CY1109006T1 - Παραγωγα πουρινης ως αναστολεις κινασης - Google Patents
Παραγωγα πουρινης ως αναστολεις κινασηςInfo
- Publication number
- CY1109006T1 CY1109006T1 CY20071100071T CY071100071T CY1109006T1 CY 1109006 T1 CY1109006 T1 CY 1109006T1 CY 20071100071 T CY20071100071 T CY 20071100071T CY 071100071 T CY071100071 T CY 071100071T CY 1109006 T1 CY1109006 T1 CY 1109006T1
- Authority
- CY
- Cyprus
- Prior art keywords
- purinis
- products
- suspensions
- moving
- moving suspensions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει αναστολείς κινάσης Τύπου Ι.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36224502P | 2002-03-05 | 2002-03-05 | |
EP03711146A EP1483265B1 (en) | 2002-03-05 | 2003-03-04 | Purine derivatives as kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1109006T1 true CY1109006T1 (el) | 2014-07-02 |
Family
ID=27805149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100071T CY1109006T1 (el) | 2002-03-05 | 2007-01-18 | Παραγωγα πουρινης ως αναστολεις κινασης |
Country Status (16)
Country | Link |
---|---|
US (4) | US7491716B2 (el) |
EP (1) | EP1483265B1 (el) |
JP (1) | JP4414232B2 (el) |
KR (1) | KR100974770B1 (el) |
CN (1) | CN1312154C (el) |
AT (1) | ATE346070T1 (el) |
AU (1) | AU2003215325B8 (el) |
BR (1) | BR0308243B1 (el) |
CA (1) | CA2477967C (el) |
CY (1) | CY1109006T1 (el) |
DE (1) | DE60309848T2 (el) |
DK (1) | DK1483265T3 (el) |
ES (1) | ES2276048T3 (el) |
IL (2) | IL163781A0 (el) |
PT (1) | PT1483265E (el) |
WO (1) | WO2003076442A1 (el) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20040091113A (ko) * | 2002-03-08 | 2004-10-27 | 일라이 릴리 앤드 캄파니 | 피롤-2,5-디온 유도체 및 gsk-3 억제제로서 그의 용도 |
GB0212049D0 (en) * | 2002-05-24 | 2002-07-03 | Merck Sharp & Dohme | Therapeutic agents |
RU2547148C2 (ru) | 2005-02-09 | 2015-04-10 | Аркьюл, Инк. | Композиции и способы лечения рака |
ATE542535T1 (de) * | 2005-05-04 | 2012-02-15 | Develogen Ag | Verwendung von azapaullonen zur vorbeugung und behandlung pankreatischer autoimmunkrankheiten |
US20080207594A1 (en) * | 2005-05-04 | 2008-08-28 | Davelogen Aktiengesellschaft | Use of Gsk-3 Inhibitors for Preventing and Treating Pancreatic Autoimmune Disorders |
CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
WO2007047978A2 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
EP2314289A1 (en) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
TW200800203A (en) | 2006-03-08 | 2008-01-01 | Astrazeneca Ab | New use |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
DK2383271T3 (da) * | 2006-03-13 | 2013-10-07 | Kyorin Seiyaku Kk | Aminoquinoloner som GSK-3-inhibitorer |
EP1845098A1 (en) | 2006-03-29 | 2007-10-17 | Ferrer Internacional, S.A. | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands |
CA2651813A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
MX2009001043A (es) | 2006-08-08 | 2009-02-06 | Sanofi Aventis | Imidazolidina-2,4-dionas sustituidas con arilaminoarilalquilo, procedimiento para preparalas, medicamentos que comprenden estos compuestos y su uso. |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
CN101302216B (zh) * | 2007-05-11 | 2011-08-10 | 上海睿智化学研究有限公司 | 稠环吲哚类化合物的制备方法 |
EP2392574B1 (en) | 2007-06-22 | 2013-12-18 | ArQule, Inc. | Indolyl pyrrolidines for the treatment of cancer |
CN101801937A (zh) | 2007-06-22 | 2010-08-11 | 艾科尔公司 | 喹唑啉酮化合物及其使用方法 |
JP5425060B2 (ja) | 2007-06-22 | 2014-02-26 | アークル インコーポレイテッド | ピロリジノン、ピロリジン−2,5−ジオン、ピロリジンおよびチオスクシンイミド誘導体、癌の治療のための組成物および方法 |
TWI428132B (zh) | 2007-07-02 | 2014-03-01 | Lilly Co Eli | 癌症化療效果之強化 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
LT2824100T (lt) * | 2008-07-08 | 2018-05-10 | Incyte Holdings Corporation | 1,2,5-oksadiazolai, kaip indolamino 2,3-dioksigenazės inhibitoriai |
UY31968A (es) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US8802668B2 (en) * | 2009-04-14 | 2014-08-12 | Eli Lilly And Company | Hematopoietic neoplasm chemotherapy |
CA2771278A1 (en) | 2009-08-26 | 2011-03-03 | Sanofi | Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
EA020847B1 (ru) | 2009-10-30 | 2015-02-27 | Янссен Фармацевтика Нв | ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-b]ПИРИДАЗИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ PDE10 |
WO2011082266A2 (en) | 2009-12-30 | 2011-07-07 | Arqule, Inc. | Substituted heterocyclic compounds |
AU2011208530A1 (en) | 2010-01-19 | 2012-08-09 | Astrazeneca Ab | Pyrazine derivatives |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TWI525091B (zh) * | 2010-12-23 | 2016-03-11 | 亞闊股份有限公司 | 吡咯並喹啉基-吡咯啶-2,5-二酮組成物類及製備和使用彼等之方法 |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
WO2012120051A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8809324B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
WO2012120058A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120057A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
BR112013033375B1 (pt) | 2011-06-27 | 2022-05-10 | Janssen Pharmaceutica N.V | Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2863909B1 (en) | 2012-06-26 | 2020-11-04 | Janssen Pharmaceutica N.V. | Combinations comprising 4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline compounds as pde 2 inhibitors and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders |
ES2607184T3 (es) | 2012-07-09 | 2017-03-29 | Janssen Pharmaceutica, N.V. | Inhibidores de la enzima fosfodiesterasa 10 |
WO2014098000A1 (en) * | 2012-12-17 | 2014-06-26 | Daiichi Sankyo Company, Limited | Process for preparation of a tricyclic heterocycle |
EP3015468A4 (en) | 2013-06-26 | 2017-02-22 | Daiichi Sankyo Co., Ltd. | Method for producing tricyclic heterocyclic compound |
EP2818471A1 (en) * | 2013-06-27 | 2014-12-31 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Nitrogen bicyclic compounds as inhibitors for Scyl1 and Grk5 |
AU2017386417B2 (en) * | 2016-12-30 | 2022-07-14 | Frequency Therapeutics, Inc. | 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells |
EP3609998A1 (en) | 2017-04-11 | 2020-02-19 | Frequency Therapeutics, Inc. | Methods for hair follicle stem cell proliferation |
WO2019126686A1 (en) * | 2017-12-21 | 2019-06-27 | Frequency Therapeutics, Inc. | 1,2-dihydro-3h-pyrazol-3-one compounds and methods of using same |
US10526343B2 (en) | 2018-03-26 | 2020-01-07 | University Of Sharjah | Heterocyclic systems and pharmaceutical applications thereof |
US20200121681A1 (en) | 2018-10-17 | 2020-04-23 | Frequency Therapeutics, Inc. | Methods for hair follicle stem cell proliferation |
WO2020132045A1 (en) | 2018-12-19 | 2020-06-25 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 in combination with neuroprotective agents |
EP3920885A1 (en) | 2019-02-08 | 2021-12-15 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
CN112390794B (zh) * | 2019-08-19 | 2023-05-26 | 鲁南制药集团股份有限公司 | 一种米诺膦酸关键中间体的制备方法 |
CN115925622A (zh) * | 2023-02-10 | 2023-04-07 | 山西永津集团有限公司 | 一种3-氰基吡啶-2-基氨基甲酸叔丁酯的合成方法 |
CN115974850B (zh) * | 2023-02-16 | 2024-08-06 | 中国药科大学 | 一类作为akr1c3抑制剂的化合物及其制备方法与用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK278989B6 (sk) | 1988-02-10 | 1998-05-06 | F. Hoffmann-La Roche Ag | Substituované pyroly, ich použitie na výrobu lieči |
GB8904161D0 (en) | 1989-02-23 | 1989-04-05 | Hoffmann La Roche | Substituted pyrroles |
AU4920397A (en) * | 1996-10-11 | 1998-05-11 | Chiron Corporation | Purine inhibitors of glycogen synthase kinase 3 (gsk3) |
GB9828640D0 (en) | 1998-12-23 | 1999-02-17 | Smithkline Beecham Plc | Novel method and compounds |
DE60010934T2 (de) * | 1999-12-16 | 2005-05-19 | Eli Lilly And Co., Indianapolis | Medikamente geeignet zur Behandlung von proliferativen Erkrankungen |
WO2001044247A2 (en) * | 1999-12-16 | 2001-06-21 | Eli Lilly And Company | Agents and methods for the treatment of proliferative diseases |
RU2003104796A (ru) | 2000-07-27 | 2004-08-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные 3-индолил-4-фенил-1н-пиррол-2, 5-диона в качестве ингибиторов гликогенсинтазы-киназы-3 бета |
DE60112611T2 (de) | 2000-12-08 | 2006-06-14 | Ortho Mcneil Pharm Inc | Makroheterocyclische verbindungen als kinase inhibitoren |
ES2263681T3 (es) | 2000-12-08 | 2006-12-16 | Ortho-Mcneil Pharmaceutical, Inc. | Compuestos de pirrolina indazolil-substituidos como inhibidores de la kinasa. |
-
2003
- 2003-03-04 WO PCT/US2003/005050 patent/WO2003076442A1/en active IP Right Grant
- 2003-03-04 KR KR1020047013828A patent/KR100974770B1/ko not_active IP Right Cessation
- 2003-03-04 DE DE60309848T patent/DE60309848T2/de not_active Expired - Lifetime
- 2003-03-04 DK DK03711146T patent/DK1483265T3/da active
- 2003-03-04 BR BRPI0308243-1A patent/BR0308243B1/pt not_active IP Right Cessation
- 2003-03-04 CN CNB03805292XA patent/CN1312154C/zh not_active Expired - Fee Related
- 2003-03-04 US US10/506,459 patent/US7491716B2/en not_active Expired - Fee Related
- 2003-03-04 JP JP2003574659A patent/JP4414232B2/ja not_active Expired - Fee Related
- 2003-03-04 CA CA2477967A patent/CA2477967C/en not_active Expired - Fee Related
- 2003-03-04 IL IL16378103A patent/IL163781A0/xx unknown
- 2003-03-04 AT AT03711146T patent/ATE346070T1/de active
- 2003-03-04 ES ES03711146T patent/ES2276048T3/es not_active Expired - Lifetime
- 2003-03-04 EP EP03711146A patent/EP1483265B1/en not_active Expired - Lifetime
- 2003-03-04 PT PT03711146T patent/PT1483265E/pt unknown
- 2003-03-04 AU AU2003215325A patent/AU2003215325B8/en not_active Ceased
-
2004
- 2004-08-26 IL IL163781A patent/IL163781A/en not_active IP Right Cessation
-
2007
- 2007-01-18 CY CY20071100071T patent/CY1109006T1/el unknown
-
2008
- 2008-12-12 US US12/333,775 patent/US8022065B2/en not_active Expired - Fee Related
-
2011
- 2011-05-04 US US13/100,618 patent/US8058425B2/en not_active Expired - Fee Related
- 2011-08-09 US US13/206,057 patent/US20110294792A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20090105229A1 (en) | 2009-04-23 |
IL163781A0 (en) | 2005-12-18 |
US7491716B2 (en) | 2009-02-17 |
KR20040087338A (ko) | 2004-10-13 |
US8022065B2 (en) | 2011-09-20 |
CN1639165A (zh) | 2005-07-13 |
CA2477967A1 (en) | 2003-09-18 |
AU2003215325B2 (en) | 2008-09-18 |
IL163781A (en) | 2010-04-15 |
EP1483265B1 (en) | 2006-11-22 |
US20110294792A1 (en) | 2011-12-01 |
BR0308243B1 (pt) | 2014-08-26 |
US20050090483A1 (en) | 2005-04-28 |
US8058425B2 (en) | 2011-11-15 |
BR0308243A (pt) | 2005-01-11 |
DK1483265T3 (da) | 2007-03-19 |
US20110207721A1 (en) | 2011-08-25 |
CN1312154C (zh) | 2007-04-25 |
AU2003215325A1 (en) | 2003-09-22 |
CA2477967C (en) | 2010-08-10 |
DE60309848T2 (de) | 2007-05-16 |
ES2276048T3 (es) | 2007-06-16 |
EP1483265A1 (en) | 2004-12-08 |
JP2005526072A (ja) | 2005-09-02 |
DE60309848D1 (de) | 2007-01-04 |
KR100974770B1 (ko) | 2010-08-06 |
AU2003215325B8 (en) | 2008-10-09 |
WO2003076442A1 (en) | 2003-09-18 |
ATE346070T1 (de) | 2006-12-15 |
JP4414232B2 (ja) | 2010-02-10 |
PT1483265E (pt) | 2007-01-31 |
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