CY1117380T1 - Λυοφιλιση συνθετικου λιποσωμικου πνευμονικου επιφανειοδραστικου - Google Patents
Λυοφιλιση συνθετικου λιποσωμικου πνευμονικου επιφανειοδραστικουInfo
- Publication number
- CY1117380T1 CY1117380T1 CY20151101180T CY151101180T CY1117380T1 CY 1117380 T1 CY1117380 T1 CY 1117380T1 CY 20151101180 T CY20151101180 T CY 20151101180T CY 151101180 T CY151101180 T CY 151101180T CY 1117380 T1 CY1117380 T1 CY 1117380T1
- Authority
- CY
- Cyprus
- Prior art keywords
- lyophilization
- pulmonary surfactant
- synthetic
- synthetic liposomal
- liposomal pulmonary
- Prior art date
Links
- 239000003580 lung surfactant Substances 0.000 title abstract 3
- 238000004108 freeze drying Methods 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/395—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0082—Lung surfactant, artificial mucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Περιγράφονται λυοφιλισμένα πνευμονικά επιφανειοδραστικά που έχουν αυξημένη ειδική περιοχή επιφανείας και πορώδες. Περιγράφεται μέθοδος κατασκευής λυοφιλισμένου πνευμονικού επιφανειοδραστικού.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616827P | 2012-03-28 | 2012-03-28 | |
| EP13716655.9A EP2723323B1 (en) | 2012-03-28 | 2013-03-28 | Lyophilization of synthetic liposomal pulmonary surfactant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1117380T1 true CY1117380T1 (el) | 2017-04-26 |
Family
ID=48096305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151101180T CY1117380T1 (el) | 2012-03-28 | 2015-12-22 | Λυοφιλιση συνθετικου λιποσωμικου πνευμονικου επιφανειοδραστικου |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US9554999B2 (el) |
| EP (2) | EP2837377A1 (el) |
| JP (1) | JP6178402B2 (el) |
| KR (1) | KR102123129B1 (el) |
| CN (1) | CN104271118B (el) |
| AU (2) | AU2013237985B2 (el) |
| BR (1) | BR112014024057A8 (el) |
| CA (1) | CA2867649C (el) |
| CL (1) | CL2014002553A1 (el) |
| CO (1) | CO7081146A2 (el) |
| CR (1) | CR20140449A (el) |
| CU (1) | CU20140116A7 (el) |
| CY (1) | CY1117380T1 (el) |
| DK (1) | DK2723323T3 (el) |
| EC (1) | ECSP14024363A (el) |
| ES (1) | ES2557805T3 (el) |
| HK (1) | HK1206979A1 (el) |
| HR (1) | HRP20151392T1 (el) |
| HU (1) | HUE026363T2 (el) |
| IL (1) | IL234688B (el) |
| IN (1) | IN2014DN08538A (el) |
| MA (1) | MA37445B1 (el) |
| MX (1) | MX359654B (el) |
| MY (1) | MY164868A (el) |
| NZ (1) | NZ630219A (el) |
| PE (1) | PE20142302A1 (el) |
| PL (1) | PL2723323T3 (el) |
| PT (1) | PT2723323E (el) |
| RS (1) | RS54513B1 (el) |
| RU (1) | RU2671500C2 (el) |
| SG (1) | SG11201405944PA (el) |
| SI (1) | SI2723323T1 (el) |
| SM (1) | SMT201500320B (el) |
| WO (2) | WO2013149013A1 (el) |
| ZA (1) | ZA201406982B (el) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2723323T1 (sl) * | 2012-03-28 | 2016-04-29 | Discovery Laboratories, Inc. | Liofilizacija sintetičnega liposomskega pulmonalnega surfaktanta |
| EP3222273B1 (en) * | 2014-11-18 | 2019-09-25 | National Institute for Materials Science | Method for producing porous particle |
| WO2016108534A1 (ko) * | 2014-12-30 | 2016-07-07 | 주식회사 삼양바이오팜 | 고분자 나노입자 동결건조물 및 그 제조방법 |
| US11077204B2 (en) * | 2015-07-10 | 2021-08-03 | Byondis B.V. | Compositions comprising antibody-duocarmycin drug conjugates |
| CA2992849C (en) | 2015-07-22 | 2023-06-13 | Nitto Denko Corporation | Compositions and methods for nanoparticle lyophile forms |
| JP7012512B2 (ja) * | 2017-11-13 | 2022-01-28 | 清水建設株式会社 | 管理装置、製造システムおよび管理方法 |
| EP3727353A4 (en) * | 2017-12-21 | 2021-10-13 | Civitas Therapeutics, Inc. | SURFACTANT FORMULATIONS FOR INHALATION |
| CN108853061A (zh) * | 2018-10-09 | 2018-11-23 | 兆科药业（合肥）有限公司 | 一种人工合成肺表面活性剂药物组合物及与之的肠溶胶囊和其制备方法及用途 |
| WO2020142420A1 (en) * | 2018-12-31 | 2020-07-09 | Novus Therapeutics, Inc. | Novel surfactant-lipid alloy drug substance, methods of making the same, and pharmaceutical compositions comprising the same |
| US11287185B1 (en) | 2020-09-09 | 2022-03-29 | Stay Fresh Technology, LLC | Freeze drying with constant-pressure and constant-temperature phases |
| KR102545292B1 (ko) * | 2021-01-28 | 2023-06-16 | 인천대학교 산학협력단 | 마이크로캡슐 형성용 생체 적합 계면활성제 합성방법 |
| WO2023280737A1 (en) * | 2021-07-05 | 2023-01-12 | Chiesi Farmaceutici S.P.A. | Process for the preparation of a pulmonary surfactant |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE751108R (fr) | 1969-06-06 | 1970-11-03 | Berliet Automobiles | Dispositif pour la mesure precise de la consommation specifiquedes moteurs a combustion |
| JPS59164724A (ja) * | 1983-03-10 | 1984-09-17 | Tokyo Tanabe Co Ltd | サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤 |
| US5260273A (en) * | 1988-01-06 | 1993-11-09 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
| JP3725166B2 (ja) | 1996-01-24 | 2005-12-07 | アルタナ ファルマ アクチエンゲゼルシャフト | 粉末状肺サーファクタント製剤の製造方法 |
| AU2322097A (en) * | 1996-03-27 | 1997-10-17 | Ortho Pharmaceutical Corporation | Lyophilized pulmonary surfactant peptide compositions |
| US6652837B1 (en) | 1996-05-24 | 2003-11-25 | Massachusetts Institute Of Technology | Preparation of novel particles for inhalation |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US7638493B2 (en) | 2004-04-29 | 2009-12-29 | Sannamu Lee | Artificial pulmonary surfactant compositions and use of the same |
| US7582312B2 (en) * | 2004-11-15 | 2009-09-01 | Discovery Laboratories, Inc. | Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof |
| ES2390354T3 (es) * | 2005-07-22 | 2012-11-12 | Amgen, Inc | Liofilizados de proteínas concentrados, procedimientos y usos |
| EP1997502A1 (en) | 2007-06-01 | 2008-12-03 | CHIESI FARMACEUTICI S.p.A. | Reconstituted surfactants having improved properties |
| SI2723323T1 (sl) * | 2012-03-28 | 2016-04-29 | Discovery Laboratories, Inc. | Liofilizacija sintetičnega liposomskega pulmonalnega surfaktanta |
-
2013
- 2013-03-28 SI SI201330112T patent/SI2723323T1/sl unknown
- 2013-03-28 PT PT137166559T patent/PT2723323E/pt unknown
- 2013-03-28 RU RU2014143247A patent/RU2671500C2/ru active
- 2013-03-28 HU HUE13716655A patent/HUE026363T2/en unknown
- 2013-03-28 PL PL13716655T patent/PL2723323T3/pl unknown
- 2013-03-28 EP EP14188473.4A patent/EP2837377A1/en not_active Withdrawn
- 2013-03-28 NZ NZ630219A patent/NZ630219A/en not_active IP Right Cessation
- 2013-03-28 PE PE2014001494A patent/PE20142302A1/es not_active Application Discontinuation
- 2013-03-28 SG SG11201405944PA patent/SG11201405944PA/en unknown
- 2013-03-28 MX MX2014011483A patent/MX359654B/es active IP Right Grant
- 2013-03-28 KR KR1020147029784A patent/KR102123129B1/ko active Active
- 2013-03-28 EP EP13716655.9A patent/EP2723323B1/en active Active
- 2013-03-28 RS RS20150867A patent/RS54513B1/en unknown
- 2013-03-28 DK DK13716655.9T patent/DK2723323T3/en active
- 2013-03-28 JP JP2015503612A patent/JP6178402B2/ja active Active
- 2013-03-28 CA CA2867649A patent/CA2867649C/en active Active
- 2013-03-28 US US14/387,707 patent/US9554999B2/en active Active
- 2013-03-28 CN CN201380022948.0A patent/CN104271118B/zh active Active
- 2013-03-28 MY MYPI2014002699A patent/MY164868A/en unknown
- 2013-03-28 IN IN8538DEN2014 patent/IN2014DN08538A/en unknown
- 2013-03-28 ES ES13716655.9T patent/ES2557805T3/es active Active
- 2013-03-28 WO PCT/US2013/034364 patent/WO2013149013A1/en active Application Filing
- 2013-03-28 AU AU2013237985A patent/AU2013237985B2/en not_active Ceased
- 2013-03-28 BR BR112014024057A patent/BR112014024057A8/pt not_active Application Discontinuation
- 2013-03-28 WO PCT/US2013/034464 patent/WO2013149074A1/en active Application Filing
- 2013-03-28 HR HRP20151392T patent/HRP20151392T1/hr unknown
- 2013-11-27 US US14/091,712 patent/US8748397B2/en active Active
- 2013-11-27 US US14/091,608 patent/US8748396B2/en active Active
-
2014
- 2014-09-16 IL IL234688A patent/IL234688B/en active IP Right Grant
- 2014-09-25 ZA ZA2014/06982A patent/ZA201406982B/en unknown
- 2014-09-25 CL CL2014002553A patent/CL2014002553A1/es unknown
- 2014-09-25 CR CR20140449A patent/CR20140449A/es unknown
- 2014-09-29 CU CUP2014000116A patent/CU20140116A7/es unknown
- 2014-09-30 CO CO14216241A patent/CO7081146A2/es unknown
- 2014-10-22 MA MA37445A patent/MA37445B1/fr unknown
- 2014-10-24 EC ECIEPI201424363A patent/ECSP14024363A/es unknown
-
2015
- 2015-08-06 HK HK15107596.6A patent/HK1206979A1/en unknown
- 2015-12-21 SM SM201500320T patent/SMT201500320B/it unknown
- 2015-12-22 CY CY20151101180T patent/CY1117380T1/el unknown
-
2017
- 2017-10-06 AU AU2017239624A patent/AU2017239624B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1117380T1 (el) | Λυοφιλιση συνθετικου λιποσωμικου πνευμονικου επιφανειοδραστικου | |
| PT2970512T (pt) | Proteínas de fusão imunomoduladoras e métodos para produção das mesmas | |
| EP2861270A4 (en) | BRIDGED THREE-DIMENSIONAL BINDING WEAVE CONSTRUCTS AND METHOD FOR THE MANUFACTURE THEREOF | |
| CO6821908A2 (es) | Prenda absorbente desechable que tiene superficies coloreadas y una pretina integral | |
| EP3008239C0 (en) | METHOD FOR PRODUCING TEXTILE PRODUCTS, PRODUCTS OBTAINED THEREFROM AND METHOD FOR RECOVERING THE PRODUCTS | |
| CO6721041A2 (es) | Anticuerpo anti-pcsk9 y métodos de uso | |
| AU350694S (en) | Floor cleaner foot | |
| BR112013016299A2 (pt) | artigo abrasivo; e método para formar o mesmo | |
| MA41088A (fr) | Matériau comprimé traité en surface | |
| UY34406A (es) | Compuestos y métodos para mejorar la respuesta inmune innata | |
| FI20105572A0 (fi) | Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt | |
| EP2995819A4 (en) | STORED ROUND PLATE AND VACUUM PUMP | |
| EP3728573C0 (en) | ENHANCED ENZYMATIC MODIFICATION OF PHOSPHOLIPIDS IN FOODS | |
| FI20115310A7 (fi) | Proteaasientsyymi ja sen käytöt | |
| EP3019660C0 (en) | ENHANCING SHEET DEHYDRATION USING SOY FLOUR OR SOY PROTEIN | |
| EP3393489A4 (en) | SYNTHETIC LUNG SURFAKTANT WITH INCREASED STABILITY AND EFFICACY | |
| CL2016000231A1 (es) | Preparados y formación de preparados usados en tecnología de concreto | |
| ES2549395B1 (es) | Sensor de suciedad y procedimiento para detectar la cantidad de suciedad de una superficie | |
| UY34155A (es) | Persiana enrollable y procedimiento para su fabricacion | |
| CO6791583A2 (es) | Elevador ciclónico y método de uso | |
| KR102448619B9 (ko) | 카펫 기포지용 부직포 및 이의 제조방법 | |
| TH1401005648A (th) | การทำให้แห้งในสภาพเยือกแข็งของสารลดแรงตึงผิวของปอดชนิดไลโพโซมสังเคราะห์ | |
| HK1197174B (en) | Lyophilization of synthetic liposomal pulmonary surfactant | |
| ES1077159Y (es) | Lanzadera aérea para personas con movilidad reducida | |
| CL2011001654A1 (es) | Metodo y procedimiento para determinar de forma eficiente la opinion de las personas. |