CO4990972A1 - Derivados de eritromicina en puente 6,11 - Google Patents
Derivados de eritromicina en puente 6,11Info
- Publication number
- CO4990972A1 CO4990972A1 CO98062727A CO98062727A CO4990972A1 CO 4990972 A1 CO4990972 A1 CO 4990972A1 CO 98062727 A CO98062727 A CO 98062727A CO 98062727 A CO98062727 A CO 98062727A CO 4990972 A1 CO4990972 A1 CO 4990972A1
- Authority
- CO
- Colombia
- Prior art keywords
- group
- substituted
- absent
- aryl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Un compuesto seleccionado del grupo que consiste de:en dondem es 0, 1, 2, 3, 4, 5, 6, o 7;n es 0, 1, 2, 3 o 4;Rp es independientemente hidrógeno o un grupo protector hidroxi cada vez que ocurre;A está ausente o es seleccionada del grupo que consiste de(1) -O-, y(2) -N(R1 )-, en donde R1 es hidrógeno o alquil- C1 -C6 opcionalmente substituido con arilo oheteroaril;B está ausente o es seleccionado del grupo que consiste de(1) -(CH2 )q -, en donde q es 0, 1, 2, 3, 4, 5 o 6,(2) -C(O)-(CH2 )q -,(3) -C(O)-O-(CH2 )q -,(4) -C(O)-NR1 -(CH2 )q -, donde R1 es como se definió previamente, y(5) -N=CH-(CH2 )q -,(6) -CH(OH)-(CH2 )q -, y(7) -CH(OH)-CH(OH)-(CH2 )q -;D está ausente o es seleccionado del grupo que consiste de(1) alquenileno,(2) arileno,(3) arileno substituido por reemplazo independiente de uno, dos o tres de los átomos de hidrógeno con halo, hidroxi, ciano, alquil C1 -C3 , alcoxi C1 -C6 , alcoxi C1 -C6 substituido con aril, haloalquil, tioalcoxi, amina, alquilamina, dialquilamina, mercapto, nitro, carboxaldehído, carboxi, alcoxicarbonil y carboxamida. Adicionalmente cualquier substituyente puede ser un grupo aril, heteroaril o heterocicloalquil,(4) heteroarileno,(5) heteroarileno substituido por reemplazo independiente de uno, dos o tres de losátomos de hidrógeno con Cl, Br, F, I, OH, CN, ...
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96040097A | 1997-10-29 | 1997-10-29 | |
| US15826998A | 1998-09-22 | 1998-09-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4990972A1 true CO4990972A1 (es) | 2000-12-26 |
Family
ID=26854886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO98062727A CO4990972A1 (es) | 1997-10-29 | 1998-10-27 | Derivados de eritromicina en puente 6,11 |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1027361B1 (es) |
| JP (1) | JP2001521038A (es) |
| KR (1) | KR20010031591A (es) |
| CN (1) | CN1278266A (es) |
| AR (1) | AR015986A1 (es) |
| AT (1) | ATE239750T1 (es) |
| AU (1) | AU1286799A (es) |
| BG (1) | BG104425A (es) |
| BR (1) | BR9813317A (es) |
| CA (1) | CA2307828A1 (es) |
| CO (1) | CO4990972A1 (es) |
| DE (1) | DE69814441T2 (es) |
| DK (1) | DK1027361T3 (es) |
| ES (1) | ES2198766T3 (es) |
| HU (1) | HUP0004323A2 (es) |
| IL (1) | IL134996A0 (es) |
| NO (1) | NO20002099L (es) |
| PL (1) | PL340253A1 (es) |
| PT (1) | PT1027361E (es) |
| SK (1) | SK6342000A3 (es) |
| TR (1) | TR200001140T2 (es) |
| TW (1) | TW486485B (es) |
| WO (1) | WO1999021864A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6437106B1 (en) * | 1999-06-24 | 2002-08-20 | Abbott Laboratories | Process for preparing 6-o-substituted erythromycin derivatives |
| US6472372B1 (en) * | 2000-12-06 | 2002-10-29 | Ortho-Mcneil Pharmaceuticals, Inc. | 6-O-Carbamoyl ketolide antibacterials |
| JP2005503416A (ja) | 2001-09-17 | 2005-02-03 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | ６−ｏ−カルバメート−１１，１２−ラクト−ケトライド抗菌剤 |
| HUP0500018A3 (en) | 2001-12-05 | 2009-09-28 | Ortho Mcneil Pharm Inc | 6-o-acyl ketolide derivatives of erythromycine processes for preparing them and using them as antibacterials |
| US7910558B2 (en) * | 2002-05-13 | 2011-03-22 | Enanta Pharmaceuticals, Inc. | Bridged macrocyclic compounds and processes for the preparation thereof |
| AU2003229037B8 (en) * | 2002-05-13 | 2009-07-02 | Enanta Pharmaceuticals, Inc. | 6,11 bicyclic erythromycin derivatives |
| US7129221B2 (en) | 2002-05-13 | 2006-10-31 | Enanta Pharmaceuticals, Inc. | 6,11-bicyclic erythromycin derivatives |
| US6753318B1 (en) | 2002-07-25 | 2004-06-22 | Enanta Pharmaceuticals, Inc. | 6,11-4-carbon bridged erythromycin derivatives |
| US6841664B2 (en) | 2002-07-25 | 2005-01-11 | Enanra Pharmaceuticals, Inc. | 6,11-4-carbon bridged ketolides |
| US7273853B2 (en) | 2002-05-13 | 2007-09-25 | Enanta Pharmaceuticals, Inc. | 6-11 bicyclic ketolide derivatives |
| US6645941B1 (en) * | 2003-03-26 | 2003-11-11 | Enanta Pharmaceuticals, Inc. | 6,11-3C-bicyclic 9a-azalide derivatives |
| US7414030B2 (en) | 2004-01-07 | 2008-08-19 | Enanta Pharmaceuticals, Inc. | 6-11 Bicyclic erythromycin derivatives |
| WO2005070113A2 (en) | 2004-01-09 | 2005-08-04 | Enanta Pharmaceuticals, Inc. | 9n-substituted 6-11 bicyclic erythromycin derivatives |
| WO2005080408A1 (en) * | 2004-01-23 | 2005-09-01 | Enanta Pharmaceuticals, Inc. | Bridged macrocyclic compounds and processes for the preparation thereof |
| US7384921B2 (en) | 2004-02-20 | 2008-06-10 | Enanta Pharmaceuticals, Inc. | Polymorphic forms of 6-11 bicyclic ketolide derivatives |
| US7384922B2 (en) | 2005-05-04 | 2008-06-10 | Enanta Pharmaceuticals, Inc. | 6-11 bridged oxime erythromycin derivatives |
| US7589067B2 (en) | 2005-10-12 | 2009-09-15 | Enanta Pharmaceuticals, Inc. | 6, 11-bridged tricyclic macrolides |
| US8273720B2 (en) | 2007-09-17 | 2012-09-25 | Enanta Pharmaceuticals, Inc. | 6,11-bicyclolides: bridged biaryl macrolide derivatives |
| WO2018201076A2 (en) * | 2017-04-28 | 2018-11-01 | Macrolide Pharmaceuticals Inc. | Macrolides with modified desosamine sugars and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0876388B1 (en) * | 1995-11-08 | 2004-02-18 | Abbott Laboratories | Tricyclic erythromycin derivatives |
-
1998
- 1998-10-27 CO CO98062727A patent/CO4990972A1/es unknown
- 1998-10-27 AR ARP980105375A patent/AR015986A1/es unknown
- 1998-10-29 CA CA002307828A patent/CA2307828A1/en not_active Abandoned
- 1998-10-29 KR KR1020007004641A patent/KR20010031591A/ko not_active Application Discontinuation
- 1998-10-29 JP JP2000517973A patent/JP2001521038A/ja not_active Withdrawn
- 1998-10-29 HU HU0004323A patent/HUP0004323A2/hu unknown
- 1998-10-29 PT PT98956314T patent/PT1027361E/pt unknown
- 1998-10-29 WO PCT/US1998/022941 patent/WO1999021864A1/en not_active Application Discontinuation
- 1998-10-29 IL IL13499698A patent/IL134996A0/xx unknown
- 1998-10-29 SK SK634-2000A patent/SK6342000A3/sk unknown
- 1998-10-29 CN CN98810785A patent/CN1278266A/zh active Pending
- 1998-10-29 PL PL98340253A patent/PL340253A1/xx unknown
- 1998-10-29 DE DE69814441T patent/DE69814441T2/de not_active Expired - Fee Related
- 1998-10-29 DK DK98956314T patent/DK1027361T3/da active
- 1998-10-29 AU AU12867/99A patent/AU1286799A/en not_active Abandoned
- 1998-10-29 BR BR9813317-9A patent/BR9813317A/pt not_active IP Right Cessation
- 1998-10-29 EP EP98956314A patent/EP1027361B1/en not_active Expired - Lifetime
- 1998-10-29 ES ES98956314T patent/ES2198766T3/es not_active Expired - Lifetime
- 1998-10-29 TR TR2000/01140T patent/TR200001140T2/xx unknown
- 1998-10-29 AT AT98956314T patent/ATE239750T1/de not_active IP Right Cessation
- 1998-11-30 TW TW087117981A patent/TW486485B/zh active
-
2000
- 2000-04-25 NO NO20002099A patent/NO20002099L/no not_active Application Discontinuation
- 2000-05-11 BG BG104425A patent/BG104425A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1027361T3 (da) | 2003-08-25 |
| CA2307828A1 (en) | 1999-05-06 |
| ATE239750T1 (de) | 2003-05-15 |
| NO20002099D0 (no) | 2000-04-25 |
| EP1027361B1 (en) | 2003-05-07 |
| HUP0004323A2 (hu) | 2001-02-28 |
| DE69814441D1 (de) | 2003-06-12 |
| NO20002099L (no) | 2000-06-29 |
| SK6342000A3 (en) | 2000-09-12 |
| AR015986A1 (es) | 2001-05-30 |
| TW486485B (en) | 2002-05-11 |
| BR9813317A (pt) | 2000-08-22 |
| DE69814441T2 (de) | 2004-04-08 |
| PL340253A1 (en) | 2001-01-29 |
| BG104425A (bg) | 2001-01-31 |
| AU1286799A (en) | 1999-05-17 |
| ES2198766T3 (es) | 2004-02-01 |
| JP2001521038A (ja) | 2001-11-06 |
| WO1999021864A1 (en) | 1999-05-06 |
| CN1278266A (zh) | 2000-12-27 |
| KR20010031591A (ko) | 2001-04-16 |
| TR200001140T2 (tr) | 2001-05-21 |
| EP1027361A1 (en) | 2000-08-16 |
| PT1027361E (pt) | 2003-09-30 |
| IL134996A0 (en) | 2001-05-20 |
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