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CY1113124T1 - Μεθοδοι ανιχνευσης αλληλουχιων νουκλεϊκων οξεων σε ουρα - Google Patents

Μεθοδοι ανιχνευσης αλληλουχιων νουκλεϊκων οξεων σε ουρα

Info

Publication number
CY1113124T1
CY1113124T1 CY20121100714T CY121100714T CY1113124T1 CY 1113124 T1 CY1113124 T1 CY 1113124T1 CY 20121100714 T CY20121100714 T CY 20121100714T CY 121100714 T CY121100714 T CY 121100714T CY 1113124 T1 CY1113124 T1 CY 1113124T1
Authority
CY
Cyprus
Prior art keywords
nucleic acid
acid sequence
detection
urine sample
urine
Prior art date
Application number
CY20121100714T
Other languages
English (en)
Inventor
Anatoly V Lichtenstein
Hovsep S Melkonyan
Samuil R Umansky
Original Assignee
Trovagene, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trovagene, Inc. filed Critical Trovagene, Inc.
Publication of CY1113124T1 publication Critical patent/CY1113124T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6879—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for sex determination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Μία μέθοδος ανάλυσης μιας αλληλουχίας στοχευόμενου νουκλεϊκού οξέος εις ένα δείγμα ούρων, όπου η εν λόγω μέθοδος περιλαμβάνει ποσοτικό προσδιορισμό, εις το εν λόγω δείγμα ούρων, της παρουσίας της εν λόγω αλληλουχίας στοχευόμενου νουκλεϊκού οξέος, που έχει διαπεράσει το διάφραγμα του νεφρού. Η παρούσα εφεύρεση παρέχει μία μέθοδο για την ανίχνευση μίας αλληλουχίας νουκλεϊκών οξέων μη ξενιστή εις έναν ασθενή, όπου η εν λόγω μέθοδος περιλαμβάνει ποσοτικό προσδιορισμό εις ένα δείγμα ούρων, που λαμβάνεται από ένα άτομο για μία αλληλουχία νουκλεϊκών οξέων, η οποία: (i) προέρχεται από το εξωτερικό του ουροποιητικού συστήματος, (ii) έχει διαπεράσει το διάφραγμα του νεφρού, και (iii) δεν προέρχεται από τις ενδογενείς αλληλουχίες νουκλεϊκών οξέων του ασθενούς, όπου τα ρυπαίνοντα νουκλεϊκά οξέα στο δείγμα ούρων που περιέχουν περισσότερα από 1000 ζεύγη βάσης, ή 1000 νουκλεοτίδια, όταν αποδιαταχθούν, αφαιρούνται από το δείγμα προ της ανίχνευσης του εν λόγω νουκλεϊκού οξέος μη ξενιστή.
CY20121100714T 1997-05-30 2012-08-08 Μεθοδοι ανιχνευσης αλληλουχιων νουκλεϊκων οξεων σε ουρα CY1113124T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4817097P 1997-05-30 1997-05-30
US4838197P 1997-06-30 1997-06-30
EP10161334A EP2216416B1 (en) 1997-05-30 1998-05-29 Methods for Detection of Nucleic Acid Sequences in Urine

Publications (1)

Publication Number Publication Date
CY1113124T1 true CY1113124T1 (el) 2016-04-13

Family

ID=26725864

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100714T CY1113124T1 (el) 1997-05-30 2012-08-08 Μεθοδοι ανιχνευσης αλληλουχιων νουκλεϊκων οξεων σε ουρα

Country Status (11)

Country Link
US (2) US6251638B1 (el)
EP (3) EP2216416B1 (el)
AT (3) ATE557103T1 (el)
AU (1) AU7703998A (el)
CY (1) CY1113124T1 (el)
DE (2) DE69833856T2 (el)
DK (3) DK0920539T3 (el)
ES (3) ES2355631T3 (el)
HK (1) HK1088363A1 (el)
PT (1) PT2216416E (el)
WO (1) WO1998054364A1 (el)

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Also Published As

Publication number Publication date
DK2216416T3 (da) 2012-08-27
US6251638B1 (en) 2001-06-26
EP1634966B1 (en) 2010-11-03
DE69833856D1 (de) 2006-05-11
WO1998054364A1 (en) 1998-12-03
DE69841989D1 (de) 2010-12-16
PT2216416E (pt) 2012-08-16
ES2389055T3 (es) 2012-10-22
ES2355631T3 (es) 2011-03-29
DE69833856T2 (de) 2006-11-23
DK1634966T3 (da) 2011-02-07
EP2216416A1 (en) 2010-08-11
EP1634966A3 (en) 2006-06-21
EP0920539A1 (en) 1999-06-09
EP0920539B9 (en) 2006-08-02
ATE320505T1 (de) 2006-04-15
AU7703998A (en) 1998-12-30
EP1634966A2 (en) 2006-03-15
EP0920539B1 (en) 2006-03-15
HK1088363A1 (en) 2006-11-03
ATE486958T1 (de) 2010-11-15
EP0920539A4 (en) 2004-06-09
EP2216416B1 (en) 2012-05-09
US6287820B1 (en) 2001-09-11
ATE557103T1 (de) 2012-05-15
DK0920539T3 (da) 2006-07-24
ES2260837T3 (es) 2006-11-01

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