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CY1114111T1 - Μεθοδοι χρησης του mirna για την ανιχνευση του in vivo θανατου των κυτταρων - Google Patents

Μεθοδοι χρησης του mirna για την ανιχνευση του in vivo θανατου των κυτταρων

Info

Publication number
CY1114111T1
CY1114111T1 CY20131100546T CY131100546T CY1114111T1 CY 1114111 T1 CY1114111 T1 CY 1114111T1 CY 20131100546 T CY20131100546 T CY 20131100546T CY 131100546 T CY131100546 T CY 131100546T CY 1114111 T1 CY1114111 T1 CY 1114111T1
Authority
CY
Cyprus
Prior art keywords
cell death
methods
vivo cell
mirna
detect
Prior art date
Application number
CY20131100546T
Other languages
English (en)
Inventor
Eugene M Shekhtman
Hovsep S Melkonyan
Samuil R Umansky
Vladimir S Scheinker
Original Assignee
Trovagene, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40378881&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1114111(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Trovagene, Inc. filed Critical Trovagene, Inc.
Publication of CY1114111T1 publication Critical patent/CY1114111T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/705—Specific hybridization probes for herpetoviridae, e.g. herpes simplex, varicella zoster
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Περιγράφονται μη-επεμβατικές μέθοδοι ανίχνευσης του in vivo θανάτου των κυττάρων μετρώντας τα επίπεδα του πανταχού παρόντος και ειδικού των ιστών miRΝΑ. Η μέθοδος μπορεί να εφαρμοστεί για την ανίχνευση παθολογιών που προκαλούνται ή συνοδεύονται από θάνατο των κυττάρων, ως επίσης και για την διάγνωση λοιμώδους πάθησης, κυτταροτοξικών επιδράσεων που επάγονται από διαφορετικούς χημικούς ή φυσικούς συντελεστές (παράγοντες), και από την παρουσία ειδικών εμβρυϊκών μη-φυσιολογικών ευρημάτων.
CY20131100546T 2007-08-22 2013-07-03 Μεθοδοι χρησης του mirna για την ανιχνευση του in vivo θανατου των κυτταρων CY1114111T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96587107P 2007-08-22 2007-08-22
EP08795523.3A EP2195450B2 (en) 2007-08-22 2008-08-22 Methods of using mirna for detection of in vivo cell death

Publications (1)

Publication Number Publication Date
CY1114111T1 true CY1114111T1 (el) 2016-07-27

Family

ID=40378881

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100546T CY1114111T1 (el) 2007-08-22 2013-07-03 Μεθοδοι χρησης του mirna για την ανιχνευση του in vivo θανατου των κυτταρων

Country Status (17)

Country Link
US (4) US8486626B2 (el)
EP (2) EP2612926B1 (el)
JP (1) JP5416110B2 (el)
CN (2) CN101861399B (el)
AU (2) AU2008289447B2 (el)
CA (1) CA2696403C (el)
CY (1) CY1114111T1 (el)
DK (2) DK2612926T3 (el)
ES (2) ES2660785T3 (el)
HK (1) HK1218767A1 (el)
HR (1) HRP20130618T1 (el)
HU (1) HUE019019T5 (el)
NO (1) NO2612926T3 (el)
PL (2) PL2612926T3 (el)
PT (2) PT2195450E (el)
TR (1) TR201802758T4 (el)
WO (1) WO2009025852A2 (el)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009132273A2 (en) * 2008-04-25 2009-10-29 Merck & Co., Inc. Microrna biomarkers of tissue injury
WO2010004562A2 (en) * 2008-07-09 2010-01-14 Rosetta Genomics Ltd. Methods and compositions for detecting colorectal cancer
WO2010009398A1 (en) * 2008-07-18 2010-01-21 Xenomics, Inc. Methods for pcr-based detection of "ultra short" nucleic acid sequences
US20120034608A1 (en) * 2009-04-14 2012-02-09 Merck Sharp & Dohme Corp. Microrna as a biomarker of pancreatic islet beta-cell engagement
US9752191B2 (en) 2009-07-09 2017-09-05 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
US8648017B2 (en) * 2009-11-04 2014-02-11 Diamir, Llc Methods of using small RNA from bodily fluids for diagnosis and monitoring of neurodegenerative diseases
GB2488289A (en) 2009-11-06 2012-08-22 Univ Leland Stanford Junior Non-invasive diagnosis of graft rejection in organ transplant patients
EP2569453B1 (en) * 2010-05-14 2015-12-16 Fluidigm Corporation Nucleic acid isolation methods
CA2833389C (en) 2011-04-18 2022-01-11 Diamir, Llc Mirna-based universal screening test (ust)
CN102188719B (zh) * 2011-05-12 2012-12-19 南方医科大学 EB病毒miR-BART3反义寡聚核苷酸在制备治疗鼻咽癌的药物中的应用
US9771617B2 (en) * 2011-06-27 2017-09-26 Eisai R&D Management Co., Ltd. Microrna biomarkers indicative of alzheimer's disease
US20130040303A1 (en) * 2011-08-08 2013-02-14 Eugenia Wang Biomarker for Alzheimer's Disease and/or Mild Cognitive Impairment, and Use Thereof
AU2012312353A1 (en) * 2011-09-22 2014-04-10 Lineage Biosciences, Inc. Compositions and methods for analyzing heterogeneous samples
ITRM20110685A1 (it) 2011-12-23 2013-06-24 Internat Ct For Genetic En Gineering And Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci
SG10201906331TA (en) * 2012-01-27 2019-08-27 Univ Leland Stanford Junior Methods for profiling and quantitating cell-free rna
US20140087964A1 (en) * 2012-09-24 2014-03-27 University Of Virginia Patent Foundation Compositions and methods for detecting aberrant regulation, expression, and levels of hgh
EP2733219B1 (en) 2012-11-16 2017-09-20 Siemens Aktiengesellschaft Diagnostic miRNA markers for Alzheimer
EP2733220B1 (en) * 2012-11-16 2017-10-18 Siemens Aktiengesellschaft Novel miRNA as a diagnostic marker for Alzheimer's Disease
WO2014075822A1 (en) 2012-11-16 2014-05-22 Siemens Aktiengesellschaft New diagnostic mirna markers for parkinson disease
CN103045736B (zh) * 2012-12-20 2014-09-17 徐勇 唐氏综合征21号染色体miRNA差异表达图谱模型、构建方法及应用
CN103045596A (zh) * 2012-12-20 2013-04-17 徐勇 唐氏综合征21号染色体相关miRNA、基因、筛选方法和应用
EP2759602A1 (en) * 2013-01-25 2014-07-30 Charité - Universitätsmedizin Berlin Non-invasive prenatal genetic diagnostic methods
EP3611262B1 (en) 2013-03-15 2020-11-11 Lineage Biosciences, Inc. Methods of sequencing the immune repertoire
WO2015073972A1 (en) 2013-11-18 2015-05-21 Diamir, Llc METHODS OF USING mIRNAs FROM BODILY FLUIDS FOR DETECTION AND MONITORING OF PARKINSON'S DISEASE (PD)
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
EP3889272A1 (en) 2014-07-18 2021-10-06 The Chinese University of Hong Kong Methylation pattern analysis of tissues in dna mixture
BR112017024747A2 (pt) 2015-05-18 2018-11-13 Karius Inc composições e métodos para enriquecer populações de ácidos nucleicos
WO2017019751A1 (en) 2015-07-27 2017-02-02 The Johns Hopkins University Method to use viral and host methylation markers for cervical cancer screening and triage in liquid prep, serum/plasma, and urine: pcr and sequencing based process methods
WO2017044710A1 (en) * 2015-09-11 2017-03-16 Corning Incorporated Compositions and methods for nucleic acid purification from blood samples
US10975436B2 (en) 2016-01-05 2021-04-13 Diamir, Llc Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders
EP3433381B1 (en) 2016-03-21 2024-07-24 Diamir, LLC Methods of using mirnas from bodily fluids for detection and differentiation of neurodegenerative diseases
WO2018045359A1 (en) * 2016-09-02 2018-03-08 Karius, Inc. Detection and treatment of infection during pregnancy
CA3043709A1 (en) 2016-11-14 2018-05-17 Berg Llc Methods for treating parkinson's disease
KR102529113B1 (ko) 2016-11-30 2023-05-08 더 차이니즈 유니버시티 오브 홍콩 소변 및 기타 샘플에서의 무세포 dna의 분석
US10907211B1 (en) 2017-02-16 2021-02-02 Quantgene Inc. Methods and compositions for detecting cancer biomarkers in bodily fluids
US10781487B2 (en) 2017-07-24 2020-09-22 Diamir, Llc miRNA-based methods for detecting and monitoring aging
EP3924972A4 (en) 2019-02-14 2023-03-29 Mirvie, Inc. Methods and systems for determining a pregnancy-related state of a subject
KR20220082914A (ko) * 2019-10-29 2022-06-17 고쿠리츠켄큐카이하츠호진 고쿠리츠쥰칸키뵤 겐큐센터 뇌경색 치료 지원 시스템
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856088A (en) * 1989-07-11 1999-01-05 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
US5168039A (en) * 1990-09-28 1992-12-01 The Board Of Trustees Of The University Of Arkansas Repetitive DNA sequence specific for mycobacterium tuberculosis to be used for the diagnosis of tuberculosis
US6020124A (en) * 1992-04-27 2000-02-01 Trustees Of Dartmouth College Detection of soluble gene sequences in biological fluids
EP0710248B1 (de) * 1993-07-20 1999-09-29 Roche Diagnostics GmbH Melanom-inhibierendes protein
WO1995004140A1 (en) 1993-07-28 1995-02-09 Akzo Nobel N.V. Process for isolating nucleic acid from gram positive microorganisms
ATE256735T1 (de) * 1993-08-30 2004-01-15 Promega Corp Zusammensetzungen und verfahren zur reinigung von nukleinsäuren
US5631130A (en) * 1994-05-13 1997-05-20 Abbott Laboratories Materials and methods for the detection of Mycobacterium tuberculosis
CA2192364C (en) * 1994-06-09 2009-01-20 Hans De Beenhouwer Method for the detection of the antibiotic resistance spectrum of mycobacterium species
US5731150A (en) * 1995-11-01 1998-03-24 Chiron Diagnostic Corporation IS6110 based molecular detection of mycobacterium tuberculosis
US6027945A (en) * 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
DK0920539T3 (da) * 1997-05-30 2006-07-24 Xenomics Fremgangsmåder til detektion af nukleinsyresekvenser i urin
US20020119478A1 (en) * 1997-05-30 2002-08-29 Diagen Corporation Methods for detection of nucleic acid sequences in urine
US6492144B1 (en) * 1997-05-30 2002-12-10 Diagen Corporation Methods for detection of nucleic acid sequences in urine
US5962665A (en) 1997-06-16 1999-10-05 Abbott Laboratories Nucleic acid primers and probes for detecting HIV-1 and HIV-2
US20060204989A1 (en) * 1998-09-22 2006-09-14 Kopreski Michael S Comparative analysis of extracellular RNA species
US7196183B2 (en) * 2001-08-31 2007-03-27 Innogenetics N.V. Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
US20040053264A1 (en) * 2002-02-01 2004-03-18 Park Sung Sup Clinical panel assay using DNA chips
EP2290067B1 (en) * 2004-05-28 2014-12-10 Asuragen, Inc. Methods and compositions involving microRNA
AU2006214444B8 (en) 2005-02-17 2012-04-05 Trovagene, Inc. Compositions and methods for detecting pathogen specific nucleic acids in urine
US7914982B2 (en) * 2005-02-17 2011-03-29 Trovagene, Inc. Methods for detecting pathogen specific nucleic acids in urine
ITRM20050067A1 (it) * 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici virali o di origine virale nelle urine.
CA2597948A1 (en) 2005-02-17 2006-08-24 Istituto Nazionale Per Le Malattie Infettive Irccs Lazzaro Spallanzani Compositions and methods for detecting viral specific nucleic acids in urine
ITRM20050068A1 (it) * 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine.
US20060292616A1 (en) * 2005-06-23 2006-12-28 U.S. Genomics, Inc. Single molecule miRNA-based disease diagnostic methods
DE102005059315A1 (de) * 2005-12-09 2007-06-14 Qiagen Gmbh Verfahren zur Anreicherung von kurzkettigen Nukleinsäuren
US20070202511A1 (en) * 2006-02-28 2007-08-30 Sigma-Aldrich Co. Methods and compositions for the rapid isolation of small RNA molecules
WO2010009398A1 (en) * 2008-07-18 2010-01-21 Xenomics, Inc. Methods for pcr-based detection of "ultra short" nucleic acid sequences

Also Published As

Publication number Publication date
PT2612926T (pt) 2018-03-02
JP2010536372A (ja) 2010-12-02
US20200283851A1 (en) 2020-09-10
CN105400868A (zh) 2016-03-16
US8486626B2 (en) 2013-07-16
CN101861399A (zh) 2010-10-13
JP5416110B2 (ja) 2014-02-12
DK2195450T3 (da) 2013-06-24
TR201802758T4 (tr) 2018-03-21
DK2195450T4 (en) 2016-10-24
PT2195450E (pt) 2013-07-10
CA2696403C (en) 2018-01-02
AU2014210676A1 (en) 2014-08-28
CA2696403A1 (en) 2009-02-26
CN101861399B (zh) 2015-11-25
PL2195450T3 (pl) 2013-09-30
WO2009025852A3 (en) 2009-05-07
AU2008289447A1 (en) 2009-02-26
PL2612926T3 (pl) 2018-07-31
ES2415245T5 (es) 2016-12-23
ES2660785T3 (es) 2018-03-26
WO2009025852A2 (en) 2009-02-26
ES2415245T3 (es) 2013-07-24
CN105400868B (zh) 2021-03-26
US20150197805A1 (en) 2015-07-16
HK1218767A1 (zh) 2017-03-10
US20090081640A1 (en) 2009-03-26
EP2195450A2 (en) 2010-06-16
EP2612926B1 (en) 2017-11-29
HRP20130618T1 (en) 2013-07-31
HUE019019T5 (en) 2017-04-28
EP2612926A1 (en) 2013-07-10
AU2008289447B2 (en) 2014-09-04
NO2612926T3 (el) 2018-04-28
US20180135126A1 (en) 2018-05-17
AU2014210676B2 (en) 2017-04-06
EP2195450B2 (en) 2016-07-20
DK2612926T3 (en) 2018-03-12
EP2195450B1 (en) 2013-04-03

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