CY1117259T1 - IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS TOY BACE Suspensions, COMPOSITIONS, AND THEIR USE - Google Patents
IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS TOY BACE Suspensions, COMPOSITIONS, AND THEIR USEInfo
- Publication number
- CY1117259T1 CY1117259T1 CY20161100195T CY161100195T CY1117259T1 CY 1117259 T1 CY1117259 T1 CY 1117259T1 CY 20161100195 T CY20161100195 T CY 20161100195T CY 161100195 T CY161100195 T CY 161100195T CY 1117259 T1 CY1117259 T1 CY 1117259T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- bace
- iminothiadiazine dioxide
- dioxide compounds
- toy
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Σε αρκετές εφαρμογές αυτής, η παρούσα εφεύρεση παρέχει ορισμένες ενώσεις διοξειδίου ιμινοθειαδιαζίνης, που συμπεριλαμβάνουν ενώσεις του Χημικού Τύπου (I): (I) και συμπεριλαμβάνουν στερεοϊσομερή εξ΄ αυτών, και φαρμακευτικώς αποδεκτά άλατα των εν λόγω στερεοϊσομερών ενώσεων, όπου το κάθε ένα από τα R1, R2, R3, R4, R5, R9, δακτύλιος Α, δακτύλιος Β, m, n, p, -L1-, -L2, και L3- επιλέγονται ανεξαρτήτως και καθορίζονται ως εις το παρόν. Καινοφανείς ενώσεις διοξειδίου ιμινοθειαδιαζίνης της εφεύρεσης έχουν ανευρεθεί κατά εκπληκτικό τρόπο να εκδηλώνουν ιδιότητες οι οποίες αναμένεται να τις καταστήσουν πλεονεκτικές ως αναστολείς του ΒACΕ και/ή για την αγωγή και πρόληψη διαφόρων παθολογιών που σχετίζονται με παραγωγή του β-αμυλοειδούς (Αβ). Φαρμακευτικές συνθέσεις που περιλαμβάνουν μία ή περισσότερες τέτοιες ενώσεις (μόνες τους ή σε συνδυασμό με έναν ή περισσότερους άλλους δραστικούς παράγοντες), και μέθοδοι για την παρασκευή και χρήση αυτών στην αγωγή παθολογιών που συσχετίζονται με πρωτεΐνη του αμυλοειδούς βήτα (Αβ), που συμπεριλαμβάνει νόσο του Αλτσχάϊμερ, αποκαλύπτονται επίσης.In several embodiments thereof, the present invention provides certain iminothiadiazine dioxide compounds, including compounds of Formula (I): (I) and comprising stereoisomers thereof, and pharmaceutically acceptable salts of said stereoisomeric compounds, each of which R1, R2, R3, R4, R5, R9, ring A, ring B, m, n, p, -L1-, -L2, and L3- are independently selected and are presently defined. Novel iminothiadiazine dioxide compounds of the invention have been surprisingly found to exhibit properties that are expected to render them advantageous as inhibitors of BACE and / or for the treatment and prevention of various pathologies related to β-amyloid production. Pharmaceutical compositions comprising one or more such compounds (alone or in combination with one or more other active agents), and methods for the preparation and use thereof in the treatment of pathologies associated with amyloid beta (Aβ) protein, including disease thereof. Alzheimer's, are also disclosed.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24968509A | 2009-10-08 | 2009-10-08 | |
| EP10822567.3A EP2485736B1 (en) | 2009-10-08 | 2010-10-06 | Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1117259T1 true CY1117259T1 (en) | 2017-04-26 |
Family
ID=58606619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161100195T CY1117259T1 (en) | 2009-10-08 | 2016-03-07 | IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS TOY BACE Suspensions, COMPOSITIONS, AND THEIR USE |
Country Status (1)
| Country | Link |
|---|---|
| CY (1) | CY1117259T1 (en) |
-
2016
- 2016-03-07 CY CY20161100195T patent/CY1117259T1/en unknown
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