CO2017010727A2 - Derivados de (2r, 3r, 4s, 5r)-2-(pirrolo[2,3-d] pirimidin-7-il)-5-[(benzil)]tetrahidrofuran-3,4-diol activos como inhibidores de la proteína arginina metiltransferasa 5 (prmt5), composiciones y métodos de elaboración de los mismos - Google Patents
Derivados de (2r, 3r, 4s, 5r)-2-(pirrolo[2,3-d] pirimidin-7-il)-5-[(benzil)]tetrahidrofuran-3,4-diol activos como inhibidores de la proteína arginina metiltransferasa 5 (prmt5), composiciones y métodos de elaboración de los mismosInfo
- Publication number
- CO2017010727A2 CO2017010727A2 CONC2017/0010727A CO2017010727A CO2017010727A2 CO 2017010727 A2 CO2017010727 A2 CO 2017010727A2 CO 2017010727 A CO2017010727 A CO 2017010727A CO 2017010727 A2 CO2017010727 A2 CO 2017010727A2
- Authority
- CO
- Colombia
- Prior art keywords
- cancer
- methods
- prmt5
- pyrrolo
- pyrimidin
- Prior art date
Links
- -1 of (2r, 3r, 4s, 5r) -2- (pyrrolo [2,3-d] pyrimidin-7-yl) -5 - [(benzyl)] tetrahydrofuran-3,4-diol Chemical class 0.000 title abstract 2
- 101000757232 Homo sapiens Protein arginine N-methyltransferase 2 Proteins 0.000 title 1
- 102000046485 human PRMT2 Human genes 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 101150097768 prmt5 gene Proteins 0.000 title 1
- 229940121649 protein inhibitor Drugs 0.000 title 1
- 239000012268 protein inhibitor Substances 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 abstract 1
- 206010005003 Bladder cancer Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 abstract 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 abstract 1
- 206010039491 Sarcoma Diseases 0.000 abstract 1
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 abstract 1
- 208000006990 cholangiocarcinoma Diseases 0.000 abstract 1
- 206010017758 gastric cancer Diseases 0.000 abstract 1
- 208000005017 glioblastoma Diseases 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 201000002528 pancreatic cancer Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Chemical class 0.000 abstract 1
- 201000011549 stomach cancer Diseases 0.000 abstract 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 abstract 1
- 201000005112 urinary bladder cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a compuestos nucleósidos 5'-sustituidos novedosos, composiciones farmacéuticas que comprenden los compuestos, y métodos de utilización de los compuestos para tratar el cáncer, más particularmente para el tratamiento del cáncer, en particular los glioblastomas, melanoma, sarcomas, cáncer gástrico, cáncer de páncreas , colangiocarcinoma, cáncer de vejiga, cáncer de mama, cáncer de pulmón de células no pequeñas, leucemias, incluyendo leucemia mieloide aguda y los linfomas .
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15382225 | 2015-05-04 | ||
| PCT/US2016/029475 WO2016178870A1 (en) | 2015-05-04 | 2016-04-27 | 5'-substituted nucleoside analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2017010727A2 true CO2017010727A2 (es) | 2018-01-31 |
Family
ID=53177322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2017/0010727A CO2017010727A2 (es) | 2015-05-04 | 2017-10-20 | Derivados de (2r, 3r, 4s, 5r)-2-(pirrolo[2,3-d] pirimidin-7-il)-5-[(benzil)]tetrahidrofuran-3,4-diol activos como inhibidores de la proteína arginina metiltransferasa 5 (prmt5), composiciones y métodos de elaboración de los mismos |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US9840532B2 (es) |
| EP (1) | EP3292128A1 (es) |
| JP (2) | JP6181889B1 (es) |
| KR (1) | KR20170132871A (es) |
| CN (1) | CN107580602A (es) |
| AR (1) | AR104326A1 (es) |
| AU (1) | AU2016258485A1 (es) |
| BR (1) | BR112017020336A2 (es) |
| CA (1) | CA2981097A1 (es) |
| CL (1) | CL2017002637A1 (es) |
| CO (1) | CO2017010727A2 (es) |
| CR (1) | CR20170443A (es) |
| DO (1) | DOP2017000255A (es) |
| EA (1) | EA201792169A1 (es) |
| EC (1) | ECSP17072987A (es) |
| HK (1) | HK1244007A1 (es) |
| IL (1) | IL254409A0 (es) |
| MA (1) | MA42036A (es) |
| MX (1) | MX2017014001A (es) |
| PE (1) | PE20180231A1 (es) |
| PH (1) | PH12017502002A1 (es) |
| SG (1) | SG11201708345XA (es) |
| TN (1) | TN2017000459A1 (es) |
| TW (1) | TWI615400B (es) |
| WO (1) | WO2016178870A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2792899T3 (es) * | 2015-02-24 | 2020-11-12 | Pfizer | Derivados de nucleósidos sustituidos útiles como agentes anticancerosos |
| EP3574917A4 (en) * | 2017-01-27 | 2020-05-06 | University of Miyazaki | Anti-cancer agent, method for screening for anti-cancer agent, kit for determination of efficacy on cancer, and method for determining efficacy on cancer |
| WO2018152548A1 (en) | 2017-02-20 | 2018-08-23 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (prmt5) |
| WO2018152501A1 (en) | 2017-02-20 | 2018-08-23 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (prmt5) |
| WO2018160855A1 (en) | 2017-03-01 | 2018-09-07 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (prmt5) |
| PT3665179T (pt) | 2017-08-09 | 2021-09-10 | Prelude Therapeutics Inc | Inibidores seletivos da proteína arginina metiltransferase 5 (prmt5) |
| EP3700906A1 (en) * | 2017-10-26 | 2020-09-02 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (prmt5) |
| SMT202200396T1 (it) | 2017-12-13 | 2022-11-18 | Lupin Ltd | Composti eterociclici biciclici sostituiti come inibitori di prmt5 |
| US10711007B2 (en) | 2018-03-14 | 2020-07-14 | Prelude Therapeutics Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (PRMT5) |
| WO2019178368A1 (en) | 2018-03-14 | 2019-09-19 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (prmt5) |
| JP7337539B2 (ja) * | 2018-06-21 | 2023-09-04 | メディヴィル・アクチエボラーグ | 白血病療法のための塩基修飾シチジンヌクレオチド |
| WO2020033285A1 (en) * | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| KR20210129051A (ko) * | 2019-02-13 | 2021-10-27 | 프렐루드 테라퓨틱스, 인코포레이티드 | 단백질 아르기닌 메틸트랜스퍼라제 5(prmt5)의 선택적 억제제 |
| EP3980417B1 (en) | 2019-06-10 | 2023-09-27 | Lupin Limited | Prmt5 inhibitors |
| JP7706166B2 (ja) * | 2019-09-18 | 2025-07-11 | プレリュード・セラピューティクス・インコーポレイテッド | タンパク質アルギニンメチルトランスフェラーゼ５（ｐｒｍｔ５）の選択的阻害剤 |
| AU2020371295A1 (en) | 2019-10-22 | 2022-04-28 | Lupin Limited | Pharmaceutical combination of PRMT5 inhibitors |
| BR112022010943A2 (pt) | 2019-12-03 | 2022-10-11 | Lupin Ltd | Análogos de nucleosídeos substituídos como inibidores de prmt5 |
| GB202117230D0 (en) | 2021-11-29 | 2022-01-12 | Argonaut Therapeutics Ltd | Peptide vaccine |
| GB202203588D0 (en) | 2022-03-15 | 2022-04-27 | Argonaut Therapeutics Ltd | Cancer diagnostic |
| CN116211869B (zh) * | 2022-12-07 | 2023-08-01 | 浙江省肿瘤医院 | 含dna损伤修复抑制剂的药物混合物及混合方法、用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1212326A4 (en) | 1999-08-27 | 2003-08-20 | Icn Pharmaceuticals | NUCLEOSIDE ANALOGS OF PYRROLO 2,3-d] PYRIMIDINE |
| NZ544187A (en) * | 2005-12-15 | 2008-07-31 | Ind Res Ltd | Deazapurine analogs of 1'-aza-l-nucleosides |
| WO2011079236A1 (en) | 2009-12-22 | 2011-06-30 | The Ohio State University Research Foundation | Compositions and methods for cancer detection and treatment |
| WO2013009735A1 (en) | 2011-07-13 | 2013-01-17 | Merck Sharp & Dohme Corp. | 5'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| LT2935222T (lt) | 2012-12-21 | 2018-12-27 | Epizyme, Inc. | Prmt5 slopikliai ir jų panaudojimas |
| US9611257B2 (en) * | 2012-12-21 | 2017-04-04 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| US20150344457A1 (en) | 2012-12-21 | 2015-12-03 | Epizyme, Inc. | Methods of inhibiting prmt5 |
| JP2016505597A (ja) | 2012-12-21 | 2016-02-25 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
| US8940726B2 (en) | 2012-12-21 | 2015-01-27 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| EP2935240A1 (en) | 2012-12-21 | 2015-10-28 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| ES2792899T3 (es) * | 2015-02-24 | 2020-11-12 | Pfizer | Derivados de nucleósidos sustituidos útiles como agentes anticancerosos |
-
2016
- 2016-04-20 AR ARP160101081A patent/AR104326A1/es unknown
- 2016-04-22 TW TW105112724A patent/TWI615400B/zh not_active IP Right Cessation
- 2016-04-27 TN TNP/2017/000459A patent/TN2017000459A1/en unknown
- 2016-04-27 CN CN201680025080.3A patent/CN107580602A/zh active Pending
- 2016-04-27 CR CR20170443A patent/CR20170443A/es unknown
- 2016-04-27 HK HK18103599.9A patent/HK1244007A1/zh unknown
- 2016-04-27 KR KR1020177031713A patent/KR20170132871A/ko not_active Withdrawn
- 2016-04-27 SG SG11201708345XA patent/SG11201708345XA/en unknown
- 2016-04-27 EP EP16720676.2A patent/EP3292128A1/en not_active Withdrawn
- 2016-04-27 CA CA2981097A patent/CA2981097A1/en not_active Abandoned
- 2016-04-27 JP JP2016575652A patent/JP6181889B1/ja not_active Expired - Fee Related
- 2016-04-27 MX MX2017014001A patent/MX2017014001A/es unknown
- 2016-04-27 WO PCT/US2016/029475 patent/WO2016178870A1/en active Application Filing
- 2016-04-27 MA MA042036A patent/MA42036A/fr unknown
- 2016-04-27 BR BR112017020336-7A patent/BR112017020336A2/pt not_active Application Discontinuation
- 2016-04-27 AU AU2016258485A patent/AU2016258485A1/en not_active Abandoned
- 2016-04-27 EA EA201792169A patent/EA201792169A1/ru unknown
- 2016-04-27 PE PE2017002330A patent/PE20180231A1/es not_active Application Discontinuation
- 2016-04-27 US US15/139,370 patent/US9840532B2/en not_active Expired - Fee Related
-
2017
- 2017-02-15 JP JP2017025494A patent/JP2017125029A/ja active Pending
- 2017-09-11 IL IL254409A patent/IL254409A0/en unknown
- 2017-10-17 CL CL2017002637A patent/CL2017002637A1/es unknown
- 2017-10-20 CO CONC2017/0010727A patent/CO2017010727A2/es unknown
- 2017-10-30 DO DO2017000255A patent/DOP2017000255A/es unknown
- 2017-11-01 EC ECIEPI201772987A patent/ECSP17072987A/es unknown
- 2017-11-03 PH PH12017502002A patent/PH12017502002A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP17072987A (es) | 2018-02-28 |
| IL254409A0 (en) | 2017-11-30 |
| TWI615400B (zh) | 2018-02-21 |
| KR20170132871A (ko) | 2017-12-04 |
| TW201712022A (zh) | 2017-04-01 |
| PH12017502002A1 (en) | 2018-03-26 |
| HK1244007A1 (zh) | 2018-07-27 |
| AR104326A1 (es) | 2017-07-12 |
| US9840532B2 (en) | 2017-12-12 |
| CL2017002637A1 (es) | 2018-04-20 |
| CN107580602A (zh) | 2018-01-12 |
| JP6181889B1 (ja) | 2017-08-16 |
| JP2017125029A (ja) | 2017-07-20 |
| AU2016258485A1 (en) | 2017-10-12 |
| CR20170443A (es) | 2017-11-07 |
| EP3292128A1 (en) | 2018-03-14 |
| TN2017000459A1 (en) | 2019-04-12 |
| BR112017020336A2 (pt) | 2019-05-14 |
| EA201792169A1 (ru) | 2018-03-30 |
| PE20180231A1 (es) | 2018-01-31 |
| MA42036A (fr) | 2018-03-14 |
| JP2017525667A (ja) | 2017-09-07 |
| MX2017014001A (es) | 2018-03-16 |
| DOP2017000255A (es) | 2018-01-15 |
| WO2016178870A1 (en) | 2016-11-10 |
| SG11201708345XA (en) | 2017-11-29 |
| CA2981097A1 (en) | 2016-11-10 |
| US20160326208A1 (en) | 2016-11-10 |
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