[go: up one dir, main page]

CO6390054A2 - Formas cristalinas de un compuesto 3-carboxipropil-aminotetralina - Google Patents

Formas cristalinas de un compuesto 3-carboxipropil-aminotetralina

Info

Publication number
CO6390054A2
CO6390054A2 CO11070977A CO11070977A CO6390054A2 CO 6390054 A2 CO6390054 A2 CO 6390054A2 CO 11070977 A CO11070977 A CO 11070977A CO 11070977 A CO11070977 A CO 11070977A CO 6390054 A2 CO6390054 A2 CO 6390054A2
Authority
CO
Colombia
Prior art keywords
carboxipropil
crystal forms
forms
crystalline solid
aminotetraline
Prior art date
Application number
CO11070977A
Other languages
English (en)
Inventor
Sean Dalziel
Miroslav Rapta
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of CO6390054A2 publication Critical patent/CO6390054A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención provee formas sólidas cristalinas de ácido (S)-4-((2S,3S)-7-carbamoil-1, 1-dietil-3-metoxi-1,2,3,4-tetrahidronaftalen-2-ilamino)-2-ciclohexilmetil-butírico. La invención también provee composiciones farmacéuticas que comprenden dichas formas sólidas cristalinas, métodos para usar dichas formas sólidas cristalinas para tratar enfermedades asociadas con la actividad de los receptores opioides mu, y procesos útiles para preparar dichas formas sólidas cristalinas.
CO11070977A 2008-12-10 2011-06-08 Formas cristalinas de un compuesto 3-carboxipropil-aminotetralina CO6390054A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12125408P 2008-12-10 2008-12-10

Publications (1)

Publication Number Publication Date
CO6390054A2 true CO6390054A2 (es) 2012-02-29

Family

ID=42122774

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11070977A CO6390054A2 (es) 2008-12-10 2011-06-08 Formas cristalinas de un compuesto 3-carboxipropil-aminotetralina

Country Status (21)

Country Link
US (4) US8101794B2 (es)
EP (1) EP2376427B1 (es)
JP (1) JP5650657B2 (es)
KR (1) KR101685187B1 (es)
CN (1) CN102245564B (es)
AR (1) AR074592A1 (es)
AU (1) AU2009324709B2 (es)
BR (1) BRPI0922920A2 (es)
CA (1) CA2745441C (es)
CL (1) CL2011001391A1 (es)
CO (1) CO6390054A2 (es)
ES (1) ES2645087T3 (es)
IL (1) IL213093A0 (es)
MX (1) MX2011006209A (es)
MY (1) MY179041A (es)
NZ (1) NZ593377A (es)
RU (1) RU2512390C2 (es)
SG (1) SG172016A1 (es)
TW (1) TWI449685B (es)
WO (1) WO2010068649A1 (es)
ZA (1) ZA201104319B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009076399A2 (en) 2007-12-11 2009-06-18 Theravance, Inc. Aminotetralin compounds as mu opioid receptor antagonists
AU2008335210B2 (en) 2007-12-11 2013-10-10 Theravance Biopharma R&D Ip, Llc 3 -carboxypropyl-aminotetralin derivatives as mu opioid receptor antagonists
KR20120092592A (ko) * 2009-09-18 2012-08-21 아돌로 코포레이션 위장관 질환을 위한 오피오이드 수용체 길항제의 용도
CA2846200A1 (en) * 2011-09-30 2013-04-04 Theravance, Inc. Crystalline forms of a 3-[2-methanesulfonyl-1-(4-trifluoromethyl-phenoxy)ethyl]pyrrolidine compound

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6498196B1 (en) 1998-12-22 2002-12-24 Edward Roberts Compounds useful in pain management
US6844368B1 (en) 1998-12-22 2005-01-18 Edward Roberts Compounds useful in pain management
US6231594B1 (en) 1999-08-11 2001-05-15 Radiant Medical, Inc. Method of controlling body temperature while reducing shivering
US6984647B2 (en) * 2002-05-17 2006-01-10 Janssen Pharmaceutica N.V. Aminotetralin-derived urea modulators of vanilloid VR1 receptor
MXPA05010821A (es) * 2003-04-08 2006-03-30 Progenics Pharm Inc Terapia de combinacion para constipacion que comprende un laxante y un antagonista opioide periferico.
SE0301794D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use III
EA200970459A1 (ru) 2006-11-07 2009-12-30 Нектар Терапьютикс Ал, Корпорэйшн Лекарственные формы и совместное введение опиоидного агониста и опиоидного антагониста
EP1997493A1 (en) * 2007-05-28 2008-12-03 Laboratorios del Dr. Esteve S.A. Combination of a 5-HT7 receptor ligand and an opioid receptor ligand
WO2009076399A2 (en) 2007-12-11 2009-06-18 Theravance, Inc. Aminotetralin compounds as mu opioid receptor antagonists
AU2008335210B2 (en) 2007-12-11 2013-10-10 Theravance Biopharma R&D Ip, Llc 3 -carboxypropyl-aminotetralin derivatives as mu opioid receptor antagonists
ES2431354T3 (es) 2008-04-01 2013-11-26 Theravance, Inc. Derivados de 2-aminotetralina como antagonistas del receptor de opioide mu

Also Published As

Publication number Publication date
NZ593377A (en) 2013-07-26
US20130065916A1 (en) 2013-03-14
JP5650657B2 (ja) 2015-01-07
CN102245564B (zh) 2015-04-01
ES2645087T3 (es) 2017-12-04
AU2009324709B2 (en) 2015-07-16
RU2512390C2 (ru) 2014-04-10
WO2010068649A1 (en) 2010-06-17
KR101685187B1 (ko) 2016-12-09
RU2011128393A (ru) 2013-01-20
CL2011001391A1 (es) 2011-11-11
ZA201104319B (en) 2012-03-28
US8969367B2 (en) 2015-03-03
US8324236B2 (en) 2012-12-04
TW201026646A (en) 2010-07-16
KR20110093938A (ko) 2011-08-18
SG172016A1 (en) 2011-07-28
BRPI0922920A2 (pt) 2019-09-24
US20100144881A1 (en) 2010-06-10
US20120088834A1 (en) 2012-04-12
CA2745441C (en) 2017-10-17
IL213093A0 (en) 2011-07-31
MY179041A (en) 2020-10-26
CA2745441A1 (en) 2010-06-17
EP2376427B1 (en) 2017-08-02
US8486958B2 (en) 2013-07-16
EP2376427A1 (en) 2011-10-19
MX2011006209A (es) 2011-07-12
US20130345466A1 (en) 2013-12-26
JP2012511580A (ja) 2012-05-24
US8101794B2 (en) 2012-01-24
AR074592A1 (es) 2011-01-26
CN102245564A (zh) 2011-11-16
TWI449685B (zh) 2014-08-21
AU2009324709A1 (en) 2011-06-30

Similar Documents

Publication Publication Date Title
CR20110579A (es) Compuestos 1-cianoetilheterociclilcarboxamida sustituidos 750
ECSP10010245A (es) Peptidil nitrilos y uso de los mismos como inhibidores de dipeptidil peptidasa i
BRPI0721905B8 (pt) composto inibidor de proteassoma, sua composição farmacêutica e seu uso
CL2007001885A1 (es) Compuestos derivados de urea de tropano, moduladores de la actividad de la 11betahsd1; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento de enfermedades tales como obesidad, diabetes, hipertension, aterosclerosis, demencia y osteoporosis.
ECSP077275A (es) Novedosos derivados de heteroarilsulfamida benzofusionados utiles como agentes anticonvulsivos
CL2008000946A1 (es) Compuestos derivados de pirrolopirimidina, inhibidores de cianasa jak3; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de rechazo de transplantes, enfermedades autoinmun
ECSP088854A (es) Moduladores bencimidazolicos de vr1
ECSP066883A (es) Derivados de heteroarilaminopirazol utiles para el tratamiento de la diabetes
EA200702586A1 (ru) Кристаллические модификации пираклостробина
MY155317A (en) Benzene sulfonamide thiazole and oxazole compounds
EA200870193A1 (ru) Цитотоксические агенты, включающие новые производные томаймицина, и их терапевтическое применение
UY30498A1 (es) Nueva clase de compuestos de benzimidazolilo, sus sales, composiciones farmacéuticas conteniéndolos y aplicaciones
EA201001205A1 (ru) Соединения, содержащие циклобутоксигруппу
CL2008002295A1 (es) Compuestos derivados de tiazolida sustituidos con alquilsulfonilos; composicion farmaceutica; y uso para el tratamiento de la hepatitis c.
CL2008002076A1 (es) Compuestos derivados de ariloxazoles sustituidos; procedimiento de preparacion de dichos compuestos; composicion farmaceutica que los comprende; y su uso para tratar diabetes, sindrome metabolico, dislipidemias, entre otras enfermedades.
EA200970532A1 (ru) Фумаратная соль (альфа s, бета r)-6-бром-альфа-[2-(диметиламино)этил]-2-метокси-альфа-1-нафталенил-бета-фенил-3-хинолинэтанола
GT200600117A (es) Nuevos compuestos farmaceuticos
UY30572A1 (es) N-(1-ftalazin-1-il-piperidin-4-il)-amidas como moduladores del receptor ep2
CR10206A (es) Acidos4-fenil-tiazol-5-carboxilicos amidas de acidos 4-fenil-tiazol-5-carboxilicos como inhibidores de la plk1
MX341849B (es) Nitrilos espirociclicos como inhibidores de proteasa.
CO6382089A2 (es) Compuestos,composiciones y metodos para el tratamiento de enfermadades causadas por un b-amiloide y sinucleinopatias
CL2012001031A1 (es) Compuestos derivados de 2-oxo-1-pirrolidinil-imidazotiadiazol; composición farmacéutica que los comprende; útiles para el tratamiento de la epilepsia, transtornos neurológicos, entre otros.
EA200900090A1 (ru) Бензиламины, способ их получения и их применение в качестве противовоспалительных средств
CL2007003223A1 (es) Compuestos derivados de piperidinil 4-arilsulfonamidas n-sustituidas, que actuan como moduladores de la proteina sfrp-1; proceso para preparar los compuestos; co mposicion farmaceutica que comprende a dichos copmpuestos y uso de los compuestos para preparar medicamentos para el tratamiento de enfermedades.
EA201001855A1 (ru) Соединения, содержащие циклобутоксигруппу

Legal Events

Date Code Title Description
FG Application granted