CU20210009A7 - Compuestos derivados de tieno pirrolo-triazina acetamida sustituida como inhibidores de la actividad inflamatoria de la proteína receptora tipo nod 3 (nlrp3) - Google Patents
Compuestos derivados de tieno pirrolo-triazina acetamida sustituida como inhibidores de la actividad inflamatoria de la proteína receptora tipo nod 3 (nlrp3)Info
- Publication number
- CU20210009A7 CU20210009A7 CU2021000009A CU20210009A CU20210009A7 CU 20210009 A7 CU20210009 A7 CU 20210009A7 CU 2021000009 A CU2021000009 A CU 2021000009A CU 20210009 A CU20210009 A CU 20210009A CU 20210009 A7 CU20210009 A7 CU 20210009A7
- Authority
- CU
- Cuba
- Prior art keywords
- nlrp3
- nod
- receptor protein
- inflammatory activity
- pyrolo
- Prior art date
Links
- 102000000874 Pyrin Domain-Containing 3 Protein NLR Family Human genes 0.000 title abstract 2
- 108010001946 Pyrin Domain-Containing 3 Protein NLR Family Proteins 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000002757 inflammatory effect Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 title 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D515/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
<p>La presente invención se refiere a nuevos compuestos de tienopirrolotriazinacetamida de la fórmula (I):</p> <p>ESPACIO PARA FÓRMULA</p> <p>(I), en donde R1, R2 y R3 se definen en el presente documento, que inhiben Ia actividad<br /> inflamatoria de Ia proteÍna 3 receptora de tipo NOD (NLRP3). La invención se refiere,<br /> además, a los procesos para su preparación, composiciones farmacéuticas y medicamentos que los contienen.</p>
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18185580 | 2018-07-25 | ||
| EP19175246 | 2019-05-17 | ||
| PCT/IB2019/056278 WO2020021447A1 (en) | 2018-07-25 | 2019-07-23 | Nlrp3 inflammasome inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU20210009A7 true CU20210009A7 (es) | 2021-08-06 |
Family
ID=67989037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU2021000009A CU20210009A7 (es) | 2018-07-25 | 2019-07-23 | Compuestos derivados de tieno pirrolo-triazina acetamida sustituida como inhibidores de la actividad inflamatoria de la proteína receptora tipo nod 3 (nlrp3) |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US12168012B2 (es) |
| EP (1) | EP3827008B1 (es) |
| JP (1) | JP7555327B2 (es) |
| KR (1) | KR20210038877A (es) |
| CN (1) | CN112424207B (es) |
| AU (1) | AU2019309727B2 (es) |
| BR (1) | BR112021000964A2 (es) |
| CA (1) | CA3103943A1 (es) |
| CL (1) | CL2021000191A1 (es) |
| CO (1) | CO2021000537A2 (es) |
| CR (1) | CR20210045A (es) |
| CU (1) | CU20210009A7 (es) |
| DO (1) | DOP2021000019A (es) |
| EC (1) | ECSP21004787A (es) |
| IL (1) | IL280336A (es) |
| JO (1) | JOP20210017A1 (es) |
| MA (1) | MA53388A (es) |
| MX (1) | MX2021000925A (es) |
| PE (1) | PE20210406A1 (es) |
| PH (1) | PH12021550166A1 (es) |
| SG (1) | SG11202012321PA (es) |
| WO (1) | WO2020021447A1 (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230330054A1 (en) * | 2020-03-31 | 2023-10-19 | Olatec Therapeutics Llc | Method for preventing or treating lung infection and lung inflammation |
| JP2023522016A (ja) | 2020-04-15 | 2023-05-26 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｎｌｒｐ３インフラマソーム経路の阻害剤としてのピラゾロ［１，５－ｄ］［１，２，４］トリアジン－５（４ｈ）－アセトアミド |
| JP2023521242A (ja) | 2020-04-15 | 2023-05-23 | ヤンセン ファーマシューティカ エヌ．ベー． | ＮＬＲＰ３インフラマソーム経路の阻害剤としてのピロロ［１，２－ｄ］［１，２，４］トリアジン－２－イル－アセトアミド |
| KR20230005252A (ko) * | 2020-04-23 | 2023-01-09 | 얀센 파마슈티카 엔.브이. | Nlrp3의 억제제로서의 삼환식 화합물 |
| EP4143192A1 (en) | 2020-04-30 | 2023-03-08 | JANSSEN Pharmaceutica NV | New triazinoindole compounds |
| CN115667225A (zh) | 2020-05-28 | 2023-01-31 | 詹森药业有限公司 | 化合物 |
| WO2021255279A1 (en) | 2020-06-19 | 2021-12-23 | Ac Immune Sa | D i h yd rooxazo le and thiourea derivatives modulating the nlrp3 inflammasome pathway |
| CA3190495A1 (en) * | 2020-08-14 | 2022-02-17 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| EP3974415A1 (en) | 2020-09-24 | 2022-03-30 | Janssen Pharmaceutica NV | Nlrp3 modulators |
| CN116194445A (zh) | 2020-09-24 | 2023-05-30 | 詹森药业有限公司 | 新化合物 |
| CN114478537B (zh) * | 2020-11-13 | 2024-02-02 | 上海拓界生物医药科技有限公司 | 环酰胺并环化合物及其医药用途 |
| KR20230152016A (ko) | 2021-03-04 | 2023-11-02 | 얀센 파마슈티카 엔브이 | Nlrp3을 조절하는 4-알콕시-6-옥소-피리다진 유도체 |
| KR20230152005A (ko) * | 2021-03-04 | 2023-11-02 | 얀센 파마슈티카 엔브이 | Nlrp3을 조절하는 4-아미노-6-옥소-피리다진 유도체 |
| CN113230240B (zh) * | 2021-03-22 | 2022-12-27 | 广州医科大学 | 1,3-二苯基丙-2-烯-1-酮衍生物及其应用 |
| CA3215235A1 (en) * | 2021-04-13 | 2022-10-20 | Sharon KLIER | Methods of treating retinal vasculopathies |
| US11932630B2 (en) | 2021-04-16 | 2024-03-19 | Novartis Ag | Heteroaryl aminopropanol derivatives |
| CN117279899A (zh) * | 2021-04-29 | 2023-12-22 | 詹森药业有限公司 | 作为nlrp3炎性小体抑制剂的酞嗪酮衍生物 |
| CA3166147A1 (en) | 2021-06-23 | 2022-12-23 | Yoda Pharmaceuticals Inc. | Benzimidazole derivatives for treatment and/or prevention of diseases and disorders mediated by nlrp3 |
| WO2023275230A1 (en) | 2021-07-01 | 2023-01-05 | Janssen Pharmaceutica Nv | 5-oxo-pyrido[2,3-d]pyridazin-6(5h)-yl acetamides |
| WO2023028536A1 (en) * | 2021-08-25 | 2023-03-02 | Ptc Therapeutics, Inc. | 1,2,4-triazine derivatives useful as inhibitors of nlrp3 |
| CN118302170A (zh) * | 2021-09-17 | 2024-07-05 | 尼科治疗有限公司 | 化合物、组合物和方法 |
| KR20230066899A (ko) | 2021-11-08 | 2023-05-16 | 제일약품주식회사 | Nlrp3 저해제로서의 신규한 화합물 및 이를 포함하는 약학적 조성물 |
| WO2023118521A1 (en) | 2021-12-22 | 2023-06-29 | Ac Immune Sa | Dihydro-oxazol derivative compounds |
| CN116375728B (zh) * | 2021-12-31 | 2025-06-10 | 成都赜灵生物医药科技有限公司 | 噻吩吡咯并三嗪酮类化合物及其用途 |
| EP4482841A1 (en) * | 2022-02-21 | 2025-01-01 | Sanofi | Thienopyrrolotriazine compounds, their preparation and their therapeutic use |
| WO2024013395A1 (en) | 2022-07-14 | 2024-01-18 | Ac Immune Sa | Pyrrolotriazine and imidazotriazine derivatives as modulators of the nlrp3 inflammasome pathway |
| US20240101563A1 (en) | 2022-07-28 | 2024-03-28 | Ac Immune Sa | Novel compounds |
| AR130151A1 (es) * | 2022-08-10 | 2024-11-06 | Takeda Pharmaceuticals Co | Compuesto heterocíclico |
| KR20240022938A (ko) | 2022-08-12 | 2024-02-20 | 제일약품주식회사 | Nlrp3 저해제로서의 신규한 화합물 및 이를 포함하는 약학적 조성물 |
| PE20251293A1 (es) | 2022-09-23 | 2025-05-14 | Merck Sharp And Dohme Llc | Derivados de ftalazina utiles como inhibidores de la proteina receptora 3 similar a nod |
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2019
- 2019-07-23 AU AU2019309727A patent/AU2019309727B2/en not_active Ceased
- 2019-07-23 CN CN201980047047.4A patent/CN112424207B/zh active Active
- 2019-07-23 JO JOP/2021/0017A patent/JOP20210017A1/ar unknown
- 2019-07-23 BR BR112021000964-7A patent/BR112021000964A2/pt not_active Application Discontinuation
- 2019-07-23 CR CR20210045A patent/CR20210045A/es unknown
- 2019-07-23 CA CA3103943A patent/CA3103943A1/en active Pending
- 2019-07-23 JP JP2021503752A patent/JP7555327B2/ja active Active
- 2019-07-23 EP EP19769892.1A patent/EP3827008B1/en active Active
- 2019-07-23 US US17/259,252 patent/US12168012B2/en active Active
- 2019-07-23 MX MX2021000925A patent/MX2021000925A/es unknown
- 2019-07-23 PE PE2021000092A patent/PE20210406A1/es unknown
- 2019-07-23 CU CU2021000009A patent/CU20210009A7/es unknown
- 2019-07-23 WO PCT/IB2019/056278 patent/WO2020021447A1/en active Application Filing
- 2019-07-23 MA MA053388A patent/MA53388A/fr unknown
- 2019-07-23 SG SG11202012321PA patent/SG11202012321PA/en unknown
- 2019-07-23 KR KR1020217001895A patent/KR20210038877A/ko not_active Withdrawn
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2021
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- 2021-01-21 PH PH12021550166A patent/PH12021550166A1/en unknown
- 2021-01-22 CO CONC2021/0000537A patent/CO2021000537A2/es unknown
- 2021-01-22 CL CL2021000191A patent/CL2021000191A1/es unknown
- 2021-01-22 DO DO2021000019A patent/DOP2021000019A/es unknown
- 2021-01-22 EC ECSENADI20214787A patent/ECSP21004787A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN112424207B (zh) | 2024-03-19 |
| CR20210045A (es) | 2021-06-18 |
| KR20210038877A (ko) | 2021-04-08 |
| AU2019309727B2 (en) | 2021-12-23 |
| JOP20210017A1 (ar) | 2021-01-21 |
| MA53388A (fr) | 2021-06-02 |
| CA3103943A1 (en) | 2020-01-30 |
| JP2021532124A (ja) | 2021-11-25 |
| CO2021000537A2 (es) | 2021-01-29 |
| IL280336A (en) | 2021-03-01 |
| AU2019309727A1 (en) | 2021-01-07 |
| CL2021000191A1 (es) | 2021-08-20 |
| PE20210406A1 (es) | 2021-03-02 |
| MX2021000925A (es) | 2021-03-31 |
| WO2020021447A1 (en) | 2020-01-30 |
| EP3827008A1 (en) | 2021-06-02 |
| SG11202012321PA (en) | 2021-02-25 |
| DOP2021000019A (es) | 2021-02-15 |
| BR112021000964A2 (pt) | 2021-04-20 |
| US12168012B2 (en) | 2024-12-17 |
| CN112424207A (zh) | 2021-02-26 |
| ECSP21004787A (es) | 2021-03-31 |
| US20210308140A1 (en) | 2021-10-07 |
| JP7555327B2 (ja) | 2024-09-24 |
| PH12021550166A1 (en) | 2021-09-13 |
| EP3827008B1 (en) | 2024-07-31 |
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