CO5271650A1 - MODIFIED AND PEPTIDOMIMETIC PEPTIDES FOR USE IN IMMUNOTHERAPY - Google Patents
MODIFIED AND PEPTIDOMIMETIC PEPTIDES FOR USE IN IMMUNOTHERAPYInfo
- Publication number
- CO5271650A1 CO5271650A1 CO00079334A CO00079334A CO5271650A1 CO 5271650 A1 CO5271650 A1 CO 5271650A1 CO 00079334 A CO00079334 A CO 00079334A CO 00079334 A CO00079334 A CO 00079334A CO 5271650 A1 CO5271650 A1 CO 5271650A1
- Authority
- CO
- Colombia
- Prior art keywords
- amino acids
- formula
- substitution
- ser
- modified
- Prior art date
Links
- 238000009169 immunotherapy Methods 0.000 title 1
- 239000000816 peptidomimetic Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Rehabilitation Therapy (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un péptido modificado derivado de H-Arg-Ser-Phe-Thr-Leu-Ala-Ser-Ser-Glu-Thr-Gly-Val-Gly-OH (fórmula I) que tiene la fórmula general Q-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-Z (fórmula II), donde A1 a A13 corresponden a los amino ácidos de la fórmula I, Q corresponde a H y Z corresponde a OH, CARACTERIZADO porque 1 a 6 modificaciones se seleccionan de uno o más de los grupos a, b ó c consistentes en: a) sustitución de 1-6, de preferencia 1-4 amino ácidos en A1 a A13 por amino ácidos no naturales o ß amino ácidos, b) sustitución de uno o más enlaces amida por enlaces amida reducidos o isoesteres de etileno, c) sustituciones en Q y / o Z: y opcionalmente d) sustitución por amino ácidos naturales hasta un total de 6 modificaciones.A modified peptide derived from H-Arg-Ser-Phe-Thr-Leu-Ala-Ser-Ser-Glu-Thr-Gly-Val-Gly-OH (formula I) having the general formula Q-A1-A2-A3 -A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-Z (formula II), where A1 to A13 correspond to the amino acids of formula I, Q corresponds to H and Z corresponds to OH , CHARACTERIZED because 1 to 6 modifications are selected from one or more of the groups a, b or c consisting of: a) substitution of 1-6, preferably 1-4 amino acids in A1 to A13 by unnatural amino acids or ß amino acids, b) substitution of one or more amide bonds by reduced amide bonds or isoesters of ethylene, c) substitutions in Q and / or Z: and optionally d) substitution by natural amino acids up to a total of 6 modifications.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99203427 | 1999-10-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5271650A1 true CO5271650A1 (en) | 2003-04-30 |
Family
ID=8240756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00079334A CO5271650A1 (en) | 1999-10-18 | 2000-10-18 | MODIFIED AND PEPTIDOMIMETIC PEPTIDES FOR USE IN IMMUNOTHERAPY |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1226167A1 (en) |
| JP (1) | JP2003512388A (en) |
| KR (1) | KR20020047245A (en) |
| CN (1) | CN1379786A (en) |
| AR (1) | AR026068A1 (en) |
| AU (1) | AU780238B2 (en) |
| BR (1) | BR0014803A (en) |
| CA (1) | CA2386398A1 (en) |
| CO (1) | CO5271650A1 (en) |
| CZ (1) | CZ20021356A3 (en) |
| HK (1) | HK1046693A1 (en) |
| HU (1) | HUP0203504A3 (en) |
| IL (1) | IL148778A0 (en) |
| MX (1) | MXPA02003520A (en) |
| NO (1) | NO20021763L (en) |
| NZ (1) | NZ518256A (en) |
| PE (1) | PE20010692A1 (en) |
| PL (1) | PL354590A1 (en) |
| RU (1) | RU2002113107A (en) |
| SK (1) | SK6842002A3 (en) |
| TR (1) | TR200201036T2 (en) |
| WO (1) | WO2001029081A1 (en) |
| ZA (1) | ZA200202577B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002951212A0 (en) * | 2002-09-04 | 2002-09-19 | Monash University | A method of modulating cellular activity and molecules for use therein |
| WO2007117665A2 (en) * | 2006-04-06 | 2007-10-18 | Purdue Research Foundation | Derivatization-enhanced analysis of amino acids and peptides |
| EP2114462B1 (en) * | 2006-12-21 | 2013-06-05 | Universite De Geneve | Compounds for fluorescence imaging |
| CA2740028A1 (en) | 2008-01-23 | 2009-07-30 | Herlev Hospital | Ykl-40 as a general marker for non-specific disease |
| AU2009291312A1 (en) | 2008-09-15 | 2010-03-18 | Herlev Hospital | YKL-40 as a marker for gastrointestinal cancers |
| AU2015342767B2 (en) | 2014-11-07 | 2021-05-13 | Pacira Pharmaceuticals, Inc. | Modifications and uses of conotoxin peptides |
| EP3466963A1 (en) * | 2017-10-05 | 2019-04-10 | Suigeneris Farmacosmetics, S.L. | Anticancer peptides and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL115744A (en) * | 1994-10-27 | 2000-07-16 | Akzo Nobel Nv | Peptides comprising a subsequence of human cartilage glycoprotein - 39 |
| TW575583B (en) * | 1996-04-24 | 2004-02-11 | Akzo Nobel Nv | Novel peptides suitable for use in antigen specific immunosuppressive therapy |
| AU727757B2 (en) * | 1996-06-07 | 2000-12-21 | Astrazeneca Ab | Peptide derivatives |
| IL122233A (en) * | 1996-12-06 | 2001-04-30 | Akzo Nobel Nv | Method of preparing cell surface monolonal antibodies and pharmaceutical compositions and diagnostic reagents containing them |
-
2000
- 2000-10-12 WO PCT/EP2000/010230 patent/WO2001029081A1/en not_active Application Discontinuation
- 2000-10-12 TR TR2002/01036T patent/TR200201036T2/en unknown
- 2000-10-12 HU HU0203504A patent/HUP0203504A3/en unknown
- 2000-10-12 RU RU2002113107/15A patent/RU2002113107A/en not_active Application Discontinuation
- 2000-10-12 BR BR0014803-2A patent/BR0014803A/en not_active IP Right Cessation
- 2000-10-12 AU AU11396/01A patent/AU780238B2/en not_active Ceased
- 2000-10-12 EP EP00972790A patent/EP1226167A1/en not_active Withdrawn
- 2000-10-12 SK SK684-2002A patent/SK6842002A3/en not_active Application Discontinuation
- 2000-10-12 JP JP2001531879A patent/JP2003512388A/en not_active Withdrawn
- 2000-10-12 IL IL14877800A patent/IL148778A0/en unknown
- 2000-10-12 PL PL00354590A patent/PL354590A1/en not_active Application Discontinuation
- 2000-10-12 KR KR1020027004940A patent/KR20020047245A/en not_active Application Discontinuation
- 2000-10-12 CN CN00814418A patent/CN1379786A/en active Pending
- 2000-10-12 MX MXPA02003520A patent/MXPA02003520A/en unknown
- 2000-10-12 NZ NZ518256A patent/NZ518256A/en unknown
- 2000-10-12 CZ CZ20021356A patent/CZ20021356A3/en unknown
- 2000-10-12 CA CA002386398A patent/CA2386398A1/en not_active Abandoned
- 2000-10-17 PE PE2000001107A patent/PE20010692A1/en not_active Application Discontinuation
- 2000-10-18 CO CO00079334A patent/CO5271650A1/en not_active Application Discontinuation
- 2000-10-18 AR ARP000105458A patent/AR026068A1/en unknown
-
2002
- 2002-04-02 ZA ZA200202577A patent/ZA200202577B/en unknown
- 2002-04-15 NO NO20021763A patent/NO20021763L/en not_active Application Discontinuation
- 2002-11-13 HK HK02108208.9A patent/HK1046693A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1379786A (en) | 2002-11-13 |
| JP2003512388A (en) | 2003-04-02 |
| WO2001029081A1 (en) | 2001-04-26 |
| TR200201036T2 (en) | 2002-08-21 |
| NO20021763D0 (en) | 2002-04-15 |
| PE20010692A1 (en) | 2001-07-06 |
| IL148778A0 (en) | 2002-09-12 |
| ZA200202577B (en) | 2003-09-23 |
| RU2002113107A (en) | 2004-01-10 |
| CZ20021356A3 (en) | 2002-07-17 |
| MXPA02003520A (en) | 2002-08-20 |
| NO20021763L (en) | 2002-04-15 |
| HUP0203504A2 (en) | 2003-04-28 |
| NZ518256A (en) | 2004-01-30 |
| HK1046693A1 (en) | 2003-01-24 |
| EP1226167A1 (en) | 2002-07-31 |
| CA2386398A1 (en) | 2001-04-26 |
| AR026068A1 (en) | 2002-12-26 |
| AU1139601A (en) | 2001-04-30 |
| PL354590A1 (en) | 2004-01-26 |
| AU780238B2 (en) | 2005-03-10 |
| KR20020047245A (en) | 2002-06-21 |
| BR0014803A (en) | 2002-06-11 |
| SK6842002A3 (en) | 2002-09-10 |
| HUP0203504A3 (en) | 2005-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |