CO6700872A2 - Derivados de 1,4-oxazepano - Google Patents
Derivados de 1,4-oxazepanoInfo
- Publication number
- CO6700872A2 CO6700872A2 CO13114306A CO13114306A CO6700872A2 CO 6700872 A2 CO6700872 A2 CO 6700872A2 CO 13114306 A CO13114306 A CO 13114306A CO 13114306 A CO13114306 A CO 13114306A CO 6700872 A2 CO6700872 A2 CO 6700872A2
- Authority
- CO
- Colombia
- Prior art keywords
- ring
- oxazepane
- derivatives
- optionally substituted
- membered aromatic
- Prior art date
Links
- 150000000324 1,4-oxazepanes Chemical class 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000000407 monoamine reuptake Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se proporciona un compuesto que tiene una actividad inhibidora de la recaptación de monoamina, que está representado por la fórmula (I)en donde el anillo A es un anillo aromático de 6 miembros opcionalmente sustituido, el anillo B esSustituyentes en el anillo A se unen opcionalmente para formar, junto con el anillo A, un anillo fusionado aromático de 9 ó 10 miembros opcionalmente sustituido y los demás símbolos son como se definen en la descripción o una de sus sales.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010227864 | 2010-10-07 | ||
| JP2011175336 | 2011-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6700872A2 true CO6700872A2 (es) | 2013-06-28 |
Family
ID=44906302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO13114306A CO6700872A2 (es) | 2010-10-07 | 2013-05-07 | Derivados de 1,4-oxazepano |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US20130267494A1 (es) |
| EP (1) | EP2625170A1 (es) |
| JP (1) | JP5873487B2 (es) |
| KR (1) | KR20130116073A (es) |
| CN (1) | CN103261176B (es) |
| AR (1) | AR083313A1 (es) |
| AU (1) | AU2011313150A1 (es) |
| BR (1) | BR112013008420A2 (es) |
| CA (1) | CA2813911A1 (es) |
| CL (1) | CL2013000927A1 (es) |
| CO (1) | CO6700872A2 (es) |
| CR (1) | CR20130158A (es) |
| DO (1) | DOP2013000074A (es) |
| EA (1) | EA201390491A1 (es) |
| EC (1) | ECSP13012593A (es) |
| GE (1) | GEP20156295B (es) |
| IL (1) | IL225189A0 (es) |
| MX (1) | MX2013003749A (es) |
| NZ (1) | NZ608499A (es) |
| PE (1) | PE20140239A1 (es) |
| PH (1) | PH12013500657A1 (es) |
| SG (1) | SG188346A1 (es) |
| TW (1) | TW201242956A (es) |
| UY (1) | UY33650A (es) |
| WO (1) | WO2012046882A1 (es) |
| ZA (1) | ZA201302112B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2630677C2 (ru) * | 2011-12-21 | 2017-09-12 | Оно Фармасьютикал Ко., Лтд. | Соединения |
| US9475809B2 (en) * | 2013-07-23 | 2016-10-25 | Bayer Pharma Aktiengesellschaft | Substituted oxopyridine derivatives and use thereof as factor xia/plasma |
| CN105693652B (zh) * | 2014-11-27 | 2019-01-08 | 常州合全药业有限公司 | 一种4-叔丁基-5-乙基-6-氧亚基-1,4-噁吖庚环-4,5-二甲酸基酯的合成方法 |
| CA2970233C (en) | 2014-12-10 | 2023-01-03 | Ono Pharmaceutical Co., Ltd. | Dihydroindolizinone derivative |
| AU2016261325A1 (en) * | 2015-05-08 | 2017-11-16 | Vertellus Holdings Llc | Processes for converting carboxamides to thiocarboxamides |
| WO2024251807A1 (en) * | 2023-06-08 | 2024-12-12 | Cybin Irl Limited | Companion animal treatments |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3018222A (en) | 1956-08-28 | 1962-01-23 | Ravensberg G M B H | Central stimulant and appetite depressant composition |
| US4010166A (en) | 1974-11-25 | 1977-03-01 | Ciba-Geigy Corporation | 1,4-Oxazepines |
| DE3242923A1 (de) | 1982-11-20 | 1984-05-24 | Basf Ag, 6700 Ludwigshafen | 7-phenyl-7-phenoxymethyl-hexahydro-1,4-oxazepine, ihre herstellung und verwendung |
| DE69621607T2 (de) | 1995-03-14 | 2003-01-02 | Praecis Pharmaceuticals Inc., Waltham | VERBINDUNGEN MIT AGGREGATIONS-MODULIERENDEN WIRKUNG AUF DAS AMYLOiD PROTEIN |
| JP2992677B2 (ja) | 1995-06-05 | 1999-12-20 | 武田薬品工業株式会社 | 骨形成促進医薬組成物 |
| AU720358B2 (en) | 1996-02-22 | 2000-06-01 | Neurosearch A/S | Tropane-derivatives, their preparation and use |
| PT929574E (pt) | 1996-08-27 | 2005-11-30 | Praecis Pharm Inc | Moduladores da agregacao de peptidos beta-amiloides compreendendo d-aminoacidos |
| WO2001079187A2 (en) | 2000-04-18 | 2001-10-25 | Cytovia, Inc. | Substituted 1,4-thiazepine and analogs and their use as activators of caspases |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| GB0229743D0 (en) * | 2002-12-20 | 2003-01-29 | Arakis Ltd | Novel benzoxazocines |
| GB0303852D0 (en) | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
| HRP20120824T1 (hr) | 2005-10-28 | 2012-11-30 | Astrazeneca Ab | Derivati 4-(3-aminopirazol) pirimidina za uporabu kao inhibitori tirozin kinaze u lijeäśenju karcinoma |
| US20090054398A1 (en) * | 2006-03-10 | 2009-02-26 | Astrazeneca Ab | Chemical compounds |
| AU2007267182A1 (en) | 2006-05-31 | 2007-12-06 | F. Hoffmann-La Roche Ag | Benzazepine derivatives as monoamine reuptake inhibitors |
| US20100056526A1 (en) | 2006-11-24 | 2010-03-04 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound and use thereof |
| GB0721178D0 (en) | 2007-10-29 | 2007-12-05 | Glaxo Group Ltd | Chemical compounds |
| WO2009119528A1 (ja) | 2008-03-24 | 2009-10-01 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2010016554A1 (ja) | 2008-08-07 | 2010-02-11 | 武田薬品工業株式会社 | 環状アミン化合物 |
-
2011
- 2011-10-05 BR BR112013008420A patent/BR112013008420A2/pt not_active IP Right Cessation
- 2011-10-05 AU AU2011313150A patent/AU2011313150A1/en not_active Abandoned
- 2011-10-05 MX MX2013003749A patent/MX2013003749A/es active IP Right Grant
- 2011-10-05 US US13/877,810 patent/US20130267494A1/en not_active Abandoned
- 2011-10-05 PH PH1/2013/500657A patent/PH12013500657A1/en unknown
- 2011-10-05 KR KR1020137011425A patent/KR20130116073A/ko not_active Withdrawn
- 2011-10-05 TW TW100136019A patent/TW201242956A/zh unknown
- 2011-10-05 PE PE2013000801A patent/PE20140239A1/es not_active Application Discontinuation
- 2011-10-05 UY UY0001033650A patent/UY33650A/es unknown
- 2011-10-05 US US13/253,293 patent/US8722662B2/en not_active Expired - Fee Related
- 2011-10-05 WO PCT/JP2011/073745 patent/WO2012046882A1/en active Application Filing
- 2011-10-05 CN CN201180059036.1A patent/CN103261176B/zh not_active Expired - Fee Related
- 2011-10-05 EA EA201390491A patent/EA201390491A1/ru unknown
- 2011-10-05 CA CA2813911A patent/CA2813911A1/en not_active Abandoned
- 2011-10-05 NZ NZ60849911A patent/NZ608499A/en not_active IP Right Cessation
- 2011-10-05 EP EP11778987.5A patent/EP2625170A1/en not_active Withdrawn
- 2011-10-05 GE GEAP201113078A patent/GEP20156295B/en unknown
- 2011-10-05 SG SG2013015268A patent/SG188346A1/en unknown
- 2011-10-05 JP JP2013515601A patent/JP5873487B2/ja not_active Expired - Fee Related
- 2011-10-05 AR ARP110103695A patent/AR083313A1/es unknown
-
2013
- 2013-03-13 IL IL225189A patent/IL225189A0/en unknown
- 2013-03-20 ZA ZA2013/02112A patent/ZA201302112B/en unknown
- 2013-04-04 DO DO2013000074A patent/DOP2013000074A/es unknown
- 2013-04-04 CR CR20130158A patent/CR20130158A/es not_active Application Discontinuation
- 2013-04-05 CL CL2013000927A patent/CL2013000927A1/es unknown
- 2013-04-29 EC ECSP13012593 patent/ECSP13012593A/es unknown
- 2013-05-07 CO CO13114306A patent/CO6700872A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2813911A1 (en) | 2012-04-12 |
| US8722662B2 (en) | 2014-05-13 |
| UY33650A (es) | 2012-04-30 |
| EP2625170A1 (en) | 2013-08-14 |
| IL225189A0 (en) | 2013-06-27 |
| KR20130116073A (ko) | 2013-10-22 |
| PH12013500657A1 (en) | 2013-05-06 |
| CN103261176A (zh) | 2013-08-21 |
| CL2013000927A1 (es) | 2013-09-13 |
| US20120088748A1 (en) | 2012-04-12 |
| AR083313A1 (es) | 2013-02-13 |
| NZ608499A (en) | 2015-03-27 |
| SG188346A1 (en) | 2013-04-30 |
| WO2012046882A1 (en) | 2012-04-12 |
| JP5873487B2 (ja) | 2016-03-01 |
| JP2013538786A (ja) | 2013-10-17 |
| DOP2013000074A (es) | 2014-07-31 |
| ECSP13012593A (es) | 2013-07-31 |
| ZA201302112B (en) | 2013-12-23 |
| PE20140239A1 (es) | 2014-03-07 |
| EA201390491A1 (ru) | 2013-11-29 |
| MX2013003749A (es) | 2013-05-09 |
| TW201242956A (en) | 2012-11-01 |
| US20130267494A1 (en) | 2013-10-10 |
| GEP20156295B (en) | 2015-06-10 |
| AU2011313150A1 (en) | 2013-04-18 |
| CN103261176B (zh) | 2015-06-03 |
| CR20130158A (es) | 2013-05-03 |
| BR112013008420A2 (pt) | 2016-06-28 |
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