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CO4940475A1 - NOVEL SULFONAMIDE INHIBITORS FROM FARNESIL-PROTEIN TRANSFERASA - Google Patents

NOVEL SULFONAMIDE INHIBITORS FROM FARNESIL-PROTEIN TRANSFERASA

Info

Publication number
CO4940475A1
CO4940475A1 CO98034142A CO98034142A CO4940475A1 CO 4940475 A1 CO4940475 A1 CO 4940475A1 CO 98034142 A CO98034142 A CO 98034142A CO 98034142 A CO98034142 A CO 98034142A CO 4940475 A1 CO4940475 A1 CO 4940475A1
Authority
CO
Colombia
Prior art keywords
hydrogen
heterocycloalkyl
cycloalkyl
aryl
alkyl
Prior art date
Application number
CO98034142A
Other languages
Spanish (es)
Inventor
George F Njoroge
Vibulbhan Bancha
Arthur G Taveras
Ronald J Doll
M Girijavalla Wiyyoor
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CO4940475A1 publication Critical patent/CO4940475A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Un compuesto de fórmula 1: o una sal o solvato farmacéuticamente aceptable de los mismos, en los cuales: A representa N o N- óxido; X representa N, CH o C, de tal manera que cuando X es N o CH, haya un solo enlace con el átomo de carbono 11 representando por la línea plena; o cuando X es C, haya un doble enlace con el átomo de carbono 11, representando por la líneas plena y de puntos; X1 y X2 son independientemente seleccionados entre bromo, yodo y cloro; X3 y X4 son independientemente seleccionados entre bromo, yodo, fluoro o hidrógeno, siempre que solo uno de X3 y X4 sea hidrógeno; cada uno de R5 , R6 , R7 y R8 representa independientemente hidrógeno, alquilo, arilo -CONR20 R21 , donde R20 y R21 representan independientemente hidrógeno, alquilo, alcoxi, arilo, aralquilo, heteroarilo, heteroarialquilo, cicloalquilo, cicloalquialquilo, heterocicloalquilo y heterocicloalquialquilo, y además donde R5 se puede combinar con R6 para representar =O o =S y/o R7 se puede combinar con R8 para representar =O o =S; R puede representar alquilo, arilo, arialquilo, heteroarilo, heteroarilalquilo, cicloalquilo, cicloalquilalquilo, heterocicloalquilo, heterocicloalquinalquilo o -NR10 R11 , donde R10 R11 puede representar independientemente hidrógeno, alquenilo, alquilo, arilo, aralquilo, heteroarilo, heteroarialquilo, cicloalquilo, cicloalquilalquilo, heterocicloalquilo o heterocicloalquilalquilo.A compound of formula 1: or a pharmaceutically acceptable salt or solvate thereof, in which: A represents N or N-oxide; X represents N, CH or C, such that when X is N or CH, there is a single bond with carbon atom 11 representing by the full line; or when X is C, there is a double bond with carbon atom 11, represented by the full and dotted lines; X1 and X2 are independently selected from bromine, iodine, and chlorine; X3 and X4 are independently selected from bromine, iodine, fluoro or hydrogen, provided that only one of X3 and X4 is hydrogen; each of R5, R6, R7 and R8 independently represents hydrogen, alkyl, aryl -CONR20 R21, where R20 and R21 independently represent hydrogen, alkyl, alkoxy, aryl, aralkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkyl, heterocycloalkyl and heterocycloalkyl, and furthermore where R5 can be combined with R6 to represent = O or = S and / or R7 can be combined with R8 to represent = O or = S; R can represent alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, -NR10 R11 heterocicloalquinalquilo or where R10 R11 can independently represent hydrogen, alkenyl, alkyl, aryl, aralkyl, heteroaryl, heteroarialquilo, cycloalkyl, cycloalkylalkyl, heterocycloalkyl or heterocycloalkylalkyl.

CO98034142A 1997-06-17 1998-06-16 NOVEL SULFONAMIDE INHIBITORS FROM FARNESIL-PROTEIN TRANSFERASA CO4940475A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87705097A 1997-06-17 1997-06-17

Publications (1)

Publication Number Publication Date
CO4940475A1 true CO4940475A1 (en) 2000-07-24

Family

ID=25369146

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98034142A CO4940475A1 (en) 1997-06-17 1998-06-16 NOVEL SULFONAMIDE INHIBITORS FROM FARNESIL-PROTEIN TRANSFERASA

Country Status (14)

Country Link
EP (1) EP0989980A1 (en)
JP (1) JP2002507192A (en)
KR (1) KR20010013826A (en)
CN (1) CN1267290A (en)
AR (1) AR012989A1 (en)
AU (1) AU8253698A (en)
CA (1) CA2293358C (en)
CO (1) CO4940475A1 (en)
HU (1) HUP0004627A2 (en)
IL (1) IL133393A0 (en)
NZ (1) NZ501619A (en)
PE (1) PE86199A1 (en)
WO (1) WO1998057949A1 (en)
ZA (1) ZA985218B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689789B2 (en) 1997-06-17 2004-02-10 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US7517884B2 (en) 1998-03-30 2009-04-14 Kalypsys Inc. Sulfonyl-substituted bicyclic compounds as modulators of PPAR
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
CA2429720C (en) * 2000-11-29 2009-12-29 Schering Corporation Tricyclic compounds useful for the inhibition of farnesyl protein transferase
JP5138377B2 (en) 2004-10-29 2013-02-06 カリプシス・インコーポレーテッド Substituted sulfonyl bicyclic compounds as modulators of PPARs
CN101331122B (en) 2005-10-25 2011-09-07 凯利普西斯公司 Salts of modulators of PPAR and methods of treating metabolic disorders
US20080176861A1 (en) 2007-01-23 2008-07-24 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
MX2015010407A (en) * 2013-02-19 2015-10-26 Icahn School Med Mount Sinai Tricyclic heterocycles as anticancer agents.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010514A1 (en) * 1993-10-15 1995-04-20 Schering Corporation Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL117797A0 (en) * 1995-04-07 1996-08-04 Pharmacopeia Inc Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
CN1267290A (en) 2000-09-20
JP2002507192A (en) 2002-03-05
CA2293358C (en) 2008-08-05
WO1998057949A1 (en) 1998-12-23
HUP0004627A2 (en) 2001-10-28
KR20010013826A (en) 2001-02-26
ZA985218B (en) 1998-12-15
IL133393A0 (en) 2001-04-30
AR012989A1 (en) 2000-11-22
PE86199A1 (en) 1999-09-24
EP0989980A1 (en) 2000-04-05
AU8253698A (en) 1999-01-04
NZ501619A (en) 2002-02-01
CA2293358A1 (en) 1998-12-23

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