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CY1109364T1 - Ενας συνδυασμος που περιλαμβανει κομβρεταστατινη και αντικαρκινικους παραγοντες - Google Patents

Ενας συνδυασμος που περιλαμβανει κομβρεταστατινη και αντικαρκινικους παραγοντες

Info

Publication number
CY1109364T1
CY1109364T1 CY20091100954T CY091100954T CY1109364T1 CY 1109364 T1 CY1109364 T1 CY 1109364T1 CY 20091100954 T CY20091100954 T CY 20091100954T CY 091100954 T CY091100954 T CY 091100954T CY 1109364 T1 CY1109364 T1 CY 1109364T1
Authority
CY
Cyprus
Prior art keywords
combination containing
cancer factors
combretastatin
containing combretastatin
cancer
Prior art date
Application number
CY20091100954T
Other languages
English (en)
Inventor
Marie-Christine Bissery
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of CY1109364T1 publication Critical patent/CY1109364T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Παρέχεται ένα αντικαρκινικός συνδυασμός που περιλαμβάνει ένα παράγωγο στιλβίνης και μια αντικαρκινική ένωση που επιλέγεται από την ομάδα που αποτελείται από ταξάνες, αλκυλοποιητικούς παράγοντες, ατιμεταβολίτες, αλκαλοειδή vinca, επιδοφυλλοπτοξίνες, και αντιβιοτικά ως τα ενεργά συστατικά στοιχεία. Παρέχονται επίσης μέθοδοι χρήσης αυτών των φαρμακευτικών παρασκευασμάτων για τη θεραπεία των στερεών καρκινομάτων και άλλων παρόμοιων ασθενειών.
CY20091100954T 2001-03-15 2009-09-16 Ενας συνδυασμος που περιλαμβανει κομβρεταστατινη και αντικαρκινικους παραγοντες CY1109364T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27562701P 2001-03-15 2001-03-15
EP02732758A EP1439839B8 (en) 2001-03-15 2002-03-15 A combination comprising combretastatin and anticancer agents

Publications (1)

Publication Number Publication Date
CY1109364T1 true CY1109364T1 (el) 2014-07-02

Family

ID=23053164

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100954T CY1109364T1 (el) 2001-03-15 2009-09-16 Ενας συνδυασμος που περιλαμβανει κομβρεταστατινη και αντικαρκινικους παραγοντες

Country Status (38)

Country Link
US (4) US20020183266A1 (el)
EP (1) EP1439839B8 (el)
JP (1) JP4991107B2 (el)
KR (1) KR100849610B1 (el)
CN (2) CN1290504C (el)
AR (1) AR032989A1 (el)
AT (1) ATE433750T1 (el)
AU (1) AU2002304574B2 (el)
BR (1) BR0208017A (el)
CA (2) CA2470484C (el)
CY (1) CY1109364T1 (el)
CZ (1) CZ302451B6 (el)
DE (1) DE60232673D1 (el)
DK (1) DK1439839T3 (el)
EA (1) EA006316B1 (el)
EC (1) ECSP034766A (el)
ES (1) ES2327617T3 (el)
HK (1) HK1067039A1 (el)
HR (1) HRPK20030734B3 (el)
HU (1) HU228510B1 (el)
IL (2) IL157891A0 (el)
MA (1) MA27000A1 (el)
ME (2) MEP16208A (el)
MX (1) MXPA03007552A (el)
NO (1) NO332661B1 (el)
NZ (1) NZ527526A (el)
PE (1) PE20020909A1 (el)
PL (1) PL205728B1 (el)
PT (1) PT1439839E (el)
RS (1) RS50682B (el)
SI (1) SI1439839T1 (el)
SK (1) SK287908B6 (el)
TN (1) TNSN03060A1 (el)
TW (1) TWI306028B (el)
UA (1) UA75127C2 (el)
UY (1) UY27208A1 (el)
WO (2) WO2004037258A1 (el)
ZA (1) ZA200306789B (el)

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WO1999051246A1 (fr) 1998-04-03 1999-10-14 Ajinomoto Co., Inc. Agents antitumoraux
US20050209310A1 (en) * 2000-12-22 2005-09-22 Chaplin David J Methods for modulating tumor growth and metastasis
GB0410817D0 (en) * 2004-05-14 2004-06-16 Angiogene Pharm Ltd Vascular damaging therapy
CN100431606C (zh) * 2004-11-22 2008-11-12 山东蓝金生物工程有限公司 一种抗癌药物组合物
CN1319978C (zh) * 2005-04-06 2007-06-06 西南合成制药股份有限公司 康布瑞汀化合物的制备方法
FR2895258B1 (fr) * 2005-12-22 2008-03-21 Aventis Pharma Sa Combinaison comprenant de la combretastatine et des agents anticancereux
US20080104512A1 (en) * 2006-10-31 2008-05-01 Motorola, Inc. Method and apparatus for providing realtime feedback in a voice dialog system
PT2219451E (pt) * 2007-11-21 2015-02-09 Oxigene Inc Processo para o tratamento de neoplasmas hematopoiéticos
WO2009103076A1 (en) * 2008-02-15 2009-08-20 Oxigene, Inc. Methods and compositions for enhancing the efficacy of rtk inhibitors
FR2939665B1 (fr) * 2008-12-12 2011-10-07 Sanofi Aventis Combinaison antitumorale associant l'ave8062a et le docetaxel
FR2945210B1 (fr) 2009-05-07 2011-07-01 Sanofi Aventis Combinaison antitumorale comprenant l'ave8062 et le sorafenib
WO2011158206A1 (en) 2010-06-18 2011-12-22 Sanofi An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative
EP2397135A1 (en) 2010-06-18 2011-12-21 Sanofi An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative
EP2481404A1 (en) 2010-11-15 2012-08-01 Sanofi An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative
EP2407161A1 (en) 2010-07-13 2012-01-18 Sanofi An antitumoral combination comprising ombrabulin and bevacizumab
FR2968557A1 (fr) 2010-12-09 2012-06-15 Sanofi Aventis Combinaison antitumorale comprenant un derive de la famille des combretastatines et le cetuximab
FR2978663A1 (fr) 2011-08-01 2013-02-08 Sanofi Sa Combinaison antitumorale comprenant l'ombrabuline et le cetuximab, associee a la radiotherapie
FR2978662A1 (fr) 2011-08-01 2013-02-08 Sanofi Sa Combinaison antitumorale comprenant l'ombrabuline et le cisplatine, associee a la radiotherapie
US11419934B2 (en) 2015-08-18 2022-08-23 Oncotelic Therapeutics, Inc. Use of VDAS to enhance immunomodulating therapies against tumors
US9980953B2 (en) * 2016-09-26 2018-05-29 Chong Kun Dang Pharmaceutical Corp. Combined composition for preventing or treating cancer comprising a benzophenone thiazole derivatives as a VDA and topoisomerase inhibitor

Family Cites Families (18)

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FR2601675B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US4996237A (en) 1987-01-06 1991-02-26 Arizona Board Of Regents Combretastatin A-4
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US5731353A (en) 1993-09-08 1998-03-24 Ajinomoto Co., Inc. Stilbene derivatives and pharmaceutical compositions containing them
TW325458B (en) 1993-09-08 1998-01-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer
US5561122A (en) 1994-12-22 1996-10-01 Arizona Board Of Regents Acting On Behalf Of Arizona State University Combretastatin A-4 prodrug
TW334418B (en) * 1995-03-07 1998-06-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions
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US6242770B1 (en) * 1998-08-31 2001-06-05 Gary Bela Bronner Diode connected to a magnetic tunnel junction and self aligned with a metallic conductor and method for forming the same
GB9903404D0 (en) * 1999-02-16 1999-04-07 Angiogene Pharm Ltd Methods of treatment and compositions useful for the treatment of diseases involving angiogenesis
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Also Published As

Publication number Publication date
HRP20030734A2 (en) 2005-06-30
NZ527526A (en) 2006-11-30
PE20020909A1 (es) 2002-12-09
ATE433750T1 (de) 2009-07-15
HUP0600233A2 (en) 2008-06-30
EP1439839B8 (en) 2010-09-01
HUP0600233A3 (en) 2010-03-29
IL157891A (en) 2010-06-16
EP1439839A1 (en) 2004-07-28
AU2002304574A1 (en) 2004-05-13
CA2673449C (en) 2011-10-18
SK287908B6 (sk) 2012-03-02
BR0208017A (pt) 2004-12-07
IL157891A0 (en) 2004-03-28
JP4991107B2 (ja) 2012-08-01
ZA200306789B (en) 2005-02-23
CA2470484A1 (en) 2004-05-06
CZ302451B6 (cs) 2011-05-25
HU228510B1 (en) 2013-03-28
SK11552003A3 (sk) 2004-03-02
TWI306028B (en) 2009-02-11
DK1439839T3 (da) 2009-10-05
TNSN03060A1 (en) 2005-12-23
PL374406A1 (en) 2005-10-17
WO2002074229A2 (en) 2002-09-26
EP1439839B1 (en) 2009-06-17
US20030060429A1 (en) 2003-03-27
PL205728B1 (pl) 2010-05-31
RS50682B (sr) 2010-06-30
KR20040067866A (ko) 2004-07-30
CN1290504C (zh) 2006-12-20
US20070149476A1 (en) 2007-06-28
US20050075295A1 (en) 2005-04-07
ES2327617T3 (es) 2009-11-02
CA2470484C (en) 2009-10-13
JP2005522527A (ja) 2005-07-28
CN1547471A (zh) 2004-11-17
KR100849610B1 (ko) 2008-07-31
ME00056B (me) 2010-06-10
HRPK20030734B3 (en) 2006-11-30
SI1439839T1 (sl) 2011-09-30
PT1439839E (pt) 2009-09-03
MA27000A1 (fr) 2004-12-20
CN1935134A (zh) 2007-03-28
UY27208A1 (es) 2002-08-30
WO2004037258A1 (en) 2004-05-06
YU71303A (sh) 2006-08-17
MEP16208A (en) 2010-06-10
NO20034022D0 (no) 2003-09-11
ECSP034766A (es) 2003-10-28
EA006316B1 (ru) 2005-10-27
US20020183266A1 (en) 2002-12-05
CN1935134B (zh) 2010-12-15
HK1067039A1 (en) 2005-04-01
DE60232673D1 (de) 2009-07-30
MXPA03007552A (es) 2004-10-15
AU2002304574B2 (en) 2005-09-15
EA200301015A1 (ru) 2004-08-26
US6933320B2 (en) 2005-08-23
AR032989A1 (es) 2003-12-03
NO332661B1 (no) 2012-11-26
NO20034022L (no) 2003-09-11
UA75127C2 (en) 2006-03-15
CA2673449A1 (en) 2004-05-06
CZ20032476A3 (en) 2004-07-14

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