CO5170535A1 - DERIVATIVES OF N- [2- (4-AMINOPHENYL) ETHYL] 2,3-DIHIDRO-1,4- BENZODIOXIN-2-METHANAMINE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS - Google Patents
DERIVATIVES OF N- [2- (4-AMINOPHENYL) ETHYL] 2,3-DIHIDRO-1,4- BENZODIOXIN-2-METHANAMINE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICSInfo
- Publication number
- CO5170535A1 CO5170535A1 CO00022433A CO00022433A CO5170535A1 CO 5170535 A1 CO5170535 A1 CO 5170535A1 CO 00022433 A CO00022433 A CO 00022433A CO 00022433 A CO00022433 A CO 00022433A CO 5170535 A1 CO5170535 A1 CO 5170535A1
- Authority
- CO
- Colombia
- Prior art keywords
- group
- alkylcarbamoyl
- oxo
- phenyl
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuesto, en forma de enantiómero puro o de mezcla de enantiómeros, que responde a la fórmula general (I)<EMI FILE="00022433_1" ID="1" IMF=JPEG >en la cual X representa un átomo de hidrógeno o de halógeno o un grupo ciano, un grupo nitro, un grupo hidroxi, un grupo (C1-C4) alquilo, un grupo fenilo, un grupo tienilo, un grupo tienilmetoxi, un grupo (C1-C4) alcoxi, un grupo ciclo (C3-C6) alquilmetoxi, un grupo fenilmetoxi, un grupo (C1-C4) alcoxicarbonilo, un grupo (C1-C4) alcoxicarbonilmetilo, un grupo pirrolidin-1-ilcarbonilo, un grupo carbamoilo, un grupo N-(C1-C4) alquilcarbamoilo, un grupo N,N-di(C1-C4) alquilcarbamoilo, un grupo trifluorometilsulfoniloxi, un grupo dimetilaminocarboniloxi, un grupo dimetilaminocarbonilmetoxi, un grupo acetilamino, un grupo acetilaminometilo, o bien dos grupos elegidos entre los átomos de halógenos y los grupos nitro, ciano, (C1-C4) alquilos y (C1-C4) alcoxi, R1 representa un átomo de hidrógeno o un grupo metilo, y R2, tomado aisladamente, representa ya sea un grupo (C1-C4) alcanoilo, ya sea un grupo fenil (C1-C4) alcanoilo, ya sea un grupo metoxiacetilo, ya sea un grupo (C3-C6) cicloalquilcarbonilo, ya sea un grupo benzoilo eventualmente sustituido por un átomo de halógeno, por un grupo (C1-C4) alquilo, por un grupo (C1-C4) alcoxi, por un grupo metoximetilo o por un grupo metoxi y un grupo etilsulfonilo, ya sea un grupo N-fenilcarbamoilo, ya sea un grupo N-((C1-C4) alquilcarbamoilo, ya sea un grupo N-(2-metoxietil) carbamoilo, ya sea un grupo (C1-C4) alcoxicarbonilo, ya sea un grupo (C1-C4)alquilsulfonilo, ya sea un grupo fenilsulfonilo, ya sea un grupo piridin-4-ilcarbonilo, ya sea también un grupo divalente de fórmula COCH2 ó COCH2CH2 enlazado al ciclo fenilo en posición orto del átomo de nitrógeno, de manera tal de formar con este ciclo un grupo 2-oxo-3H-indol-5-ilo ó 2-oxo-3,4-dihidroquinolein-6-ilo, o también NR1R2 representa un grupo 2-oxo-4,5-dihidrooxazolidin-3-ilo, en estado de base o de sal de adición a un ácido.Compound, in the form of a pure enantiomer or mixture of enantiomers, which responds to the general formula (I) <EMI FILE = "00022433_1" ID = "1" IMF = JPEG> in which X represents a hydrogen or halogen atom or a cyano group, a nitro group, a hydroxy group, a (C1-C4) alkyl group, a phenyl group, a thienyl group, a thienylmethoxy group, an (C1-C4) alkoxy group, a cyclo (C3-C6) group ) alkylmethoxy, a phenylmethoxy group, a (C1-C4) alkoxycarbonyl group, a (C1-C4) alkoxycarbonylmethyl group, a pyrrolidin-1-ylcarbonyl group, a carbamoyl group, an N- (C1-C4) alkylcarbamoyl group, a group N, N-di (C1-C4) alkylcarbamoyl, a trifluoromethylsulfonyloxy group, a dimethylaminocarbonyloxy group, a dimethylaminocarbonylmethoxy group, an acetylamino group, an acetylaminomethyl group, or two groups chosen from halogen atoms and nitro, cyano groups, ( C1-C4) alkyls and (C1-C4) alkoxy, R1 represents a hydrogen atom or a methyl group, and R2, taken in isolation, represents either a (C1-C4) alkanoyl group, either a phenyl (C1-C4) alkanoyl group, either a methoxyacetyl group, either a (C3-C6) cycloalkylcarbonyl group, or a benzoyl group optionally substituted by a halogen atom, by a (C1-C4) alkyl group, by a (C1-C4) alkoxy group, by a methoxymethyl group or by a methoxy group and an ethylsulfonyl group, either an N-phenylcarbamoyl group, either a group N - ((C1-C4) alkylcarbamoyl, either an N- (2-methoxyethyl) carbamoyl group, either a (C1-C4) alkoxycarbonyl group, either a (C1-C4) alkylsulfonyl group, or a phenylsulfonyl group , either a pyridin-4-ylcarbonyl group, also a divalent group of formula COCH2 or COCH2CH2 linked to the ortho-phenyl cycle of the nitrogen atom, so as to form a 2-oxo-3H- group with this cycle. indole-5-yl or 2-oxo-3,4-dihydroquinoline-6-yl, or NR1R2 also represents a 2-oxo-4,5-dihydrooxazolidin-3-yl group, in the base or additive salt state On to an acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9903936A FR2791675B1 (en) | 1999-03-30 | 1999-03-30 | DERIVATIVES OF N- [2- (4-AMINOPHENYL) ETHYL] -2,3-DIHYDRO-1,4- BENZODIOXINNE-2-METHANAMINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5170535A1 true CO5170535A1 (en) | 2002-06-27 |
Family
ID=9543788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00022433A CO5170535A1 (en) | 1999-03-30 | 2000-03-29 | DERIVATIVES OF N- [2- (4-AMINOPHENYL) ETHYL] 2,3-DIHIDRO-1,4- BENZODIOXIN-2-METHANAMINE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS |
Country Status (6)
| Country | Link |
|---|---|
| AU (1) | AU3660700A (en) |
| CO (1) | CO5170535A1 (en) |
| FR (1) | FR2791675B1 (en) |
| PE (1) | PE20001598A1 (en) |
| UY (1) | UY26085A1 (en) |
| WO (1) | WO2000058301A1 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0117396D0 (en) | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
| GB0308208D0 (en) | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
| US7297704B2 (en) | 2005-02-17 | 2007-11-20 | Wyeth | Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives |
| BRPI0610027A2 (en) | 2005-04-22 | 2010-05-18 | Wyeth Corp | chroman and chromene derivatives and their uses |
| CN101218223A (en) * | 2005-04-22 | 2008-07-09 | 惠氏公司 | Benzodioxane and benzodioxolane derivatives and uses thereof |
| AR060493A1 (en) * | 2006-04-18 | 2008-06-18 | Wyeth Corp | DERIVATIVES OF BENZODIOXAN AND BENZODIOXOLAN. OBTAINING PROCESSES. |
| TW200823187A (en) * | 2006-10-24 | 2008-06-01 | Wyeth Corp | Benzodioxane derivatives and uses thereof |
| WO2009133110A1 (en) | 2008-04-29 | 2009-11-05 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Modulators of dopamine neurotransmission |
| US20110105462A1 (en) * | 2008-04-29 | 2011-05-05 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Modulators of dopamine neurotransmission |
| WO2009133107A1 (en) | 2008-04-29 | 2009-11-05 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Modulators of dopamine neurotransmission |
| GB201801128D0 (en) | 2018-01-24 | 2018-03-07 | Univ Oxford Innovation Ltd | Compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL281245A (en) * | 1962-07-20 | |||
| CA1147342A (en) * | 1977-10-12 | 1983-05-31 | Kazuo Imai | Process of producing novel phenylethanolamine derivatives |
-
1999
- 1999-03-30 FR FR9903936A patent/FR2791675B1/en not_active Expired - Fee Related
-
2000
- 2000-03-27 WO PCT/FR2000/000762 patent/WO2000058301A1/en active Application Filing
- 2000-03-27 AU AU36607/00A patent/AU3660700A/en not_active Abandoned
- 2000-03-29 CO CO00022433A patent/CO5170535A1/en not_active Application Discontinuation
- 2000-03-29 UY UY26085A patent/UY26085A1/en unknown
- 2000-03-30 PE PE2000000275A patent/PE20001598A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000058301A1 (en) | 2000-10-05 |
| UY26085A1 (en) | 2000-10-31 |
| AU3660700A (en) | 2000-10-16 |
| FR2791675A1 (en) | 2000-10-06 |
| PE20001598A1 (en) | 2001-04-01 |
| FR2791675B1 (en) | 2001-05-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |