CY1117377T1 - COMPOSITION AND PRODUCTION OF PENTOSTATININE AND ITS PRODUCTS, ANALOGES AND PRODUCERS - Google Patents
COMPOSITION AND PRODUCTION OF PENTOSTATININE AND ITS PRODUCTS, ANALOGES AND PRODUCERSInfo
- Publication number
- CY1117377T1 CY1117377T1 CY20161100178T CY161100178T CY1117377T1 CY 1117377 T1 CY1117377 T1 CY 1117377T1 CY 20161100178 T CY20161100178 T CY 20161100178T CY 161100178 T CY161100178 T CY 161100178T CY 1117377 T1 CY1117377 T1 CY 1117377T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pentostatin
- production
- heterocyclic
- compositions
- pentostatinine
- Prior art date
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Εδώ παρέχονται μέθοδοι και συνθέσεις για την αποτελεσματική παρασκευή και παραγωγή πεντοστατίνης. Επίσης παρέχονται νέες πρόδρομες ενώσεις της πεντοστατίνης, ανάλογα και παράγωγα πεντοστατίνης. Σε μια άποψη της εφεύρεσης, παρέχεται μια μέθοδος για ολική χημική σύνθεση της πεντοστατίνης μέσω μιας οδού μεγέθυνσης ετεροκυκλικού δακτυλίου. Για παράδειγμα, ένα ετεροκυκλικό φαρμακευτικό ενδιάμεσο για φάρμακα όπως η πεντοστατίνη, π.χ., η πρόδρομη ένωση διαζεπινόνη, μπορεί να ληφθεί αποτελεσματικά μέσω μιας μεγέθυνσης δακτυλίου μιας δραστικής ομάδας Ο-C-N σε ένα παράγωγο υποξανθίνης ή 2'-δεοξυ-ινοσίνης. Οι μέθοδοι και συνθέσεις μπορούν επίσης να χρησιμοποιηθούν για την παρασκευή και παραγωγή ετεροκυκλικών ενώσεων διαφορετικών από πεντοστατίνη, ειδικότερα φαρμακευτικώς σημαντικών ετεροκυκλικών ενώσεων.Here are provided methods and compositions for the efficient preparation and production of pentostatin. Also provided are new pentostatin precursors, analogues and pentostatin derivatives. In one aspect of the invention, there is provided a method for total chemical synthesis of pentostatin via a heterocyclic ring magnification pathway. For example, a heterocyclic drug intermediate for drugs such as pentostatin, e.g., the diazepinone precursor, can be effectively obtained by a ring enlargement of an O-C-N functional group on a hypoxanthine or 2'-deoxyin derivative. The methods and compositions can also be used to prepare and produce heterocyclic compounds other than pentostatin, in particular pharmaceutically important heterocyclic compounds.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50323703A | 2003-09-15 | 2003-09-15 | |
| EP04784157.2A EP1670809B1 (en) | 2003-09-15 | 2004-09-15 | Synthesis and manufacture of pentostatin and its precursors, analogs and derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1117377T1 true CY1117377T1 (en) | 2017-04-26 |
Family
ID=58606618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161100178T CY1117377T1 (en) | 2003-09-15 | 2016-03-01 | COMPOSITION AND PRODUCTION OF PENTOSTATININE AND ITS PRODUCTS, ANALOGES AND PRODUCERS |
Country Status (1)
| Country | Link |
|---|---|
| CY (1) | CY1117377T1 (en) |
-
2016
- 2016-03-01 CY CY20161100178T patent/CY1117377T1/en unknown
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