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CY1115020T1 - LYRICAL CARRIERS WHICH ARE GLYPROPERINATED IN THE SINDBIS VIRTUAL FILE - Google Patents

LYRICAL CARRIERS WHICH ARE GLYPROPERINATED IN THE SINDBIS VIRTUAL FILE

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Publication number
CY1115020T1
CY1115020T1 CY20141100265T CY141100265T CY1115020T1 CY 1115020 T1 CY1115020 T1 CY 1115020T1 CY 20141100265 T CY20141100265 T CY 20141100265T CY 141100265 T CY141100265 T CY 141100265T CY 1115020 T1 CY1115020 T1 CY 1115020T1
Authority
CY
Cyprus
Prior art keywords
glycoprotein
variant
sindbis
glyproperinated
lyrical
Prior art date
Application number
CY20141100265T
Other languages
Greek (el)
Inventor
James M Allen
Hoeven Neal S Van
jin zhong Li
Derek D Sloan
Thomas W Dubensky Jr
Original Assignee
Immune Design Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP10737715.2A external-priority patent/EP2456786B2/en
Application filed by Immune Design Corp filed Critical Immune Design Corp
Publication of CY1115020T1 publication Critical patent/CY1115020T1/en

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Παρέχονται σωματίδια λεντιϊικού φορέα τα οποία αποτελούνται από μια παραλλαγή γλυκοπρωτεΐνης Ε2 ιού Sindbis και ένα γονιδίωμα λεντιϊικού φορέα που αποτελείται από μια αλληλουχία που ενδιαφέρει. Ένα σωματίδιο λεντιϊικού φορέα το οποίο αποτελείται από: (α) έναν φάκελο που περιλαμβάνει μια παραλλαγή γλυκοπρωτεΐνης Ε2 ιού Sindbis, και (β) ένα γονιδίωμα λεντιϊικού φορέα που αποτελείται από μια αλληλουχία που ενδιαφέρει, όπου η παραλλαγή γλυκοπρωτεΐνης Ε2 διευκολύνει τη μόλυνση των δενδριτικών κυττάρων από το σωματίδιο λεντιϊικού φορέα, και όπου η παραλλαγή γλυκοπρωτεΐνης Ε2 έχει μειωμένη πρόσδεση σε θειική ηπαράνη σε σύγκριση με μια αλληλουχία αναφοράς (στέλεχος HR).Lentiviral vector particles are provided which consist of a variant of Sindbis virus E2 glycoprotein and a lentiviral vector genome consisting of a sequence of interest. A lentiviral vector particle comprising: (a) a envelope comprising a Sindbis virus E2 glycoprotein variant, and (b) a lentiviral vector genome consisting of a sequence of interest, where the E2 glycoprotein variant does not facilitate infection of from the lentiviral carrier particle, and wherein the glycoprotein E2 variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain).

CY20141100265T 2009-07-24 2014-04-08 LYRICAL CARRIERS WHICH ARE GLYPROPERINATED IN THE SINDBIS VIRTUAL FILE CY1115020T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22849109A 2009-07-24 2009-07-24
EP10737715.2A EP2456786B2 (en) 2009-07-24 2010-07-22 Lentiviral vectors pseudotyped with a sindbis virus envelope glycoprotein

Publications (1)

Publication Number Publication Date
CY1115020T1 true CY1115020T1 (en) 2016-12-14

Family

ID=58464080

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100265T CY1115020T1 (en) 2009-07-24 2014-04-08 LYRICAL CARRIERS WHICH ARE GLYPROPERINATED IN THE SINDBIS VIRTUAL FILE

Country Status (1)

Country Link
CY (1) CY1115020T1 (en)

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