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CO4230016A1 - FENILTIOFENIL CICLOALQUENIL HIDROXIUREAS - Google Patents

FENILTIOFENIL CICLOALQUENIL HIDROXIUREAS

Info

Publication number
CO4230016A1
CO4230016A1 CO94056489A CO94056489A CO4230016A1 CO 4230016 A1 CO4230016 A1 CO 4230016A1 CO 94056489 A CO94056489 A CO 94056489A CO 94056489 A CO94056489 A CO 94056489A CO 4230016 A1 CO4230016 A1 CO 4230016A1
Authority
CO
Colombia
Prior art keywords
hidroxiureas
feniltiofenil
cicloalquenil
alkyl
hydrogen
Prior art date
Application number
CO94056489A
Other languages
Spanish (es)
Inventor
Akiyoshi Kawai
Rodney W Stevens
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CO4230016A1 publication Critical patent/CO4230016A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/47—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN COMPUESTO CON LA SIGUIENTE FORMULA QUIMICA: FIGURA 1 Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, EN LA QUE A Y B, SON INDEPENDIENTEMENTE HIDROGENO, HALOGENO, ALQUILO DE C1-C4, ALCOXI DE C1-C4, AL- QUILO DE C1-C4 HALO SUSTITUIDO O ALCOXI DE C1-C4 HALO SUSTITUIDO; R1 Y R2, SON INDEPENDIENTEMENTE, HIDROGENO, O ALQUILO DE C1-C4; X ES S, SO o SO2; Y Z ES METILO O ETILENO.A COMPOUND WITH THE FOLLOWING CHEMICAL FORMULA: FIGURE 1 AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS, IN WHICH AYB, ARE INDEPENDENTLY HYDROGEN, HALOGEN, ALKYL OF C1-C4, ALKYL OF C1-CX-AUTO FROM C1-C4 HALO REPLACED; R1 AND R2, ARE INDEPENDENTLY, HYDROGEN, OR C1-C4 ALKYL; X IS S, SO, or SO2; Y Z IS METHYL OR ETHYLENE.

CO94056489A 1993-12-22 1994-12-14 FENILTIOFENIL CICLOALQUENIL HIDROXIUREAS CO4230016A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP34561893 1993-12-22

Publications (1)

Publication Number Publication Date
CO4230016A1 true CO4230016A1 (en) 1995-10-19

Family

ID=18377822

Family Applications (1)

Application Number Title Priority Date Filing Date
CO94056489A CO4230016A1 (en) 1993-12-22 1994-12-14 FENILTIOFENIL CICLOALQUENIL HIDROXIUREAS

Country Status (9)

Country Link
EP (1) EP0736006A1 (en)
JP (1) JP2756732B2 (en)
AU (1) AU1120795A (en)
CA (1) CA2178833A1 (en)
CO (1) CO4230016A1 (en)
FI (1) FI946007L (en)
IL (1) IL111994A0 (en)
PE (1) PE36395A1 (en)
WO (1) WO1995017379A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3007138B2 (en) * 1990-11-27 2000-02-07 ファイザー製薬株式会社 Novel hydroxamic acid and N-hydroxyurea derivatives and compositions thereof
US5283361A (en) * 1991-04-23 1994-02-01 Eli Lilly And Company N-hydroxy-N-[3-[2-(halophenylthio)phenyl]prop-2-enyl]ureas as lipoxygenase inhibitors
JPH05294921A (en) * 1992-04-17 1993-11-09 Pfizer Pharmaceut Co Ltd New phenyl-substituted cycloalkylurea derivative and composition

Also Published As

Publication number Publication date
PE36395A1 (en) 1995-11-07
AU1120795A (en) 1995-07-10
CA2178833A1 (en) 1995-06-29
JPH09503226A (en) 1997-03-31
WO1995017379A1 (en) 1995-06-29
IL111994A0 (en) 1995-03-15
FI946007L (en) 1995-06-23
JP2756732B2 (en) 1998-05-25
EP0736006A1 (en) 1996-10-09
FI946007A0 (en) 1994-12-21

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