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CO2020005351A2 - Uso de inhibidores de p38 para reducir la expresión de dux4 - Google Patents

Uso de inhibidores de p38 para reducir la expresión de dux4

Info

Publication number
CO2020005351A2
CO2020005351A2 CONC2020/0005351A CO2020005351A CO2020005351A2 CO 2020005351 A2 CO2020005351 A2 CO 2020005351A2 CO 2020005351 A CO2020005351 A CO 2020005351A CO 2020005351 A2 CO2020005351 A2 CO 2020005351A2
Authority
CO
Colombia
Prior art keywords
dux4
expression
inhibitors
dux4 expression
reduce
Prior art date
Application number
CONC2020/0005351A
Other languages
English (en)
Inventor
Angela Marie Cacace
Soto Luis Gustavo Alejandro Rojas
Lorin A Thompson Iii
Owen Brendan Wallace
Lucienne V Ronco
Ning Shen
Alan Scott Robertson
Aaron Nakwon Chang
Original Assignee
Fulcrum Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fulcrum Therapeutics Inc filed Critical Fulcrum Therapeutics Inc
Publication of CO2020005351A2 publication Critical patent/CO2020005351A2/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

La presente invención hace referencia a composiciones y métodos para inhibir la cinasa p38 para reducir la expresión de proteínas y genes de DUX4 y los genes posteriores regulados por DUX4. La presente invención hace referencia además a métodos para el tratamiento de pacientes que padecen de enfermedades y trastornos asociados con un aumento de la expresión de DUX4 o la expresión de una forma anómala de DUX4, tal como distrofia muscular facioescapulohumeral (FSHD).
CONC2020/0005351A 2017-10-05 2020-04-29 Uso de inhibidores de p38 para reducir la expresión de dux4 CO2020005351A2 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762568673P 2017-10-05 2017-10-05
US201762568754P 2017-10-05 2017-10-05
US201862682563P 2018-06-08 2018-06-08
US201862682565P 2018-06-08 2018-06-08
PCT/US2018/054638 WO2019071144A1 (en) 2017-10-05 2018-10-05 USE OF P38 INHIBITORS TO REDUCE DUX4 EXPRESSION

Publications (1)

Publication Number Publication Date
CO2020005351A2 true CO2020005351A2 (es) 2020-05-15

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Family Applications (2)

Application Number Title Priority Date Filing Date
CONC2020/0005351A CO2020005351A2 (es) 2017-10-05 2020-04-29 Uso de inhibidores de p38 para reducir la expresión de dux4
CONC2020/0005417A CO2020005417A2 (es) 2017-10-05 2020-04-30 Inhibidores de la quinasa p38 que reducen la expresión de dux4 y de los genes corriente abajo para el tratamiento de fshd

Family Applications After (1)

Application Number Title Priority Date Filing Date
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