CY1115966T1 - ANTI-HTNFSF13B COMPETITIVE ANTIBODIES - Google Patents
ANTI-HTNFSF13B COMPETITIVE ANTIBODIESInfo
- Publication number
- CY1115966T1 CY1115966T1 CY20151100041T CY151100041T CY1115966T1 CY 1115966 T1 CY1115966 T1 CY 1115966T1 CY 20151100041 T CY20151100041 T CY 20151100041T CY 151100041 T CY151100041 T CY 151100041T CY 1115966 T1 CY1115966 T1 CY 1115966T1
- Authority
- CY
- Cyprus
- Prior art keywords
- htnfsf13b
- tnfsf13b
- antibodies
- activity
- sec
- Prior art date
Links
- 230000002860 competitive effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 3
- 238000010494 dissociation reaction Methods 0.000 abstract 1
- 230000005593 dissociations Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Φέρονται στο προσκήνιο μονοκλωνικά αντισώματα ανθρώπου τα οποία δεσμεύονται ειδικά σε πολυπεπτίδια TNFSF13b. Αυτά τα αντισώματα έχουν υψηλή συγγένεια για hTNFSF13b (π.χ. KD = 10-8 Μ ή μικρότερη), βραδεία ταχύτητα διάστασης από την ένωση τους με τα TNFSF13b (π.χ., Koff = 10-3 sec-1 ή μικρότερη) και εξουδετερώνουν τη δραστικότητα TNFSF13b in vitro και in vivo. Τα αντισώματα κατά την εφεύρεση είναι χρήσιμα σε μία υλοποίηση αναστολής της δραστικότητας των TNFSF13b σε άνθρωπο που πάσχει από διαταραχή στην οποία η δραστικότητα των hTNFSF13b είναι επιβλαβής. Στην εφεύρεση περικλείονται επίσης νουκλεϊκά οξέα που κωδικοποιούν τα αντισώματα κατά την παρούσα εφεύρεση, ως επίσης φορείς και ξενιστικά κύτταρα προς έκφραση αυτών.Human monoclonal antibodies that bind specifically to TNFSF13b polypeptides are brought to the forefront. These antibodies have a high affinity for hTNFSF13b (e.g. KD = 10-8 sec or less), slow dissociation rate from their association with TNFSF13b (e.g., Koff = 10-3 sec-1 or less) and neutralize TNFSF13b activity in vitro and in vivo. The antibodies according to the invention are useful in an embodiment of inhibiting TNFSF13b activity in a human suffering from a disorder in which the activity of hTNFSF13b is harmful. Also included in the invention are nucleic acids encoding the antibodies of the present invention, as well as vectors and host cells for expression thereof.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31280801A | 2001-08-16 | 2001-08-16 | |
| EP10184675.6A EP2348048B1 (en) | 2001-08-16 | 2002-08-15 | Antagonistic Anti-HTNFSF13B Human Antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1115966T1 true CY1115966T1 (en) | 2017-01-25 |
Family
ID=58448919
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121100901T CY1113602T1 (en) | 2001-08-16 | 2012-09-28 | ANTI-HTNFSF13B COMPETITIVE ANTIBODIES |
| CY20151100041T CY1115966T1 (en) | 2001-08-16 | 2015-01-16 | ANTI-HTNFSF13B COMPETITIVE ANTIBODIES |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121100901T CY1113602T1 (en) | 2001-08-16 | 2012-09-28 | ANTI-HTNFSF13B COMPETITIVE ANTIBODIES |
Country Status (1)
| Country | Link |
|---|---|
| CY (2) | CY1113602T1 (en) |
-
2012
- 2012-09-28 CY CY20121100901T patent/CY1113602T1/en unknown
-
2015
- 2015-01-16 CY CY20151100041T patent/CY1115966T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1113602T1 (en) | 2016-06-22 |
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