CU20140107A7 - MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF DISEASES - Google Patents
MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF DISEASESInfo
- Publication number
- CU20140107A7 CU20140107A7 CU2014000107A CU20140107A CU20140107A7 CU 20140107 A7 CU20140107 A7 CU 20140107A7 CU 2014000107 A CU2014000107 A CU 2014000107A CU 20140107 A CU20140107 A CU 20140107A CU 20140107 A7 CU20140107 A7 CU 20140107A7
- Authority
- CU
- Cuba
- Prior art keywords
- compounds
- diseases
- treatment
- salts
- alk
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 abstract 2
- 101710168331 ALK tyrosine kinase receptor Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a compuestos de la fórmula (1) ESPACIO PARA FÓRMULA como se define además en la presente y a sus sales farmacéuticamente aceptables, a composiciones farmacéuticas que comprenden dichos compuestos y sales, y a sus usos. Los compuestos y las sales de la presente invención inhiben la quinasa del linfoma anaplásico ( ALK) y/o EML4-ALK y son útiles para tratar o mejorar los trastornos proliferativos celulares anormales, tales como cáncer.The invention relates to compounds of the formula (1) FORMULA SPACE as further defined herein and its pharmaceutically acceptable salts, pharmaceutical compositions comprising said compounds and salts, and their uses. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and / or EML4-ALK and are useful for treating or improving abnormal cell proliferative disorders, such as cancer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361759307P | 2013-01-31 | 2013-01-31 | |
| PCT/IB2013/051391 WO2013132376A1 (en) | 2012-03-06 | 2013-02-20 | Macrocyclic derivatives for the treatment of proliferative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU20140107A7 true CU20140107A7 (en) | 2014-12-26 |
Family
ID=53365645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU2014000107A CU20140107A7 (en) | 2013-01-31 | 2014-09-08 | MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF DISEASES |
Country Status (2)
| Country | Link |
|---|---|
| CU (1) | CU20140107A7 (en) |
| TN (1) | TN2014000371A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112321604A (en) * | 2019-08-05 | 2021-02-05 | 华东理工大学 | Macrocyclic JAK2 inhibitors and their applications |
| WO2024146541A1 (en) * | 2023-01-03 | 2024-07-11 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Macrocyclic compounds as usp1 inhibitors |
-
2014
- 2014-08-28 TN TNP2014000371A patent/TN2014000371A1/en unknown
- 2014-09-08 CU CU2014000107A patent/CU20140107A7/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112321604A (en) * | 2019-08-05 | 2021-02-05 | 华东理工大学 | Macrocyclic JAK2 inhibitors and their applications |
| WO2024146541A1 (en) * | 2023-01-03 | 2024-07-11 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Macrocyclic compounds as usp1 inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| TN2014000371A1 (en) | 2015-12-21 |
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