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CY1118461T1 - Φαρμακευτικες συνθεσεις που περιλαμβανουν αναστολεα αρωματασης - Google Patents

Φαρμακευτικες συνθεσεις που περιλαμβανουν αναστολεα αρωματασης

Info

Publication number
CY1118461T1
CY1118461T1 CY20171100074T CY171100074T CY1118461T1 CY 1118461 T1 CY1118461 T1 CY 1118461T1 CY 20171100074 T CY20171100074 T CY 20171100074T CY 171100074 T CY171100074 T CY 171100074T CY 1118461 T1 CY1118461 T1 CY 1118461T1
Authority
CY
Cyprus
Prior art keywords
pharmaceutical compositions
aromatology
ingredients
compositions containing
relates
Prior art date
Application number
CY20171100074T
Other languages
English (en)
Inventor
Ann Taylor
Lloyd B Klickstein
Jeewan Thakur
Original Assignee
Mereo Biopharma 2 Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46846026&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1118461(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mereo Biopharma 2 Limited filed Critical Mereo Biopharma 2 Limited
Publication of CY1118461T1 publication Critical patent/CY1118461T1/el

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833Encapsulating processes; Filling of capsules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/485Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06Anabolic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26Androgens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σε χαμηλής-δόσης φαρμακευτικές συνθέσεις που περιλαμβάνουν τον αναστολέα αρωματάσης 4,4'-[φθορο-(1-Η-1,2,4-τριαζολ-1-υλ)μεθυλενο]δισβενζονιτρίλιο ως το δραστικό συστατικό σε κατάλληλο φορέα. Η παρούσα εφεύρεση επίσης αφορά σε μία μέθοδο για παρασκευή αυτού και χρήση αυτού ως φάρμακα.
CY20171100074T 2011-09-08 2017-01-18 Φαρμακευτικες συνθεσεις που περιλαμβανουν αναστολεα αρωματασης CY1118461T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161532459P 2011-09-08 2011-09-08
US201261638588P 2012-04-26 2012-04-26
PCT/US2012/053846 WO2013036563A1 (en) 2011-09-08 2012-09-06 Pharmaceutical compositions comprising an aromatase inhibitor

Publications (1)

Publication Number Publication Date
CY1118461T1 true CY1118461T1 (el) 2017-07-12

Family

ID=46846026

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20171100074T CY1118461T1 (el) 2011-09-08 2017-01-18 Φαρμακευτικες συνθεσεις που περιλαμβανουν αναστολεα αρωματασης
CY20171100100T CY1118499T1 (el) 2011-09-08 2017-01-24 Χρηση ενος αναστολεα αρωματασης για την αντιμετωπιση υπογοναδισμου και σχετικων νοσων

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20171100100T CY1118499T1 (el) 2011-09-08 2017-01-24 Χρηση ενος αναστολεα αρωματασης για την αντιμετωπιση υπογοναδισμου και σχετικων νοσων

Country Status (31)

Country Link
US (4) US9295668B2 (el)
EP (2) EP2753313B1 (el)
JP (2) JP6280501B2 (el)
KR (3) KR20140071358A (el)
CN (2) CN103781476B (el)
AR (1) AR087790A1 (el)
AU (2) AU2012304694B2 (el)
BR (2) BR112014005434B1 (el)
CA (2) CA2845929C (el)
CL (1) CL2014000552A1 (el)
CY (2) CY1118461T1 (el)
DK (2) DK2753312T3 (el)
ES (2) ES2613666T3 (el)
HR (2) HRP20170003T1 (el)
HU (2) HUE031435T2 (el)
IL (1) IL231234A (el)
IN (1) IN2014DN01619A (el)
LT (2) LT2753312T (el)
MX (2) MX343902B (el)
PE (1) PE20141584A1 (el)
PH (1) PH12014500435A1 (el)
PL (2) PL2753312T3 (el)
PT (2) PT2753312T (el)
RU (2) RU2628808C2 (el)
SG (2) SG10201607503WA (el)
SI (2) SI2753312T1 (el)
TN (1) TN2014000059A1 (el)
TW (1) TW201316987A (el)
UY (1) UY34315A (el)
WO (2) WO2013036563A1 (el)
ZA (1) ZA201401040B (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2628808C2 (ru) * 2011-09-08 2017-08-22 Новартис Аг Применение ингибитора ароматазы для лечения гипогонадизма и родственных заболеваний
WO2015148549A1 (en) * 2014-03-26 2015-10-01 The Regents Of The University Of California Ultrasensitive androgen receptor bioassay
KR102468610B1 (ko) * 2014-07-07 2022-11-21 리코다티 아게 제약 투여 형태
GB201614179D0 (en) * 2016-08-19 2016-10-05 Mereo Biopharma 2 Ltd Dosage regimen for the treatment of endometriosis
WO2018165145A1 (en) * 2017-03-08 2018-09-13 Ariad Pharmaceuticals, Inc. Pharmaceutical formulations comprising 5-chloro-n4-[2-(dimethylphosphoryl) phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl} pyrimidine-2,4-diamine
USD894149S1 (en) * 2018-08-16 2020-08-25 Alibaba Group Holding Limited Information terminal for payment
USD894148S1 (en) * 2018-08-16 2020-08-25 Alibaba Group Holding Limited Information terminal for payment
JP7121999B2 (ja) * 2019-09-26 2022-08-19 学校法人九州文化学園 男性性腺機能低下症治療剤

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US4749713A (en) 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
TW210334B (el) 1990-12-12 1993-08-01 Ciba Geigy Ag
DE4435368A1 (de) * 1994-09-22 1996-03-28 Schering Ag Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann
US5972921A (en) * 1997-12-12 1999-10-26 Hormos Medical Oy Ltd. Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men
WO2002002113A1 (en) * 2000-07-05 2002-01-10 Astrazeneca Ab Pharmaceutical combination of an anti-androgen and letrozole for providing an anit-androgenic effect and aromatase inhibition
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WO2006114702A2 (en) * 2005-04-25 2006-11-02 Pfizer Products Inc. Pharmaceutical compositions and methods comprising a combination of a selective estrogen receptor modulator and an aromatase inhibitor
CN102335269B (zh) * 2007-11-21 2013-06-19 客乐谐制药株式会社 芳香酶抑制剂
RU2628808C2 (ru) * 2011-09-08 2017-08-22 Новартис Аг Применение ингибитора ароматазы для лечения гипогонадизма и родственных заболеваний

Also Published As

Publication number Publication date
RU2014113575A (ru) 2015-10-20
TW201316987A (zh) 2013-05-01
EP2753312B1 (en) 2016-12-14
US20140309267A1 (en) 2014-10-16
DK2753312T3 (da) 2017-02-13
AU2012304693A1 (en) 2014-03-13
HUE031478T2 (hu) 2017-07-28
US9750724B2 (en) 2017-09-05
SI2753313T1 (sl) 2017-04-26
JP6280501B2 (ja) 2018-02-14
KR101872561B1 (ko) 2018-06-28
MX2014002780A (es) 2014-06-05
BR112014005434A2 (pt) 2017-04-04
CY1118499T1 (el) 2017-07-12
JP6051467B2 (ja) 2016-12-27
PE20141584A1 (es) 2014-11-13
CA2845929A1 (en) 2013-03-14
IL231234A (en) 2016-12-29
PL2753313T3 (pl) 2017-07-31
PL2753312T3 (pl) 2017-06-30
AR087790A1 (es) 2014-04-16
MX360315B (es) 2018-10-29
BR112014005434B1 (pt) 2021-01-05
US9370505B2 (en) 2016-06-21
CA2845929C (en) 2018-06-19
JP2014526465A (ja) 2014-10-06
AU2012304693B2 (en) 2016-03-31
RU2628808C2 (ru) 2017-08-22
PH12014500435A1 (en) 2019-03-22
CN103796644A (zh) 2014-05-14
AU2012304694A1 (en) 2014-03-20
CA2846884C (en) 2019-04-09
US20160346257A1 (en) 2016-12-01
BR112014004879A2 (pt) 2017-03-14
EP2753312A1 (en) 2014-07-16
HRP20170003T1 (hr) 2017-03-10
LT2753313T (lt) 2017-02-10
WO2013036562A1 (en) 2013-03-14
DK2753313T3 (en) 2017-02-13
SI2753312T1 (sl) 2017-10-30
NZ621476A (en) 2016-02-26
CN103781476B (zh) 2016-12-07
US9295668B2 (en) 2016-03-29
EP2753313B1 (en) 2016-12-14
PT2753313T (pt) 2017-02-02
HUE031435T2 (en) 2017-07-28
IL231234A0 (en) 2014-04-30
IN2014DN01619A (el) 2015-05-15
SG2014012132A (en) 2014-06-27
US20160243084A1 (en) 2016-08-25
TN2014000059A1 (en) 2015-07-01
EP2753313A1 (en) 2014-07-16
UY34315A (es) 2013-04-30
CN103781476A (zh) 2014-05-07
HRP20170002T1 (hr) 2017-02-24
SG10201607503WA (en) 2016-10-28
ES2613667T3 (es) 2017-05-25
CN103796644B (zh) 2017-05-03
RU2617510C2 (ru) 2017-04-25
ZA201401040B (en) 2015-12-23
KR20140071358A (ko) 2014-06-11
US20140213622A1 (en) 2014-07-31
KR20140058619A (ko) 2014-05-14
PT2753312T (pt) 2017-02-03
CA2846884A1 (en) 2013-03-14
US10064844B2 (en) 2018-09-04
JP2014528932A (ja) 2014-10-30
BR112014004879B1 (pt) 2020-01-28
CL2014000552A1 (es) 2014-09-12
WO2013036563A1 (en) 2013-03-14
ES2613666T3 (es) 2017-05-25
LT2753312T (lt) 2017-01-25
KR20180030254A (ko) 2018-03-21
MX343902B (es) 2016-11-28
MX2014002773A (es) 2014-06-05
RU2014113334A (ru) 2015-10-20
AU2012304694B2 (en) 2016-04-07

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