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CR20120630A - NEW PROCESS - Google Patents

NEW PROCESS

Info

Publication number
CR20120630A
CR20120630A CR20120630A CR20120630A CR20120630A CR 20120630 A CR20120630 A CR 20120630A CR 20120630 A CR20120630 A CR 20120630A CR 20120630 A CR20120630 A CR 20120630A CR 20120630 A CR20120630 A CR 20120630A
Authority
CR
Costa Rica
Prior art keywords
new process
formula
atherosclerosis
preparing
compounds
Prior art date
Application number
CR20120630A
Other languages
Spanish (es)
Inventor
Kevin Stuart Cardwell
Claire Frances Crawford
Suzanne Helen Davies
Charles Edward Wade
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44992024&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20120630(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CR20120630A publication Critical patent/CR20120630A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Esta invención se refiere a métodos para preparar un compuesto de fórmula (I) y a intermedios para ello, siendo los compuestos de fórmula (I) útiles para tratar enfermedades cardiovasculares e inflamatorias tales como aterosclerosis.This invention relates to methods for preparing a compound of formula (I) and intermediates therefor, the compounds of formula (I) being useful for treating cardiovascular and inflammatory diseases such as atherosclerosis.

CR20120630A 2010-05-17 2012-12-12 NEW PROCESS CR20120630A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34522410P 2010-05-17 2010-05-17

Publications (1)

Publication Number Publication Date
CR20120630A true CR20120630A (en) 2013-02-15

Family

ID=44992024

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20120630A CR20120630A (en) 2010-05-17 2012-12-12 NEW PROCESS

Country Status (25)

Country Link
US (2) US9447052B2 (en)
EP (1) EP2571857B1 (en)
JP (1) JP6027529B2 (en)
KR (1) KR20130089157A (en)
CN (2) CN103003249B (en)
AR (1) AR081399A1 (en)
AU (1) AU2011256270B2 (en)
BR (1) BR112012030532A2 (en)
CA (1) CA2799520C (en)
CL (1) CL2012003206A1 (en)
CO (1) CO6630197A2 (en)
CR (1) CR20120630A (en)
DO (1) DOP2012000289A (en)
EA (1) EA026569B1 (en)
IL (1) IL223068A0 (en)
MA (1) MA34301B1 (en)
MX (1) MX2012013387A (en)
NZ (1) NZ603672A (en)
PE (1) PE20130318A1 (en)
PH (1) PH12012502247A1 (en)
SG (1) SG185559A1 (en)
TW (1) TW201209043A (en)
UY (1) UY33388A (en)
WO (1) WO2011146494A1 (en)
ZA (1) ZA201208631B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY33388A (en) * 2010-05-17 2011-12-01 Glaxo Group Ltd NEW PROCESSES FOR THE PREPARATION OF PIRIMIDINONE COMPOUNDS
WO2015087239A1 (en) 2013-12-11 2015-06-18 Ranbaxy Laboratories Limited Processes for the preparation of darapladib and its intermediates
WO2015092687A2 (en) 2013-12-17 2015-06-25 Ranbaxy Laboratories Limited Process for the purification of darapladib
WO2019063634A1 (en) 2017-09-26 2019-04-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Radiolabeled darapladib and analogs thereof and their use as imaging compounds
US10866963B2 (en) * 2017-12-28 2020-12-15 Dropbox, Inc. File system authentication

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1143516B (en) * 1961-04-27 1963-02-14 Bayer Ag Process for the production of peptides
US4277465A (en) 1978-08-26 1981-07-07 Kyoto Yakuhin Kogyo Kabushiki Kaisha Adjuvant for promoting absorption of therapeutically active substances through the digestive tract
US4235776A (en) * 1979-03-15 1980-11-25 Eli Lilly And Company Tetrahydro-2H-benzo[c]pyrroles
DE2941597A1 (en) * 1979-10-13 1981-04-23 Basf Ag, 6700 Ludwigshafen PIPERIDE DERIVATIVES OF 4,5-DIALKYL-3-HYDROXY-PYRROL-2-CARBONIC ACID ESTERS, THEIR PRODUCTION AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM
US4619941A (en) * 1984-11-19 1986-10-28 American Cyanamid Company N-[(1H-imidazol-1-yl)alkyl]-1H-indolecarboxamides useful as thromboxane synthetase inhibitors and antihypertensive agents
CA2309177A1 (en) 1997-11-06 1999-05-20 Stephen Allan Smith Pyrimidinone compounds and pharmaceutical compositions containing them
US6750228B1 (en) * 1997-11-14 2004-06-15 Pharmacia Corporation Aromatic sulfone hydroxamic acid metalloprotease inhibitor
WO2000028328A1 (en) 1998-11-05 2000-05-18 Biocryst Pharmaceuticals, Inc. New cyclopentane and cyclopentene compounds and use for detecting influenza virus
DE60016397T2 (en) * 1999-05-01 2005-12-01 Smithkline Beecham P.L.C., Brentford Pyrimidinone compound (s)
EP1263740B1 (en) * 2000-02-16 2006-07-19 SmithKline Beecham plc Pyrimidine-4-one derivative as ldl-pla2 inhibitor
GB0119795D0 (en) * 2001-08-14 2001-10-03 Smithkline Beecham Plc Novel process
UY33388A (en) * 2010-05-17 2011-12-01 Glaxo Group Ltd NEW PROCESSES FOR THE PREPARATION OF PIRIMIDINONE COMPOUNDS

Also Published As

Publication number Publication date
CN103003249B (en) 2016-04-27
DOP2012000289A (en) 2013-04-15
US20160347720A1 (en) 2016-12-01
CN105837520A (en) 2016-08-10
BR112012030532A2 (en) 2015-09-29
US9447052B2 (en) 2016-09-20
AU2011256270B2 (en) 2015-11-26
US9725420B2 (en) 2017-08-08
NZ603672A (en) 2015-01-30
EP2571857A4 (en) 2013-11-20
AU2011256270A1 (en) 2012-12-20
JP2013530948A (en) 2013-08-01
CA2799520A1 (en) 2011-11-24
TW201209043A (en) 2012-03-01
WO2011146494A1 (en) 2011-11-24
EA026569B1 (en) 2017-04-28
CA2799520C (en) 2016-09-13
ZA201208631B (en) 2013-09-25
MX2012013387A (en) 2012-12-10
KR20130089157A (en) 2013-08-09
IL223068A0 (en) 2013-02-03
CL2012003206A1 (en) 2013-01-25
UY33388A (en) 2011-12-01
AR081399A1 (en) 2012-08-29
EP2571857A1 (en) 2013-03-27
PH12012502247A1 (en) 2013-02-04
CO6630197A2 (en) 2013-03-01
PE20130318A1 (en) 2013-04-11
US20130060028A1 (en) 2013-03-07
MA34301B1 (en) 2013-06-01
JP6027529B2 (en) 2016-11-16
CN103003249A (en) 2013-03-27
EP2571857B1 (en) 2017-08-23
SG185559A1 (en) 2012-12-28
EA201291235A1 (en) 2013-04-30

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