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CO5300520A1 - NEW SULFONAMIDE COMPOUNDS AND USES OF THE SAME - Google Patents

NEW SULFONAMIDE COMPOUNDS AND USES OF THE SAME

Info

Publication number
CO5300520A1
CO5300520A1 CO00013540A CO00013540A CO5300520A1 CO 5300520 A1 CO5300520 A1 CO 5300520A1 CO 00013540 A CO00013540 A CO 00013540A CO 00013540 A CO00013540 A CO 00013540A CO 5300520 A1 CO5300520 A1 CO 5300520A1
Authority
CO
Colombia
Prior art keywords
substituted
unsubstituted
optionally
heterocycle
double bonds
Prior art date
Application number
CO00013540A
Other languages
Spanish (es)
Inventor
David W Smith
Benito Munoz
Srinivasan Kumar
Carl P Bergstron
V Chaturvedula Prasad
S Deshpande Milind
Daniel J Keavy
Yu Lau Wai
Michael F Parker
Charles F Psoal
B Wallace Owen
Wang Henry Hui
Original Assignee
Merck & Co Inc
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Bristol Myers Squibb Co filed Critical Merck & Co Inc
Publication of CO5300520A1 publication Critical patent/CO5300520A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se Provee una nueva clase de compuestos sulfonamida de fórmula: <EMI FILE="00013540_1" ID="1" IMF=JPEG >y su sales farmaceúticamente aceptables, en donde:D es hidrógeno, un hidrocarbilo sustituido ó no sustituido, un heterociclo sustituido ó no sustituido que tiene opcionalmente uno ó más dobles enlaces, halógeno, éster, amida oD y G, tomados juntos, forman una estructura cíclica sustituida ó no sustituida; yE, es hidrógeno, un hidrocarbilo sustituido ó no sustituido, un heterociclo sustituido o no sustituido, que opcionalmente tiene uno ó más dobles enlaces, alcoxilo, amida, sulfonilo, sulfonamidilo, sulfuro ó alcoxilo; óJ y E, tomados juntos, forman una estructura cíclica sustituida o no sustituida; yG, cuando no es parte de una estructura clínica que incluya D, es un hidrocarbilo sustituido o no sustituido, un heterociclo sustituido o no sustituido que tiene opcionalmente uno o mas dobles enlaces, amina, amida, éster, éter o carbamato; ysustituido o no sustituido, un heterociclo que opcionalmente tiene uno o más dobles enlaces.Los compuestos de la invención pueden actuar para modular la producción de proteína ß-amiloide y son de utilidad en la prevención y tratamiento de diversas enfermedades. También se proveen composiciones que contienen los compuestos de la invención.A new class of sulfonamide compounds of the formula is provided: <EMI FILE = "00013540_1" ID = "1" MFI = JPEG> and its pharmaceutically acceptable salts, wherein: D is hydrogen, a substituted or unsubstituted hydrocarbyl, a substituted heterocycle or unsubstituted optionally having one or more double bonds, halogen, ester, amide oD and G, taken together, form a substituted or unsubstituted cyclic structure; and E, is hydrogen, a substituted or unsubstituted hydrocarbyl, a substituted or unsubstituted heterocycle, which optionally has one or more double bonds, alkoxy, amide, sulfonyl, sulfonamidyl, sulfide or alkoxy; óJ and E, taken together, form a substituted or unsubstituted cyclic structure; and G, when not part of a clinical structure that includes D, is a substituted or unsubstituted hydrocarbyl, a substituted or unsubstituted heterocycle that optionally has one or more double bonds, amine, amide, ester, ether or carbamate; and substituted or unsubstituted, a heterocycle that optionally has one or more double bonds.The compounds of the invention can act to modulate the production of β-amyloid protein and are useful in the prevention and treatment of various diseases. Compositions containing the compounds of the invention are also provided.

CO00013540A 1999-02-26 2000-02-25 NEW SULFONAMIDE COMPOUNDS AND USES OF THE SAME CO5300520A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12274899P 1999-02-26 1999-02-26
US12274699P 1999-02-26 1999-02-26
US13099599P 1999-04-23 1999-04-23
US13099499P 1999-04-23 1999-04-23

Publications (1)

Publication Number Publication Date
CO5300520A1 true CO5300520A1 (en) 2003-07-31

Family

ID=40953681

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00013540A CO5300520A1 (en) 1999-02-26 2000-02-25 NEW SULFONAMIDE COMPOUNDS AND USES OF THE SAME

Country Status (1)

Country Link
CO (1) CO5300520A1 (en)

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