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CY1113816T1 - Μορια ταυτοποιησης τα οποια ρυθμιζουν τις αλληλεπιδρασεις πρωτεϊνης-πρωτεϊνης με τη χρηση ανταποκριτων που ενεργοποιουνται με μια πρωτεαση - Google Patents

Μορια ταυτοποιησης τα οποια ρυθμιζουν τις αλληλεπιδρασεις πρωτεϊνης-πρωτεϊνης με τη χρηση ανταποκριτων που ενεργοποιουνται με μια πρωτεαση

Info

Publication number
CY1113816T1
CY1113816T1 CY20121101062T CY121101062T CY1113816T1 CY 1113816 T1 CY1113816 T1 CY 1113816T1 CY 20121101062 T CY20121101062 T CY 20121101062T CY 121101062 T CY121101062 T CY 121101062T CY 1113816 T1 CY1113816 T1 CY 1113816T1
Authority
CY
Cyprus
Prior art keywords
protein
responders
acting
regulate
identification molecules
Prior art date
Application number
CY20121101062T
Other languages
English (en)
Inventor
Jidong Cai
Paul S Wright
Paul Weissensee
Haifeng Eishingdrelo
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Publication of CY1113816T1 publication Critical patent/CY1113816T1/el

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Μέθοδοι δοκιμασιών και συστήματα στα οποία χρησιμοποιείται μία ενζυμική διάσπαση η οποία επέρχεται από την αλληλεπίδραση πρωτεΐνης- πρωτεΐνης προκειμένου να ρυθμιστεί (να ενεργοποιηθεί ή να αδρανοποιηθεί) ένας ανταποκριτής.
CY20121101062T 2007-09-04 2012-11-08 Μορια ταυτοποιησης τα οποια ρυθμιζουν τις αλληλεπιδρασεις πρωτεϊνης-πρωτεϊνης με τη χρηση ανταποκριτων που ενεργοποιουνται με μια πρωτεαση CY1113816T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96975607P 2007-09-04 2007-09-04
US8498708P 2008-07-30 2008-07-30
EP20080829659 EP2191275B1 (en) 2007-09-04 2008-08-28 Identifying molecules that modulate protein- protein interactions using protease activated reporters

Publications (1)

Publication Number Publication Date
CY1113816T1 true CY1113816T1 (el) 2016-07-27

Family

ID=40029329

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121101062T CY1113816T1 (el) 2007-09-04 2012-11-08 Μορια ταυτοποιησης τα οποια ρυθμιζουν τις αλληλεπιδρασεις πρωτεϊνης-πρωτεϊνης με τη χρηση ανταποκριτων που ενεργοποιουνται με μια πρωτεαση

Country Status (22)

Country Link
US (2) US8574865B2 (el)
EP (1) EP2191275B1 (el)
JP (1) JP5618829B2 (el)
KR (1) KR101636306B1 (el)
CN (1) CN102187225B (el)
AU (1) AU2008296501B2 (el)
BR (1) BRPI0816289B1 (el)
CA (1) CA2698362C (el)
CL (1) CL2008002602A1 (el)
CY (1) CY1113816T1 (el)
DK (1) DK2191275T3 (el)
ES (1) ES2393642T3 (el)
HK (1) HK1162664A1 (el)
IL (1) IL204260A (el)
MX (1) MX2010002399A (el)
MY (1) MY155343A (el)
PL (1) PL2191275T3 (el)
PT (1) PT2191275E (el)
RU (1) RU2476891C2 (el)
TW (1) TWI425094B (el)
UY (1) UY31323A1 (el)
WO (1) WO2009032716A1 (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2191275B1 (en) * 2007-09-04 2012-08-08 Sanofi Identifying molecules that modulate protein- protein interactions using protease activated reporters
US20160109438A1 (en) * 2013-06-06 2016-04-21 Agency For Science, Technology And Research Protease-responsive peptide biosensors and methods for analyte detection
WO2015070038A1 (en) 2013-11-11 2015-05-14 University Hospitals Cleveland Medical Center Targeted treatment of anerobic cancer
JP6909156B2 (ja) 2014-11-25 2021-07-28 ヴェンタナ メディカル システムズ， インク． 化学ライゲーション及びハプテン移行を用いた近接アッセイ
WO2016153880A2 (en) * 2015-03-23 2016-09-29 The Regents Of The University Of California Methods for detection of rnase activity
RU2639539C2 (ru) * 2015-12-29 2017-12-21 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Репортерная система на основе лентивирусных репортерных конструкций для изучения белок-белковых взаимодействий
US20180301048A1 (en) * 2017-04-12 2018-10-18 Age Of Learning, Inc. Remote live tutoring platform
EP3830580A4 (en) * 2018-07-30 2022-06-08 Montana Molecular LLC BIOSENSORS FOR DETECTING ARRESTINE SIGNALING
CA3119530A1 (en) * 2018-12-10 2020-06-18 Yale University Microbiota metabolites that shape host physiology
CN114450310A (zh) * 2019-10-15 2022-05-06 瑞士苏黎世联邦理工学院 用于检测胞内或囊内生物分子相互作用的人工跨膜蛋白

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528271B1 (en) * 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
US7128915B2 (en) * 1997-09-18 2006-10-31 Research Development Foundation Membrane virus host range mutations and their uses as vaccine substrates
US6884870B2 (en) * 1998-03-20 2005-04-26 California Institute Of Technology Fusion proteins for identifying proteases, protease target sites and regulators of protease activity in living cells
US20030157553A1 (en) * 2000-03-03 2003-08-21 Gabriel Berstein Methods of assaying for G protein-coupled receptor ligands and modulators
EP1205191A1 (en) * 2000-11-13 2002-05-15 Centre National De La Recherche Scientifique Targeted modification of intracellular compounds
EP1353182A3 (en) * 2002-04-12 2004-02-04 Smithkline Beecham Corporation Method of predicting cell-based assay results using binding profiles
US20070224615A1 (en) * 2003-07-09 2007-09-27 Invitrogen Corporation Methods for assaying protein-protein interactions
JP4734498B2 (ja) 2003-07-09 2011-07-27 ライフ テクノロジーズ コーポレイション タンパク質−タンパク質相互作用を解析する方法
US7524925B2 (en) * 2004-11-18 2009-04-28 Washington State University Protein interaction reporter agents and methods for using same
EP2191275B1 (en) * 2007-09-04 2012-08-08 Sanofi Identifying molecules that modulate protein- protein interactions using protease activated reporters
EP2990479B1 (en) * 2010-05-11 2019-03-27 Promega Corporation Mutant protease biosensors with enhanced detection characteristics

Also Published As

Publication number Publication date
EP2191275B1 (en) 2012-08-08
US8574865B2 (en) 2013-11-05
RU2476891C2 (ru) 2013-02-27
PL2191275T3 (pl) 2013-01-31
CL2008002602A1 (es) 2009-06-05
CA2698362C (en) 2013-03-26
US20100311096A1 (en) 2010-12-09
DK2191275T3 (da) 2012-11-26
MX2010002399A (es) 2010-03-25
ES2393642T3 (es) 2012-12-26
PT2191275E (pt) 2012-11-16
JP2010537669A (ja) 2010-12-09
BRPI0816289B1 (pt) 2019-01-15
MY155343A (en) 2015-10-15
RU2010112854A (ru) 2011-10-10
TWI425094B (zh) 2014-02-01
WO2009032716A8 (en) 2011-02-17
AU2008296501B2 (en) 2014-07-03
US9023610B2 (en) 2015-05-05
BRPI0816289A8 (pt) 2018-05-08
BRPI0816289A2 (pt) 2016-11-01
JP5618829B2 (ja) 2014-11-05
HK1162664A1 (zh) 2012-08-31
US20140162289A1 (en) 2014-06-12
KR20100058526A (ko) 2010-06-03
EP2191275A1 (en) 2010-06-02
TW200925281A (en) 2009-06-16
IL204260A (en) 2013-12-31
CN102187225A (zh) 2011-09-14
CA2698362A1 (en) 2009-03-12
UY31323A1 (es) 2009-04-30
AU2008296501A1 (en) 2009-03-12
WO2009032716A1 (en) 2009-03-12
CN102187225B (zh) 2015-08-05
KR101636306B1 (ko) 2016-07-05

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