CY1115096T1 - PROCEDURE FOR PREPARATION OF TRIFLUOROACETYL GLATIRAMER ACETATE MIXES USING PURIFIED HYDROBROMIC ACID - Google Patents
PROCEDURE FOR PREPARATION OF TRIFLUOROACETYL GLATIRAMER ACETATE MIXES USING PURIFIED HYDROBROMIC ACIDInfo
- Publication number
- CY1115096T1 CY1115096T1 CY20141100172T CY141100172T CY1115096T1 CY 1115096 T1 CY1115096 T1 CY 1115096T1 CY 20141100172 T CY20141100172 T CY 20141100172T CY 141100172 T CY141100172 T CY 141100172T CY 1115096 T1 CY1115096 T1 CY 1115096T1
- Authority
- CY
- Cyprus
- Prior art keywords
- procedure
- preparation
- hydrobromic acid
- glatiramer acetate
- acetate mixes
- Prior art date
Links
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 title 1
- 108010072051 Glatiramer Acetate Proteins 0.000 title 1
- FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 title 1
- 229960003776 glatiramer acetate Drugs 0.000 title 1
- 125000004044 trifluoroacetyl group Chemical class FC(C(=O)*)(F)F 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 235000018977 lysine Nutrition 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 235000002374 tyrosine Nutrition 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
- 150000003668 tyrosines Chemical class 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Η εφεύρεση του θέματος παρέχει μία βελτιωμένη διαδικασία για την λήψη ενός μίγματος πολύ-πεπτιδίων που έχουν μη ομοιόμορφες αλληλουχίες αμινοξέος, όπου κάθε πολύ-πεπτίδιο αποτελείται ουσιαστικά από αλανίνη (alanine), γλουταμικό (glutamic) οξύ, τυροσίνη (tyrosine) και λυσίνη (lysine) όπου το μίγμα που προκύπτει των πολύ-πεπτιδίων περιλαμβάνει από 0,3% brominated tyrosine και λιγότερο από 1000 ppm ακαθαρσίες μεταλλικών ιόντων.The subject invention provides an improved process for obtaining a mixture of polypeptides having non-uniform amino acid sequences, wherein each polypeptide consists essentially of alanine, glutamic acid, tyrosine and lysine. ) wherein the resulting mixture of polypeptides comprises 0.3% brominated tyrosine and less than 1000 ppm metal ion impurities.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60884304A | 2004-09-09 | 2004-09-09 | |
| EP10194363.7A EP2361924B1 (en) | 2004-09-09 | 2005-09-09 | Process for the preparation of mixtures of trifluoroacetyl glatiramer acetate using purified hydrobromic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1115096T1 true CY1115096T1 (en) | 2016-12-14 |
Family
ID=58459807
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121100221T CY1116737T1 (en) | 2004-09-09 | 2012-03-06 | PROCEDURE FOR PREPARATION OF TRIFLUOROACETYL GLATIRAMER ACETATE MIXES USING CLEANED HYDROBROMIC ACID |
| CY20141100172T CY1115096T1 (en) | 2004-09-09 | 2014-03-04 | PROCEDURE FOR PREPARATION OF TRIFLUOROACETYL GLATIRAMER ACETATE MIXES USING PURIFIED HYDROBROMIC ACID |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121100221T CY1116737T1 (en) | 2004-09-09 | 2012-03-06 | PROCEDURE FOR PREPARATION OF TRIFLUOROACETYL GLATIRAMER ACETATE MIXES USING CLEANED HYDROBROMIC ACID |
Country Status (1)
| Country | Link |
|---|---|
| CY (2) | CY1116737T1 (en) |
-
2012
- 2012-03-06 CY CY20121100221T patent/CY1116737T1/en unknown
-
2014
- 2014-03-04 CY CY20141100172T patent/CY1115096T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1116737T1 (en) | 2017-03-15 |
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