CO5380036A1 - PROCESS FOR QUICK SYNTHESIS OF PEPTIDES IN SOLUTION - Google Patents
PROCESS FOR QUICK SYNTHESIS OF PEPTIDES IN SOLUTIONInfo
- Publication number
- CO5380036A1 CO5380036A1 CO02061736A CO02061736A CO5380036A1 CO 5380036 A1 CO5380036 A1 CO 5380036A1 CO 02061736 A CO02061736 A CO 02061736A CO 02061736 A CO02061736 A CO 02061736A CO 5380036 A1 CO5380036 A1 CO 5380036A1
- Authority
- CO
- Colombia
- Prior art keywords
- stage
- activated carboxylic
- solution
- sweeping agent
- peptides
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 238000010408 sweeping Methods 0.000 abstract 3
- 150000001450 anions Chemical class 0.000 abstract 2
- 238000010511 deprotection reaction Methods 0.000 abstract 2
- 238000000605 extraction Methods 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- ODIGIKRIUKFKHP-UHFFFAOYSA-N (n-propan-2-yloxycarbonylanilino) acetate Chemical compound CC(C)OC(=O)N(OC(C)=O)C1=CC=CC=C1 ODIGIKRIUKFKHP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000008033 biological extinction Effects 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un procedimiento para la síntesis rápida de un péptido en solución en un solvente orgánico o una mezcla de solventes orgánicos, donde el procedimiento comprende ciclos repetidos de las etapas (a) -(d) : (a) una etapa de acoplamiento, usando un exceso de un componente carboxílico activado para acilar un componente amino, (b) una etapa de extinción en que se usa un agente barredor para remover las funciones carboxílicas activadas residuales, donde el agente barredor también puede usarse para la desprotección del péptido en crecimiento, (c) una o más extracciones acuosas yopcionalmente, (d) una etapa de desprotección separada, seguida por una o más extracciones acuosas, CARACTERIZADO porqueel procedimiento comprende al menos una etapa (b), denominada etapa (bAND#39), en que una amina que comprende un anión libre o un anión latente es usada como agente barredor de las funciones carboxílicas activadas residuales. A process for the rapid synthesis of a peptide in solution in an organic solvent or a mixture of organic solvents, where the process comprises repeated cycles of steps (a) - (d): (a) a coupling stage, using an excess of an activated carboxylic component to acylate an amino component, (b) an extinction step in which a sweeping agent is used to remove residual activated carboxylic functions, where the sweeping agent can also be used for deprotection of the growing peptide, (c ) one or more aqueous extractions and optionally, (d) a separate deprotection stage, followed by one or more aqueous extractions, CHARACTERIZED because the process comprises at least one stage (b), called stage (band # 39), in which an amine which It comprises a free anion or a latent anion is used as a sweeping agent for residual activated carboxylic functions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1202753 | 2001-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5380036A1 true CO5380036A1 (en) | 2004-03-31 |
Family
ID=29245008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO02061736A CO5380036A1 (en) | 2001-07-19 | 2002-07-17 | PROCESS FOR QUICK SYNTHESIS OF PEPTIDES IN SOLUTION |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2002300066B2 (en) |
| CO (1) | CO5380036A1 (en) |
| NZ (1) | NZ520267A (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2373816A1 (en) * | 1999-05-26 | 2000-11-30 | Abbott Laboratories | Minimal isolation peptide synthesis process using ion-exchange resins as scavenging agents |
-
2002
- 2002-07-10 AU AU2002300066A patent/AU2002300066B2/en not_active Expired
- 2002-07-17 CO CO02061736A patent/CO5380036A1/en not_active Application Discontinuation
- 2002-07-18 NZ NZ52026702A patent/NZ520267A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002300066B2 (en) | 2004-06-03 |
| NZ520267A (en) | 2003-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted | ||
| FD | Application lapsed |