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CO4410338A1 - DERIVATIVES ACETIDINILALQUIL-LACTAMA, PROCEDURES FOR THE PREPARATION OF SUCH DERIVATIVES, INTERMEDIATES USED IN THE PREPARATION OF THE SAME AND COMPOSITIONS THAT CONTAIN THEM. - Google Patents

DERIVATIVES ACETIDINILALQUIL-LACTAMA, PROCEDURES FOR THE PREPARATION OF SUCH DERIVATIVES, INTERMEDIATES USED IN THE PREPARATION OF THE SAME AND COMPOSITIONS THAT CONTAIN THEM.

Info

Publication number
CO4410338A1
CO4410338A1 CO95035201A CO95035201A CO4410338A1 CO 4410338 A1 CO4410338 A1 CO 4410338A1 CO 95035201 A CO95035201 A CO 95035201A CO 95035201 A CO95035201 A CO 95035201A CO 4410338 A1 CO4410338 A1 CO 4410338A1
Authority
CO
Colombia
Prior art keywords
cycloalkyl
derivatives
alkyl
preparation
compositions
Prior art date
Application number
CO95035201A
Other languages
Spanish (es)
Inventor
Alexander Roderick Mackenzie
Middleton Donald Stuart
Alan Patrick Marchington
Meadows Sandra Dora
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of CO4410338A1 publication Critical patent/CO4410338A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA COMPUESTOS DE LA FORMULA (I): FIGURA 1 Y SUS SALES ACEPTABLES FARMACEUTICAMENTE, EN LA QUE R ES CICLOALQUILO DE C3-C7, ARILO O ALQUILO DE C1-C6, ESTANDO DICHO ALQUILO DE C1-C6 OPCIONALMEN- TE SUBSTITUIDO POR FLUOR, -COOH, -COO (ALQUILO DE C1-C4), CICLOALQUILO DE C3-C7, ADAMANTILO, ARILO O HET1, Y ESTANDO DICHO CICLOALQUILO DE C3-C7 OPCIO- NALMENTE SUBSTITUIDO POR 1 o 2 SUBSTITUYENTES, CA- DA UNO SELECCIONADO INDEPENDIENTEMENTE DE ALQUILO DE C1-C4, CICLOALQUILO DE C3-C7, ALCOXI DE C1-C4, HIDROXI, FLUOR, FLUOROALQUILO DE (C1-C4) Y FLUORO- ALCOXI DE (C1-C4), R1 ES FENILO, NAFTILO, TIENILO, BENZOTIENILO O IN- DOLILO, CADA UNO SUBSTITUIDO OPCIONALMENTE POR 1 o 2 SUBSTITUYENTES, CADA UNO SELECCIONADO INDEPEN- DIENTEMENTE DE ALQUILO DE C1-C4, ALCOXI DE C1-C4, HALO Y TRIFLUOROMETILO: R2 ES -CO2H, -CONR3R4, -CONR5 (CICLOALQUILO DE C3- C7), -NR5-(ALCANOILO DE C2-C5), -NR3R4, -NR5CONR5R6, (CICLOALQUILO DE C3-C7-ALQUILO DE C1-C4)R5N-, (CICLOALQUILO DE C3-C7-ALQUILO DE C1-C4)2N-, -NR5COCF3, -NR5SO2CF3, -NR5(SO2 ALQUILO DE C1-C4), -NR5SO2NR5R6, -NR5(SO2 ARILO), -N(ARILO)(SO2 AL- QUILO DE C1-C4), -OR5, -O(CICLOALQUILO DE C3-C7), -SO2NR5R6, het3 O UN GRUPO DE LA FORMULA FIGURA 2 X ES ALQUILENO DE C1-C4; X1 ES UN ENLACE DIRECTO O ALQUILENO DE C1-C6; X2 ES UN ENLACE DIRECTO, CO, SO2 o NR5CO; Y m ES 0, 1 o 2; JUNTO CON INTERMEDIOS USADOS EN LA PREPARACION DE TALES DERIVADOS, COMPOSICIONES QUE LOS CONTIENEN Y EL USO DE TALES DERIVADOS COMO AN- TAGONISTAS DE TAQUICININA.THE PRESENT INVENTION PROVIDES COMPOUNDS OF FORMULA (I): FIGURE 1 AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS, IN WHICH R IS CYCLOALKYL OF C3-C7, ARYL OR ALKYL OF C1-C6, OPTIONAL BUTTEN BY FLUORINE, -COOH, -COO (C1-C4 ALKYL), C3-C7 CYCLOALKYL, ADAMANTILO, ARYL OR HET1, AND BEING SAID C3-C7 CYCLOALKYL OPTIONALLY SUBSTITUTED BY 1 OR 2 SUBSTITUTES, CA- ONE SELECTED INDEPENDENTLY FROM C1-C4 ALKYL, C3-C7 CYCLOALKYL, C1-C4 ALCOXY, HYDROXY, FLUOR, FLUORO-ALKYL FROM (C1-C4), R1 ESPHYLENE, FLUORO-ALCOXY, (C1-C4) , BENZOTIENYL OR INDOLYL, EACH ONE OPTIONALLY SUBSTITUTED BY 1 or 2 SUBSTITUTES, EACH SELECTED INDEPENDENTLY FROM C1-C4 ALKYL, ALCOXI FROM C1-C4, HALO AND TRIFLUOROMETILE: R2 ES-CO3, R2 (CYCLOALKYL OF C3- C7), -NR5- (C2-C5 ALCANOYL), -NR3R4, -NR5CONR5R6, (CYCLLOALKYL OF C3-C7-ALKYL OF C1-C4) R5N-, (CYCLOALKYL OF C3-C7- O DE C1-C4) 2N-, -NR5COCF3, -NR5SO2CF3, -NR5 (SO2 ALQUILO DE C1-C4), -NR5SO2NR5R6, -NR5 (SO2 ARILO), -N (ARILO) (SO2 AL- QUILO DE C1-C4 ), -OR5, -O (C3-C7 CYCLOALKYL), -SO2NR5R6, het3 OR A GROUP OF THE FORMULA FIGURE 2 X IS C1-C4 ALKYLENE; X1 IS A DIRECT OR ALKYLENE LINK OF C1-C6; X2 IS A DIRECT LINK, CO, SO2 or NR5CO; Y m IS 0, 1 or 2; TOGETHER WITH INTERMEDIATES USED IN THE PREPARATION OF SUCH DERIVATIVES, COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH DERIVATIVES AS TACHYCININE ANTAGONISTS.

CO95035201A 1994-08-09 1995-08-08 DERIVATIVES ACETIDINILALQUIL-LACTAMA, PROCEDURES FOR THE PREPARATION OF SUCH DERIVATIVES, INTERMEDIATES USED IN THE PREPARATION OF THE SAME AND COMPOSITIONS THAT CONTAIN THEM. CO4410338A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9416084A GB9416084D0 (en) 1994-08-09 1994-08-09 Lactams
GB9417898A GB9417898D0 (en) 1994-08-09 1994-09-06 Lactams

Publications (1)

Publication Number Publication Date
CO4410338A1 true CO4410338A1 (en) 1997-01-09

Family

ID=10759627

Family Applications (1)

Application Number Title Priority Date Filing Date
CO95035201A CO4410338A1 (en) 1994-08-09 1995-08-08 DERIVATIVES ACETIDINILALQUIL-LACTAMA, PROCEDURES FOR THE PREPARATION OF SUCH DERIVATIVES, INTERMEDIATES USED IN THE PREPARATION OF THE SAME AND COMPOSITIONS THAT CONTAIN THEM.

Country Status (5)

Country Link
KR (1) KR100218626B1 (en)
CO (1) CO4410338A1 (en)
GB (2) GB9416084D0 (en)
PE (1) PE34696A1 (en)
PL (1) PL183180B1 (en)

Also Published As

Publication number Publication date
GB9417898D0 (en) 1994-10-26
KR100218626B1 (en) 1999-09-01
PL318534A1 (en) 1997-06-23
GB9416084D0 (en) 1994-09-28
KR970704729A (en) 1997-09-06
PL183180B1 (en) 2002-05-31
PE34696A1 (en) 1996-10-01

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