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CY1111669T1 - Πολυμερεις συνθεσεις σε υγρη μορφη για ελεγχομενη απελευθερωση βιοδραστικων ουσιων - Google Patents

Πολυμερεις συνθεσεις σε υγρη μορφη για ελεγχομενη απελευθερωση βιοδραστικων ουσιων

Info

Publication number
CY1111669T1
CY1111669T1 CY20111100461T CY111100461T CY1111669T1 CY 1111669 T1 CY1111669 T1 CY 1111669T1 CY 20111100461 T CY20111100461 T CY 20111100461T CY 111100461 T CY111100461 T CY 111100461T CY 1111669 T1 CY1111669 T1 CY 1111669T1
Authority
CY
Cyprus
Prior art keywords
substances
controlled
liquid
multilateral
liberty
Prior art date
Application number
CY20111100461T
Other languages
English (en)
Inventor
Rey T Chern
Joel R Zingerman
Original Assignee
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9815801.7A external-priority patent/GB9815801D0/en
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of CY1111669T1 publication Critical patent/CY1111669T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Ελεγχόμενη απελευθέρωση υδρόφοβων βιοδραστικών ουσιών in vivo σε εκτεταμένη χρονική διάρκεια και χωρίς «εκρήξεις» απελευθέρωσης φαρμάκου, επιτυγχάνεται χρησιμοποιώντας πολυμερή σύνθεση σε υγρή μορφή, μεταξύ των οποίων πολυμερές, όπως πολυ(λακτιδιο-συν-γλυκολιδιο) συμπολυμερές, σε μίγμα υδρόφιλου και λιπόφιλου διαλύτη.
CY20111100461T 1998-03-19 2011-05-16 Πολυμερεις συνθεσεις σε υγρη μορφη για ελεγχομενη απελευθερωση βιοδραστικων ουσιων CY1111669T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7957498P 1998-03-19 1998-03-19
GBGB9815801.7A GB9815801D0 (en) 1998-07-21 1998-07-21 Liquid polymeric compositions for controlled released bioactive substances
EP04076699A EP1484033B1 (en) 1998-03-19 1999-03-18 Liquid polymeric compositions for controlled release of bioactive substances

Publications (1)

Publication Number Publication Date
CY1111669T1 true CY1111669T1 (el) 2015-10-07

Family

ID=26314072

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100461T CY1111669T1 (el) 1998-03-19 2011-05-16 Πολυμερεις συνθεσεις σε υγρη μορφη για ελεγχομενη απελευθερωση βιοδραστικων ουσιων

Country Status (30)

Country Link
EP (2) EP1063942B1 (el)
KR (1) KR100684055B1 (el)
CN (1) CN1263435C (el)
AT (1) ATE269676T1 (el)
AU (1) AU745841B2 (el)
BG (1) BG64782B1 (el)
BR (1) BRPI9908893B8 (el)
CA (1) CA2324265C (el)
CY (1) CY1111669T1 (el)
CZ (1) CZ300822B6 (el)
DE (1) DE69918275T2 (el)
DK (1) DK1063942T3 (el)
EA (1) EA003460B1 (el)
EE (1) EE04216B1 (el)
ES (1) ES2222694T3 (el)
HK (2) HK1031990A1 (el)
HR (1) HRP20000618B1 (el)
HU (1) HU226711B1 (el)
ID (1) ID25808A (el)
IL (2) IL137982A0 (el)
IS (1) IS2221B (el)
ME (1) ME00867B (el)
NO (1) NO329589B1 (el)
NZ (1) NZ506415A (el)
PL (1) PL192270B1 (el)
PT (1) PT1063942E (el)
SI (1) SI1063942T1 (el)
SK (1) SK286612B6 (el)
TR (1) TR200002685T2 (el)
WO (1) WO1999047073A1 (el)

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ATE506942T1 (de) * 2000-09-01 2011-05-15 Palmaya Pty Ltd Pharmazeutische zubereitung und methode diese zu verabreichen
WO2002067991A1 (en) 2001-02-23 2002-09-06 Genentech, Inc. Erodible polymers for injection
ES2329346T3 (es) * 2001-11-14 2009-11-25 Durect Corporation Composicion de deposito inyectable.
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
US20040247672A1 (en) * 2003-05-16 2004-12-09 Alkermes Controlled Therapeutics, Inc. Injectable sustained release compositions
CN1293921C (zh) * 2003-08-18 2007-01-10 王玉万 含乙基纤维素和脂肪酸酯类的长效注射剂
US8048101B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US9238127B2 (en) 2004-02-25 2016-01-19 Femasys Inc. Methods and devices for delivering to conduit
US8052669B2 (en) 2004-02-25 2011-11-08 Femasys Inc. Methods and devices for delivery of compositions to conduits
US8048086B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
TWI369218B (en) * 2004-12-14 2012-08-01 Novartis Ag In situ forming implant for animals
US8362086B2 (en) * 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
NZ552040A (en) * 2006-12-13 2009-04-30 Bomac Research Ltd Veterinary formulation comprising an anthelmintic compound and glyceryl acetate
TW200924647A (en) * 2007-08-30 2009-06-16 Schering Plough Ltd Local topical administration formulations containing fipronil
BRPI0705822A2 (pt) * 2007-10-25 2009-06-23 Schering Plough Saude Animal Ltda formulação injetável com ação prolongada e uso de um agente semi-sintético derivado do grupo das avermectinas, em combinação com um polìmero biodegradável
US20090181068A1 (en) 2008-01-14 2009-07-16 Dunn Richard L Low Viscosity Liquid Polymeric Delivery System
US20090281150A1 (en) * 2008-04-09 2009-11-12 Nicola Frances Bateman Compound 249
BRPI0802255A2 (pt) * 2008-06-17 2010-03-16 Sespo Ind E Com Ltda composição de uso tópico para controle de ectoparasitos em cães e gatos
US12171463B2 (en) 2008-10-03 2024-12-24 Femasys Inc. Contrast agent generation and injection system for sonographic imaging
US9554826B2 (en) 2008-10-03 2017-01-31 Femasys, Inc. Contrast agent injection system for sonographic imaging
US10070888B2 (en) 2008-10-03 2018-09-11 Femasys, Inc. Methods and devices for sonographic imaging
WO2010106325A2 (en) 2009-03-18 2010-09-23 Omnipharm Limited Parasiticidal formulation
DE102011114986A1 (de) * 2011-09-28 2013-03-28 Ethris Gmbh Sprühsystem
JP6564369B2 (ja) 2013-12-09 2019-08-21 デュレクト コーポレイション 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法
US8785426B1 (en) 2013-12-13 2014-07-22 Upsher-Smith Laboratories, Inc. Testosterone gel compositions and related methods
CN107811967B (zh) * 2016-09-09 2021-08-24 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心) 抗寄生虫药物原位固化缓释注射剂及其制备方法
KR102101969B1 (ko) 2017-09-06 2020-04-22 (주)인벤티지랩 목시덱틴을 포함하는 마이크로 입자 및 이의 제조 방법
WO2019050259A1 (ko) * 2017-09-06 2019-03-14 (주)인벤티지랩 목시덱틴을 포함하는 마이크로 입자 및 이의 제조 방법
CN115666621A (zh) 2020-01-13 2023-01-31 度勒科特公司 具有减少的杂质的持续释放药物递送系统及相关方法
CN111675778B (zh) * 2020-06-15 2021-11-02 苏州大学 基于pisa方法制备的偶氮还原酶响应性的近红外聚合物荧光探针及其应用
ES2948624T3 (es) 2020-11-19 2023-09-14 Fis Fabbrica Italiana Sintetici Spa Proceso mejorado para la preparación de trembolona y/o acetato de trembolona
EP4000688A1 (en) 2020-11-19 2022-05-25 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of trenbolone acetate having a definite particle size distribution
EP4001288A1 (en) 2020-11-19 2022-05-25 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of trenbolone acetate having a definite particle size distribution and a irregular hexagon plates crystal habit

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Also Published As

Publication number Publication date
HUP0102385A3 (en) 2002-12-28
BRPI9908893B8 (pt) 2021-05-25
BR9908893A (pt) 2000-11-28
NO20004616D0 (no) 2000-09-15
IS5599A (is) 2000-08-22
NO329589B1 (no) 2010-11-15
EP1063942A1 (en) 2001-01-03
EP1063942B1 (en) 2004-06-23
BG64782B1 (bg) 2006-04-28
EE04216B1 (et) 2004-02-16
PT1063942E (pt) 2004-10-29
KR100684055B1 (ko) 2007-02-16
BG104838A (en) 2001-07-31
SI1063942T1 (en) 2004-10-31
CA2324265C (en) 2008-08-05
EP1063942A4 (en) 2002-07-10
PL342858A1 (en) 2001-07-16
EE200000539A (et) 2002-02-15
IS2221B (is) 2007-03-15
KR20010041987A (ko) 2001-05-25
NZ506415A (en) 2003-06-30
DE69918275T2 (de) 2005-07-07
DE69918275D1 (de) 2004-07-29
ATE269676T1 (de) 2004-07-15
CZ20003420A3 (en) 2001-05-16
CN1263435C (zh) 2006-07-12
TR200002685T2 (tr) 2000-12-21
SK286612B6 (sk) 2009-02-05
CN1293553A (zh) 2001-05-02
HRP20000618A2 (en) 2001-08-31
PL192270B1 (pl) 2006-09-29
WO1999047073A1 (en) 1999-09-23
AU3010099A (en) 1999-10-11
NO20004616L (no) 2000-09-15
HUP0102385A2 (hu) 2002-03-28
HK1031990A1 (en) 2001-07-06
EP1484033B1 (en) 2011-02-23
ID25808A (id) 2000-11-09
HK1036579A1 (en) 2002-01-11
DK1063942T3 (da) 2005-11-07
EA003460B1 (ru) 2003-06-26
CA2324265A1 (en) 1999-09-23
EP1484033A1 (en) 2004-12-08
CZ300822B6 (cs) 2009-08-19
IL137982A0 (en) 2001-10-31
SK13752000A3 (sk) 2001-03-12
IL137982A (en) 2006-10-05
HU226711B1 (en) 2009-07-28
EA200000964A1 (ru) 2001-02-26
HRP20000618B1 (en) 2010-10-31
ES2222694T3 (es) 2005-02-01
AU745841B2 (en) 2002-04-11
ME00867B (me) 2008-08-07
BR9908893B1 (pt) 2013-11-19

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