CO2018001237A2 - Apramycin derivatives effective against multidrug resistant bacteria and compositions thereof - Google Patents
Apramycin derivatives effective against multidrug resistant bacteria and compositions thereofInfo
- Publication number
- CO2018001237A2 CO2018001237A2 CONC2018/0001237A CO2018001237A CO2018001237A2 CO 2018001237 A2 CO2018001237 A2 CO 2018001237A2 CO 2018001237 A CO2018001237 A CO 2018001237A CO 2018001237 A2 CO2018001237 A2 CO 2018001237A2
- Authority
- CO
- Colombia
- Prior art keywords
- compositions
- effective against
- resistant bacteria
- multidrug resistant
- against multidrug
- Prior art date
Links
- 241000894006 Bacteria Species 0.000 title abstract 3
- XZNUGFQTQHRASN-XQENGBIVSA-N apramycin Chemical class O([C@H]1O[C@@H]2[C@H](O)[C@@H]([C@H](O[C@H]2C[C@H]1N)O[C@@H]1[C@@H]([C@@H](O)[C@H](N)[C@@H](CO)O1)O)NC)[C@@H]1[C@@H](N)C[C@@H](N)[C@H](O)[C@H]1O XZNUGFQTQHRASN-XQENGBIVSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 208000035473 Communicable disease Diseases 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
Abstract
RESUMEN Se divulga un compuesto que se representa mediante la siguiente fórmula general (I) o una de sus sales o solvatos farmacéuticamente aceptables, y una de sus composiciones farmacéuticas y su uso para prevenir o tratar enfermedades infecciosas y un método para prevenir o tratar enfermedades infecciosas con el uso de aquellos regímenes. El compuesto que se representa mediante la fórmula (I) tiene una actividad antibacteriana frente a bacterias tanto gram-positivas como gram-negativas y es de utilidad en la prevención o el tratamiento de enfermedades infecciosas causadas por estas bacterias.SUMMARY A compound is disclosed which is represented by the following general formula (I) or one of its pharmaceutically acceptable salts or solvates, and one of its pharmaceutical compositions and its use for preventing or treating infectious diseases and a method for preventing or treating infectious diseases with the use of those regimes. The compound represented by formula (I) has antibacterial activity against both gram-positive and gram-negative bacteria and is useful in the prevention or treatment of infectious diseases caused by these bacteria.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015151250 | 2015-07-30 | ||
| PCT/JP2016/072400 WO2017018528A1 (en) | 2015-07-30 | 2016-07-29 | Novel aminoglycoside antibiotic effective against multidrug-resistant bacteria |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2018001237A2 true CO2018001237A2 (en) | 2018-05-10 |
Family
ID=57884581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2018/0001237A CO2018001237A2 (en) | 2015-07-30 | 2018-02-06 | Apramycin derivatives effective against multidrug resistant bacteria and compositions thereof |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10617704B2 (en) |
| EP (2) | EP3330275A4 (en) |
| JP (1) | JP6938376B2 (en) |
| KR (1) | KR102590696B1 (en) |
| CN (1) | CN108026133B (en) |
| AR (1) | AR105547A1 (en) |
| AU (1) | AU2016300993B2 (en) |
| CA (1) | CA2993425A1 (en) |
| CL (1) | CL2018000228A1 (en) |
| CO (1) | CO2018001237A2 (en) |
| HK (1) | HK1254239A1 (en) |
| IL (1) | IL257151B (en) |
| MX (1) | MX383996B (en) |
| MY (1) | MY186959A (en) |
| PH (1) | PH12018500202B1 (en) |
| RU (1) | RU2751634C2 (en) |
| SA (1) | SA518390825B1 (en) |
| SG (2) | SG10201913231RA (en) |
| TW (1) | TWI699372B (en) |
| UA (1) | UA123629C2 (en) |
| WO (1) | WO2017018528A1 (en) |
| ZA (1) | ZA201801312B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201913231RA (en) * | 2015-07-30 | 2020-03-30 | Microbial Chem Res Found | New effective aminoglycoside antibiotic for multidrug-resistant bacteria |
| JP2020055749A (en) * | 2017-01-27 | 2020-04-09 | 公益財団法人微生物化学研究会 | Novel aminoglycoside antibiotics effective against multidrug resistant bacteria |
| WO2018204358A1 (en) * | 2017-05-01 | 2018-11-08 | Wayne State University | Apramycin derivatives |
| JP2021138615A (en) * | 2018-05-31 | 2021-09-16 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | Method for producing aminoglycoside antibiotics effective against multidrug-resistant bacteria |
| KR102811984B1 (en) * | 2021-08-04 | 2025-05-26 | 서울대학교산학협력단 | Novel amikacin derivatives, process for their preparation, and their antibacterial use |
| CN116462721B (en) * | 2023-04-18 | 2024-02-02 | 江南大学 | Antibacterial aminoglycoside derivatives |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4424345A (en) | 1980-09-22 | 1984-01-03 | Eli Lilly And Company | 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process |
| US4468513A (en) | 1980-09-22 | 1984-08-28 | Eli Lilly And Company | 2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides |
| JPS5782399A (en) | 1980-09-22 | 1982-05-22 | Lilly Co Eli | 2-deoxystreptamine aminoglycoside derivative and manufacture |
| US4424344A (en) | 1980-09-22 | 1984-01-03 | Eli Lilly And Company | 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process |
| JPS5782398A (en) | 1980-09-22 | 1982-05-22 | Lilly Co Eli | 2-deoxystreptamine aminoglycoside derivative |
| JPS5772998A (en) | 1980-10-24 | 1982-05-07 | Shionogi & Co Ltd | Novel appamycin derivative |
| JPS5772999A (en) | 1980-10-24 | 1982-05-07 | Shionogi & Co Ltd | Novel 5-deoxyapramycin |
| US4385585A (en) * | 1981-10-27 | 1983-05-31 | Copco, Inc. | Teakettle having whistle cap |
| US4360665A (en) | 1981-12-24 | 1982-11-23 | Eli Lilly And Company | 4"-N-(Substituted)-apramycin antibiotic derivatives and intermediates therefor |
| US4379917A (en) | 1981-12-24 | 1983-04-12 | Eli Lilly And Company | 6"-(Substituted)-apramycin antibiotic derivatives and intermediates and starting materials therefor |
| US4458065A (en) | 1983-02-17 | 1984-07-03 | Eli Lilly And Company | 7-N-(Substituted-apramycin antibiotic derivatives and intermediates therefor |
| EP2010552B1 (en) | 2006-04-07 | 2011-07-06 | E.I. Du Pont De Nemours And Company | Processes for chemical synthesis of lipochitooligosaccharides |
| CN101495493B (en) * | 2006-06-02 | 2012-11-14 | 明治制果药业株式会社 | Novel aminoglycoside antibiotic |
| HUE030523T2 (en) | 2007-11-21 | 2017-05-29 | Achaogen Inc | Antibacterial aminoglycoside analogs |
| TWI472521B (en) | 2008-07-17 | 2015-02-11 | Lexicon Pharmaceuticals Inc | Solid forms of (2s,3r,4r,5s,6r)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2h-pyran-3,4,5-triol and methods of their use |
| CN111388489A (en) * | 2010-09-13 | 2020-07-10 | 苏黎世大学 | Application of apramycin in preparation of bacterial infectious disease treatment |
| WO2013191550A1 (en) | 2012-06-20 | 2013-12-27 | Rijksuniversiteit Groningen | Regioselective diazotation of aminoglycosides |
| RU2491921C1 (en) | 2012-07-11 | 2013-09-10 | Общество с ограниченной ответственностью "Опытно-технологическая фирма "Этрис" | Method of treating mastitis in non-lactating cows |
| SG10201913231RA (en) * | 2015-07-30 | 2020-03-30 | Microbial Chem Res Found | New effective aminoglycoside antibiotic for multidrug-resistant bacteria |
-
2016
- 2016-07-29 SG SG10201913231RA patent/SG10201913231RA/en unknown
- 2016-07-29 MX MX2018001022A patent/MX383996B/en unknown
- 2016-07-29 HK HK18113382.9A patent/HK1254239A1/en unknown
- 2016-07-29 MY MYPI2018700342A patent/MY186959A/en unknown
- 2016-07-29 RU RU2018107150A patent/RU2751634C2/en active
- 2016-07-29 SG SG11201800510WA patent/SG11201800510WA/en unknown
- 2016-07-29 AR ARP160102333A patent/AR105547A1/en unknown
- 2016-07-29 AU AU2016300993A patent/AU2016300993B2/en active Active
- 2016-07-29 TW TW105124162A patent/TWI699372B/en active
- 2016-07-29 KR KR1020187005745A patent/KR102590696B1/en active Active
- 2016-07-29 JP JP2017530947A patent/JP6938376B2/en active Active
- 2016-07-29 EP EP16830631.4A patent/EP3330275A4/en not_active Withdrawn
- 2016-07-29 US US15/747,581 patent/US10617704B2/en active Active
- 2016-07-29 CA CA2993425A patent/CA2993425A1/en active Pending
- 2016-07-29 CN CN201680044421.1A patent/CN108026133B/en active Active
- 2016-07-29 UA UAA201802040A patent/UA123629C2/en unknown
- 2016-07-29 WO PCT/JP2016/072400 patent/WO2017018528A1/en active Application Filing
- 2016-07-29 EP EP19154615.9A patent/EP3498723A1/en active Pending
-
2018
- 2018-01-25 IL IL257151A patent/IL257151B/en active IP Right Grant
- 2018-01-25 PH PH12018500202A patent/PH12018500202B1/en unknown
- 2018-01-26 CL CL2018000228A patent/CL2018000228A1/en unknown
- 2018-01-28 SA SA518390825A patent/SA518390825B1/en unknown
- 2018-02-06 CO CONC2018/0001237A patent/CO2018001237A2/en unknown
- 2018-02-26 ZA ZA2018/01312A patent/ZA201801312B/en unknown
-
2020
- 2020-01-22 US US16/749,191 patent/US11135234B2/en active Active
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