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CO2023015244A2 - Inhibidores heteroaromáticos bicíclicos de la klk5 - Google Patents

Inhibidores heteroaromáticos bicíclicos de la klk5

Info

Publication number
CO2023015244A2
CO2023015244A2 CONC2023/0015244A CO2023015244A CO2023015244A2 CO 2023015244 A2 CO2023015244 A2 CO 2023015244A2 CO 2023015244 A CO2023015244 A CO 2023015244A CO 2023015244 A2 CO2023015244 A2 CO 2023015244A2
Authority
CO
Colombia
Prior art keywords
klk5
bicyclic heteroaromatic
inhibitors
klk5 inhibitors
compounds
Prior art date
Application number
CONC2023/0015244A
Other languages
English (en)
Inventor
Yarlagadda S Babu
Weihe Zhang
zhao Dang
Krishnan Raman
peng-cheng Lu
Pravin L Kotian
Original Assignee
Biocryst Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc
Publication of CO2023015244A2 publication Critical patent/CO2023015244A2/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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Abstract

Se divulgan compuestos de las Fórmulas (I) – (IV) y sales aceptables desde el punto de vista farmacéutico de estos, que son inhibidores de la peptidasa 5 relacionada con calicreína (KLK5). También se proporcionan composiciones farmacéuticas que comprenden tal compuesto, y métodos de uso de los compuestos y composiciones en el tratamiento o la prevención de una enfermedad o afección caracterizada por la actividad aberrante de KLK5, tal como el síndrome de Netherton.
CONC2023/0015244A 2021-04-14 2023-11-10 Inhibidores heteroaromáticos bicíclicos de la klk5 CO2023015244A2 (es)

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US202163174860P 2021-04-14 2021-04-14
PCT/US2022/024805 WO2022221526A1 (en) 2021-04-14 2022-04-14 Bicyclic heteroaromatic inhibitors of klk5

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CO2023015244A2 true CO2023015244A2 (es) 2023-11-30

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JP (1) JP2024513943A (es)
KR (1) KR20230171455A (es)
CN (1) CN117120419A (es)
AR (1) AR125358A1 (es)
AU (1) AU2022258575A1 (es)
BR (1) BR112023021030A2 (es)
CA (1) CA3216032A1 (es)
CL (1) CL2023003036A1 (es)
CO (1) CO2023015244A2 (es)
CR (1) CR20230522A (es)
CU (1) CU20230045A7 (es)
DO (1) DOP2023000221A (es)
EC (1) ECSP23084907A (es)
IL (1) IL307597A (es)
MX (1) MX2023012120A (es)
PE (1) PE20241352A1 (es)
PH (1) PH12023552856A1 (es)
TW (1) TW202304890A (es)
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WO2024179529A1 (zh) * 2023-02-28 2024-09-06 上海海雁医药科技有限公司 取代的三环衍生物及其药物组合物和用途
TW202448861A (zh) 2023-04-06 2024-12-16 美商輝瑞大藥廠 經取代吲唑丙酸衍生化合物及其用途

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HUE027370T2 (en) * 2005-06-22 2016-10-28 Plexxikon Inc Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors
UY38912A (es) * 2019-10-09 2021-05-31 Biocryst Pharm Inc Inhibidores del factor d del complemento para administración oral

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EP4323344A1 (en) 2024-02-21
CU20230045A7 (es) 2024-05-07
ECSP23084907A (es) 2023-12-29
UY39727A (es) 2022-11-30
BR112023021030A2 (pt) 2023-12-12
JP2024513943A (ja) 2024-03-27
CN117120419A (zh) 2023-11-24
PE20241352A1 (es) 2024-07-03
IL307597A (en) 2023-12-01
WO2022221526A1 (en) 2022-10-20
PH12023552856A1 (en) 2024-05-20
CL2023003036A1 (es) 2024-03-22
DOP2023000221A (es) 2023-11-15
AR125358A1 (es) 2023-07-12
MX2023012120A (es) 2023-10-24
TW202304890A (zh) 2023-02-01
AU2022258575A1 (en) 2023-11-23
CR20230522A (es) 2024-02-20
CA3216032A1 (en) 2022-10-20
KR20230171455A (ko) 2023-12-20
US20240239752A1 (en) 2024-07-18

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