CY1105160T1 - ΠΑΡΑΓΩΓΑ ΟΞΑΖΟΛΙΟΥ ΜΕ ΥΠΟΚΑΤΑΣΤΑΤΕΣ ΤΥΠΟΥ ΚΑΡΒΟΞΥΛΙΚΟΥ ΟΞΕΟΣ ΓΙΑ ΧΡΗΣΗ ΩΣ PPAR-α ΚΑΙ -γ ΕΝEPΓΟΠΟΙΗΤΕΣ ΓΙΑ ΤΗΝ ΑΝΤΙΜΕΤΩΠΙΣΗ ΤΟΥ ΔΙΑΒΗΤΗ - Google Patents
ΠΑΡΑΓΩΓΑ ΟΞΑΖΟΛΙΟΥ ΜΕ ΥΠΟΚΑΤΑΣΤΑΤΕΣ ΤΥΠΟΥ ΚΑΡΒΟΞΥΛΙΚΟΥ ΟΞΕΟΣ ΓΙΑ ΧΡΗΣΗ ΩΣ PPAR-α ΚΑΙ -γ ΕΝEPΓΟΠΟΙΗΤΕΣ ΓΙΑ ΤΗΝ ΑΝΤΙΜΕΤΩΠΙΣΗ ΤΟΥ ΔΙΑΒΗΤΗInfo
- Publication number
- CY1105160T1 CY1105160T1 CY20061101162T CY061101162T CY1105160T1 CY 1105160 T1 CY1105160 T1 CY 1105160T1 CY 20061101162 T CY20061101162 T CY 20061101162T CY 061101162 T CY061101162 T CY 061101162T CY 1105160 T1 CY1105160 T1 CY 1105160T1
- Authority
- CY
- Cyprus
- Prior art keywords
- diabetes
- ppar
- activators
- treatment
- carboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με ενώσεις του τύπου (Ι) όπου τα R1 έως R7 είναι όπως ορίζονται στην περιγραφή και στις αξιώσεις, και με φαρμακευτικώς αποδεκτά άλατα και εστέρες αυτών. Οι ενώσεις είναι χρήσιμες για την αντιμετώπιση παθήσεων όπως ο διαβήτης.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01111745 | 2001-05-15 | ||
| EP02742955A EP1392295B1 (en) | 2001-05-15 | 2002-05-06 | Carboxylic acid substituted oxazole derivatives for use as ppar-alpha and -gamma activators in the treatment of diabetes |
| PCT/EP2002/004962 WO2002092084A1 (en) | 2001-05-15 | 2002-05-06 | Carboxylic acid substituted oxazole derivatives for use as ppar-alpha and -gamma activators in the treatment of diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1105160T1 true CY1105160T1 (el) | 2009-11-04 |
Family
ID=8177436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20061101162T CY1105160T1 (el) | 2001-05-15 | 2006-08-22 | ΠΑΡΑΓΩΓΑ ΟΞΑΖΟΛΙΟΥ ΜΕ ΥΠΟΚΑΤΑΣΤΑΤΕΣ ΤΥΠΟΥ ΚΑΡΒΟΞΥΛΙΚΟΥ ΟΞΕΟΣ ΓΙΑ ΧΡΗΣΗ ΩΣ PPAR-α ΚΑΙ -γ ΕΝEPΓΟΠΟΙΗΤΕΣ ΓΙΑ ΤΗΝ ΑΝΤΙΜΕΤΩΠΙΣΗ ΤΟΥ ΔΙΑΒΗΤΗ |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US6642389B2 (el) |
| EP (1) | EP1392295B1 (el) |
| JP (2) | JP4330883B2 (el) |
| KR (1) | KR100654516B1 (el) |
| CN (1) | CN100356917C (el) |
| AR (1) | AR035892A1 (el) |
| AT (1) | ATE327753T1 (el) |
| AU (1) | AU2002342244B2 (el) |
| BG (1) | BG66316B1 (el) |
| BR (1) | BRPI0209821B1 (el) |
| CA (1) | CA2445145C (el) |
| CY (1) | CY1105160T1 (el) |
| CZ (1) | CZ20033037A3 (el) |
| DE (1) | DE60211891T2 (el) |
| DK (1) | DK1392295T3 (el) |
| EC (1) | ECSP034848A (el) |
| EG (1) | EG25755A (el) |
| ES (1) | ES2264482T3 (el) |
| GT (1) | GT200200085A (el) |
| HK (1) | HK1067534A1 (el) |
| HR (1) | HRP20030889B1 (el) |
| HU (1) | HU230224B1 (el) |
| IL (2) | IL158589A0 (el) |
| JO (1) | JO2282B1 (el) |
| MA (1) | MA27025A1 (el) |
| ME (1) | ME01310B (el) |
| MX (1) | MXPA03010435A (el) |
| MY (1) | MY136761A (el) |
| NO (1) | NO333833B1 (el) |
| NZ (1) | NZ529033A (el) |
| PA (1) | PA8544901A1 (el) |
| PE (1) | PE20021152A1 (el) |
| PL (1) | PL208074B1 (el) |
| PT (1) | PT1392295E (el) |
| RU (1) | RU2278859C2 (el) |
| SI (1) | SI1392295T1 (el) |
| SK (1) | SK287842B6 (el) |
| WO (1) | WO2002092084A1 (el) |
| ZA (1) | ZA200308538B (el) |
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| US7041691B1 (en) | 1999-06-30 | 2006-05-09 | Amgen Inc. | Compounds for the modulation of PPARγ activity |
| UA72625C2 (uk) * | 2000-05-26 | 2005-03-15 | Ніппон Сіняку Ко., Лтд. | Гетероциклічні сполуки |
| US20030171399A1 (en) | 2000-06-28 | 2003-09-11 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| PT1392295E (pt) * | 2001-05-15 | 2006-09-29 | Hoffmann La Roche | Derivados de oxazole substituidos por acidos carboxilicos para serem utilizados como activadores de rapp alfa e gama no tratamento de diabetes |
| US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| CA2462200A1 (en) * | 2001-08-10 | 2003-02-20 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| US7655658B2 (en) * | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| US7732451B2 (en) * | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
| US7456184B2 (en) * | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| WO2003072102A1 (en) | 2002-02-25 | 2003-09-04 | Eli Lilly And Company | Peroxisome proliferator activated receptor modulators |
| PL375779A1 (en) * | 2002-08-30 | 2005-12-12 | F.Hoffmann-La Roche Ag | Novel 2-arylthiazole compounds as pparalpha and ppargamma agonists |
| TWI343915B (en) * | 2002-10-07 | 2011-06-21 | Hoffmann La Roche | Chirale ppar agonists |
| OA12960A (en) * | 2002-11-15 | 2006-10-13 | Cadila Healthcare Ltd | Substituted aralkyl derivatives. |
| EP1567523B1 (en) * | 2002-11-25 | 2008-08-20 | F.Hoffmann-La Roche Ag | Indolyl derivatives |
| US7268157B2 (en) * | 2002-11-26 | 2007-09-11 | Shenzhen Chipscreen Biosciences, Ltd. | Substituted arylalcanoic acid derivatives as PPAR pan agonists with potent antihyperglycemic and antihyperlipidemic activity |
| FR2849849B1 (fr) | 2003-01-13 | 2006-08-04 | Merck Sante Sas | Nouveaux acides carboxyliques et derives pour le traitement et la prevention du diabete et des dyslipemies |
| US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
| US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
| US7968548B2 (en) * | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
| US7262303B2 (en) * | 2003-09-29 | 2007-08-28 | Hoffman-La Roche Inc. | Process for the production of chiral propionic acid derivatives |
| US7223761B2 (en) | 2003-10-03 | 2007-05-29 | Amgen Inc. | Salts and polymorphs of a potent antidiabetic compound |
| JP2007509998A (ja) * | 2003-11-05 | 2007-04-19 | エフ．ホフマン−ラ ロシュ アーゲー | Ｐｐａｒ活性化剤としてのベンズ環付加された化合物 |
| CN1875002B (zh) * | 2003-11-05 | 2011-08-03 | 霍夫曼-拉罗奇有限公司 | 作为ppar激动剂的苯基衍生物 |
| WO2005056536A1 (en) * | 2003-12-10 | 2005-06-23 | Ranbaxy Laboratories Limited | Antidiabetic agents which exhibit activity against ppar |
| US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| EP1756096B1 (en) | 2004-05-03 | 2009-08-12 | F.Hoffmann-La Roche Ag | Indolyl derivatives as liver-x-receptor modulators |
| CN100436430C (zh) * | 2004-05-24 | 2008-11-26 | 北京摩力克科技有限公司 | 作为hPPARα和hPPARγ激动剂的烷酰基取代的酪氨酸衍生物 |
| CN100344618C (zh) * | 2004-05-24 | 2007-10-24 | 北京摩力克科技有限公司 | 作为hPPARα和hPPARγ激动剂的N－芳丙烯酰基取代的酪氨酸衍生物 |
| WO2006108491A1 (en) * | 2005-04-11 | 2006-10-19 | Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg | Improved process for preparing oxazole nitriles |
| US20060241073A1 (en) * | 2005-04-20 | 2006-10-26 | Wanders Ronaldus J A | Means and methods for counteracting fatty acid accumulation |
| US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
| KR100847780B1 (ko) * | 2006-10-26 | 2008-07-23 | 재단법인서울대학교산학협력재단 | 2-에톡시프로피온산 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로함유하는 당뇨병 예방 및 치료제 |
| GB2460784A (en) * | 2007-03-07 | 2009-12-16 | Dong A Pharmtech Co Ltd | Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators,method of the same,and pharmaceutical composition |
| PT2100604E (pt) * | 2008-03-10 | 2012-07-24 | Nestec Sa | Ácidos dicarboxílicos de cadeia média e os seus derivados e doenças metabólicas |
| EP2291078A4 (en) * | 2008-05-15 | 2011-08-24 | Merck Sharp & Dohme | OXAZOLBENZIMIDAZOLDERIVATE |
| JP5694948B2 (ja) | 2008-12-23 | 2015-04-01 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 慢性病患者の診断支援または治療支援のための構造化検査方法及びその装置 |
| PE20160746A1 (es) * | 2009-01-23 | 2016-08-01 | Hoffmann La Roche | Composicion farmaceutica que comprende aleglitazar |
| CN101805337B (zh) * | 2009-02-13 | 2012-05-23 | 天津药物研究院 | 一类含脯氨酸和异恶唑骨架的化合物、其制备方法和用途 |
| US8450496B2 (en) | 2009-03-24 | 2013-05-28 | Hoffman-La Roche Inc. | Process for the preparation of propionic acid derivatives |
| ES2552310T3 (es) | 2009-12-07 | 2015-11-27 | F. Hoffmann-La Roche Ag | Proceso para la obtención de derivados de ácido propiónico |
| CN102351852B (zh) * | 2011-08-23 | 2014-06-18 | 上海交通大学 | 苯并呋喃类化合物及其制备方法、用途 |
| WO2013181384A1 (en) | 2012-05-31 | 2013-12-05 | Ratiopharm Gmbh | Solid state forms of aleglitazar sodium |
| WO2014040936A1 (en) | 2012-09-12 | 2014-03-20 | F. Hoffmann-La Roche Ag | Solid forms of (s)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid and of salts thereof |
| CN109588042A (zh) | 2015-11-18 | 2019-04-05 | 豪夫迈·罗氏有限公司 | 用于治疗糖尿病肾病的阿格列扎 |
| EP3478297A1 (en) | 2016-06-30 | 2019-05-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cardiomyopathies |
| WO2020156683A1 (en) | 2019-02-01 | 2020-08-06 | F. Hoffmann-La Roche Ag | Aleglitazar for use in the treatment or prevention of major adverse cardiac events |
| WO2020201263A1 (en) | 2019-04-01 | 2020-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment and prevention of cardiac remodeling |
| MX2024001889A (es) * | 2021-08-13 | 2024-02-29 | Alebund Pharmaceuticals Hong Kong Ltd | Compuestos deuterados. |
| WO2024100051A1 (en) | 2022-11-08 | 2024-05-16 | Genfit | Ppar-alpha/gamma agonist for use in the treatment of liver failure |
| CN118480034B (zh) * | 2023-02-13 | 2025-02-11 | 礼邦医药(香港)有限公司 | 氘代化合物的晶型或盐 |
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| PT1392295E (pt) * | 2001-05-15 | 2006-09-29 | Hoffmann La Roche | Derivados de oxazole substituidos por acidos carboxilicos para serem utilizados como activadores de rapp alfa e gama no tratamento de diabetes |
-
2002
- 2002-05-06 PT PT02742955T patent/PT1392295E/pt unknown
- 2002-05-06 JP JP2002589001A patent/JP4330883B2/ja not_active Expired - Fee Related
- 2002-05-06 EP EP02742955A patent/EP1392295B1/en not_active Expired - Lifetime
- 2002-05-06 KR KR1020037014816A patent/KR100654516B1/ko active IP Right Grant
- 2002-05-06 DK DK02742955T patent/DK1392295T3/da active
- 2002-05-06 PL PL367087A patent/PL208074B1/pl unknown
- 2002-05-06 CN CNB028100964A patent/CN100356917C/zh not_active Expired - Fee Related
- 2002-05-06 RU RU2003134150/04A patent/RU2278859C2/ru not_active IP Right Cessation
- 2002-05-06 NZ NZ529033A patent/NZ529033A/en not_active IP Right Cessation
- 2002-05-06 AU AU2002342244A patent/AU2002342244B2/en not_active Ceased
- 2002-05-06 IL IL15858902A patent/IL158589A0/xx unknown
- 2002-05-06 CA CA002445145A patent/CA2445145C/en not_active Expired - Fee Related
- 2002-05-06 SI SI200230340T patent/SI1392295T1/sl unknown
- 2002-05-06 MX MXPA03010435A patent/MXPA03010435A/es active IP Right Grant
- 2002-05-06 HU HU0400992A patent/HU230224B1/hu not_active IP Right Cessation
- 2002-05-06 ME MEP-2008-775A patent/ME01310B/me unknown
- 2002-05-06 AT AT02742955T patent/ATE327753T1/de active
- 2002-05-06 CZ CZ20033037A patent/CZ20033037A3/cs unknown
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2006
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