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CO7151491A2 - Método para la identificación del origen de un cancer de origen primario desconocido - Google Patents

Método para la identificación del origen de un cancer de origen primario desconocido

Info

Publication number
CO7151491A2
CO7151491A2 CO14270873A CO14270873A CO7151491A2 CO 7151491 A2 CO7151491 A2 CO 7151491A2 CO 14270873 A CO14270873 A CO 14270873A CO 14270873 A CO14270873 A CO 14270873A CO 7151491 A2 CO7151491 A2 CO 7151491A2
Authority
CO
Colombia
Prior art keywords
origin
cpd
methods
unknown primary
cancer
Prior art date
Application number
CO14270873A
Other languages
English (en)
Inventor
Badosa Manel Esteller
Original Assignee
Fundacio Inst D Investigació Biomédica De Bellvitge Idibell
Fundacio Institució Catalana De Recerca I Estudis Avancats
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacio Inst D Investigació Biomédica De Bellvitge Idibell, Fundacio Institució Catalana De Recerca I Estudis Avancats filed Critical Fundacio Inst D Investigació Biomédica De Bellvitge Idibell
Publication of CO7151491A2 publication Critical patent/CO7151491A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La invención se refiere a métodos y reactivos para la identificación del origen deun carcinoma de origen primario desconocido (CPD) basada en la determinación delperfil de metilación en el genoma del CPD. La invención se refiere también a métodospara seleccionar una terapia adecuada para un paciente que padece un CPD así como amétodos para la medicina personalizada de pacientes que adecen un CPD basándose enel uso de un tratamiento que sea adecuado para el tumor primario del que deriva elCPD. La invención también se refiere a kits que comprenden reactivos adecuados pararealizar los métodos anteriores así como a sistemas y programas informáticos que sepueden usar para implementar los métodos de la invención.
CO14270873A 2012-05-24 2014-12-10 Método para la identificación del origen de un cancer de origen primario desconocido CO7151491A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2012/059687 WO2013174432A1 (en) 2012-05-24 2012-05-24 Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis

Publications (1)

Publication Number Publication Date
CO7151491A2 true CO7151491A2 (es) 2014-12-29

Family

ID=46168453

Family Applications (1)

Application Number Title Priority Date Filing Date
CO14270873A CO7151491A2 (es) 2012-05-24 2014-12-10 Método para la identificación del origen de un cancer de origen primario desconocido

Country Status (6)

Country Link
US (1) US10233503B2 (es)
AU (1) AU2012380717B2 (es)
CA (1) CA2874407A1 (es)
CO (1) CO7151491A2 (es)
MX (1) MX2014014356A (es)
WO (1) WO2013174432A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2741400T3 (es) 2014-07-18 2020-02-10 Univ Hong Kong Chinese Análisis de patrones de metilación de tejidos en mezcla de ADN
US9984201B2 (en) * 2015-01-18 2018-05-29 Youhealth Biotech, Limited Method and system for determining cancer status
CN115881230A (zh) * 2015-12-17 2023-03-31 伊路敏纳公司 区分复杂生物样品中的甲基化水平
US9396251B1 (en) * 2016-01-07 2016-07-19 International Business Machines Corporation Detecting and tracking virtual containers
TWI648403B (zh) * 2016-07-29 2019-01-21 臺北醫學大學 婦科腫瘤的診斷方法
CN116064795A (zh) * 2016-09-02 2023-05-05 梅约医学教育与研究基金会 确定差异甲基化区域的甲基化状态的方法和试剂盒
JP2020503003A (ja) 2016-11-30 2020-01-30 ザ チャイニーズ ユニバーシティ オブ ホンコン 尿および他のサンプルにおける無細胞dnaの分析
ES2928068T3 (es) * 2017-03-10 2022-11-15 Self Screen Bv Clasificador de metilación para detección de cánceres invasivos inducidos por HPV, cánceres ginecológicos y anogenitales no inducidos por HPV y sus lesiones precursoras de alto grado
CN108319969B (zh) * 2018-01-12 2021-06-22 复旦大学 基于稀疏表示框架的脑胶质瘤生存期预测方法和系统
US12027237B2 (en) 2018-03-13 2024-07-02 Grail, Llc Anomalous fragment detection and classification
CN109182518A (zh) * 2018-09-12 2019-01-11 黄映辉 基于焦磷酸测序技术的gstp1基因启动子甲基化检测方法
EP3899952A1 (en) * 2018-12-21 2021-10-27 Grail, Inc. Anomalous fragment detection and classification
EP3899953A1 (en) 2018-12-21 2021-10-27 Grail, Inc. Source of origin deconvolution based on methylation fragments in cell-free-dna samples
CN118910258A (zh) * 2019-01-24 2024-11-08 梅约医学教育与研究基金会 癌症筛查方法及试剂盒、组合物和系统
US11773450B2 (en) 2019-04-03 2023-10-03 Grail, Llc Methylation-based false positive duplicate marking reduction
CN110257513B (zh) * 2019-05-28 2020-08-04 深圳市人民医院 一种用于乳腺癌早期筛查的检测试剂、试剂盒及检测试剂的应用
AU2020329191A1 (en) 2019-08-12 2022-03-31 Regeneron Pharmaceuticals, Inc. Macrophage stimulating 1 receptor (MST1R) variants and uses thereof
WO2021029462A1 (ko) * 2019-08-13 2021-02-18 한국식품연구원 고혈압 또는 비만의 예측 또는 진단용 조성물
CN114438201A (zh) * 2020-11-05 2022-05-06 复旦大学附属华山医院 一种肿瘤标志物组合及其应用
WO2024112741A1 (en) * 2022-11-23 2024-05-30 Salk Institute For Biological Studies Dna methylation barcodes for identifying brain cells
CN117089622A (zh) * 2023-10-05 2023-11-21 上海奕谱生物科技有限公司 可用于肿瘤鉴定的新型DNA甲基化标志物TAGMe-5及其用途

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US533A (en) 1837-12-26 Truss for hermta
US4943A (en) 1847-01-26 Harness-buckle
CU22545A1 (es) 1994-11-18 1999-03-31 Centro Inmunologia Molecular Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
JP2975679B2 (ja) 1989-09-08 1999-11-10 ザ・ジョーンズ・ホプキンス・ユニバーシティ ヒト神経膠腫のegf受容体遺伝子の構造変化
US5525462A (en) 1991-05-02 1996-06-11 Toyo Boseki Kabushiki Kaisha Nucleic acid sequence amplification method, detection method, and reagent kit therefor
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
WO1996040210A1 (en) 1995-06-07 1996-12-19 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth of tumors
GB9517955D0 (en) 1995-07-25 1995-11-08 Univ Strathclyde Nucleotide sequence detection and analysis
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
EP2369007B1 (en) 1996-05-29 2015-07-29 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5858665A (en) 1996-07-25 1999-01-12 Navix, Inc. Homogeneous diagnostic assay method utilizing simultaneous target and signal amplification
AU4667297A (en) 1996-10-04 1998-04-24 Chronix Biomedical, Inc. Diagnostic detection of nucleic acids
JPH10253632A (ja) 1997-03-10 1998-09-25 Nissui Pharm Co Ltd 分析方法、キット及び装置
US6558901B1 (en) 1997-05-02 2003-05-06 Biomerieux Vitek Nucleic acid assays
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
US6292169B1 (en) 1998-02-13 2001-09-18 Kabushiki Kaisha Toshiba Information input apparatus
US6054276A (en) 1998-02-23 2000-04-25 Macevicz; Stephen C. DNA restriction site mapping
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
CA2330673C (en) 1998-05-01 2009-05-26 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and dna molecules
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
US6331393B1 (en) 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
EP1470254A2 (en) 2002-01-30 2004-10-27 Epigenomics AG Method for the analysis of cytosine methylation patterns
DK1660680T3 (da) 2003-07-31 2009-06-22 Sequenom Inc Fremgangsmåde til multipleks-polymerasekædereaktioner på höjt niveau og homogene masseforlængelsesreaktioner til genotypebestemmelse af polymorfismer
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
JP2005328709A (ja) 2004-05-18 2005-12-02 Toyobo Co Ltd 高速dnaポリメラーゼを用いた高速pcr
EP1778865A1 (en) * 2004-06-23 2007-05-02 Epigenomics AG Methods and nucleic acids for the detection of metastasis of colon cell proliferative disorders
US7643818B2 (en) 2004-11-22 2010-01-05 Seven Networks, Inc. E-mail messaging to/from a mobile terminal
CA2589487C (en) 2004-11-29 2014-07-29 Klinikum Der Universitat Regensburg Means and methods for detecting methylated dna
WO2007035690A2 (en) 2005-09-19 2007-03-29 Veridex, Llc Methods for diagnosing pancreatic cancer
WO2007039234A2 (en) * 2005-09-29 2007-04-12 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with tissue classification
GB0700374D0 (en) 2007-01-09 2007-02-14 Oncomethylome Sciences S A NDRG family methylation markers
US8911937B2 (en) 2007-07-19 2014-12-16 Brainreader Aps Method for detecting methylation status by using methylation-independent primers
WO2009021141A1 (en) 2007-08-07 2009-02-12 The Johns Hopkins University Comprehensive high throughput arrays for relative methylation
EP2053131A1 (en) 2007-10-19 2009-04-29 Ludwig-Maximilians-Universität München Method for determining methylation at deoxycytosine residues
US20110028333A1 (en) * 2009-05-01 2011-02-03 Brown University Diagnosing, prognosing, and early detection of cancers by dna methylation profiling

Also Published As

Publication number Publication date
AU2012380717A1 (en) 2015-01-15
US10233503B2 (en) 2019-03-19
WO2013174432A1 (en) 2013-11-28
AU2012380717B2 (en) 2018-08-16
CA2874407A1 (en) 2013-11-28
MX2014014356A (es) 2015-07-06
US20160017430A1 (en) 2016-01-21

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