CS130592A3 - 3-/indole-2-carboxamido/quinuclidine, process for preparing thereof and apharmaceutical composition which contains it - Google Patents

3-/indole-2-carboxamido/quinuclidine, process for preparing thereof and apharmaceutical composition which contains it

Info

Publication number: CS130592A3
Authority: CS; Czechoslovakia
Prior art keywords: quinuclidine; carboxamido; indole; preparing; apharmaceutical composition
Prior art date: 1991-05-10

Application number

CS921305A

Other languages

Czech (cs)

English (en)

Inventor

Henning Dr Bottcher

Christoph Dr Seyfried

Gerd Bartoszyk

Klaus-Otto Dr Minck

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-10

Filing date

1992-04-29

Publication date

1992-11-18

1992-04-29 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1992-11-18 Publication of CS130592A3 publication Critical patent/CS130592A3/cs

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

CS921305A 1991-05-10 1992-04-29 3-/indole-2-carboxamido/quinuclidine, process for preparing thereof and apharmaceutical composition which contains it CS130592A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4115215A DE4115215A1 (de)	1991-05-10	1991-05-10	Indolderivate

Publications (1)

Publication Number	Publication Date
CS130592A3 true CS130592A3 (en)	1992-11-18

Family

ID=6431344

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS921305A CS130592A3 (en)	1991-05-10	1992-04-29	3-/indole-2-carboxamido/quinuclidine, process for preparing thereof and apharmaceutical composition which contains it

Country Status (14)

Country	Link
EP (1)	EP0512350A3 (zh)
JP (1)	JPH05155886A (zh)
KR (1)	KR920021507A (zh)
AU (1)	AU1604492A (zh)
CA (1)	CA2068238A1 (zh)
CS (1)	CS130592A3 (zh)
DE (1)	DE4115215A1 (zh)
HU (1)	HU208136B (zh)
IE (1)	IE921488A1 (zh)
MX (1)	MX9202152A (zh)
NO (1)	NO921831L (zh)
PL (1)	PL294457A2 (zh)
TW (1)	TW221807B (zh)
ZA (1)	ZA923351B (zh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE125808T1 (de) *	1990-08-31	1995-08-15	Nippon Shinyaku Co Ltd	Indolederivate und ihre verwendung als serotonin- antagoniste.
IT1255467B (it) *	1992-07-29	1995-11-02	Dompe Farmaceutici Spa	Ammidi acriliche farmacologicamente attive
WO2002016357A2 (en)	2000-08-18	2002-02-28	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
WO2002016358A2 (en)	2000-08-18	2002-02-28	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
US6492385B2 (en)	2000-08-18	2002-12-10	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease
US6599916B2 (en)	2000-08-21	2003-07-29	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease
WO2002017358A2 (en)	2000-08-21	2002-02-28	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
DE10045112A1 (de) *	2000-09-11	2002-03-21	Merck Patent Gmbh	Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
AR036041A1 (es)	2001-06-12	2004-08-04	Upjohn Co	Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
AR036040A1 (es)	2001-06-12	2004-08-04	Upjohn Co	Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
DK1432707T3 (da)	2001-10-02	2012-06-11	Pharmacia & Upjohn Co Llc	Azabicyklisk-substituerede kondenserede heteroarylforbindelser til behandling af sygdomme
US6849620B2 (en)	2001-10-26	2005-02-01	Pfizer Inc	N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
DE10164139A1 (de)	2001-12-27	2003-07-10	Bayer Ag	2-Heteroarylcarbonsäureamide
WO2003070731A2 (en)	2002-02-19	2003-08-28	Pharmacia & Upjohn Company	Azabicyclic compounds for the treatment of disease
BR0307735A (pt)	2002-02-19	2005-01-25	Upjohn Co	Carboxamidas heteroaromáticas com ligação-n em ponte biciclìcas fundidas para o tratamento de doença
US7176198B2 (en)	2002-08-01	2007-02-13	Pfizer Inc.	1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease
WO2009158375A1 (en) *	2008-06-25	2009-12-30	Abbott Laboratories	Aza-cylic indole- 2 -carboxamides and methods of use thereof
HUE037938T2 (hu)	2008-11-19	2018-09-28	Forum Pharmaceuticals Inc	Skizofrénia negatív tüneteinek kezelése (R)-7-klór-N-(kinuklidin-3-il)benzo[b]tiofén-2-karboxamiddal és ennek gyógyszerészetileg elfogadható sójával
MY165234A (en)	2010-05-17	2018-03-14	Forum Pharmaceuticals Inc	A crystalline form of (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate
RU2017136693A (ru)	2012-05-08	2019-02-08	Форум Фармасьютикалз, Инк.	Способы поддержания, лечения или улучшения когнитивной функции

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU202108B (en) *	1986-07-30	1991-02-28	Sandoz Ag	Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol
DE3881950T2 (de) *	1987-04-25	1993-09-30	Beecham Group Plc	Azabicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen.
NZ227841A (en) *	1988-02-12	1991-08-27	Merck Sharp & Dohme	Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
DE3810552A1 (de) *	1988-03-29	1989-10-19	Sandoz Ag	Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben

1991
- 1991-05-10 DE DE4115215A patent/DE4115215A1/de not_active Withdrawn
1992
- 1992-04-27 EP EP19920107132 patent/EP0512350A3/de not_active Withdrawn
- 1992-04-29 CS CS921305A patent/CS130592A3/cs unknown
- 1992-05-05 AU AU16044/92A patent/AU1604492A/en not_active Abandoned
- 1992-05-07 PL PL29445792A patent/PL294457A2/xx unknown
- 1992-05-07 TW TW081103571A patent/TW221807B/zh active
- 1992-05-08 CA CA002068238A patent/CA2068238A1/en not_active Abandoned
- 1992-05-08 HU HU9201550A patent/HU208136B/hu not_active IP Right Cessation
- 1992-05-08 ZA ZA923351A patent/ZA923351B/xx unknown
- 1992-05-08 MX MX9202152A patent/MX9202152A/es unknown
- 1992-05-08 KR KR1019920007824A patent/KR920021507A/ko not_active Application Discontinuation
- 1992-05-08 NO NO92921831A patent/NO921831L/no unknown
- 1992-05-11 JP JP4143642A patent/JPH05155886A/ja active Pending
- 1992-07-01 IE IE148892A patent/IE921488A1/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
JPH05155886A (ja)	1993-06-22
MX9202152A (es)	1992-11-01
DE4115215A1 (de)	1992-11-12
AU1604492A (en)	1992-11-12
IE921488A1 (en)	1992-11-18
NO921831D0 (no)	1992-05-08
EP0512350A2 (de)	1992-11-11
NO921831L (no)	1992-11-11
HU9201550D0 (en)	1992-07-28
EP0512350A3 (en)	1992-12-16
KR920021507A (ko)	1992-12-18
PL294457A2 (en)	1992-11-16
HU208136B (en)	1993-08-30
ZA923351B (en)	1993-01-27
CA2068238A1 (en)	1992-11-11
TW221807B (zh)	1994-03-21
HUT61541A (en)	1993-01-28

Publication	Publication Date	Title
CS130592A3 (en)	1992-11-18	3-/indole-2-carboxamido/quinuclidine, process for preparing thereof and apharmaceutical composition which contains it
PH31205A (en)	1998-05-05	Pharmaceutical composition.
HU9201975D0 (en)	1992-09-28	Method for preparing medical compositions
GB9521654D0 (en)	1996-01-03	1-N-Ethyl gentamicin derivatives and the method for preparing thereof
HUT64734A (en)	1994-02-28	Anthraquinone-derivativdes, process for preparing them and pharmaceutical compositions containing them
EP0660700A4 (fr)	1997-02-14	Procede de deformation permanente des matieres keratiniques.
PH31073A (en)	1998-02-05	Pharmaceutical composition and process for the preparation thereof.
OA09810A (en)	1994-04-15	Pharmaceutical composition.
EP0435333A3 (en)	1992-01-29	Cephalosporin derivatives, the process for preparing the same, and antimicrobial composition containing the derivatives
EP0464545A3 (en)	1992-10-28	Paste composition and method for preparing the same
ZA929001B (en)	1993-06-01	Process for preparing sintered shapes and compositions for use therein.
GB9123353D0 (en)	1991-12-18	New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
PH27259A (en)	1993-05-04	Solid correction composition
ZA938745B (en)	1994-06-30	Process for preparing immunoconjugates.
HRP931016A2 (en)	1997-04-30	Thienothiazin derivatives, process for the preparation and application thereof
AU8714391A (en)	1992-04-15	Apparatus for preventing whiplash
ZA926937B (en)	1993-04-28	Substituted aminopropanes,processes for their preparation and their use
PH31154A (en)	1998-03-20	Process for preparing 1-alkylryl-2-alkyl-5-formyl-imidazole.
ZA922354B (en)	1993-02-24	Pharmaceutical composition and process for the preparation thereof
IL116967A (en)	2000-08-13	Ethyl-6-formyloxy-4-hexenoate and process for the preparation thereof
ZA92505B (en)	1992-10-28	Substituted 3-aminosydnone imines,process for the preparation therefore and the use thereof
AU1355792A (en)	1992-10-06	A pulverous composition, a method for preparing it, and a method for improving the taste of the composition
IL96282A0 (en)	1991-08-16	Method for the preparation of 5-chlorcarbonyl-5h-dibenz-/b,f/-azepin
IL106433A0 (en)	1993-11-15	Furylthiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same
ZA915631B (en)	1992-03-25	Process for the preparation n-alkylsulfonylaminosulfonylureas