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Priority to CO12158743ApriorityCriticalpatent/CO6551663A2/en
Publication of CO6551663A2publicationCriticalpatent/CO6551663A2/en
Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Abstract
Se proporciona un hidrato del hidrocloruro de agomelatina de fórmula (I), en la que X es CI, preparación, uso y composición farmacéutica del mismo. Dicho hidrato obtenido mediante el presente método tiene una solubilidad significativamente aumentada que la agomelatina, y por ello es más adecuada para fabricar formulaciones farmacéuticas. Usando el presente método, se puede obtener una pureza elevada mediante de un proceso simple, sin ninguna etapa complicada.An agomelatine hydrochloride hydrate of formula (I) is provided, wherein X is CI, preparation, use and pharmaceutical composition thereof. Said hydrate obtained by the present method has a significantly increased solubility than agomelatine, and is therefore more suitable for manufacturing pharmaceutical formulations. Using the present method, high purity can be obtained by a simple process, without any complicated stage.
CO12158743A2012-09-142012-09-14
AGOMELATINE HYDROCHLORIDE HYDROCHLORIDE AND PREPARATION OF THIS
CO6551663A2
(en)
Compounds derived from benzofuran substituted in position 6 by a radical containing boron; pharmaceutical composition comprising them; use in the treatment of hepatitis c (divisional of cl 393-2014)