CR20220091A - 4,4A, 5,7,8,8A-HEXAPIRIDE [4,3-B][1,4]OXAZIN-3-ONE COMPOUNDS AS MAGL INHIBITORS - Google Patents
4,4A, 5,7,8,8A-HEXAPIRIDE [4,3-B][1,4]OXAZIN-3-ONE COMPOUNDS AS MAGL INHIBITORSInfo
- Publication number
- CR20220091A CR20220091A CR20220091A CR20220091A CR20220091A CR 20220091 A CR20220091 A CR 20220091A CR 20220091 A CR20220091 A CR 20220091A CR 20220091 A CR20220091 A CR 20220091A CR 20220091 A CR20220091 A CR 20220091A
- Authority
- CR
- Costa Rica
- Prior art keywords
- sup
- compounds
- hexapiride
- oxazin
- magl inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- XEKAWZARUWARND-UHFFFAOYSA-N 6h-oxazin-3-one Chemical class O=C1NOCC=C1 XEKAWZARUWARND-UHFFFAOYSA-N 0.000 title 1
- 102100029814 Monoglyceride lipase Human genes 0.000 title 1
- 101710116393 Monoglyceride lipase Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000005398 Monoacylglycerol Lipase Human genes 0.000 abstract 2
- 108020002334 Monoacylglycerol lipase Proteins 0.000 abstract 2
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La invención proporciona nuevos compuestos heterocíclicos que tienen la Fórmula general (I) en donde A, B, L, X, R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup> y R<sup>4</sup> son como se describen en la presente, composiciones que incluyen los compuestos, procesos para fabricar los compuestos y métodos para usar los compuestos como inhibidores de monoacilglicerol lipasa (MAGL).The invention provides new heterocyclic compounds having the general Formula (I) where A, B, L, X, R<sup>1</sup>, R<sup>2</sup>, R<sup>3< /sup> and R<sup>4</sup> are as described herein, compositions including the compounds, processes for making the compounds, and methods for using the compounds as monoacylglycerol lipase (MAGL) inhibitors.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19196089 | 2019-09-09 | ||
| PCT/EP2020/074897 WO2021048036A1 (en) | 2019-09-09 | 2020-09-07 | 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20220091A true CR20220091A (en) | 2022-04-01 |
Family
ID=67902336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20220091A CR20220091A (en) | 2019-09-09 | 2020-09-07 | 4,4A, 5,7,8,8A-HEXAPIRIDE [4,3-B][1,4]OXAZIN-3-ONE COMPOUNDS AS MAGL INHIBITORS |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20210094971A1 (en) |
| EP (1) | EP4028401B1 (en) |
| JP (1) | JP2022546853A (en) |
| KR (1) | KR20220061119A (en) |
| CN (1) | CN114364682A (en) |
| AR (1) | AR119910A1 (en) |
| AU (1) | AU2020344921A1 (en) |
| BR (1) | BR112022003704A2 (en) |
| CA (1) | CA3151218A1 (en) |
| CL (1) | CL2022000551A1 (en) |
| CO (1) | CO2022002339A2 (en) |
| CR (1) | CR20220091A (en) |
| IL (1) | IL289233A (en) |
| MX (1) | MX2022002554A (en) |
| PE (1) | PE20220904A1 (en) |
| PH (1) | PH12022550321A1 (en) |
| TW (1) | TW202124392A (en) |
| WO (1) | WO2021048036A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR114136A1 (en) | 2017-10-10 | 2020-07-29 | Hoffmann La Roche | HETEROCYCLIC COMPOUNDS |
| WO2019105915A1 (en) | 2017-11-28 | 2019-06-06 | F. Hoffmann-La Roche Ag | New heterocyclic compounds |
| JP7269943B2 (en) | 2018-01-08 | 2023-05-09 | エフ． ホフマン－ラ ロシュ アーゲー | Octahydropyrido[1,2-alpha]pyrazine as a MAGL inhibitor |
| UA127629C2 (en) | 2018-08-13 | 2023-11-08 | Ф. Хоффманн-Ля Рош Аг | New heterocyclic compounds as monoacylglycerol lipase inhibitors |
| WO2021048242A1 (en) | 2019-09-12 | 2021-03-18 | F. Hoffmann-La Roche Ag | 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors |
| EP4208456A1 (en) | 2020-09-03 | 2023-07-12 | F. Hoffmann-La Roche AG | Heterocyclic compounds |
| TW202421635A (en) * | 2022-09-30 | 2024-06-01 | 日商小野藥品工業股份有限公司 | ABHD6 antagonist |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7579495B2 (en) | 2003-12-19 | 2009-08-25 | Momentive Performance Materials Inc. | Active-releasing cyclic siloxanes |
| WO2011059118A1 (en) | 2009-11-10 | 2011-05-19 | Kim Hyun Jeen | System for testing olfactory perception |
| KR20180005250A (en) | 2015-05-21 | 2018-01-15 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Benzimidazole derivatives as PAD4 inhibitors |
| US10323038B2 (en) * | 2015-11-20 | 2019-06-18 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
| US10385057B2 (en) * | 2015-11-20 | 2019-08-20 | Lundbeck La Jolla Research Center, Inc. | Pyrazole compounds and methods of making and using same |
| TW201930300A (en) * | 2017-12-15 | 2019-08-01 | 瑞士商赫孚孟拉羅股份公司 | New heterocyclic compounds |
| JP7269943B2 (en) * | 2018-01-08 | 2023-05-09 | エフ． ホフマン－ラ ロシュ アーゲー | Octahydropyrido[1,2-alpha]pyrazine as a MAGL inhibitor |
| HRP20230388T1 (en) * | 2018-03-22 | 2023-06-23 | F. Hoffmann - La Roche Ag | Oxazine monoacylglycerol lipase (magl) inhibitors |
| UA127629C2 (en) * | 2018-08-13 | 2023-11-08 | Ф. Хоффманн-Ля Рош Аг | New heterocyclic compounds as monoacylglycerol lipase inhibitors |
| MX2020013719A (en) * | 2018-08-13 | 2021-03-02 | Hoffmann La Roche | New heterocyclic compounds as monoacylglycerol lipase inhibitors. |
| CN113166170A (en) * | 2018-11-22 | 2021-07-23 | 豪夫迈·罗氏有限公司 | new heterocyclic compounds |
-
2020
- 2020-09-04 US US17/012,589 patent/US20210094971A1/en not_active Abandoned
- 2020-09-07 EP EP20772007.9A patent/EP4028401B1/en active Active
- 2020-09-07 BR BR112022003704A patent/BR112022003704A2/en unknown
- 2020-09-07 PH PH1/2022/550321A patent/PH12022550321A1/en unknown
- 2020-09-07 WO PCT/EP2020/074897 patent/WO2021048036A1/en active Application Filing
- 2020-09-07 PE PE2022000300A patent/PE20220904A1/en unknown
- 2020-09-07 AR ARP200102489A patent/AR119910A1/en not_active Application Discontinuation
- 2020-09-07 MX MX2022002554A patent/MX2022002554A/en unknown
- 2020-09-07 AU AU2020344921A patent/AU2020344921A1/en not_active Abandoned
- 2020-09-07 KR KR1020227007722A patent/KR20220061119A/en active Pending
- 2020-09-07 CN CN202080062559.0A patent/CN114364682A/en active Pending
- 2020-09-07 CA CA3151218A patent/CA3151218A1/en active Pending
- 2020-09-07 JP JP2022515504A patent/JP2022546853A/en active Pending
- 2020-09-07 CR CR20220091A patent/CR20220091A/en unknown
- 2020-09-08 TW TW109130703A patent/TW202124392A/en unknown
-
2021
- 2021-12-21 IL IL289233A patent/IL289233A/en unknown
-
2022
- 2022-02-28 CO CONC2022/0002339A patent/CO2022002339A2/en unknown
- 2022-03-04 CL CL2022000551A patent/CL2022000551A1/en unknown
- 2022-05-05 US US17/737,656 patent/US20220275005A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20220275005A1 (en) | 2022-09-01 |
| CN114364682A (en) | 2022-04-15 |
| EP4028401A1 (en) | 2022-07-20 |
| CO2022002339A2 (en) | 2022-03-08 |
| TW202124392A (en) | 2021-07-01 |
| US20210094971A1 (en) | 2021-04-01 |
| IL289233A (en) | 2022-02-01 |
| WO2021048036A1 (en) | 2021-03-18 |
| BR112022003704A2 (en) | 2022-05-24 |
| AU2020344921A1 (en) | 2022-02-17 |
| CL2022000551A1 (en) | 2022-11-18 |
| PE20220904A1 (en) | 2022-05-30 |
| EP4028401B1 (en) | 2023-11-22 |
| JP2022546853A (en) | 2022-11-09 |
| AR119910A1 (en) | 2022-01-19 |
| PH12022550321A1 (en) | 2023-02-13 |
| EP4028401C0 (en) | 2023-11-22 |
| KR20220061119A (en) | 2022-05-12 |
| CA3151218A1 (en) | 2021-03-18 |
| MX2022002554A (en) | 2022-03-22 |
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