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CR20110131A - Derivados de prostaglandinas - Google Patents

Derivados de prostaglandinas

Info

Publication number
CR20110131A
CR20110131A CR20110131A CR20110131A CR20110131A CR 20110131 A CR20110131 A CR 20110131A CR 20110131 A CR20110131 A CR 20110131A CR 20110131 A CR20110131 A CR 20110131A CR 20110131 A CR20110131 A CR 20110131A
Authority
CR
Costa Rica
Prior art keywords
prostaglandinas
derivatives
nitroderivatives
prostaglandin
glaucoma
Prior art date
Application number
CR20110131A
Other languages
English (en)
Inventor
Ongini Ennio
Francesca Benedini
Valerio Chiroli
Soldato Piero Del
Original Assignee
Nicox Sa
Xia Tian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34778199&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20110131(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nicox Sa, Xia Tian filed Critical Nicox Sa
Publication of CR20110131A publication Critical patent/CR20110131A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

Se describen nitroderivados de prostaglandina que tienen actividad farmacológica mejorada y tolerabilidad potenciada. Se pueden emplear para el tratamiento de glaucoma e hipertensión ocular.
CR20110131A 2004-01-05 2011-03-11 Derivados de prostaglandinas CR20110131A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04100001 2004-01-05

Publications (1)

Publication Number Publication Date
CR20110131A true CR20110131A (es) 2011-03-30

Family

ID=34778199

Family Applications (2)

Application Number Title Priority Date Filing Date
CR8498A CR8498A (es) 2004-01-05 2006-06-30 Derivados de prostaglandinas
CR20110131A CR20110131A (es) 2004-01-05 2011-03-11 Derivados de prostaglandinas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CR8498A CR8498A (es) 2004-01-05 2006-06-30 Derivados de prostaglandinas

Country Status (40)

Country Link
US (5) US7273946B2 (es)
EP (3) EP1704141B1 (es)
JP (1) JP3984283B2 (es)
KR (2) KR100850133B1 (es)
CN (1) CN100469765C (es)
AP (1) AP2006003638A0 (es)
AR (2) AR047081A1 (es)
AU (1) AU2004313688B2 (es)
BR (1) BRPI0418245B8 (es)
CA (1) CA2551409C (es)
CR (2) CR8498A (es)
CY (1) CY1117417T1 (es)
DK (1) DK1704141T3 (es)
EA (1) EA010595B1 (es)
EC (1) ECSP066684A (es)
ES (2) ES2767136T3 (es)
GE (1) GEP20094780B (es)
GT (1) GT200500293A (es)
HK (1) HK1096084A1 (es)
HR (1) HRP20160500T1 (es)
HU (1) HUE027357T2 (es)
IL (1) IL176416A (es)
MA (1) MA28284A1 (es)
ME (1) ME02433B (es)
MX (1) MXPA06007678A (es)
MY (1) MY147181A (es)
NO (2) NO337217B1 (es)
NZ (1) NZ548271A (es)
OA (1) OA13356A (es)
PA (1) PA8620901A1 (es)
PE (1) PE20051052A1 (es)
PL (1) PL1704141T3 (es)
RS (1) RS54717B1 (es)
SI (1) SI1704141T1 (es)
TN (1) TNSN06210A1 (es)
TW (1) TWI337994B (es)
UA (1) UA84726C2 (es)
UY (1) UY28709A1 (es)
WO (1) WO2005068421A1 (es)
ZA (1) ZA200605354B (es)

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WO2007000641A2 (en) * 2005-06-29 2007-01-04 Pfizer Inc. Prostaglandin derivatives
WO2007000642A1 (en) * 2005-06-29 2007-01-04 Pfizer Inc. Fluoroprostaglandins nitroderivatives
US8067414B2 (en) * 2006-03-29 2011-11-29 Nicox S.A. Nitric oxide enhancing prostaglandin compounds, compositions and methods of use
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
DE102006052755A1 (de) * 2006-11-08 2008-05-15 N-Zyme Biotec Gmbh Michaelsysteme als Transglutaminaseinhibitoren
WO2008071421A1 (en) * 2006-12-15 2008-06-19 Nicox S.A. Nitrate esters of carbonic anhydrase inhibitors
WO2008075155A2 (en) 2006-12-15 2008-06-26 Nicox S.A. Carbonic anhydrase inhibitors derivatives
RU2509076C2 (ru) 2007-06-04 2014-03-10 Текфилдз Инк Пролекарства нестероидных противовоспалительных средств (nsaia) c очень высокой скоростью проникновения через кожу и мембраны и новые медицинские применения указанных пролекарств
WO2009035565A1 (en) * 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Prostaglandin analogues for implant devices and methods
US7638557B2 (en) * 2007-10-31 2009-12-29 Meta Cosmetics, Llc Prostaglandin analog compositions to treat epithelial-related conditions
AR076731A1 (es) * 2008-05-09 2011-07-06 Pfizer Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas
US7807716B2 (en) * 2008-09-24 2010-10-05 Oral Delivery Technology Ltd. Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
RU2765463C2 (ru) 2008-12-04 2022-01-31 Чунси ЮЙ Композиции интенсивного проникновения и их применение
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WO2011032936A1 (en) * 2009-09-15 2011-03-24 Dsm Ip Assets B.V. Nitrooxyesters, their preparation and use
CN101885684B (zh) * 2010-07-01 2013-10-30 南京中医药大学 带有一氧化氮供体的芳香酸前体药物及其制备方法和其应用
EP2750660B1 (en) 2011-08-29 2016-10-12 Mati Therapeutics Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
HU231203B1 (hu) * 2011-12-21 2021-10-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás travoprost előállítására
CN105473130A (zh) 2012-05-03 2016-04-06 麦提疗法有限公司 治疗开角型青光眼和高眼压症的药物递送系统和方法
CN104994845B (zh) * 2012-10-23 2017-11-17 尼科斯科学爱尔兰公司 用于眼科应用的醌基一氧化氮供体化合物
CN105263487B (zh) * 2013-04-18 2017-09-22 尼科斯科学爱尔兰公司 用于眼科应用的醌基一氧化氮供体化合物
US9913849B2 (en) 2014-01-10 2018-03-13 Manistee Partners Llc Treatment of migraines
MX2020012011A (es) * 2014-10-15 2022-04-19 Alcon Inc Conjugados y derivados de prostaglandina para tratar el glaucoma y la hipertension ocular.
US10280138B2 (en) 2015-03-31 2019-05-07 Nicox S.A. Nitric oxide donating derivatives of fluprostenol
WO2016156104A1 (en) 2015-03-31 2016-10-06 Nicox S.A. Nitric oxide donating derivatives of latanoprost free acid
EP3088388A1 (en) 2015-04-30 2016-11-02 NicOx S.A. Nitric oxide donating derivatives of prostaglandins
US9808531B2 (en) 2015-09-22 2017-11-07 Graybug Vision, Inc. Compounds and compositions for the treatment of ocular disorders
HU231175B1 (hu) * 2015-12-04 2021-06-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Tetszőleges, előre meghatározott minőségű Latanoprostene bunod előállítása gravitációs kromatográfiával
JP7055802B2 (ja) * 2016-11-08 2022-04-18 ボシュ・アンド・ロム・インコーポレイテッド 正常眼圧緑内障を処置するための一酸化窒素放出プロスタグランジン誘導体
KR102069205B1 (ko) * 2017-08-09 2020-01-22 연성정밀화학(주) 라타노프로스틴 부노드의 제조 방법 및 그를 위한 중간체
RU2718744C2 (ru) * 2018-05-17 2020-04-14 Общество с ограниченной ответственностью "Гурус БиоФарм" Производные простагландина F2альфа для снижения внутриглазного давления
CN109988089B (zh) * 2018-05-29 2022-04-26 上海凡秦医药科技有限公司 一种前列腺素化合物、制备方法及其用途
CN108892624B (zh) * 2018-06-20 2020-12-15 重庆威鹏药业有限公司 沙库巴曲硝基氧衍生物及其制备方法和应用
US11332433B2 (en) * 2020-07-24 2022-05-17 Chirogate International Inc. Process for the preparation of latanoprostene bunod and intermediate thereof and compositions comprising the same
CN113943266A (zh) * 2021-11-18 2022-01-18 广州楷石医药有限公司 一种氧化氮供体型贝前列素类衍生物及其药物组合物和用途
CN116444377A (zh) * 2022-01-07 2023-07-18 广州楷石医药有限公司 一种氧化氮供体型曲前列尼尔类衍生物及其药物组合物和用途
CA3195291A1 (en) * 2022-04-13 2023-10-13 Caravel Therapeutics, Inc. Preservative-free ophthalmic pharmaceutical emulsion and its application

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US4952581A (en) 1987-04-03 1990-08-28 The Trustees Of Columbia University In The City Of New York Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure
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Also Published As

Publication number Publication date
JP2007518716A (ja) 2007-07-12
EP1704141B1 (en) 2016-02-24
US7273946B2 (en) 2007-09-25
CA2551409C (en) 2011-02-22
ES2566800T3 (es) 2016-04-15
US20050272743A1 (en) 2005-12-08
TNSN06210A1 (fr) 2007-12-03
WO2005068421A8 (en) 2006-02-09
ECSP066684A (es) 2006-10-25
PE20051052A1 (es) 2005-12-17
KR100850133B1 (ko) 2008-08-04
KR100854838B1 (ko) 2008-08-29
IL176416A (en) 2013-05-30
US20100130507A1 (en) 2010-05-27
GEP20094780B (en) 2009-09-25
KR20080007415A (ko) 2008-01-18
PA8620901A1 (es) 2005-08-30
HRP20160500T1 (hr) 2016-06-03
AU2004313688A1 (en) 2005-07-28
NO20063567L (no) 2006-09-07
HUE027357T2 (en) 2016-09-28
BRPI0418245B1 (pt) 2017-05-30
TW200526567A (en) 2005-08-16
NO339685B1 (no) 2017-01-23
TWI337994B (en) 2011-03-01
HK1096084A1 (en) 2007-05-25
EP1704141A1 (en) 2006-09-27
OA13356A (en) 2007-04-13
US7910767B2 (en) 2011-03-22
US20110136904A1 (en) 2011-06-09
CY1117417T1 (el) 2017-04-26
US7449469B2 (en) 2008-11-11
AU2004313688B2 (en) 2010-08-05
JP3984283B2 (ja) 2007-10-03
KR20060113753A (ko) 2006-11-02
UA84726C2 (ru) 2008-11-25
DK1704141T3 (en) 2016-05-02
AR098931A2 (es) 2016-06-22
ES2767136T3 (es) 2020-06-16
CN100469765C (zh) 2009-03-18
EP3002277A1 (en) 2016-04-06
BRPI0418245A (pt) 2007-04-17
GT200500293A (es) 2007-07-06
US20080058392A1 (en) 2008-03-06
ME02433B (me) 2016-09-20
US8058467B2 (en) 2011-11-15
MA28284A1 (fr) 2006-11-01
AP2006003638A0 (en) 2006-06-30
UY28709A1 (es) 2005-08-31
ZA200605354B (en) 2009-09-30
EP3643702A1 (en) 2020-04-29
MY147181A (en) 2012-11-14
WO2005068421A1 (en) 2005-07-28
NZ548271A (en) 2010-01-29
EP3002277B1 (en) 2019-11-06
BRPI0418245B8 (pt) 2021-05-25
NO20151341A1 (no) 2006-09-07
AR047081A1 (es) 2006-01-04
NO337217B1 (no) 2016-02-15
IL176416A0 (en) 2006-10-05
EA010595B1 (ru) 2008-10-30
CR8498A (es) 2006-11-15
US7629345B2 (en) 2009-12-08
RS54717B1 (en) 2016-08-31
EA200601099A1 (ru) 2006-10-27
PL1704141T3 (pl) 2016-08-31
CA2551409A1 (en) 2005-07-28
US20090030076A1 (en) 2009-01-29
CN1906159A (zh) 2007-01-31
SI1704141T1 (sl) 2016-04-29
MXPA06007678A (es) 2006-09-01

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