheumatoid arthritis, leukemia, or non-Hodgkin's lymphoma.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4539908P | 2008-04-16 | 2008-04-16 | |
| US4541708P | 2008-04-16 | 2008-04-16 | |
| US4540608P | 2008-04-16 | 2008-04-16 | |
| US12034408P | 2008-12-05 | 2008-12-05 | |
| US12034108P | 2008-12-05 | 2008-12-05 | |
| US12034808P | 2008-12-05 | 2008-12-05 | |
| PCT/US2009/002420 WO2009145856A1 (en) | 2008-04-16 | 2009-04-16 | 2, 6-diamino-pyrimidin- 5-yl-carboxamides as syk or jak kinases inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1118559T1 true CY1118559T1 (en) | 2017-07-12 |
Family
ID=43570275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161101026T CY1118559T1 (en) | 2008-04-16 | 2016-10-13 | 2,6-DIAMINO-PYRIMIDIN-5-YLO-CARBOXAMIDES AS SUSPENSIONS OF SYK-JAK CHINESE |
Country Status (18)
| Country | Link |
|---|---|
| AU (1) | AU2009251863B2 (en) |
| BR (1) | BRPI0910560B8 (en) |
| CO (1) | CO6331433A2 (en) |
| CY (1) | CY1118559T1 (en) |
| DK (1) | DK2321283T3 (en) |
| ES (1) | ES2597441T3 (en) |
| GT (1) | GT201000298A (en) |
| HK (1) | HK1158179A1 (en) |
| HU (1) | HUE031638T2 (en) |
| IL (3) | IL208637A (en) |
| LT (1) | LT2321283T (en) |
| MX (1) | MX353206B (en) |
| NI (1) | NI201000176A (en) |
| NZ (1) | NZ589314A (en) |
| PL (1) | PL2321283T3 (en) |
| PT (1) | PT2321283T (en) |
| SI (1) | SI2321283T1 (en) |
| ZA (1) | ZA201007045B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013202496B2 (en) * | 2008-06-27 | 2016-08-04 | Celgene Car Llc | Heteroaryl compounds and uses thereof |
| KR101892989B1 (en) | 2008-06-27 | 2018-08-30 | 셀젠 카르 엘엘씨 | Heteroaryl compounds and uses thereof |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| KR20130099040A (en) | 2010-08-10 | 2013-09-05 | 셀진 아빌로믹스 리서치, 인코포레이티드 | Besylate salt of a btk inhibitor |
| WO2014124230A2 (en) | 2013-02-08 | 2014-08-14 | Celgene Avilomics Research, Inc. | Erk inhibitors and uses thereof |
| DK3179858T3 (en) | 2014-08-13 | 2019-07-22 | Celgene Car Llc | Forms and compositions of an ERK inhibitor |
| EP4306172A4 (en) * | 2021-03-09 | 2025-03-26 | Cspc Zhongqi Pharmaceutical Tech Shijiazhuang Co Ltd | USE OF A TRICYCLIC HETEROARYL-CONTAINING COMPOUND |
| CN114196651B (en) * | 2021-12-15 | 2023-06-30 | 中国林业科学研究院亚热带林业研究所 | New application of D6 protein kinase D6PKL2 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432963B1 (en) * | 1997-12-15 | 2002-08-13 | Yamanouchi Pharmaceutical Co., Ltd. | Pyrimidine-5-carboxamide derivatives |
| US7449456B2 (en) * | 2002-06-28 | 2008-11-11 | Astellas Pharma, Inc. | Diaminopyrimidinecarboxamide derivative |
| WO2008009458A1 (en) * | 2006-07-21 | 2008-01-24 | Novartis Ag | 2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors |
-
2009
- 2009-04-16 SI SI200931540A patent/SI2321283T1/en unknown
- 2009-04-16 PT PT97552194T patent/PT2321283T/en unknown
- 2009-04-16 DK DK09755219.4T patent/DK2321283T3/en active
- 2009-04-16 NZ NZ589314A patent/NZ589314A/en not_active IP Right Cessation
- 2009-04-16 LT LTEP09755219.4T patent/LT2321283T/en unknown
- 2009-04-16 AU AU2009251863A patent/AU2009251863B2/en active Active
- 2009-04-16 MX MX2010011464A patent/MX353206B/en active IP Right Grant
- 2009-04-16 HU HUE09755219A patent/HUE031638T2/en unknown
- 2009-04-16 ES ES09755219.4T patent/ES2597441T3/en active Active
- 2009-04-16 PL PL09755219T patent/PL2321283T3/en unknown
- 2009-04-16 BR BRPI0910560A patent/BRPI0910560B8/en active IP Right Grant
-
2010
- 2010-10-04 ZA ZA2010/07045A patent/ZA201007045B/en unknown
- 2010-10-11 IL IL208637A patent/IL208637A/en active IP Right Grant
- 2010-10-15 GT GT201000298A patent/GT201000298A/en unknown
- 2010-10-15 NI NI201000176A patent/NI201000176A/en unknown
- 2010-11-16 CO CO10143190A patent/CO6331433A2/en active IP Right Grant
-
2011
- 2011-11-16 HK HK11112350.6A patent/HK1158179A1/en not_active IP Right Cessation
-
2016
- 2016-10-13 CY CY20161101026T patent/CY1118559T1/en unknown
-
2017
- 2017-04-09 IL IL251655A patent/IL251655B/en active IP Right Grant
-
2020
- 2020-05-07 IL IL274522A patent/IL274522A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0910560B8 (en) | 2023-03-21 |
| IL274522A (en) | 2020-06-30 |
| BRPI0910560B1 (en) | 2023-01-24 |
| AU2009251863A1 (en) | 2009-12-03 |
| PL2321283T3 (en) | 2017-01-31 |
| ES2597441T3 (en) | 2017-01-18 |
| AU2009251863A2 (en) | 2011-06-09 |
| NI201000176A (en) | 2011-08-08 |
| LT2321283T (en) | 2016-12-12 |
| PT2321283T (en) | 2016-10-19 |
| HK1158179A1 (en) | 2012-07-13 |
| IL251655B (en) | 2020-05-31 |
| NZ589314A (en) | 2012-10-26 |
| IL251655A0 (en) | 2017-06-29 |
| HUE031638T2 (en) | 2017-07-28 |
| GT201000298A (en) | 2014-05-07 |
| MX353206B (en) | 2018-01-08 |
| IL208637A (en) | 2017-04-30 |
| IL208637A0 (en) | 2010-12-30 |
| ZA201007045B (en) | 2012-08-29 |
| CO6331433A2 (en) | 2011-10-20 |
| AU2009251863B2 (en) | 2014-09-25 |
| DK2321283T3 (en) | 2016-10-31 |
| BRPI0910560A2 (en) | 2021-04-27 |
| SI2321283T1 (en) | 2017-01-31 |
| MX2010011464A (en) | 2014-06-16 |
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