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CY1110261T1 - Παραγωγα της κουμαρινης που χρησιμοποιουνται σαν αντιπηκτικα - Google Patents

Παραγωγα της κουμαρινης που χρησιμοποιουνται σαν αντιπηκτικα

Info

Publication number
CY1110261T1
CY1110261T1 CY20081100594T CY081100594T CY1110261T1 CY 1110261 T1 CY1110261 T1 CY 1110261T1 CY 20081100594 T CY20081100594 T CY 20081100594T CY 081100594 T CY081100594 T CY 081100594T CY 1110261 T1 CY1110261 T1 CY 1110261T1
Authority
CY
Cyprus
Prior art keywords
drugs
taught
toxicity
anticoagulants
chemical compounds
Prior art date
Application number
CY20081100594T
Other languages
English (en)
Inventor
Pascal Druzgala
Xiaoming Zhang
Jurg R. Pfister
Original Assignee
Aryx Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aryx Therapeutics filed Critical Aryx Therapeutics
Publication of CY1110261T1 publication Critical patent/CY1110261T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Η εφεύρεση αυτή απεικονίζει χημικές ενώσεις οι οποίες μεταβολίζονται ευκολότερα από τα συστήματα μείωσης της τοξικότητας των φαρμάκων με χημικές μεταβολές που προκαλούνται στο σώμα. Ιδιαίτερα, διδάσκονται ανάλογα της βαρφαρίνης τα οποία έχουν σχεδιαστεί να περιλαμβάνουν εστέρες μέσα στη δομή των χημικών ενώσεων. Η εφεύρεση διδάσκει μεθόδους για τη μείωση της τοξικότητας των φαρμάκων, που περιλαμβάνουν την εισαγωγή εστερομάδων μέσα σε φάρμακα κατά τη διάρκεια της σύνθεσης του φαρμάκου. Η εφεύρεση αυτή απεικονίζει επίσης μεθόδους για την θεραπευτική αντιμετώπιση διαταραχών της πήξης, οι οποίες περιλαμβάνουν τη χορήγηση χημικών ενώσεων οι οποίες έχουν σχεδιαστεί να μεταβολίζονται από ευρισκόμενες στον ορό ή ενδοκυτταρικές υδρολάσες και εστεράσες. Διδάσκονται επίσης φαρμακευτικές συνθέσεις των αναλόγων βαρφαρίνης που περιλαμβάνουν τον εστέρα.
CY20081100594T 2001-04-24 2008-06-05 Παραγωγα της κουμαρινης που χρησιμοποιουνται σαν αντιπηκτικα CY1110261T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28607901P 2001-04-24 2001-04-24
PCT/US2002/013163 WO2002085882A1 (en) 2001-04-24 2002-04-24 Coumarin derivatives to be used as anticoagulants

Publications (1)

Publication Number Publication Date
CY1110261T1 true CY1110261T1 (el) 2012-05-23

Family

ID=23096978

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100594T CY1110261T1 (el) 2001-04-24 2008-06-05 Παραγωγα της κουμαρινης που χρησιμοποιουνται σαν αντιπηκτικα

Country Status (12)

Country Link
US (2) US6864279B2 (el)
EP (1) EP1383756B1 (el)
JP (2) JP4662690B2 (el)
AT (1) ATE388143T1 (el)
AU (1) AU2002256361B2 (el)
CA (1) CA2445160A1 (el)
CY (1) CY1110261T1 (el)
DE (1) DE60225434T2 (el)
DK (1) DK1383756T3 (el)
ES (1) ES2301635T3 (el)
PT (1) PT1383756E (el)
WO (1) WO2002085882A1 (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030054974A1 (en) * 2001-08-24 2003-03-20 Aryx Therapeutics Non-oxidatively metabolized compounds and compositions, synthetic pathways therefor, and uses thereof
DE60225434T2 (de) * 2001-04-24 2009-03-12 Aryx Therapeutics, Fremont Cumarin derivate und ihre verwendung als antikoagulantien
US7145020B2 (en) * 2001-04-24 2006-12-05 Aryx Therapeutics Materials and methods for treating coagulation disorders
BRPI0508392A (pt) 2004-04-08 2007-08-07 Aryx Therapeutics materiais e métodos para tratar distúrbios de coagulação
CN1950353B (zh) 2004-04-08 2011-06-01 ARYx医疗有限公司 治疗凝血紊乱的药物和方法
EP2161261B1 (en) 2004-04-08 2013-08-28 Armetheon, Inc. Materials and methods for treating coagulation disorders
KR100794515B1 (ko) 2005-07-12 2008-01-16 제일약품주식회사 항염증 활성을 갖는 크로멘-2-온 모핵 히드록사민 산유도체, 이의 제조방법 및 이를 포함하는 염증 질환의치료를 위한 조성물
WO2007008037A1 (en) * 2005-07-12 2007-01-18 Jeil Pharmaceutical Co., Ltd. Novel chromen-2-one based hydroxamic acid derivatives having anti-inflammatory activity, the preparation thereof and a composition containing the same for treating inflammatory disease
AU2007238548A1 (en) * 2006-01-30 2007-10-25 Caridianbct, Inc. Adjusting pH in a method of separating whole blood
AR059339A1 (es) 2006-02-09 2008-03-26 Chugai Pharmaceutical Co Ltd Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene
KR101511396B1 (ko) 2007-07-20 2015-04-13 추가이 세이야쿠 가부시키가이샤 ｐ27 단백질 유도제
WO2010056914A1 (en) * 2008-11-12 2010-05-20 Microbiotix, Inc. Bacterial helicase inhibitor compounds and uses thereof
US9549912B2 (en) 2009-11-23 2017-01-24 Armetheon, Inc. Methods for treating atrial fibrillation
US20110136779A1 (en) * 2009-11-23 2011-06-09 Milner Peter G Methods for stroke reduction in atrial fibrillation patients
CA2781888C (en) * 2009-12-11 2019-06-18 Nono Inc. Agents and methods for treating ischemic and other diseases
LV14606B (lv) 2011-05-17 2013-01-20 Tetra, Sia Jauns XII faktora inhibitors

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US2465293A (en) * 1942-08-29 1949-03-22 Wisconsin Alumni Res Found Synthesis of 4-hydroxycoumarins
NL286657A (el) * 1961-12-19
NL286658A (el) * 1961-12-19
FR1463767A (fr) * 1963-04-03 1966-07-22 Clin Byla Ets Dérivés de la coumarine et leur préparation
GB8531388D0 (en) * 1985-12-20 1986-02-05 Shell Int Research 4-hydroxycoumarin derivatives
JPS63165368A (ja) * 1986-01-07 1988-07-08 Yamanouchi Pharmaceut Co Ltd 新規複素環化合物およびその製造法
DK0574545T3 (da) * 1991-03-06 1995-01-30 Searle & Co Phenylamidinderivater som blodpladeaggregationsinhibitorer
JPH0826011B2 (ja) * 1991-04-25 1996-03-13 アサヒビール株式会社 アミノメチルイソクロマン誘導体およびその製造方法
IL108459A0 (en) 1993-02-05 1994-04-12 Opjohn Company 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses
JPH06340649A (ja) * 1993-05-31 1994-12-13 Lab Farmaceut Rovi Sa クマリンから誘導される新規な抗血栓剤及びその製造法
DE59402281D1 (de) * 1993-06-28 1997-05-07 Bayer Ag Massefärben von Kunststoffen
IL110172A (en) * 1993-07-22 2001-10-31 Lilly Co Eli Bicycle compounds and pharmaceuticals containing them
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ZA965853B (en) * 1995-07-13 1998-01-12 Du Pont Merck Pharma Asymmetric synthesis of r and s warfarin and its analogs.
PT883405E (pt) * 1995-12-29 2004-06-30 Dimensional Pharm Inc Inibidores de amidino-protease
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FR2765579A1 (fr) * 1997-07-01 1999-01-08 Lipha Nouveaux derives de 4-hydroxy-2h-1-(thio)pyran-2-ones leurs preparations et leurs utilisations comme rodonticides
DE60225434T2 (de) * 2001-04-24 2009-03-12 Aryx Therapeutics, Fremont Cumarin derivate und ihre verwendung als antikoagulantien
US7145020B2 (en) * 2001-04-24 2006-12-05 Aryx Therapeutics Materials and methods for treating coagulation disorders
BRPI0508392A (pt) * 2004-04-08 2007-08-07 Aryx Therapeutics materiais e métodos para tratar distúrbios de coagulação
CN1950353B (zh) * 2004-04-08 2011-06-01 ARYx医疗有限公司 治疗凝血紊乱的药物和方法

Also Published As

Publication number Publication date
AU2002256361B2 (en) 2008-01-24
EP1383756A1 (en) 2004-01-28
DK1383756T3 (da) 2008-06-23
PT1383756E (pt) 2008-06-19
WO2002085882A1 (en) 2002-10-31
US6864279B2 (en) 2005-03-08
JP2004527547A (ja) 2004-09-09
ATE388143T1 (de) 2008-03-15
EP1383756B1 (en) 2008-03-05
US20080221204A1 (en) 2008-09-11
JP2010143937A (ja) 2010-07-01
JP4662690B2 (ja) 2011-03-30
ES2301635T3 (es) 2008-07-01
DE60225434D1 (de) 2008-04-17
DE60225434T2 (de) 2009-03-12
CA2445160A1 (en) 2002-10-31
US20030199573A1 (en) 2003-10-23

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