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CO4130314A1 - Cepa de streptomyces para producir compuestos antiparasitos y procedimientos con la misma - Google Patents

Cepa de streptomyces para producir compuestos antiparasitos y procedimientos con la misma

Info

Publication number
CO4130314A1
CO4130314A1 CO93419322A CO93419322A CO4130314A1 CO 4130314 A1 CO4130314 A1 CO 4130314A1 CO 93419322 A CO93419322 A CO 93419322A CO 93419322 A CO93419322 A CO 93419322A CO 4130314 A1 CO4130314 A1 CO 4130314A1
Authority
CO
Colombia
Prior art keywords
mutant
compounds
community
variant
niger nrrl
Prior art date
Application number
CO93419322A
Other languages
English (en)
Inventor
Rosanne Bonjouklian
Webster Godfrey Otis Jr
Allen Smitka Tim
Raymond Che-Fong Yao
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO4130314A1 publication Critical patent/CO4130314A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

REIVINDICAICON NUMERO UN CULTIVO BIOLOGICAMENTE PURO DEL MICROORGANISMO STREPTOMYCES AVERMITILIS SUBESPECIE NIGER NRRL 21005, O UN MUTANTE O VARIANTE PRODUCTOR DE AVER- MECTINAS DEL MISMO". REIVINDICACION NUMERO UN PROCEDIMIENTO PARA PRODUCIR AL MENOS UN COM- PUESTO DE AVERMECTINA, QUE COMPRENDE CULTIVAR ES- TREPTOMYCES AVERMITILIS SUBESPECIE NIGER NRRL 21005, O UN MUTANTE O VARIANTE PRODUCTO DE AVER- MECTINAS DEL DEL MISMO, EN UN MEDIO DE CULTIVO ACUOSO QUE CONTENGA FUENTES ASIMILABLES DE CARBO- NO, NITROGENO Y SALES INORGANICAS BAJO CONDICIONES AEROBICAS SUMERGIDAS HASTA QUE SE PRODUZCA AL ME- NOS UN COMPUESTO DE AVERMECTINA". REIVINDICACION NUMERO UN PROCEDIMIENTO PARA PRODUCIR INVERMECTINA, QUE COMPRENDE CULTIVAR STREPTOMYCES AVERMITILIS SUB- ESPECIE NIGER NRRL 21005, O UN MUTANTE O VARIANTE PRODUCTOR DE AVERMECTINAS DEL MISMO, EN UN MEDIO DE CULTIVO ACUOSO QUE CONTENGA FUENTES ASIMILABLES DE CARBONO, NITROGENO Y SALES INORGANICAS BAJO CONDICIONES AEROBICAS SUMERGIDAS, HASTA QUE SE PRODUZCAN LOS COMPUESTOS DE AVERMECTINA B1a y B1b, Y REDUCIR DICHOS COMPUESTOS B1a y B1b.
CO93419322A 1992-11-30 1993-11-22 Cepa de streptomyces para producir compuestos antiparasitos y procedimientos con la misma CO4130314A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/984,078 US5292647A (en) 1992-11-30 1992-11-30 Strain of streptomyces for producing avermectins and processes therewith

Publications (1)

Publication Number Publication Date
CO4130314A1 true CO4130314A1 (es) 1995-02-13

Family

ID=25530287

Family Applications (1)

Application Number Title Priority Date Filing Date
CO93419322A CO4130314A1 (es) 1992-11-30 1993-11-22 Cepa de streptomyces para producir compuestos antiparasitos y procedimientos con la misma

Country Status (21)

Country Link
US (1) US5292647A (es)
EP (1) EP0600656A3 (es)
JP (1) JPH06237761A (es)
KR (1) KR940011630A (es)
CN (1) CN1088983A (es)
AU (1) AU667141B2 (es)
BR (1) BR9304843A (es)
CA (1) CA2109767A1 (es)
CO (1) CO4130314A1 (es)
CZ (1) CZ282908B6 (es)
FI (1) FI935246A7 (es)
HU (1) HUT69970A (es)
IL (1) IL107702A (es)
MX (1) MX9307410A (es)
MY (1) MY109797A (es)
NO (1) NO934293L (es)
NZ (1) NZ250247A (es)
PH (1) PH30116A (es)
PL (1) PL301204A1 (es)
RU (1) RU2125609C1 (es)
ZA (1) ZA938723B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197591B1 (en) * 1998-09-14 2001-03-06 Pfizer Inc. Streptomyces avermitilis regulatory genes for increased avermectin production
RU2147320C1 (ru) * 1999-09-22 2000-04-10 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Штамм streptomyces avermitilis ницб 132-продуцент авермектинов
KR100419554B1 (ko) * 1999-10-29 2004-02-19 주식회사유한양행 아버멕틴의 정제방법
RU2182174C2 (ru) * 2000-01-31 2002-05-10 Мосин Владимир Александрович Способ выделения авермектиновых комплексов
CN1902537B (zh) * 2004-01-08 2010-12-08 夏普株式会社 显示装置用照明装置和液晶显示装置
CN100448984C (zh) * 2006-03-07 2009-01-07 广东省微生物研究所 粤蓝链霉菌
RU2391396C2 (ru) * 2007-04-27 2010-06-10 Государственное учреждение научно-исследовательский институт по изысканию новых антибиотиков им. Г.Ф. Гаузе РАМН (ГУ НИИНА им. Г.Ф.Гаузе РАМН) ШТАММ Streptomyces roseolus ВКПМ S-1082 - ПРОДУЦЕНТ ЛИНКОМИЦИНА И СПОСОБ ПОЛУЧЕНИЯ ЛИНКОМИЦИНА
WO2009131264A1 (en) * 2008-04-25 2009-10-29 Amorepacific Corporation Method for preparing ortho-dihydroxyisoflavones using a biotransformation system
CN102443555B (zh) * 2011-11-16 2013-04-24 南开大学 链霉菌Streptomyces sp.NK-660及其用于生产ε-聚赖氨酸的发酵培养方法
WO2017052232A1 (ko) * 2015-09-22 2017-03-30 주식회사 팜한농 밀베마이신을 생산하는 재조합 미생물 및 이를 이용한 밀베마이신 생산
KR102017788B1 (ko) * 2017-09-18 2019-09-03 주식회사 팜한농 밀베마이신 d를 생산하는 재조합 미생물 및 밀베마이신 d 생산 방법
CN114075527B (zh) * 2021-10-25 2024-03-26 成都大学 一种脂溶性抗生素生物发酵调控的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
US4378353A (en) * 1981-02-17 1983-03-29 Merck & Co., Inc. Novel C-076 compounds
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
EP0284176B1 (en) * 1987-01-23 1993-08-25 Pfizer Inc. Process for production of avermectins and cultures therefor
IN167980B (es) * 1987-01-23 1991-01-19 Pfizer
US5015662A (en) * 1988-10-18 1991-05-14 Merck & Co., Inc. Anthelmintic bioconversion products
JP2888586B2 (ja) * 1990-03-05 1999-05-10 社団法人北里研究所 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法

Also Published As

Publication number Publication date
PH30116A (en) 1996-12-27
FI935246L (fi) 1994-05-31
NZ250247A (en) 1994-12-22
IL107702A0 (en) 1994-02-27
FI935246A7 (fi) 1994-05-31
CZ282908B6 (cs) 1997-11-12
AU667141B2 (en) 1996-03-07
BR9304843A (pt) 1994-06-14
RU2125609C1 (ru) 1999-01-27
HU9303366D0 (en) 1994-03-28
CN1088983A (zh) 1994-07-06
NO934293L (no) 1994-05-31
KR940011630A (ko) 1994-06-21
FI935246A0 (fi) 1993-11-25
MY109797A (en) 1997-07-31
JPH06237761A (ja) 1994-08-30
US5292647A (en) 1994-03-08
NO934293D0 (no) 1993-11-26
AU5196093A (en) 1994-06-09
MX9307410A (es) 1994-07-29
CA2109767A1 (en) 1994-05-31
ZA938723B (en) 1995-05-22
EP0600656A3 (en) 1995-07-05
EP0600656A2 (en) 1994-06-08
PL301204A1 (en) 1994-06-13
IL107702A (en) 1998-10-30
CZ250293A3 (en) 1994-06-15
HUT69970A (en) 1995-09-28

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