CO5070698A1 - STREPTOMYCES GENE AVERMITILIS THAT DIRECTS THE RELATIONSHIP OF AVERMECTINES B2: B1 - Google Patents
STREPTOMYCES GENE AVERMITILIS THAT DIRECTS THE RELATIONSHIP OF AVERMECTINES B2: B1Info
- Publication number
- CO5070698A1 CO5070698A1 CO99008652A CO99008652A CO5070698A1 CO 5070698 A1 CO5070698 A1 CO 5070698A1 CO 99008652 A CO99008652 A CO 99008652A CO 99008652 A CO99008652 A CO 99008652A CO 5070698 A1 CO5070698 A1 CO 5070698A1
- Authority
- CO
- Colombia
- Prior art keywords
- avermitilis
- avermectines
- directs
- relationship
- streptomyces gene
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a moléculas polinucleotídicas que comprenden secuencias de nucleótidos que codifican un producto génico AveC, moléculas polinucleotídicas que pueden usarse para alterar la relación o cantidad de avermectinas de clases 2:1 producidas en cultivos de fermentación de S. Avermitilis. La presente invensión se refiere además a vectores, células hospedadoras y cepas mutantes de S. Avermitilis en las que el gen aveC se ha inactivado o mutado para cambiar la relación o cantidad de avermectinas de clases 2:1 producidas.The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an AveC gene product, polynucleotide molecules that can be used to alter the ratio or amount of 2: 1 class avermectins produced in S. Avermitilis fermentation cultures. The present invention further relates to vectors, host cells and mutant strains of S. Avermitilis in which the aveC gene has been inactivated or mutated to change the ratio or amount of 2: 1 class avermectins produced.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7463698P | 1998-02-13 | 1998-02-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5070698A1 true CO5070698A1 (en) | 2001-08-28 |
Family
ID=22120706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99008652A CO5070698A1 (en) | 1998-02-13 | 1999-02-12 | STREPTOMYCES GENE AVERMITILIS THAT DIRECTS THE RELATIONSHIP OF AVERMECTINES B2: B1 |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP1053335A1 (en) |
| JP (2) | JP2002503473A (en) |
| KR (3) | KR20040053390A (en) |
| CN (2) | CN1521180A (en) |
| AP (1) | AP9901463A0 (en) |
| AR (1) | AR018085A1 (en) |
| AU (1) | AU752343C (en) |
| BG (1) | BG64911B1 (en) |
| BR (1) | BR9907893A (en) |
| CA (2) | CA2320031A1 (en) |
| CO (1) | CO5070698A1 (en) |
| DZ (1) | DZ2720A1 (en) |
| EA (1) | EA003905B1 (en) |
| GT (1) | GT199900014A (en) |
| HN (1) | HN1999000008A (en) |
| HR (1) | HRP20000539A2 (en) |
| HU (1) | HUP0100784A3 (en) |
| IL (2) | IL137610A0 (en) |
| IS (1) | IS5567A (en) |
| MA (1) | MA24760A1 (en) |
| NO (1) | NO20004044L (en) |
| NZ (2) | NZ505676A (en) |
| OA (1) | OA11449A (en) |
| PA (1) | PA8467601A1 (en) |
| PE (1) | PE20000352A1 (en) |
| PL (1) | PL194270B1 (en) |
| SK (1) | SK11722000A3 (en) |
| TN (1) | TNSN99017A1 (en) |
| TW (1) | TW585910B (en) |
| WO (1) | WO1999041389A1 (en) |
| YU (1) | YU50900A (en) |
| ZA (1) | ZA991138B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6248579B1 (en) * | 1998-02-13 | 2001-06-19 | Pfizer Inc | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins |
| KR20040053390A (en) * | 1998-02-13 | 2004-06-23 | 화이자 프로덕츠 인코포레이티드 | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
| PT1200606E (en) * | 1999-08-12 | 2006-12-29 | Pfizer Prod Inc | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
| US7630836B2 (en) | 2001-05-30 | 2009-12-08 | The Kitasato Institute | Polynucleotides |
| CA2475214C (en) * | 2002-02-12 | 2012-07-31 | Pfizer Products Inc. | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
| CN107338210B (en) * | 2017-09-05 | 2021-08-17 | 天津科技大学 | A kind of Streptomyces avermitilis synthetic medium and preparation method of fermentation broth thereof |
| CN111269296B (en) * | 2020-03-06 | 2021-11-05 | 山东大学 | nLsA protein, structural gene thereof and application thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE434277B (en) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | SET TO MAKE NEW ANTIHELMINTICALLY EFFECTIVE ASSOCIATIONS BY CULTIVATING STREPTOMYCS AVERMITILIS |
| US4429042A (en) * | 1978-09-08 | 1984-01-31 | Merck & Co., Inc. | Strain of Streptomyces for producing antiparasitic compounds |
| IN167980B (en) * | 1987-01-23 | 1991-01-19 | Pfizer | |
| ES2054822T3 (en) * | 1987-10-23 | 1994-08-16 | Pfizer | PROCEDURE FOR THE PRODUCTION OF AVERMECTIN AGLICONES AND THEIR CROPS. |
| JPH0747171B2 (en) * | 1988-09-20 | 1995-05-24 | 株式会社東芝 | Rolling mill setting method and device |
| ATE129286T1 (en) * | 1989-03-31 | 1995-11-15 | Merck & Co Inc | CLONING OF STREPTOMYCES AVERMITILIS GENES FOR BIOSYNTHESIS OF AVERMECTIN AND METHOD FOR USE THEREOF. |
| US5252474A (en) * | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| JP2888586B2 (en) * | 1990-03-05 | 1999-05-10 | 社団法人北里研究所 | Microorganism for selective production of specific components of avermectin and its selective production method |
| FI942725A (en) * | 1993-12-16 | 1995-06-17 | Pfizer | Genes encoding branched chain alpha-keto acid dehydrogenase complex from Streptomyces avermitilis |
| KR20040053390A (en) * | 1998-02-13 | 2004-06-23 | 화이자 프로덕츠 인코포레이티드 | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
-
1999
- 1999-01-25 KR KR10-2004-7008310A patent/KR20040053390A/en active Search and Examination
- 1999-01-25 WO PCT/IB1999/000130 patent/WO1999041389A1/en not_active Application Discontinuation
- 1999-01-25 JP JP2000531570A patent/JP2002503473A/en active Pending
- 1999-01-25 CN CNA2004100054154A patent/CN1521180A/en active Pending
- 1999-01-25 NZ NZ505676A patent/NZ505676A/en unknown
- 1999-01-25 CA CA002320031A patent/CA2320031A1/en not_active Abandoned
- 1999-01-25 CN CN99805027A patent/CN1297485A/en active Pending
- 1999-01-25 PL PL99342468A patent/PL194270B1/en not_active IP Right Cessation
- 1999-01-25 CA CA002521289A patent/CA2521289A1/en not_active Abandoned
- 1999-01-25 EA EA200000758A patent/EA003905B1/en not_active IP Right Cessation
- 1999-01-25 IL IL13761099A patent/IL137610A0/en unknown
- 1999-01-25 NZ NZ518657A patent/NZ518657A/en unknown
- 1999-01-25 BR BR9907893-7A patent/BR9907893A/en not_active Application Discontinuation
- 1999-01-25 AU AU18878/99A patent/AU752343C/en not_active Ceased
- 1999-01-25 KR KR10-2000-7008870A patent/KR100499214B1/en not_active IP Right Cessation
- 1999-01-25 SK SK1172-2000A patent/SK11722000A3/en unknown
- 1999-01-25 EP EP99900270A patent/EP1053335A1/en not_active Withdrawn
- 1999-01-25 KR KR10-2004-7015691A patent/KR20040099389A/en active Search and Examination
- 1999-01-25 YU YU50900A patent/YU50900A/en unknown
- 1999-01-25 HU HU0100784A patent/HUP0100784A3/en not_active Application Discontinuation
- 1999-01-26 PA PA19998467601A patent/PA8467601A1/en unknown
- 1999-02-01 GT GT199900014A patent/GT199900014A/en unknown
- 1999-02-05 HN HN1991000008A patent/HN1999000008A/en unknown
- 1999-02-08 PE PE1999000099A patent/PE20000352A1/en not_active Application Discontinuation
- 1999-02-09 TW TW088102005A patent/TW585910B/en active
- 1999-02-10 TN TNTNSN99017A patent/TNSN99017A1/en unknown
- 1999-02-10 DZ DZ990021A patent/DZ2720A1/en active
- 1999-02-10 MA MA25460A patent/MA24760A1/en unknown
- 1999-02-11 AP APAP/P/1999/001463A patent/AP9901463A0/en unknown
- 1999-02-11 AR ARP990100571A patent/AR018085A1/en unknown
- 1999-02-12 CO CO99008652A patent/CO5070698A1/en unknown
- 1999-02-12 ZA ZA9901138A patent/ZA991138B/en unknown
-
2000
- 2000-07-20 IS IS5567A patent/IS5567A/en unknown
- 2000-08-04 OA OA1200000217A patent/OA11449A/en unknown
- 2000-08-11 NO NO20004044A patent/NO20004044L/en not_active Application Discontinuation
- 2000-08-11 HR HR20000539A patent/HRP20000539A2/en not_active Application Discontinuation
- 2000-09-12 BG BG104759A patent/BG64911B1/en unknown
-
2004
- 2004-04-27 JP JP2004130624A patent/JP4011036B2/en not_active Expired - Fee Related
-
2007
- 2007-05-31 IL IL183596A patent/IL183596A0/en unknown
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