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CY1113439T1 - Ενωση αζολιου - Google Patents

Ενωση αζολιου

Info

Publication number
CY1113439T1
CY1113439T1 CY20121101178T CY121101178T CY1113439T1 CY 1113439 T1 CY1113439 T1 CY 1113439T1 CY 20121101178 T CY20121101178 T CY 20121101178T CY 121101178 T CY121101178 T CY 121101178T CY 1113439 T1 CY1113439 T1 CY 1113439T1
Authority
CY
Cyprus
Prior art keywords
neuropathic pain
compound
activity
present
faah
Prior art date
Application number
CY20121101178T
Other languages
English (en)
Inventor
Satoshi Aoki
Ryosuke Munakata
Noriyuki Kawano
Kiyohiro Samizu
Hiromasa Oka
Takahiro Ishii
Takashi Sugane
Original Assignee
Astellas Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc. filed Critical Astellas Pharma Inc.
Publication of CY1113439T1 publication Critical patent/CY1113439T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

[Προβλήματα] Παρέχεται ένωση που είναι χρήσιμη ως δραστικό συστατικό φαρμακευτικής σύνθεσης για θεραπεία νευροπαθητικού πόνου. [Μέσα για επίλυση] Οι παρόντες εφευρέτες έχουν πραγματοποιήσει εκτενείς μελέτες σε ενώσεις που έχουν ανασταλτική δραστικότητα FAAH και ως αποτέλεσμα, έχουν βρει ότι ένωση αζολίου, υποκατεστημένη με Ν-(πυριδιν-3-υλ)οξ-υκαρβονυλ-πιπεριδιν-4-ύλ ομάδα και φαινύλ ομάδα ή φαρμακευτικώς αποδεκτό άλας αυτής έχει εξαιρετική ανασταλτική δραστικότητα FAAH, ολοκληρώνοντας έτσι την παρούσα εφεύρεση. Επιβεβαιώνεται ότι η ένωση της παρούσας εφεύρεσης έχει ανασταλτική δραστικότητα FAAH και κατά της αλλοδυνίας δράση σε μοντέλα αρουραίου με νευροπαθητικό πόνο και έτσι είναι χρήσιμη ως παράγων για πρόληψη ή/και παράγων για θεραπεία νευροπαθητικού πόνου.
CY20121101178T 2008-07-14 2012-12-03 Ενωση αζολιου CY1113439T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008182251 2008-07-14
EP09797891A EP2308869B1 (en) 2008-07-14 2009-07-13 Azole compound

Publications (1)

Publication Number Publication Date
CY1113439T1 true CY1113439T1 (el) 2016-06-22

Family

ID=41550369

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121101178T CY1113439T1 (el) 2008-07-14 2012-12-03 Ενωση αζολιου

Country Status (21)

Country Link
US (1) US8207199B2 (el)
EP (1) EP2308869B1 (el)
JP (1) JP5423675B2 (el)
KR (1) KR101566051B1 (el)
CN (1) CN102099354B (el)
AU (1) AU2009273105B2 (el)
BR (1) BRPI0915876B1 (el)
CA (1) CA2730793C (el)
CY (1) CY1113439T1 (el)
DK (1) DK2308869T3 (el)
ES (1) ES2393245T3 (el)
HR (1) HRP20120969T1 (el)
IL (1) IL210226A (el)
MX (1) MX2011000415A (el)
PL (1) PL2308869T3 (el)
PT (1) PT2308869E (el)
RU (1) RU2493154C2 (el)
SI (1) SI2308869T1 (el)
TW (1) TWI434842B (el)
WO (1) WO2010007966A1 (el)
ZA (1) ZA201100139B (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130150346A1 (en) 2010-01-08 2013-06-13 Quest Ventures Ltd. Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome
WO2011123719A2 (en) 2010-03-31 2011-10-06 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating abdominal, visceral and pelvic pain
JP2013147430A (ja) * 2010-04-28 2013-08-01 Astellas Pharma Inc 夜間頻尿の予防又は治療剤
TW201206440A (en) * 2010-04-28 2012-02-16 Astellas Pharma Inc Prophylactic or therapeutic agent for diseases associated with pains in urinary organs
FR2974365B1 (fr) * 2011-04-20 2017-08-25 Centre Nat De La Rech Scient (C N R S) 1,2,3-triazoles 1,4-disubstituees, leurs procedes de preparation et leurs utilisations diagnostiques et therapeutiques
DE102012018115A1 (de) 2012-09-13 2014-03-13 Matthias Lehr Aryl-N-(arylalkyl)carbamate als Hemmstoffe der Fatty Acid Amide Hydrolase
JPWO2014054635A1 (ja) * 2012-10-02 2016-08-25 大日本住友製薬株式会社 イミダゾール誘導体
DE102013016573A1 (de) 2013-10-04 2015-04-09 Matthias Lehr 1-Tetrazolylpropan-2-one als Inhibitoren von cytosolischer Phospholipase A2 und Fatty Acid Amide Hydrolase, insbesondere geeignet zur topischen Anwendung
CN106632260B (zh) * 2016-09-29 2019-04-26 上海天慈生物谷生物工程有限公司 一种小分子激酶抑制剂的制备方法
MA46589A (fr) * 2016-10-24 2019-08-28 Yumanity Therapeutics Inc Composés et utilisations de ces derniers
US11873298B2 (en) 2017-10-24 2024-01-16 Janssen Pharmaceutica Nv Compounds and uses thereof
CN108409727A (zh) * 2017-10-25 2018-08-17 巨德峰 一种脂肪酰胺水解酶抑制剂及其制备方法
SG11202009280RA (en) 2018-03-23 2020-10-29 Yumanity Therapeutics Inc Compounds and uses thereof
JP2021522253A (ja) 2018-04-25 2021-08-30 ユマニティ セラピューティクス，インコーポレーテッド 化合物及びその使用
CN108912112A (zh) * 2018-08-14 2018-11-30 李敬敬 一种化合物、制备方法以及其在治疗疼痛中的应用
US12098146B2 (en) 2019-01-24 2024-09-24 Janssen Pharmaceutica Nv Compounds and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU713171B2 (en) * 1996-06-29 1999-11-25 Samjin Pharmaceutical Co., Ltd. Piperazine derivatives and process for the preparation thereof
CN1326519C (zh) 2001-12-14 2007-07-18 诺沃挪第克公司 化合物及其降低激素－敏感性脂肪酶活性的用途
WO2003065989A2 (en) 2002-02-08 2003-08-14 Bristol-Myers Squibb Company (oxime)carbamoyl fatty acid amide hydrolase inhibitors
EA010267B1 (ru) 2002-10-07 2008-06-30 Те Риджентс Оф Те Юниверсити Оф Калифорния Модуляция тревоги через блокаду гидролиза анандамида
FR2854633B1 (fr) * 2003-05-07 2005-06-24 Sanofi Synthelabo Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
FR2866884B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique
TW200633990A (en) 2004-11-18 2006-10-01 Takeda Pharmaceuticals Co Amide compound
KR101063663B1 (ko) * 2005-02-17 2011-09-07 아스텔라스세이야쿠 가부시키가이샤 피리딜 비방향족 질소 함유 헤테로환-1-카르복실산에스테르유도체
GB2424955B (en) 2005-04-09 2008-07-16 Siemens Ag Flow meter with conductive coating
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
PE20070099A1 (es) 2005-06-30 2007-02-06 Janssen Pharmaceutica Nv N-heteroarilpiperazinil ureas como moduladores de la amida hidrolasa del acido graso
US7812025B2 (en) * 2005-08-12 2010-10-12 Takeda Pharmaceutical Company Limited Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder

Also Published As

Publication number Publication date
BRPI0915876A2 (pt) 2015-11-03
IL210226A (en) 2014-07-31
CN102099354B (zh) 2013-07-10
AU2009273105A1 (en) 2010-01-21
DK2308869T3 (da) 2012-10-08
PL2308869T3 (pl) 2013-02-28
TWI434842B (zh) 2014-04-21
SI2308869T1 (sl) 2012-12-31
JP5423675B2 (ja) 2014-02-19
CN102099354A (zh) 2011-06-15
IL210226A0 (en) 2011-03-31
WO2010007966A1 (ja) 2010-01-21
EP2308869A4 (en) 2011-07-27
EP2308869A1 (en) 2011-04-13
AU2009273105B2 (en) 2013-09-05
RU2493154C2 (ru) 2013-09-20
ES2393245T3 (es) 2012-12-19
ZA201100139B (en) 2012-03-28
MX2011000415A (es) 2011-03-15
RU2011105151A (ru) 2012-08-20
TW201014840A (en) 2010-04-16
HRP20120969T1 (hr) 2012-12-31
US8207199B2 (en) 2012-06-26
US20110118311A1 (en) 2011-05-19
CA2730793A1 (en) 2010-01-21
KR20110038671A (ko) 2011-04-14
BRPI0915876B1 (pt) 2019-07-09
EP2308869B1 (en) 2012-09-19
JPWO2010007966A1 (ja) 2012-01-05
KR101566051B1 (ko) 2015-11-04
CA2730793C (en) 2014-12-30
PT2308869E (pt) 2012-12-06

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