CO5700818A2 - OXAZOL TETRACICLINE DERIVATIVES - Google Patents
OXAZOL TETRACICLINE DERIVATIVESInfo
- Publication number
- CO5700818A2 CO5700818A2 CO06055450A CO06055450A CO5700818A2 CO 5700818 A2 CO5700818 A2 CO 5700818A2 CO 06055450 A CO06055450 A CO 06055450A CO 06055450 A CO06055450 A CO 06055450A CO 5700818 A2 CO5700818 A2 CO 5700818A2
- Authority
- CO
- Colombia
- Prior art keywords
- optionally substituted
- carbon atoms
- substituted carbon
- alkyl
- atoms
- Prior art date
Links
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 13
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 2
- 229920002554 vinyl polymer Polymers 0.000 abstract 2
- -1 -CH2NR1R2 Chemical group 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/62—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems having two or more ring systems containing condensed 1,3-oxazole rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
De acuerdo con la presente invención, se suministran compuestos representados por la Fórmula (I); En donde: X se selecciona del grupo hidrógeno, amino, NR11R12, alquilo de 1 a 12 átomos de carbono opcionalmente sustituido, arilo de 6, 10 o 14 átomos de carbono opcionalmente sustituido, vinilo opcionalmente sustituido, alquinilo de 2 a 12 átomos de carbono opcionalmente sustituido y halógeno;A" es una porción seleccionada del grupo: R11 y R12 son cada uno independientemente H o alquilo de 1 a 12 átomos de carbono o R11 y R12 cuando se toman opcionalmente juntos con el átomo de nitrógeno al cual cada uno está unido forman un anillo de hidrocarburo saturado de 3 a 7 miembros; Y se selecciona de hidrógeno, alquilo de 1 a 12 átomos de carbono opcionalmente sustituido, arilo de 6, 10 o 14 átomos de carbono opcionalmente sustituido, alquenilo de 2 a 12 átomos de carbono opcionalmente sustituido, vinilo, alquinilo de 2 a 12 átomos de carbono opcionalmente sustituido y halógeno;R se selecciona de alquilo de 1 a 12 átomos de carbono opcionalmente sustituido, alquenilo de 2 a 12 átomos de carbono opcionalmente sustituido, alquinilo de 2 a 12 átomos de carbono opcionalmente sustituido, -CH2NR1R2, arilo de 6, 10 o 14 átomos de carbono opcionalmente sustituido, aralquilo de 7 a 16 átomos de carbono opcionalmente sustituido, aroilo de 7 a 13 átomos de carbono opcionalmente sustituido, SR3, heteroarilo de 5 o 6 átomos por anillo opcionalmente sustituido, que contiene 1 a 4 heteroátomos que pueden ser iguales o diferentes, independientemente seleccionados de nitrógeno, oxígeno y azufre, y heteroarilcarbonilo de 5 o 6 átomos por anillo opcionalmente sustituido que contiene 1 a 4 heteroátomos que pueden ser iguales o diferentes, independientemente seleccionados de nitrógeno, oxígeno y azufre; ...In accordance with the present invention, compounds represented by Formula (I) are supplied; Where: X is selected from the group hydrogen, amino, NR11R12, alkyl of 1 to 12 optionally substituted carbon atoms, aryl of 6, 10 or 14 optionally substituted carbon atoms, optionally substituted vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; A "is a portion selected from the group: R11 and R12 are each independently H or alkyl of 1 to 12 carbon atoms or R11 and R12 when optionally taken together with the nitrogen atom to which each is attached form a 3 to 7-membered saturated hydrocarbon ring; and is selected from hydrogen, optionally substituted alkyl of 1 to 12 carbon atoms, optionally substituted aryl of 6, 10 or 14 carbon atoms, alkenyl of 2 to 12 atoms of optionally substituted carbon, vinyl, alkynyl of 2 to 12 optionally substituted carbon atoms and halogen; R is selected from alkyl of 1 to 12 optionally substituted carbon atoms, alkenyl of 2 to 12 optionally substituted carbon atoms, alkynyl of 2 to 12 optionally substituted carbon atoms, -CH2NR1R2, aryl of 6, 10 or 14 optionally substituted carbon atoms, aralkyl of 7 to 16 optionally substituted carbon atoms, aroyl of 7 to 13 optionally substituted carbon atoms, SR3, heteroaryl of 5 or 6 atoms per optionally substituted ring, containing 1 to 4 heteroatoms that may be the same or different, independently selected from nitrogen, oxygen and sulfur, and heteroarylcarbonyl of 5 or 6 atoms per ring optionally substituted containing 1 to 4 heteroatoms that may be the same or different, independently selected from nitrogen, oxygen and sulfur; ...
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52792803P | 2003-12-08 | 2003-12-08 | |
| US58482304P | 2004-07-01 | 2004-07-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5700818A2 true CO5700818A2 (en) | 2006-11-30 |
Family
ID=34681543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO06055450A CO5700818A2 (en) | 2003-12-08 | 2006-06-08 | OXAZOL TETRACICLINE DERIVATIVES |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US7176225B2 (en) |
| EP (2) | EP2157085B1 (en) |
| JP (1) | JP4848287B2 (en) |
| KR (1) | KR101164262B1 (en) |
| CN (1) | CN100545151C (en) |
| AR (1) | AR047274A1 (en) |
| AT (2) | ATE444290T1 (en) |
| AU (1) | AU2004297243B2 (en) |
| BR (1) | BRPI0417421A (en) |
| CA (1) | CA2546895A1 (en) |
| CO (1) | CO5700818A2 (en) |
| CR (1) | CR8437A (en) |
| DE (1) | DE602004023417D1 (en) |
| EC (1) | ECSP066605A (en) |
| ES (2) | ES2372635T3 (en) |
| IL (2) | IL176162A (en) |
| MY (1) | MY146098A (en) |
| NO (1) | NO20062629L (en) |
| PA (1) | PA8619601A1 (en) |
| PE (1) | PE20050995A1 (en) |
| RU (1) | RU2415844C2 (en) |
| SG (1) | SG148216A1 (en) |
| TW (1) | TW200528437A (en) |
| UA (2) | UA83266C2 (en) |
| WO (1) | WO2005056538A1 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT1753713T (en) | 2004-05-21 | 2016-11-25 | President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
| EP1805134B1 (en) | 2004-10-25 | 2012-06-20 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| AR057033A1 (en) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | TIGECICLINE AND METHODS TO PREPARE 9-NITROMINOCICLINE |
| AR057324A1 (en) * | 2005-05-27 | 2007-11-28 | Wyeth Corp | TIGECICLINE AND METHODS TO PREPARE 9-AMINOMINOCICLINE |
| AR057032A1 (en) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | TIGECICLINE AND PREPARATION METHODS |
| WO2007014154A2 (en) * | 2005-07-21 | 2007-02-01 | Paratek Pharmaceuticals, Inc. | 10-substituted tetracyclines and methods of use thereof |
| US8486921B2 (en) | 2006-04-07 | 2013-07-16 | President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
| EP2487160B1 (en) | 2006-10-11 | 2016-02-03 | President and Fellows of Harvard College | Synthesis of Enone Intermediate |
| WO2008045507A2 (en) | 2006-10-11 | 2008-04-17 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of bacillus anthracis infections |
| US8121767B2 (en) * | 2007-11-02 | 2012-02-21 | GM Global Technology Operations LLC | Predicted and immediate output torque control architecture for a hybrid powertrain system |
| US8252946B2 (en) | 2007-11-14 | 2012-08-28 | Sandoz Ag | Crystalline forms of tigecycline hydrochloride |
| US8338477B2 (en) | 2008-07-11 | 2012-12-25 | Neumedics | Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits |
| SI2376433T1 (en) | 2008-12-18 | 2015-03-31 | Sandoz Ag | Crystalline form c of tigecycline dihydrochloride and methods for its preparation |
| US9073829B2 (en) | 2009-04-30 | 2015-07-07 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US26253A (en) * | 1859-11-29 | Vegetable-cutter | ||
| US2482055A (en) | 1948-02-11 | 1949-09-13 | American Cyanamid Co | Aureomycin and preparation of same |
| US3007965A (en) | 1959-02-13 | 1961-11-07 | American Cyanamid Co | New tetracyclines produced by streptomyces aureofaciens |
| US3043875A (en) | 1959-10-22 | 1962-07-10 | Pfizer & Co C | Halogenated tetracycline derivatives and processes for their preparation |
| FR1430859A (en) | 1960-05-23 | 1966-05-25 | ||
| US3338963A (en) | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
| US3148212A (en) | 1961-12-22 | 1964-09-08 | American Cyanamid Co | Reductive alkylation process |
| US3360557A (en) | 1963-05-10 | 1967-12-26 | American Cyanamid Co | 9-hydroxytetracyclines and a process of preparing same |
| USRE26253E (en) | 1963-05-17 | 1967-08-15 | And z-alkylamino-g-deoxytetracycline | |
| US3341585A (en) | 1966-05-06 | 1967-09-12 | American Cyanamid Co | Substituted 7-and/or 9-amino-6-deoxytetracyclines |
| US3360561A (en) | 1967-06-19 | 1967-12-26 | American Cyanamid Co | Nitration of tetracyclines |
| US3518306A (en) | 1968-02-19 | 1970-06-30 | American Cyanamid Co | 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines |
| US4806529A (en) | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
| US5494903A (en) * | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
| DE122006000058I1 (en) * | 1991-10-04 | 2007-01-18 | Wyeth Corp | 7-Substituted-9-substituted-amino-6-demethyl-6-deoxy-tetracyclines |
| US5328902A (en) | 1992-08-13 | 1994-07-12 | American Cyanamid Co. | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
| WO2001010385A2 (en) * | 1999-08-10 | 2001-02-15 | Smithkline Beecham Corporation | 1,4-substituted 4,4-diaryl cyclohexanes |
| EP2301550A1 (en) * | 2001-07-13 | 2011-03-30 | Paratek Pharmaceuticals, Inc. | Tetracycline compounds having target therapeutic activities |
-
2004
- 2004-07-12 UA UAA200606344A patent/UA83266C2/en unknown
- 2004-10-30 UA UAA200606646A patent/UA83268C2/en unknown
- 2004-12-01 TW TW093137032A patent/TW200528437A/en unknown
- 2004-12-07 PA PA20048619601A patent/PA8619601A1/en unknown
- 2004-12-07 AT AT04813199T patent/ATE444290T1/en not_active IP Right Cessation
- 2004-12-07 WO PCT/US2004/040850 patent/WO2005056538A1/en active Application Filing
- 2004-12-07 KR KR1020067013606A patent/KR101164262B1/en not_active IP Right Cessation
- 2004-12-07 ES ES09010915T patent/ES2372635T3/en not_active Expired - Lifetime
- 2004-12-07 AT AT09010915T patent/ATE525365T1/en not_active IP Right Cessation
- 2004-12-07 EP EP09010915A patent/EP2157085B1/en not_active Expired - Lifetime
- 2004-12-07 MY MYPI20045049A patent/MY146098A/en unknown
- 2004-12-07 DE DE602004023417T patent/DE602004023417D1/en not_active Expired - Lifetime
- 2004-12-07 AR ARP040104570A patent/AR047274A1/en unknown
- 2004-12-07 ES ES04813199T patent/ES2331574T3/en not_active Expired - Lifetime
- 2004-12-07 CN CNB2004800364939A patent/CN100545151C/en not_active Expired - Fee Related
- 2004-12-07 SG SG200809014-4A patent/SG148216A1/en unknown
- 2004-12-07 PE PE2004001203A patent/PE20050995A1/en not_active Application Discontinuation
- 2004-12-07 JP JP2006542866A patent/JP4848287B2/en not_active Expired - Fee Related
- 2004-12-07 CA CA002546895A patent/CA2546895A1/en not_active Abandoned
- 2004-12-07 EP EP04813199A patent/EP1692117B1/en not_active Expired - Lifetime
- 2004-12-07 BR BRPI0417421-6A patent/BRPI0417421A/en not_active IP Right Cessation
- 2004-12-07 AU AU2004297243A patent/AU2004297243B2/en not_active Ceased
- 2004-12-07 RU RU2006118367/04A patent/RU2415844C2/en not_active IP Right Cessation
- 2004-12-08 US US11/007,621 patent/US7176225B2/en not_active Expired - Fee Related
-
2006
- 2006-06-05 EC EC2006006605A patent/ECSP066605A/en unknown
- 2006-06-06 IL IL176162A patent/IL176162A/en not_active IP Right Cessation
- 2006-06-06 CR CR8437A patent/CR8437A/en not_active Application Discontinuation
- 2006-06-08 NO NO20062629A patent/NO20062629L/en not_active Application Discontinuation
- 2006-06-08 CO CO06055450A patent/CO5700818A2/en unknown
- 2006-12-13 US US11/638,138 patent/US7365087B2/en not_active Expired - Fee Related
-
2008
- 2008-03-24 US US12/053,856 patent/US20080177080A1/en not_active Abandoned
-
2010
- 2010-05-27 IL IL206050A patent/IL206050A/en not_active IP Right Cessation
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