[go: up one dir, main page]

CO6592098A2 - Formulacion estable de mia/cd-rap - Google Patents

Formulacion estable de mia/cd-rap

Info

Publication number
CO6592098A2
CO6592098A2 CO12153702A CO12153702A CO6592098A2 CO 6592098 A2 CO6592098 A2 CO 6592098A2 CO 12153702 A CO12153702 A CO 12153702A CO 12153702 A CO12153702 A CO 12153702A CO 6592098 A2 CO6592098 A2 CO 6592098A2
Authority
CO
Colombia
Prior art keywords
rap
formulation
mia
amino acid
stable formulation
Prior art date
Application number
CO12153702A
Other languages
English (en)
Inventor
Klaus Hellerbrand
Rainer Sigl
Original Assignee
Scil Technology Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scil Technology Gmbh filed Critical Scil Technology Gmbh
Publication of CO6592098A2 publication Critical patent/CO6592098A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se relaciona con formulaciones acuosas estables que comprenden al menos 5mg/mL de CD-RAP y un aminoácido cargado, el aminoácido tiene preferentemente una carga neta a un pH entre aproximadamente 6 y 8. Los ingredientes de la formulación preferentemente proporcionan estabilidad sobre ciclos repetidos de congelamiento-deshielo. En un aspecto preferido, la formulación es para usarse en terapia, preferentemente para usarse en el tratamiento contra trastornos inflamatorios, preferentemente osteoartritis. Más aún, se proporciona un kit que comprende la formulación de la invención.
CO12153702A 2010-04-27 2012-09-07 Formulacion estable de mia/cd-rap CO6592098A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10161160 2010-04-27

Publications (1)

Publication Number Publication Date
CO6592098A2 true CO6592098A2 (es) 2013-01-02

Family

ID=43806879

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12153702A CO6592098A2 (es) 2010-04-27 2012-09-07 Formulacion estable de mia/cd-rap

Country Status (21)

Country Link
US (2) US9511116B2 (es)
EP (1) EP2563809B1 (es)
JP (2) JP2013525406A (es)
KR (1) KR101880905B1 (es)
CN (1) CN102869679B (es)
AU (1) AU2011247659B2 (es)
BR (1) BR112012027361A2 (es)
CA (1) CA2792965A1 (es)
CL (1) CL2012002948A1 (es)
CO (1) CO6592098A2 (es)
HK (1) HK1179273A1 (es)
IL (1) IL222712B (es)
MA (1) MA34225B1 (es)
MX (1) MX344732B (es)
MY (1) MY160916A (es)
NZ (1) NZ601927A (es)
PH (1) PH12012502140A1 (es)
RU (2) RU2588658C2 (es)
SG (3) SG10201502398RA (es)
WO (1) WO2011134979A2 (es)
ZA (1) ZA201206235B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12012502140A1 (en) * 2010-04-27 2013-02-04 Scil Tech Gmbh Stable mia/cd-rap formulation
WO2014098232A1 (ja) * 2012-12-21 2014-06-26 Yamashita Chikamasa Ｐｉ３キナーゼ阻害剤を含む医薬組成物、ビタミンｄ受容体に作用する化合物を含む医薬組成物、凍結乾燥組成物、凍結乾燥組成物の製造方法、及び経肺投与用医薬組成物
CA2950392A1 (en) * 2014-05-28 2015-12-03 Nono Inc. Lyophilized formulation of tat-nr2b9c with acetylation scavenger
JP6976254B2 (ja) * 2015-09-18 2021-12-08 バイオネット ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツングBioNet Pharma GmbH Ｃｄ−ｒａｐ前駆体タンパク質の使用による、ｃｄ−ｒａｐの製造方法における発現およびフォールディングの改善
KR20190027878A (ko) * 2016-07-13 2019-03-15 리폼 바이오로직스, 엘엘씨 치료 단백질 제제용 안정화 부형제
JP7113429B2 (ja) * 2016-11-29 2022-08-05 Ｓｐｉｂｅｒ株式会社 タンパク質組成物、その製造方法及び熱安定性向上方法
JP7179717B2 (ja) * 2017-03-31 2022-11-29 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 水性製剤及び注射器入り水性製剤、並びに、抗体タンパク脱凝集剤及び抗体タンパク脱凝集方法
KR20190066941A (ko) 2017-12-06 2019-06-14 주식회사 에코에너젠 반도체 제조 공정의 복합오염물질 저감 장치
CN112386575B (zh) * 2019-08-19 2023-03-21 鲁南制药集团股份有限公司 一种代谢调节融合蛋白的冻干制剂
KR102427935B1 (ko) 2022-05-23 2022-08-03 주식회사 동우이엔티 습식 스크러버를 포함한 입자상 및 가스상 오염물질이 혼합된 복합가스의 동시 처리가 가능한 습식 전기집진시스템

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54147916A (en) * 1978-05-12 1979-11-19 Sumitomo Chem Co Ltd Preparation of urokinase injection
DE2916711A1 (de) 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4783441A (en) 1979-04-30 1988-11-08 Hoechst Aktiengesellschaft Aqueous protein solutions stable to denaturation
US4374763A (en) * 1979-09-17 1983-02-22 Morishita Pharmaceutical Co., Ltd. Method for producing gamma-globulin for use in intravenous administration and method for producing a pharmaceutical preparation thereof
EP0158487B1 (en) 1984-04-09 1991-08-28 Takeda Chemical Industries, Ltd. Stable composition of interleukin-2
US4877608A (en) * 1987-11-09 1989-10-31 Rorer Pharmaceutical Corporation Pharmaceutical plasma protein formulations in low ionic strength media
GB8903593D0 (en) 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
FR2684878B1 (fr) * 1991-12-12 1994-02-11 Roussel Uclaf Composition pharmaceutique stabilisee d'il2 humaine recombinante non glycosylee sous forme reduite et son procede de preparation.
DE4242863A1 (de) * 1992-12-18 1994-06-23 Boehringer Mannheim Gmbh Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF
DK0710248T3 (da) 1993-07-20 2000-04-10 Roche Diagnostics Gmbh Melanom-inhiberende protein
US5580856A (en) * 1994-07-15 1996-12-03 Prestrelski; Steven J. Formulation of a reconstituted protein, and method and kit for the production thereof
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
CA2226575C (en) * 1995-07-27 2011-10-18 Genentech, Inc. Stabile isotonic lyophilized protein formulation
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
US20020103360A1 (en) * 1998-09-01 2002-08-01 Yang Pan Novel protein related to melanoma-inhibiting protein and uses thereof
AU5702099A (en) 1998-09-01 2000-03-21 Millennium Pharmaceuticals, Inc. A novel protein related to melanoma-inhibiting protein and uses thereof
EP1025871A1 (en) 1999-01-28 2000-08-09 F. Hoffmann-La Roche Ag Use of a melanoma inhibiting activity factor (MIA) for cartilage and bone repair
CZ299516B6 (cs) * 1999-07-02 2008-08-20 F. Hoffmann-La Roche Ag Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
RU2197238C2 (ru) * 1999-11-22 2003-01-27 Российский научный центр "Восстановительная травматология и ортопедия" им. академика Г.А. Илизарова Способ профилактики и лечения остеоартроза, средство для его осуществления и способ получения средства для лечения остеоартроза
US6743446B2 (en) * 1999-12-15 2004-06-01 The Ohio State University Research Foundation Methods for stabilizing biologically active agents encapsulated in biodegradable controlled-release polymers
AU2001232967A1 (en) 2000-01-25 2001-08-07 Hyseq, Inc. Methods and materials relating to novel growth regulatory-like polypeptides and polynucleotides
NZ520346A (en) * 2000-03-23 2004-07-30 Akzo Nobel Nv Use of MIA in immunotherapy
CA2466054C (en) * 2001-11-13 2012-01-03 Genentech, Inc. Apo-2 ligand/trail formulations
PL215168B1 (pl) * 2002-02-27 2013-10-31 Immunex Corp Formulacja polipeptydowa
WO2004015078A2 (en) * 2002-08-08 2004-02-19 Nuvelo, Inc. Methods and materials relating to novel growth regulatory-like polypeptides and polynucleotides
DE10360483B4 (de) 2003-12-22 2007-11-15 Scil Proteins Gmbh Expressionsvektor und dessen Verwendung
TW200806317A (en) * 2006-03-20 2008-02-01 Wyeth Corp Methods for reducing protein aggregation
TWI455731B (zh) * 2006-10-06 2014-10-11 Scil Technology Gmbh 醫藥應用的乾燥重建之囊胞結構
AU2008204901A1 (en) * 2007-01-09 2008-07-17 Wyeth Anti-IL-13 antibody formulations and uses thereof
PH12012502140A1 (en) * 2010-04-27 2013-02-04 Scil Tech Gmbh Stable mia/cd-rap formulation

Also Published As

Publication number Publication date
AU2011247659A1 (en) 2012-09-06
MX2012012115A (es) 2013-01-29
US20170042971A1 (en) 2017-02-16
CA2792965A1 (en) 2011-11-03
HK1179273A1 (zh) 2013-09-27
SG183561A1 (en) 2012-09-27
JP6078129B2 (ja) 2017-02-08
JP2016034958A (ja) 2016-03-17
MX344732B (es) 2017-01-04
RU2739078C2 (ru) 2020-12-21
JP2013525406A (ja) 2013-06-20
EP2563809B1 (en) 2020-04-01
EP2563809A2 (en) 2013-03-06
US9907829B2 (en) 2018-03-06
KR101880905B1 (ko) 2018-07-23
ZA201206235B (en) 2021-04-28
BR112012027361A2 (pt) 2021-04-27
MY160916A (en) 2017-03-31
IL222712A0 (en) 2012-12-31
WO2011134979A3 (en) 2012-06-14
WO2011134979A2 (en) 2011-11-03
CN102869679B (zh) 2015-11-25
MA34225B1 (fr) 2013-05-02
SG10201502398RA (en) 2015-05-28
PH12012502140A1 (en) 2013-02-04
SG10201908916UA (en) 2019-11-28
RU2012144771A (ru) 2014-06-10
RU2016118646A (ru) 2018-11-02
CN102869679A (zh) 2013-01-09
RU2588658C2 (ru) 2016-07-10
RU2016118646A3 (es) 2019-06-20
IL222712B (en) 2018-02-28
US20130137639A1 (en) 2013-05-30
AU2011247659B2 (en) 2014-07-24
KR20130086531A (ko) 2013-08-02
WO2011134979A9 (en) 2012-08-16
US9511116B2 (en) 2016-12-06
NZ601927A (en) 2013-07-26
CL2012002948A1 (es) 2013-02-15

Similar Documents

Publication Publication Date Title
CO6592098A2 (es) Formulacion estable de mia/cd-rap
AR124134A2 (es) Formulación de uso tópico para un inhibidor de jak
UY33802A (es) Composiciones inmunógenas que comprenden un antígeno relacionado con M72 y que tienen una fuerza iónica baja
CL2012001836A1 (es) Compuestos de pirazol, antagonista de crth2; composicion farmacéutica; uso en el tratamiento de trastornos inflamatorios, infecciosos, inmunoreguladores, enfermedades respiratorias, gastrointestinales o dolencias, entre otros.
NI201200184A (es) Morfolinopirimidinas y su uso en terapia
CO2023000866A2 (es) Composiciones dirigidas al músculo genomodificadas
BR112015020453A8 (pt) "formas de dosagem de liberação prolongada orais de tofacitinibe e uso de tofacitinibe
CL2008000894A1 (es) Composicion para el cuidado oral que comprende un aminoacido basico en forma libre o sal, una sal de fluoruro soluble, una sal de calcio de un acido organico; uso en el tratamiento de dientes desmineralizados y lesiones de esmalte de los dientes de un sujeto.
CL2009000498A1 (es) Compuestos derivados de benzo [f][1,7]naftiridin sustituidos, moduladores de receptor toll; composicion farmaceutica que los comprende; y su uso en el tratamiento de enfermedad infecciosa, inflamatoria, dermatologica, respiratoria o inmune.
UA106636C2 (uk) Морфолінотіазоли як позитивні алостеричні модулятори альфа 7
DOP2011000264A (es) Derivados de aminotetralina, composiciones farmaceuticas que los contienen y sus usos en terapia
MX358716B (es) Composiciones estables para el cuidado bucal que comprenden un aminoácido básico , una sal de estroncio y una fuente de ion fluoruro y usos de las mismas.
MX2012004869A (es) Formulaciones espesantes estables.
CO6541605A2 (es) Composiciones de uso oral que contienen extractos de garcinia mangostana l. y métodos asociados
UY33277A (es) Compuestos de anillo espiro-tetraciclico como moduladores de beta-secretasa y métodos de uso
MX344840B (es) Producto de cuidado oral y metodos de uso y fabricación de los mismos.
UY31294A1 (es) Derivados de tetrahidrocarbozol, métodos para obtenerlos, formulaciones que los contienen y usos de los mismos
CO6541604A2 (es) Composiciones orales que contienen extractos de myristica fragrans y métodos relacionados
GB2523707A (en) Novel pharmaceutical formulations and their use in the treatment of periodontal disease
MX2014000066A (es) Formulaciones mucoadhesivas en gel de alta dosificación de metronidazol de base acuosa y su uso para tratar la vaginosis bacteriana.
PT2459153E (pt) Composição farmacêutica ou cosmética ou dietética tendo o efeito de favorecer a pigmentação capilar
PH12015500864A1 (en) Liquid formulation comprising gm-csf neutralizing compound
BR112013026698A2 (pt) formulações do tipo tópica compreendendo depsipeptídeo cíclico
IT1398773B1 (it) Sequenze oligonucleotidiche inibitrici dell'espressione della chimera ciclina d1/trop2 e loro uso in campo medico.
IN2014DN10134A (es)

Legal Events

Date Code Title Description
FC Application refused