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CU20190099A7 - Dominio de unión a antígeno anti-trbc1, y receptor de antígeno quimérico, anticuerpo, acoplador biespecífico de células t y conjugado anticuerpo-fármaco que comprenden el mismo - Google Patents

Dominio de unión a antígeno anti-trbc1, y receptor de antígeno quimérico, anticuerpo, acoplador biespecífico de células t y conjugado anticuerpo-fármaco que comprenden el mismo

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Publication number
CU20190099A7
CU20190099A7 CU2019000099A CU20190099A CU20190099A7 CU 20190099 A7 CU20190099 A7 CU 20190099A7 CU 2019000099 A CU2019000099 A CU 2019000099A CU 20190099 A CU20190099 A CU 20190099A CU 20190099 A7 CU20190099 A7 CU 20190099A7
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CU
Cuba
Prior art keywords
seq
antibody
antigen
binding domain
bispecific
Prior art date
Application number
CU2019000099A
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English (en)
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CU24663B1 (es
Inventor
Shaun Cordoba
Ram Jha
Wen Chean Lim
Shimobi Onuoha
Simon Thomas
Original Assignee
Autolus Ltd
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Publication date
Application filed by Autolus Ltd filed Critical Autolus Ltd
Publication of CU20190099A7 publication Critical patent/CU20190099A7/es
Publication of CU24663B1 publication Critical patent/CU24663B1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C12N15/09—Recombinant DNA-technology
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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Abstract

<p>La presente invención proporciona un dominio de unión a antígeno anti-TRBC1 el cual comprende:</p> <p>a) un dominio VH que tiene una secuencia de aminoácidos que se selecciona de SEQ ID No. 9, SEQ ID No. 10, SEQ ID No. 11, SEQ ID No. 12, SEQ ID No. 13, SEQ ID No. 14, SEQ ID No. 15, SEQ ID No. 16, SEQ ID No. 17 y SEQ ID No. 18; y</p> <p>b) un dominio VL que tiene una secuencia de aminoácidos que se selecciona de SEQ ID No. 19, SEQ ID No. 20, SEQ ID No. 21, SEQ ID No. 22, SEQ ID No. 23, SEQ ID No. 24, SEQ ID No. 25, SEQ ID No. 26, SEQ ID No. 27, SEQ ID No. 28, SEQ ID No. 29, SEQ ID No. 30, SEQ ID No. 31, SEQ ID No. 32, SEQ ID No. 33, SEQ ID No. 34.</p> <p>La presente invención también proporciona un receptor de antígeno quimérico, un anticuerpo, un acoplador biespecífico de células T y un conjugado anticuerpo-fármaco que comprende a dicho dominio de unión a antígeno anti-TRBC1.</p>
CU2019000099A 2017-06-09 2018-06-08 Dominio de unión a antígeno anti-trbc1, receptor de antígeno quimérico, anticuerpo y acoplador biespecífico de células t que comprenden el mismo CU24663B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1709203.2A GB201709203D0 (en) 2017-06-09 2017-06-09 Antigen-binding domain
PCT/GB2018/051570 WO2018224844A1 (en) 2017-06-09 2018-06-08 Anti trbc1 antigen binding domains

Publications (2)

Publication Number Publication Date
CU20190099A7 true CU20190099A7 (es) 2020-10-20
CU24663B1 CU24663B1 (es) 2023-05-11

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US (3) US11440961B2 (es)
EP (1) EP3635006A1 (es)
JP (2) JP7177794B2 (es)
KR (1) KR102743539B1 (es)
CN (2) CN110741018B (es)
AU (1) AU2018282038B2 (es)
BR (1) BR112019025990A2 (es)
CA (1) CA3065006A1 (es)
CL (1) CL2019003536A1 (es)
CO (1) CO2019013614A2 (es)
CU (1) CU24663B1 (es)
GB (1) GB201709203D0 (es)
IL (1) IL270731B2 (es)
MX (1) MX2019013387A (es)
MY (1) MY205039A (es)
PE (1) PE20191717A1 (es)
PH (1) PH12019502785A1 (es)
WO (1) WO2018224844A1 (es)
ZA (1) ZA201907524B (es)

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JP2023523011A (ja) * 2020-04-24 2023-06-01 マレンゴ・セラピューティクス，インコーポレーテッド Ｔ細胞関連のがん細胞に結合する多機能性分子およびその使用
JP2022008152A (ja) 2020-06-25 2022-01-13 住友化学株式会社 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法
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